mph Bangladesh


Neomycin + Bacitracin

(nee oh mye' sin) (bass i tray' sin)

PCaution when used during lactation  - Caution when used during pregnancy

LCaution when used during lactation  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Topical/Cutaneous
Bacterial skin infections
Adult: As cream containing 3300 units/g of neomycin and 250 units/g of bacitracin zinc: Apply a thin layer up to 3 times daily. As powder containing 5000 units/g of neomycin and 250 units/g of bacitracin zinc: Apply 2-4 times daily.
Overdosage Symptoms: Nephrotoxicity and ototoxicity may occur if significant amounts are absorbed systemically. Management: Discontinue the product and monitor patient's hearing acuity, renal, neuromuscular function and serum concentrations of neomycin and bacitracin. Haemodialysis may be useful in reducing neomycin levels.
Contraindications Hypersensitivity to aminoglycosides. Pre-existing nerve deafness. Neonates and infants <2 yr.
Special Precautions Neuromuscular disorders, hearing impaired, extensive skin damage. Avoid application in large quantities and prolonged use. Do not use if tympanic membrane is perforated. Pregnancy and lactation. Liver and renal impairment.
Adverse Drug Reactions Hypersensitivity reactions. Possibility of ototoxicity and nephrotoxicity if used in large quantities or on large areas for prolonged use.
Drug Interactions Additive toxicity with neurotoxic, ototoxic or nephrotoxic drugs. Increased neuromuscular blockade and possibly respiratory depression with neuromuscular blocking agents if significant amount of neomycin is absorbed systemically. Please consult detailed drug interactions before prescribing. 
Mechanism of Action Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci. Bacitracin, on the other hand, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g.Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents.
Absorption: Neomycin: Poorly absorbed from GI tract. Absorption may occur from peritoneum, respiratory tract, bladder, wounds and inflamed skin; increased when mucosa is damaged or inflamed. Bacitracin: Poorly absorbed from the GI tract or from intact or denuded skin, wounds or mucous membranes.
Distribution: Bacitracin: Diffuses into pleural and ascitic fluids.
Excretion: Neomycin: 97% of oral dose excreted unchanged in faeces; absorbed neomycin excreted by kidneys in active form; half life: 2-3 hr. Bacitracin: 10-40% of injected dose excreted slowly by kidney and appears in urine within 24 hr.
ATC Classification D06AX04 - neomycin; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. 
D06AX05 - bacitracin; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. 
B05CA09 - neomycin; Belongs to the class of antiinfectives used as irrigating solutions. 
J01GB05 - neomycin; Belongs to the class of other aminoglycosides. Used in the treatment of systemic infections. 
S02AA07 - neomycin; Belongs to the class of antiinfectives used in the treatment of ear infections. 
A07AA01 - neomycin; Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
R02AB01 - neomycin; Belongs to the class of antibiotics used in throat preparations. 
R02AB04 - bacitracin; Belongs to the class of antibiotics used in throat preparations. 
S03AA01 - neomycin; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. 
A01AB08 - neomycin; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
S01AA03 - neomycin; Belongs to the class of antibiotics. Used in the treatment of eye infections.

Brand/Product Info


Total Products : 6      
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
NEOCIN Plus Opsonin Pharma Limited Neomycin 3.5mg+ Bacitracin Zinc 400 IU+ Polymyxin B Sulphate 5000 IU /gm Ointment 10gm: 30.00 MRP
NEOGEN Plus General Pharmaceuticals Ltd Neomycin Zinc bacitracin Polymyxin B Sulphate 3mg+400 IU+5000 IU Ointment 10gm: 30.11 MRP
NEPRANOL CRM Square Pharmaceuticals Ltd. Neomycin + Polymyxin B + Pramoxine HCl (3.5mg + 10,000 IU + 10mg)/gm Cream 10 gm: 75.50 MRP
NUBA Plus Biopharma Laboratories Ltd Neomycin 3.5mg+ Bacitracin Zinc 400 IU+ Polymyxin B Sulphate 5000 IU /gm Ointment 10gm: 30.11 MRP
NUPRIN Alco Pharma Ltd Neomycin Sulphate 5.84mg+ Polymyxin B 10,000 unit+ Pramoxine 10mg Cream 5gm, 10gm & 30gm: 40.00, 75.00 & 140.00 MRP
TYBAC Somatec Pharmaceuticals Ltd. Neomycin Sulphate 5mg+ Bacitracin Zinc 4.56mg/gm Powder 5gm: 10.04 MRP

Gen. MedInfo

Neomycin, Bacitracin and Polymyxin

(nee oh mye' sin) (bass i tray' sin) (pol i mix' in) 

Why is this medication prescribed?

Neomycin, polymyxin, and bacitracin combination is used to prevent minor skin injuries such as cuts, scrapes, and burns from becoming infected. Neomycin, polymyxin, and bacitracin are in a class of medications called antibiotics. Neomycin, polymyxin, and bacitracin combination works by stopping the growth of bacteria.

How should this medicine be used?

Neomycin, polymyxin, and bacitracin combination comes as an ointment to apply to the skin. It is usually used one to three times a day. Neomycin, polymyxin, and bacitracin ointment is available without a prescription. However, your doctor may give you special directions on the proper use of this medication for your medical problem. Follow the directions on the package or those given to you by your doctor carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use neomycin, polymyxin, and bacitracin combination exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor or written on the package.

This medication is for use only on the skin. Do not let neomycin, polymyxin, and bacitracin combination get into your eyes, nose, or mouth and do not swallow it.

You may use neomycin, polymyxin, and bacitracin combination to treat minor skin injuries. However, you should not use this medication to treat deep cuts, puncture wounds, animal bites, serious burns, or any injuries that affect large areas of your body. You should call your doctor or get emergency medical help if you have these types of injuries. A different treatment may be needed. You should also stop using this medication and call your doctor if you use this medication to treat a minor skin injury and your symptoms do not go away within 1 week.

Do not apply this medication to a child's diaper area, especially if the skin surface is broken or raw, unless told to do so by a doctor. If you are told to apply it to a child's diaper area, do not use tightly fitting diapers or plastic pants.

To use the ointment, follow these steps:

  1. Wash your hands well with soap and water. Wash the injured area with soap and water and pat dry thoroughly with a clean towel.

  2. Apply a small amount of the ointment (an amount equal to the size of your finger tip) to the injured skin. A thin layer is all that is needed. Do not touch the tip of the tube to your skin, hands, or anything else.

  3. Replace and tighten the cap right away.

  4. You may cover the affected area with a sterile bandage.

  5. Wash your hands again.

Other uses for this medicine

 

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using neomycin, polymyxin, and bacitracin combination,

  • tell your doctor if you are allergic to neomycin; polymyxin; bacitracin; aminoglycoside antibiotics such as amikacin, gentamicin, kanamycin, paromomycin, and tobramycin; zinc; or any other medications.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention aminoglycoside antibiotics such as amikacin, gentamicin, kanamycin, paromomycin, and tobramycin. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had hearing problems or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using neomycin, polymyxin, and bacitracin combination, call your doctor.

What special dietary instructions should I follow?

 

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

 

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.

What side effects can this medication cause?

Neomycin, polymyxin, and bacitracin combination may cause side effects. If you experience any of the following symptoms, call your doctor immediately:

  • skin pain, irritation, burning, swelling, or redness

  • itching

  • rash

  • hives

  • red, scaly patches on skin

  • difficulty breathing or swallowing

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • hoarseness

  • chest tightness

  • faintness

  • dizziness

Neomycin, polymyxin, and bacitracin combination may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

What should I know about storage and disposal of this medication? 

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

What other information should I know? 

If your doctor has told you to use this medication, keep all appointments with your doctor. Call your doctor if you still have symptoms of infection after you finish using this medication as directed.

Ask your Doctor any questions you have about neomycin, polymyxin, and bacitracin combination.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.  

Ref:  U.S. National Library of Medicine.

 


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

 

 

Simple Breath Test Might Diagnose Heart Failure An experimental breath test, designed to quickly identify patients suffering from heart failure simply by analyzing the contents of a...
Osteoporosis drug stops Breast cancer growth   News & Events News & Events     HIGHLIGHTS Osteoporosis drug stops growth of breast cancer...
Generic drug safety info loophole FDA plans to close generic drug safety info loophole The US Food and Drug Administration has announced plans to speed up the dissemination of...
Large trials unpublished   News & Events News & Events   HIGHLIGHTS Almost 1 in 3 of large clinical trials unpublished after...
TB activists boo Indian minister News & Events News & Events   HIGHLIGHTS TB activists at world conference boo Indian minister off...
Key bone marrow protein identified News & Events News & Events   HIGHLIGHTS Key bone marrow protein identified as potential new leukemia...