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P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Topical/Cutaneous
Severe inflammatory skin disorders
Adult: As cream/ointment. Each g contains clobetasol propionate 0.5 mg, neomycin sulfate 5 mg and nystatin 100 000 units. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision. 
Child: >2 yr: As cream/ointment. Each g contains clobetasol propionate 0.5 mg, neomycin sulfate 5 mg and nystatin 100 000 units. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision.
Contraindications Primary cutaneous viral infections, rosacea, acne vulgaris and perioral dermatitis. Neonates and infants.
Special Precautions Avoid prolonged treatment. Caution when applied to area near to the eyes. Renal impairment, elderly and children. Pregnancy and lactation.
Adverse Drug Reactions May cause atrophic changes in the skin e.g. skin thinning, striae and dilatation of superficial blood vessels. Pigmentation and hypertrichosis.
Drug Interactions If there is substantial systemic absorption, neomycin may prolong and intensify respiratory depressant effects of neuromuscular blockers. Please consult detailed drug interactions before prescribing.
Storage Store below 25°C.
Pharmacology Clobetasol is a highly active corticosteroid that has topical anti-inflammatory action brought about partly by vasoconstriction and reduced collagen synthesis. Neomycin is an aminoglycoside antibiotic that binds to ribosomal 30S and 50S subunits of susceptible bacteria, thus inhibiting protein synthesis; it also causes misreading of the genetic codes on the mRNA template. Nystatin works by binding to ergosterol in the cell membrane of fungus resulting in a change in the cell wall permeability and leakage of cellular components.
ATC Classification D01AA01 - nystatin; Belongs to the class of antibiotics for topical use. Used in the treatment of fungal infection. 
D07AD01 - clobetasol; Belongs to the class of very potent (group IV) corticosteroids. Used in the treatment of dermatological diseases. 
D06AX04 - neomycin; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. 
B05CA09 - neomycin; Belongs to the class of antiinfectives used as irrigating solutions. 
J01GB05 - neomycin; Belongs to the class of other aminoglycosides. Used in the treatment of systemic infections. 
S02AA07 - neomycin; Belongs to the class of antiinfectives used in the treatment of ear infections. 
A07AA02 - nystatin; Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
A07AA01 - neomycin; Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
R02AB01 - neomycin; Belongs to the class of antibiotics used in throat preparations. 
S03AA01 - neomycin; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. 
G01AA01 - nystatin; Belongs to the class of antibiotics. Used in the treatment of gynecological infections. 
A01AB08 - neomycin; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
S01AA03 - neomycin; Belongs to the class of antibiotics. Used in the treatment of eye infections.

Brand/Product Info


Total Products : 10          
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ACLOBET-N The Acme Laboratories Ltd. Clobetasol propionate BP 0.05% w/w+ Neomycin Sulphate BP 0.5% w/w+ Nystatin USP 100,000 unit/gm Cream/Ointment 10gm Cream, 15mg Oint.: 60.00 & 65.25 MRP
CLOBEON R A K Pharmaceuticals Pvt. Ltd. Clobetasol propionate BP 0.05% w/w+ Neomycin Sulphate BP 0.5% w/w+ Nystatin USP 100,000 unit/gm Cream 10gm: 60.00 MRP
CLOVATE-N ACI Ltd. Clobetasol propionate BP 0.05% w/w+ Neomycin Sulphate BP 0.5% w/w+ Nystatin USP 100,000 unit/gm Cream/Ointment 10gm Cream, 15mg Oint.: 60.23 & 65.25 MRP
DERMASOL-N CRM Square Pharmaceuticals Ltd. Clobetasol Propionate + Neomycin Sulphate + Nystatin (0.5mg + 5mg + 1 lac unit)/gm Cream 15 gm: 70.21 MRP
DERMASOL-N OINT Square Pharmaceuticals Ltd. Clobetasol Propionate + Neomycin Sulphate + Nystatin (0.5mg + 5mg + 1 lac unit)/gm Ointment 15 gm: 75.22 MRP
DERMEX NN Opsonin Pharma Limited Clobetasol propionate BP 0.05% w/w+ Neomycin Sulphate BP 0.5% w/w+ Nystatin USP 100,000 unit/gm Cream 10gm: 55.00 MRP
EXOVATE N Beximco Pharmaceuticals Ltd Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin 1 Lac IU/gm Ointment Cream 25gm: 75.00 MRP
Nyclobate NN 10 Incepta Pharmaceuticals Limited Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin 1 Lac IU/gm Ointment Cream 10gm x 1:MRP 60 Tk
Nyclobate NN 20 Incepta Pharmaceuticals Limited Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin 1 Lac IU/gm Ointment Cream 20gm x 1:MRP 80 Tk
VESOL-N Novo Healthcare and Pharma Ltd. Clobetasol propionate BP 0.05% w/w+ Neomycin Sulphate BP 0.5% w/w+ Nystatin USP 100,000 unit/gm Cream 10gm: 60.00 MRP
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