Nystatin

(nye stat' in)

P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Oral
Intestinal or oropharyngeal candidiasis
Adult: 500,000 or 1,000,000 units 3-4 times daily.
Child: As oral suspension: 100,000 units 4 times daily.
Oral
Oral candidiasis
Adult: As pastilles or oral suspension; 100,000 units 4 times daily (US recommendation 200,000-400,000 units as lozenges or 400,000-600,000 units as oral suspension 4 times daily). Keep in contact with affected area for as long as possible. Avoid food and drink for 1 hr after dose. Continue for 48 hr after lesions have healed.
Child: >1 mth: As pastilles or oral suspension; 100,000 units 4 times daily (US recommendation 200,000-400,000 units as lozenges or 400,000-600,000 units as oral suspension 4 times daily). Keep in contact with affected area for as long as possible. Avoid food and drink for 1 hr after dose. Continue for 48 hr after lesions have healed.
Oral
Prophylaxis of intestinal candidiasis
Adult: 1,000,000 units daily in divided doses.
Child: Infants, as oral suspension: 100,000 units daily.
Vaginal
Vaginal candidiasis
Adult: 100,000-200,000 units daily for 14 days as pessaries or vaginal cream.
Topical/Cutaneous
Cutaneous or mucocutaneous mycotic infections
Adult: As ointment, gel, cream, or dusting powder containing 100,000 units/g: apply 2-4 times daily.
Child: As ointment, gel, cream, or dusting powder containing 100,000 units/g: apply 2-4 times daily.
Administration May be taken with or without food.
Contraindications Hypersensitivity.
Special Precautions Pregnancy, lactation.
Adverse Drug Reactions Diarrhoea, GI distress, nausea and vomiting. vaginal pessaries/cream: May damage latex contraceptives (e.g. diaphragms, condoms), additional contraceptive measures should be taken. Topical application: Irritation.
Food Interaction Oral suspension/drops: Reduced efficacy if food/drink taken within 1 hr of drug admin.
Pregnancy Category (US FDA) ROUTE: Vaginal
Category A
: Controlled studies in women fail to demonstrate a risk to the foetus in the 1st trimester (and there is no evidence of a risk in later trimesters), and the possibility of foetal harm remains remote.
 
ROUTE(S) : Mouth / Throat / PO / Topical
Category C
: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Oral: Store at 15-30°C. Topical/Cutaneous: Store at 15-30°C. Vaginal: Store at room temperature.
Pharmacology Nystatin, a polyene antifungal, binds to ergosterol in the fungal cell membrane. This binding affects the cell wall permeability allowing leakage of cellular contents.
ATC Classification D01AA01 - nystatin; Belongs to the class of antibiotics for topical use. Used in the treatment of fungal infection. 
A07AA02 - nystatin; Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
G01AA01 - nystatin; Belongs to the class of antibiotics. Used in the treatment of gynecological infections.

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Brand/Product Info


Total Products : 15               
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
CANDEX SUSP Square Pharmaceuticals Ltd. Nystatin 1 Lac Unit/ml Suspension 30 ml: 46.840 MRP
CANSTAT Jayson Pharmaceuticals Ltd. Nystatin 500,000 units Tablet 100's: 278.00 MRP
CANSTAT Drop Jayson Pharmaceuticals Ltd. Nystatin 100,000 Units Drop 10ml: 17.20 MRP
FEFUN Amico Laboratories Ltd. Nystatin 100,000 Units Drop 12ml: 21.00 MRP
FUNGISTIN Beximco Pharmaceuticals Ltd Nystatin BP 100,000 units/ml Suspension 12ml: 22.74 MRP
MYCOCIN IBN SINA Pharmaceutical Industry Ltd. Nystatin 500,000 units Tablet 28's: 141.40 MRP
MYCOCIN Drop IBN SINA Pharmaceutical Industry Ltd. Nystatin 100,000 Units Drop 12ml: 21.00 MRP
NAF Opsonin Pharma Limited Nystatin 100,000units/ml Drop 12ml: 20.00 MRP
NYSOL Edruc Limited Nystatin 100,000 Units Drop 12ml: 22.00 MRP
NYST Somatec Pharmaceuticals Ltd. Nystatin 100,000 Units Drop 12ml: 20.59 MRP
NYSTAT The Acme Laboratories Ltd. Nystatin 1 lac unit Tablet (Vaginal) 15's: 29.25 MRP
NYSTAT Drop The Acme Laboratories Ltd. Nystatin 100,000units/ml Drop 12ml: 22.59 MRP
NYSTAT Ointment The Acme Laboratories Ltd. Nystatin 100,000 Units Ointment 10gm: 20.23 MRP
ORNYS Kemiko Pharmaceuticals Ltd Nystatin 100,000 Units Drop 12ml: 20.00 MRP
ZENISTIN Zenith Pharmaceuticals Ltd. Nystatin 100,000 Units Drop 12ml: 20.11 MRP

Gen. MedInfo

Why is this medication prescribed?

Nystatin is used to treat fungal infections of the skin, mouth, vagina, and intestinal tract. Fungal medicines will not work for colds, flu, or other viral infections.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Nystatin may come as a tablet, capsule, and a liquid to take by mouth; a soft lozenge (pastille) to be dissolved slowly in the mouth; a tablet and vaginal cream to be inserted into the vagina; and in powder, ointment, and cream to be applied to the skin.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use nystatin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Allow the lozenges, if available (pastilles) to dissolve slowly in your mouth. Do not chew or swallow lozenges whole. Continue to use nystatin lozenges (pastilles) for at least 48 hours after symptoms of your mouth infection disappear.

Nystatin liquid usually is used three to five times a day for mouth infections and three times a day for intestinal infections. Shake the bottle well before each use to mix the medication evenly. If you are using liquid nystatin for a mouth infection, place half of the dose in each side of the mouth and hold it there or swish it throughout the mouth for several minutes before swallowing. Good oral hygiene, including proper care of dentures, is important for the cure of mouth infections. If you are using liquid nystatin for an intestinal infection, just swallow the liquid you measured from the dropper; there is no need to hold it or swish it in your mouth.

Nystatin skin ointment or cream usually is used several times a day for skin infections. Wash the affected area thoroughly. Apply a small amount of cream or ointment and gently and thoroughly massage it into your skin. If you use this medication on your face, keep it out of your eyes.

If you are using powder for infected feet, dust the powder inside your shoes and stockings as well as on your feet.

Nystatin vaginal tablets and cream usually are used once or twice a day for vaginal infections. Nystatin vaginal tablets usually are used for 2 weeks in women who are not pregnant and for 3 to 6 weeks before delivery in pregnant women. Continue to use the vaginal tablets and cream even if symptoms improve after a few days. Insert the vaginal tablets or cream high into the vagina. They each come with a special applicator for inserting them and directions. Unwrap the vaginal tablets just before inserting them. Read the directions provided with the tablets or cream and follow these steps:

1.         Fill the special applicator to the level indicated.

2.         Lie on your back with your knees drawn upward and spread apart.

3.         Gently insert the applicator into your vagina and push the plunger to release the medication.

4.         Withdraw the applicator and wash it with soap and warm water.

5.         Wash your hands promptly to avoid spreading the infection.

You may wish to wear a sanitary napkin while using the vaginal cream to protect your clothing against stains. Do not use a tampon because it will absorb the drug. Do not douche unless your doctor tells you to do so. Continue using nystatin vaginal cream or tablets even if you get your period during treatment.

What special precautions should I follow?

Before using nystatin,

•          tell your doctor if you are allergic to nystatin or any other drugs.

•          tell your doctor what prescription and nonprescription medications you are taking, including vitamins.

•          tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using nystatin, call your doctor.

What should I do if I forget a dose?

Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

What side effects can this medication cause?

Nystatin may cause side effects. Tell your doctor if any of these symptoms from the vaginal tablets and cream or skin ointment or cream are severe or do not go away:

•          itching

•          irritation

•          burning

If you experience any of the following symptoms from the oral tablets and liquid, call your doctor immediately:

•          diarrhea

•          nausea

•          stomach pain

•          skin rash

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Store nystatin powder, lozenges (pastilles), and vaginal tablets and cream in the refrigerator. Do not allow nystatin to freeze. Throw away any medication that is outdated or no longer needed.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to nystatin.

Do not let anyone else use your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the nystatin, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.