Ketotifen

(kee toe tye' fen)

PCaution when used during lactation / LCaution when used during lactation : Caution - pregnancy &  lactation (breast feeding)

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication & Dosage

Oral route
Allergic conditions
Adult: 1 mg bid up to 2 mg bid, as needed. Alternatively, 0.5-1 mg at night for the 1st few days of treatment to minimise drowsiness.
Child: 6 mth to 3 yr: 0.5 mg bid; >3 yr: 1 mg bid.

Asthma prophylaxis
Adult: 1 mg bid up to 2 mg bid, as needed. Alternatively, 0.5-1 mg at night for the 1st few days of treatment to minimise drowsiness.
Child: 6 mth to 3 yr: 0.5 mg bid; >3 yr: 1 mg bid.

Ophthalmic route
Allergic conjunctivitis
Adult: As 0.025% solution: Instill 1 drop into the affected eye(s) bid. 
Child: ≥3 yr: As 0.025% solution: Instill 1 drop into the affected eye(s) bid.

Administration Should be taken with food.
Overdosage Symptoms: Drowsiness, confusion, dyspnoea, bradycardia or tachycardia, disorientation, convulsions, severe hypotension, reversible coma. Management: Supportive and symptomatic.
Contraindications Acute asthma attack.
Special Precautions May impair tasks requring mental alertness e.g. driving or operating machinery. History of epilepsy. Pregnancy and lactation. Children <3 yr.
Adverse Drug Reactions Sedation, drowsiness, dizziness, dry mouth, weight gain, increased appetite, CNS stimulation. Rarely, cystitis. Conjunctival injection, headaches and rhinitis (ophthalmic).
Drug Interactions Reduced platelet count with oral antidiabetics.
Potentially Fatal: May potentiate CNS effects of sedatives, hypnotics, antihistamines and alcohol. Please consult detailed drug interactions before prescribing.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Ophthalmic: Store at 25°C. Oral: Store below 25°C (77°F).
Pharmacology Ketotifen selectively and noncompetitively inhibits the release of mediators from cells involved in hypersensitivity reactions. It is also a mast cell stabiliser.
Onset: Within min (ophthalmic).
Absorption: Absorbed completely for the GIT (oral); bioavailability: 50%; peak plasma concentrations after 2-4 hr.
Distribution: Protein-binding: 75%.
Metabolism: Hepatic first-pass metabolism.
Excretion: Via urine (as inactive metabolites and traces of unchanged drug); 21 hr (elimination half-life).
ATC Classification R06AX17 - ketotifen; Belongs to the class of other agents used as systemic antihistamines. 
S01GX08 - ketotifen; Belongs to the class of other agent used as ophthalmologic antiallergics.

Brand/Product Info


Total Products : 55                                                       
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
AEROFEN Silva Pharmaceuticals Limited Ketotifen fumerate 1mg Tablet 50's: 75.29 MRP
AEROFEN Syrup Silva Pharmaceuticals Limited Ketotifen fumerate 1mg/5ml Syrup 100ml: 35.14 MRP
ALACOT 0.025% Square Pharmaceuticals Ltd. Ketotifen Fumarate 0.025% Eye Drops 5 ml: 100.30 MRP
ALARID Square Pharmaceuticals Ltd. Ketotifen Fumarate 1mg Tablet 10x10's: 151.00 MRP
ALARID SYP Square Pharmaceuticals Ltd. Ketotifen Fumarate 1mg/5 ml Syrup 100 ml: 50.15 MRP
ALJEN Apex Pharmaceuticals Ltd. Ketotifen fumarate BP 0.025% Eye Drop 5ml: 95.00 MRP
ASMAFEN Globe Pharmaceuticals Ltd Ketotifen fumerate 1mg Tablet 100's: 150.00 MRP
ASMAFEN Syrup Globe Pharmaceuticals Ltd Ketotifen fumerate 1mg/5ml Syrup 100ml: 35.00 MRP
BROKET Orion Pharma Ltd. Ketotifen fumerate 1mg Tablet 100's: 151.00 MRP
BROKET Syrup Orion Pharma Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 40.15 MRP
FENAT Drug International Ltd Ketotifen fumerate 1mg Tablet 100's: 155.00 MRP
FENAT Drop Drug International Ltd Ketotifen fumarate BP 0.025% Eye Drop 5ml: 75.00 MRP
FENAT Syrup Drug International Ltd Ketotifen fumerate 1mg/5ml Syrup 100ml: 40.00 MRP
KETIFEN The Acme Laboratories Ltd. Ketotifen fumerate 1mg Tablet 100's: 150.00 MRP
KETIFEN Syrup The Acme Laboratories Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 40.15 MRP
KETODIL Techno Drugs Ketotifen fumerate 1mg Capsule 50's: 75.00 MRP
KETOF IBN SINA Pharmaceutical Industry Ltd. Ketotifen fumerate 1mg Tablet 100's: 160.00 IP
KETOF Drop IBN SINA Pharmaceutical Industry Ltd. Ketotifen fumarate BP 0.025% Eye Drop 5ml: 100.00 MRP
KETOF Syrup IBN SINA Pharmaceutical Industry Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 50.00 IP
Ketomar Incepta Pharmaceuticals Limited Ketotifen Fumarate BP 1.38 mg equivalent to Ketotifen 1 mg Tablet 10x10's:MRP 150 Tk
Ketomar Drop Incepta Pharmaceuticals Limited Ketotifen Fumarate BP equivalent to Ketotifen 0.25mg/ml Eye Drop 5ml:MRP 100 Tk
Ketomar Syrup Incepta Pharmaceuticals Limited Ketotifen Fumarate BP 1.38 mg equivalent to Ketotifen 1mg/5ml Syrup 100ml:MRP 40 Tk
KETOPAC Pacific Pharmaceuticals Ltd. Ketotifen fumerate 1mg Tablet 100's: 150.00 MRP
KETOPAC Syrup Pacific Pharmaceuticals Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 40.00 MRP
KETOTIF Delta Pharma Limited Ketotifen fumerate 1mg Tablet 100's: 150.00 MRP
KETOTIF Syrup Delta Pharma Limited Ketotifen fumerate 1mg/5ml Syrup 100ml: 35.01 MRP
KETOTIFEN Reman Drug Laboratories Ltd. Ketotifen fumarate BP 0.025% Eye Drop 5ml: 100.00 MRP
KOFEN Opsonin Pharma Limited Ketotifen fumerate 1mg Tablet 100's: 150.00 MRP
KOFEN Syrup Opsonin Pharma Limited Ketotifen fumerate 1mg/5ml Syrup 100ml: 35.00 MRP
MINIA Novo Healthcare and Pharma Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 40.00 MRP
OCUTIF ACI Ltd. Ketotifen fumarate BP 0.025% Eye Drop 5ml: 95.36 MRP
PROSMA ACI Ltd. Ketotifen fumerate 1mg Tablet 100's: 151.00 MRP
PROSMA Syrup ACI Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 42.00 MRP
S-KIT Sharif Pharmaceuticals Ltd. Ketotifen fumerate 1mg Tablet 50's: 75.00 MRP
S-KIT Syrup Sharif Pharmaceuticals Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 40.00 MRP
SANKETO Sandoz/Novartis Ketotifen Fumarate BP equivalent to Ketotifen 1mg Tablet 10x10's, MRP 250
STAFEN Aristopharma Ltd. Ketotifen fumerate 1mg Tablet 100's: 160.00 MRP
STAFEN Drop Aristopharma Ltd. Ketotifen fumarate BP 0.025% Eye Drop 5ml: 100.00 MRP
STAFEN Syrup Aristopharma Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 42.00 MRP
TIFEN Somatec Pharmaceuticals Ltd. Ketotifen fumerate 1mg Tablet 100's: 151.00 MRP
TIFEN Syrup Somatec Pharmaceuticals Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 37.14 MRP
TOFEN Beximco Pharmaceuticals Ltd Ketotifen Fumarate BP equivalent to Ketotifen 1mg Tablet 100 & 200's: 200 & 400 MRP
TOFEN DROP Beximco Pharmaceuticals Ltd Ketotifen Fumarate BP eq. to Ketotifen 0.25mg/ml Drop 5ml: 95.00 MRP
TOFEN SYRUP Beximco Pharmaceuticals Ltd Ketotifen Fumarate BP equivalent to Ketotifen 1mg/5ml Syrup 100ml: 50.00 MRP
TOMA Navana Pharmaceuticals Limited Ketotifen fumerate 1mg Tablet 100's: 151.00 IP
TOMA Syrup Navana Pharmaceuticals Limited Ketotifen fumerate 1mg/5ml Syrup 50ml, 100ml: 20.08, 35.13 IP
TOTI Eskayef Bangladesh Ltd Ketotifen Fumarate BP equivalent to Ketotifen 1mg Tablet 100's MRP: 150.00
TOTI Syrup Eskayef Bangladesh Ltd Ketotifen Fumarate BP equivalent to Ketotifen 1mg/5ml Syrup 100ml MRP: 38.00
TOTIFEN Renata Limited Ketotifen fumerate 1mg Tablet 100's: 150.00 MRP
TOTIFEN Syrup Renata Limited Ketotifen fumerate 1mg/5ml Syrup 100ml: 40.00 MRP
ZADIFEN Unimed & Unihealth Manufacturers Ltd. Ketotifen fumerate 1mg Tablet 50's: 75.00 MRP
ZADIFEN Syrup Unimed & Unihealth Manufacturers Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 35.00 MRP
ZADIT Popular Pharmaceuticals Ltd. Ketotifen fumerate 1mg Tablet 100's: 150.96 MRP
ZADIT Drop Popular Pharmaceuticals Ltd. Ketotifen fumarate BP 0.025% Eye Drop 5ml: 95.36 MRP
ZADIT Syrup Popular Pharmaceuticals Ltd. Ketotifen fumerate 1mg/5ml Syrup 100ml: 40.15 MRP

Gen. MedInfo

Why is this medication prescribed?

Ophthalmic ketotifen is used to relieve the itching of allergic pinkeye. Ketotifen is in a class of medications called antihistamines. It works by blocking histamine, a substance in the body that causes allergic symptoms.

How should this medicine be used?

Ophthalmic ketotifen comes as a solution (liquid) to instill in the eye. It is usually instilled in the affected eye(s) twice daily, 8 to 12 hours apart. Instill ketotifen eye drops at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Use ketotifen exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

To instill the eye drops, follow these steps:

  1. Wash your hands thoroughly with soap and water.

  2. Check the dropper tip to make sure that it is not chipped or cracked.

  3. Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.

  4. While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.

  5. Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.

  6. Brace the remaining fingers of that hand against your face.

  7. While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.

  8. Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.

  9. Place a finger on the tear duct and apply gentle pressure.

  10. Wipe any excess liquid from your face with a tissue.

  11. If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.

  12. Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.

  13. Wash your hands to remove any medication.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor for more information.

What special precautions should I follow?

Before using ketotifen eye drops,

  • tell your doctor if you are allergic to ketotifen or any other medications.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using ketotifen, call your doctor.
  • you should know that you should not wear contact lenses if your eye(s) is/are red. If your eyes are not red and you wear contact lenses, you should know that ketotifen solution contains benzalkonium chloride, which can be absorbed by soft contact lenses. Remove your contact lenses before instilling ketotifen and put them back in 10 minutes later.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Instill the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.

What side effects can this medication cause?

Ketotifen eye drops may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • runny nose

  • burning or stinging of the eye

  • eye discharge

  • dry eyes

  • eye pain

  • eyelid problems

  • itching

  • problem with tear production

  • blurred vision

  • sensitivity to light

  • rash

  • flu-like symptoms

  • sore throat

Ketotifen eye drops may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.