P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage

Oral
Cough and common cold
Adult: Per 5 ml syrup contains triprolidine HCl 1.25 mg, pseudoephedrine HCl 30 mg and dextromethorphan HBr 10 mg: 10 ml 4 -6 hrly, up to 4 times daily; may be diluted 1:1 - 1:3 with unpreserved syrup BP. 
Child: Per 5 ml syrup contains triprolidine HCl 1.25 mg, pseudoephedrine HCl 30 mg and dextromethorphan HBr 10 mg: >12 yr: 10 ml 4 -6 hrly, up to 4 times daily; 6-12 yr: 5 ml 4 -6 hrly, up 4 times daily; 2-5 yr: 2.5 ml 4 - 6 hrly, up to 4 times daily; may be diluted 1:1 - 1:3 with unpreserved syrup BP.

 

Administration

May be taken with or without food.

 

Overdosage

Symptoms: Nausea, vomiting, drowsiness, dizziness, lethargy, ataxia, weakness, hypotonicity, tachycardia, hypertension, fever, hyperactivity, irritability, seizures, difficulty in urination. Management: Empty stomach by gastric lavage. Treatment is supportive and symptomatic with support of respiratory functions. Acid diuresis or dialysis may be useful in the removal of pseudoephedrine. Naloxone may be used as an antidote for dextromethorphan overdose in children.

 

Contraindications

Severe hypertension or coronary artery disease. Patient at risk of respiratory failure. Avoid use in patients where cough is associated with asthma or with excessive secretion. Concurrent use or within 2 wk of stopping MAOIs.

 

Special Precautions

Pregnancy and lactation. Severe hepatic impairment, severe or moderate renal impairment. Hypertension, heart disease, DM, hyperthyroidism, increased intra-ocular pressure, prostatic hypertrophy. May impair ability to drive or operate machinery.

 

Adverse Drug Reactions

Nausea, vomiting, dry mouth, nose and throat, GI disturbances, skin rashes, drowsiness, sleep disturbance, tachycardia, urinary retention. Rarely, hallucinations.

 

Drug Interactions

Increased BP with other sympathomimetic agents e.g. decongestants, amphetamine-like psychostimulants. May reduce hypotensive effect of bretylium, betanidine, guanethidine, debrisoquine, methyldopa, α- and β- blockers.
Potentially Fatal: Increased risk of hypertensive crisis with furazolidine; avoid concurrent use. Increased risk of hypertensive crisis with MAOIs; avoid concurrent use or within 2 wk after stopping MAOIs.

 

Storage

Oral: Syrup: Do not store above 25°C. Store diluted syrup at 25°C, up to 4 wk.

 

Pharmacology

Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Pseudoephedrine, an α- and β-adrenergic receptor agonist, mediates vasoconstriction via direct stimulation of α-adrenergic receptors of the respiratory mucosa. Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.
Onset: Antihistamine: Within 1-2 hr; Decongestant: Within 30 minutes; Cough suppressant: 15- 30 minutes
Duration: Antihistamine: >8 hr; Decongestant: Within 30 minutes; Cough suppressant: Up to 6 hr.
Absorption: Dextromethorphan and pseudoephedrine: Both are readily absorbed from GI tract
Distribution: Triprolidine and pseudoephedrine: Both are excreted into breast milk.
Metabolism: Pseudoephedrine: Undergoes incomplete hepatic metabolism (<1%). Dextromethorphan: Undergoes hepatic metabolism.
Excretion: Triprolidine: Half life of 3-5 hr. Pseudoephedrine: Excreted from urine mainly as unchanged drug and small amounts as metabolites; half life 5.5 hr (urine pH 5-7), half life increased by alkalinisation and decreased by acidification of urine. Dextromethorphan: Excreted in urine as metabolites and unchanged drug.

 

mph Class Cough & Cold Preparations
ATC Classification R01BA02 - pseudoephedrine ; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants. 
R06AX07 - triprolidine ; Belongs to the class of other agents used as systemic antihistamines. 
R05DA09 - dextromethorphan ; Belongs to the class of cough suppressants, opium alkaloids and derivatives. Used in the treatment of dry cough.
 

Brand/Product Info


Total Products : 20                    
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
A-COF The Acme Laboratories Ltd. Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.20 MRP
ANKOF General Pharmaceuticals Ltd Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.19 MRP
CASICA Pharmadesh Laboratories Limited Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 51.38 MRP
COFNO Alco Pharma Ltd Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 MRP
COPRIN Doctors Chemical Works Ltd Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 55.00 MRP
DECOFF Hudson Pharmaceuticals Ltd Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 50ml, 100ml: 27.00 & 50.00 MRP
DEXDIN Somatec Pharmaceuticals Ltd. Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.19 MRP
DEXITRA Novo Healthcare and Pharma Ltd. Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 MRP
DEXODEL Delta Pharma Limited Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 MRP
DEXTROP Edruc Limited Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 IP
DIXXAR ACI Ltd. Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.19 MRP
EXORDIN Millat Pharmaceuticals Ltd Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 MRP
FREECOF Aristopharma Ltd. Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 MRP
KOFTEX-D Amico Laboratories Ltd. Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 MRP
NILKOF Ambee Pharmaceuticals Ltd. Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.19 MRP
OFKOF SYP Square Pharmaceuticals Ltd. Dextromethorphan + Pseudoephedrine + Triprolidine (10mg + 30mg + 1.25mg)/5 ml Syrup 100 ml: 70.21 MRP
PRUDEX Beximco Pharmaceuticals Ltd Dextromethorphan Hydrobromide BP 10mg+ Pseudoephedrine Hydrochloride BP 30mg +Triprolidine Hydrochloride BP 1.25mg Syrup 100ml: 70.00 MRP
Sudocof Incepta Pharmaceuticals Limited Dextromethorphan 10 mg + Pseudoephedrine Hydrochloride 30 mg + Triprolidine Hydrochloride 1.25 mg/5 ml Syrup Syrup 100ml:MRP 60 Tk
TEXCO Globe Pharmaceuticals Ltd Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 MRP
TUSIVA Opsonin Pharma Limited Dextromethorphan HBr 10mg+ Pseudoephedrine HCl 30mg+ Triprolidine HCl 1.25mg/5ml Syrup Syrup 100ml: 50.00 MRP