(kee toe tye' fen)
P / L : Caution - pregnancy & lactation (breast feeding)
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication & Dosage||
|Administration||Should be taken with food.
|Overdosage||Symptoms: Drowsiness, confusion, dyspnoea, bradycardia or tachycardia, disorientation, convulsions, severe hypotension, reversible coma. Management: Supportive and symptomatic.|
|Contraindications||Acute asthma attack.|
|Special Precautions||May impair tasks requring mental alertness e.g. driving or operating machinery. History of epilepsy. Pregnancy and lactation. Children <3 yr.|
|Adverse Drug Reactions||Sedation, drowsiness, dizziness, dry mouth, weight gain, increased appetite, CNS stimulation. Rarely, cystitis. Conjunctival injection, headaches and rhinitis (ophthalmic).|
|Drug Interactions||Reduced platelet count with oral antidiabetics.
Potentially Fatal: May potentiate CNS effects of sedatives, hypnotics, antihistamines and alcohol. Please consult detailed drug interactions before prescribing.
|Pregnancy Category (FDA)||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Storage||Ophthalmic: Store at 25°C. Oral: Store below 25°C (77°F).|
|Pharmacology||Ketotifen selectively and noncompetitively inhibits the release of mediators from cells involved in hypersensitivity reactions. It is also a mast cell stabiliser.
Onset: Within min (ophthalmic).
Absorption: Absorbed completely for the GIT (oral); bioavailability: 50%; peak plasma concentrations after 2-4 hr.
Distribution: Protein-binding: 75%.
Metabolism: Hepatic first-pass metabolism.
Excretion: Via urine (as inactive metabolites and traces of unchanged drug); 21 hr (elimination half-life).
|ATC Classification||R06AX17 - ketotifen; Belongs to the class of other agents used as systemic antihistamines.
S01GX08 - ketotifen; Belongs to the class of other agent used as ophthalmologic antiallergics.
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|AEROFEN||Silva Pharmaceuticals Limited||Ketotifen fumerate 1mg||Tablet||50's: 75.29 MRP|
|AEROFEN Syrup||Silva Pharmaceuticals Limited||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 35.14 MRP|
|ALACOT 0.025%||Square Pharmaceuticals Ltd.||Ketotifen Fumarate 0.025%||Eye Drops||5 ml: 100.30 MRP|
|ALARID||Square Pharmaceuticals Ltd.||Ketotifen Fumarate 1mg||Tablet||10x10's: 151.00 MRP|
|ALARID SYP||Square Pharmaceuticals Ltd.||Ketotifen Fumarate 1mg/5 ml||Syrup||100 ml: 50.15 MRP|
|ALJEN||Apex Pharmaceuticals Ltd.||Ketotifen fumarate BP 0.025%||Eye Drop||5ml: 95.00 MRP|
|ASMAFEN||Globe Pharmaceuticals Ltd||Ketotifen fumerate 1mg||Tablet||100's: 150.00 MRP|
|ASMAFEN Syrup||Globe Pharmaceuticals Ltd||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 35.00 MRP|
|BROKET||Orion Pharma Ltd.||Ketotifen fumerate 1mg||Tablet||100's: 151.00 MRP|
|BROKET Syrup||Orion Pharma Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 40.15 MRP|
|FENAT||Drug International Ltd||Ketotifen fumerate 1mg||Tablet||100's: 155.00 MRP|
|FENAT Drop||Drug International Ltd||Ketotifen fumarate BP 0.025%||Eye Drop||5ml: 75.00 MRP|
|FENAT Syrup||Drug International Ltd||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 40.00 MRP|
|KETIFEN||The Acme Laboratories Ltd.||Ketotifen fumerate 1mg||Tablet||100's: 150.00 MRP|
|KETIFEN Syrup||The Acme Laboratories Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 40.15 MRP|
|KETODIL||Techno Drugs||Ketotifen fumerate 1mg||Capsule||50's: 75.00 MRP|
|KETOF||IBN SINA Pharmaceutical Industry Ltd.||Ketotifen fumerate 1mg||Tablet||100's: 160.00 IP|
|KETOF Drop||IBN SINA Pharmaceutical Industry Ltd.||Ketotifen fumarate BP 0.025%||Eye Drop||5ml: 100.00 MRP|
|KETOF Syrup||IBN SINA Pharmaceutical Industry Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 50.00 IP|
|Ketomar||Incepta Pharmaceuticals Limited||Ketotifen Fumarate BP 1.38 mg equivalent to Ketotifen 1 mg||Tablet||10x10's:MRP 150 Tk|
|Ketomar Drop||Incepta Pharmaceuticals Limited||Ketotifen Fumarate BP equivalent to Ketotifen 0.25mg/ml||Eye Drop||5ml:MRP 100 Tk|
|Ketomar Syrup||Incepta Pharmaceuticals Limited||Ketotifen Fumarate BP 1.38 mg equivalent to Ketotifen 1mg/5ml||Syrup||100ml:MRP 40 Tk|
|KETOPAC||Pacific Pharmaceuticals Ltd.||Ketotifen fumerate 1mg||Tablet||100's: 150.00 MRP|
|KETOPAC Syrup||Pacific Pharmaceuticals Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 40.00 MRP|
|KETOTIF||Delta Pharma Limited||Ketotifen fumerate 1mg||Tablet||100's: 150.00 MRP|
|KETOTIF Syrup||Delta Pharma Limited||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 35.01 MRP|
|KETOTIFEN||Reman Drug Laboratories Ltd.||Ketotifen fumarate BP 0.025%||Eye Drop||5ml: 100.00 MRP|
|KOFEN||Opsonin Pharma Limited||Ketotifen fumerate 1mg||Tablet||100's: 150.00 MRP|
|KOFEN Syrup||Opsonin Pharma Limited||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 35.00 MRP|
|MINIA||Novo Healthcare and Pharma Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 40.00 MRP|
|OCUTIF||ACI Ltd.||Ketotifen fumarate BP 0.025%||Eye Drop||5ml: 95.36 MRP|
|PROSMA||ACI Ltd.||Ketotifen fumerate 1mg||Tablet||100's: 151.00 MRP|
|PROSMA Syrup||ACI Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 42.00 MRP|
|S-KIT||Sharif Pharmaceuticals Ltd.||Ketotifen fumerate 1mg||Tablet||50's: 75.00 MRP|
|S-KIT Syrup||Sharif Pharmaceuticals Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 40.00 MRP|
|SANKETO||Sandoz/Novartis||Ketotifen Fumarate BP equivalent to Ketotifen 1mg||Tablet||10x10's, MRP 250|
|STAFEN||Aristopharma Ltd.||Ketotifen fumerate 1mg||Tablet||100's: 160.00 MRP|
|STAFEN Drop||Aristopharma Ltd.||Ketotifen fumarate BP 0.025%||Eye Drop||5ml: 100.00 MRP|
|STAFEN Syrup||Aristopharma Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 42.00 MRP|
|TIFEN||Somatec Pharmaceuticals Ltd.||Ketotifen fumerate 1mg||Tablet||100's: 151.00 MRP|
|TIFEN Syrup||Somatec Pharmaceuticals Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 37.14 MRP|
|TOFEN||Beximco Pharmaceuticals Ltd||Ketotifen Fumarate BP equivalent to Ketotifen 1mg||Tablet||100 & 200's: 200 & 400 MRP|
|TOFEN DROP||Beximco Pharmaceuticals Ltd||Ketotifen Fumarate BP eq. to Ketotifen 0.25mg/ml||Drop||5ml: 95.00 MRP|
|TOFEN SYRUP||Beximco Pharmaceuticals Ltd||Ketotifen Fumarate BP equivalent to Ketotifen 1mg/5ml||Syrup||100ml: 50.00 MRP|
|TOMA||Navana Pharmaceuticals Limited||Ketotifen fumerate 1mg||Tablet||100's: 151.00 IP|
|TOMA Syrup||Navana Pharmaceuticals Limited||Ketotifen fumerate 1mg/5ml||Syrup||50ml, 100ml: 20.08, 35.13 IP|
|TOTI||Eskayef Bangladesh Ltd||Ketotifen Fumarate BP equivalent to Ketotifen 1mg||Tablet||100's MRP: 150.00|
|TOTI Syrup||Eskayef Bangladesh Ltd||Ketotifen Fumarate BP equivalent to Ketotifen 1mg/5ml||Syrup||100ml MRP: 38.00|
|TOTIFEN||Renata Limited||Ketotifen fumerate 1mg||Tablet||100's: 150.00 MRP|
|TOTIFEN Syrup||Renata Limited||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 40.00 MRP|
|ZADIFEN||Unimed & Unihealth Manufacturers Ltd.||Ketotifen fumerate 1mg||Tablet||50's: 75.00 MRP|
|ZADIFEN Syrup||Unimed & Unihealth Manufacturers Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 35.00 MRP|
|ZADIT||Popular Pharmaceuticals Ltd.||Ketotifen fumerate 1mg||Tablet||100's: 150.96 MRP|
|ZADIT Drop||Popular Pharmaceuticals Ltd.||Ketotifen fumarate BP 0.025%||Eye Drop||5ml: 95.36 MRP|
|ZADIT Syrup||Popular Pharmaceuticals Ltd.||Ketotifen fumerate 1mg/5ml||Syrup||100ml: 40.15 MRP|
Why is this medication prescribed?
Ophthalmic ketotifen is used to relieve the itching of allergic pinkeye. Ketotifen is in a class of medications called antihistamines. It works by blocking histamine, a substance in the body that causes allergic symptoms.
How should this medicine be used?
Ophthalmic ketotifen comes as a solution (liquid) to instill in the eye. It is usually instilled in the affected eye(s) twice daily, 8 to 12 hours apart. Instill ketotifen eye drops at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Use ketotifen exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
To instill the eye drops, follow these steps:
Wash your hands thoroughly with soap and water.
Check the dropper tip to make sure that it is not chipped or cracked.
Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.
While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.
Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.
Brace the remaining fingers of that hand against your face.
While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.
Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.
Place a finger on the tear duct and apply gentle pressure.
Wipe any excess liquid from your face with a tissue.
If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.
Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.
- Wash your hands to remove any medication.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor for more information.
What special precautions should I follow?
Before using ketotifen eye drops,
- tell your doctor if you are allergic to ketotifen or any other medications.
- tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using ketotifen, call your doctor.
- you should know that you should not wear contact lenses if your eye(s) is/are red. If your eyes are not red and you wear contact lenses, you should know that ketotifen solution contains benzalkonium chloride, which can be absorbed by soft contact lenses. Remove your contact lenses before instilling ketotifen and put them back in 10 minutes later.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Instill the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.
What side effects can this medication cause?
Ketotifen eye drops may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
burning or stinging of the eye
problem with tear production
sensitivity to light
Ketotifen eye drops may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.