P  - Caution when used during pregnancy

Molecule Info

 
Indication & Dosage

Otic/Aural
Otitis externa
Adult: As otic ointment containing triamcinolone acetonide 0.1%, neomycin (as sulphate) 0.25%, gramicidin 0.025%, nystatin 100,000 units/g: Apply a small amount directly into the aural canal 2-3 times daily.
Child: As otic ointment containing triamcinolone acetonide 0.1%, neomycin (as sulphate) 0.25%, gramicidin 0.025%, nystatin 100,000 units/g: Apply a small amount directly into the aural canal 2-3 times daily.
Elderly: Use sparingly for short periods of time. 

Topical/Cutaneous
Corticosteriod-responsive dermatoses with secondary infection
Adult: As cream/ointment containing triamcinolone acetonide 0.1%, neomycin (as sulphate) 0.25%, gramicidin 0.025%, nystatin 100,000 units/g: Apply sparingly to the affected area 2-3 times daily. 
Child: As cream/ointment containing triamcinolone acetonide 0.1%, neomycin (as sulphate) 0.25%, gramicidin 0.025%, nystatin 100,000 units/g: Apply sparingly to the affected area 2-3 times daily. 
Elderly: Use sparingly for short periods of time.

Administration Should be taken with food.
Contraindications Tuberculous, viral lesions of the skin (e.g. herpes simplex and varicella); fungal lesions not susceptible to nystatin, facial rosacea, acne vulgaris or perioral dermatitis. Not to be applied to the external auditory canal in patients with perforated tympanic membranes. Do not use on extensive areas to reduce risk of systemic absorption and neomycin-induced ototoxicity. Not recommended for <1 yr.
Special Precautions Patients with established hearing loss. Avoid occlusive dressing and prolonged or recurrent use. Avoid contact with eyes or mucous membranes. If there is no clinical improvement after 7 days, discontinue use as the infection may be masked by the steroid. Limit use to 5 days if used on the face or on children >1 yr. Use with caution and sparingly on inflamed or damaged skin (e.g extensive burns, trophic ulceration). Pregnancy.
Adverse Drug Reactions Prolonged use may cause sensitivity reactions, impaired wound healing, thinning of skin, striae, telangiectasia, hirsutism, hypothalamic-pituitary-adrenal axis suppression, Cushing's syndrome. Ototoxicity and nephrotoxicity.
Storage Otic/Aural: Do not store above 25°C. Topical/Cutaneous: Ointment: Do not store above 25°C. Cream: Do not store above 25°C. Do not freeze.
Pharmacology Triamcinolone is a fluorinated corticosteroid with anti-inflammatory, antipruritic and anti-allergic actions. Nystatin, a polyene antifungal antibiotic, binds to ergosterol and interferes with the permeability of cell membrane of susceptible fungi e.g Candida spp. Neomycin is an aminoglycoside, often used topically in the infections against susceptible staphylococci and other organisms. Gramicidin, an antibacterial substance extracted from tyrothricin, is active against many Gram-positive bacteria. Used together, this combination provides a wide coverage against gram-positive, gram-negative bacteria and yeast which are responsible for most of the skin infections.
Absorption: Nystatin: Poorly absorbed from GI tract; not absorbed from skin and mucous membranes when applied topically. Neomycin: Poorly absorbed from GI tract, absorption increased in damaged or inflamed mucosa or skin.
Distribution: Triamcinolone: Crosses placenta
Excretion: Triamcinolone: Plasma half life: 2- >5 hr. Neomycin: Rapidly excreted by kidneys; half life: 2-3 hr.
ATC Classification D01AA01 - nystatin;Belongs to the class of antibiotics for topical use. Used in the treatment of fungal infection. 
D06AX04 - neomycin;Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. 
H02AB08 - triamcinolone;Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations. 
B05CA09 - neomycin;Belongs to the class of antiinfectives used as irrigating solutions. 
J01GB05 - neomycin;Belongs to the class of other aminoglycosides. Used in the treatment of systemic infections. 
S02AA07 - neomycin;Belongs to the class of antiinfectives used in the treatment of ear infections. 
D07AB09 - triamcinolone;Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases. 
A07AA02 - nystatin;Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
A07AA01 - neomycin;Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
R03BA06 - triamcinolone;Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticooids. 
R01AD11 - triamcinolone;Belongs to the class of topical corticosteroids used as nasal decongestants. 
R02AB01 - neomycin;Belongs to the class of antibiotics used in throat preparations. 
R02AB30 - gramicidin;Belongs to the class of antibiotics used in throat preparations. 
S03AA01 - neomycin;Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. 
G01AA01 - nystatin;Belongs to the class of antibiotics. Used in the treatment of gynecological infections. 
A01AB08 - neomycin;Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
A01AC01 - triamcinolone;Belongs to the class of local corticosteroid preparations. Used in the treatment of diseases of the mouth. 
D07XB02 - triamcinolone;Belongs to the class of moderately potent (group II) corticosteroids in other combinations. Used in the treatment of dermatological diseases. 
S01AA03 - neomycin;Belongs to the class of antibiotics. Used in the treatment of eye infections. 
S01BA05 - triamcinolone;Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.

Brand/Product Info


Total Products : 5     
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
FUNGISTAT Drug International Ltd Triamcinolone acetonide 1mg+ Neomycin sulphate 2.5mg+ Nystatin 10,000 unit+ Gramicidin 0.25mg /gm Cream 10gm: 40.00 MRP
FUNGISTAT Ointment Drug International Ltd Triamcinolone acetonide 1mg+ Neomycin sulphate 2.5mg+ Nystatin 10,000 unit+ Gramicidin 0.25mg /gm Ointment 5gm &10gm: 18.90 & 40.00 MRP
GANACOMB Gaco Pharmaceutical Ltd. Triamcinolone acetonide 1mg+ Neomycin sulphate 2.5mg+ Nystatin 10,000 unit+ Gramicidin 0.25mg /gm Cream 5gm: 18.80 MRP
MONACOM Amico Laboratories Ltd. Triamcinolone acetonide 1mg+ Neomycin sulphate 2.5mg+ Nystatin 10,000 unit+ Gramicidin 0.25mg /gm Cream 5gm &10gm: 30.00 & 40.00 MRP
TETRACOMB Pharmasia Limited Triamcinolone acetonide 1mg+ Neomycin sulphate 2.5mg+ Nystatin 10,000 unit+ Gramicidin 0.25mg /gm Cream/Ointment Cream 5 &10gm: 22.00 & 35.00; Oint. 5 &10gm: 22.00 & 35.00 MRP