Mupirocin

(myoo peer' oh sin)

P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Nasal
Eradication of nasal colonisation with Staphylococci aureus
Adult: As 2% nasal ointment: Apply into each nostril bid-tid for a max of 7 days. After application, the nostrils should be closed by pressing together and releasing the sides of the nose. 
Child: Adolescents (≥12 yr): Apply nasal ointment to the inner surface of both nostrils 2-3 times daily for 5-14 days. After application, the nostrils should be closed by pressing together and releasing the sides of the nose for approximately 1 min.
Topical/Cutaneous
Impetigo
Adult: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Child: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Topical/Cutaneous
Secondary skin infections
Adult: Apply a 2% cream tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Child: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Administration May be taken with or without food.
Contraindications Hypersensitivity to mupirocin or polyethylene glycol.
Special Precautions Mucosal surfaces of eye; renal impairment; extensive burns or open wounds. Pregnancy, lactation, children <3 mth.
Adverse Drug Reactions Burning, stinging, pain, itching, erythema, dryness, tenderness, dermatitis and rash.
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Storage Nasal: Store at or below 25°. Do not freeze. Topical/Cutaneous: Store at or below 25°. Do not freeze.
Pharmacology Mupirocin inhibits protein synthesis of the bacteria by binding to isoleucyl transfer RNA-synthetase. It is active against gram-positive and some gram-negative bacteria.
Absorption: Minimal systemic absorption through intact skin (<0.3%).
Distribution: Protein-binding: 95%
Metabolism: Hepatic, converted to monic acid.
Excretion: Urine; 17-36 min (elimination half-life).
ATC Classification D06AX09 - mupirocin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. 
R01AX06 - mupirocin ; Belongs to the class of other topical preparations used as nasal decongestants.

Brand/Product Info


Total Products : 11           
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
BACRON Biopharma Laboratories Ltd Mupirocin 2% w/w in Polyethylene glycol base Ointment 10gm: 125.47 MRP
BACTODERM UniDerma Pharmaceuticals Ltd. Mupirocin 2% w/w in Polyethylene glycol base Ointment 10gm: 140.00 MRP
BACTROBAN GlaxoSmithKline Bangladesh Limited Mupirocin 2% w/w in Polyethylene glycol base Ointment 15gm: 140.53 MRP
BACTROCIN 2% Square Pharmaceuticals Ltd. Mupirocin 2% Ointment 10 gm: 140.42 MRP
DERMOBAN Opsonin Pharma Limited Mupirocin 2% w/w in Polyethylene glycol base Ointment 10gm: 120.00 MRP
MUPI Alco Pharma Ltd Mupirocin 2% w/w in Polyethylene glycol base Ointment 10gm: 120.45 MRP
MUPIDERM OINMENT Healthcare Pharmacuticals Ltd. Mupirocin 20mg/gm (2%) Ointment 10gm, MRP 140 Tk
MUPIRON Eskayef Bangladesh Ltd Mupirocin 20mg/gm Ointment 10mg MRP: 130.00
MURODERM General Pharmaceuticals Ltd Mupirocin 2% w/w in Polyethylene glycol base Ointment 10gm: 140.53 MRP
MURON Drug International Ltd Mupirocin 2% w/w in Polyethylene glycol base Ointment 15gm: 130.00 MRP
Trego Incepta Pharmaceuticals Limited Mupirocin 20mg/gm Ointment 10gm x 1:MRP 140 Tk

Gen. MedInfo

Why is this medication prescribed? 

Mupirocin, an antibiotic, is used to treat impetigo as well as other skin infections caused by bacteria. It is not effective against fungal or viral infections.

This medication is sometimes prescribed for other uses; ask your doctor for more information.

How should this medicine be used?

Mupirocin comes in an ointment that is applied to the skin. Mupirocin usually is applied three times a day for 1 to 2 weeks. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Use mupirocin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Wash the affected skin area thoroughly, and then gently apply a small amount (a thin film) of the ointment. You may cover the area with a sterile gauze dressing.

Do not apply mupirocin to your eyes.

Do not apply mupirocin to burns unless told to do so by your doctor.

What special precautions should I follow?

Before using mupirocin,

  • tell your doctor if you are allergic to mupirocin or any other drugs.
  • tell your doctor what prescription and nonprescription medications you are taking, especially chloramphenicol (Chloromycetin).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using mupirocin, call your doctor.

What should I do if I forget a dose?

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.

What side effects can this medication cause?

Mupirocin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • burning, stinging, pain, itching, or rash

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.