Molecule Info

 

 
Indication & Dosage Oral
Peripheral neuropathies
Adult: 1500 mcg/day in 3 divided doses.
Parenteral
Peripheral neuropathies
Adult: 500 mcg daily IM/IV 3 times/wk.
Parenteral
Megaloblastic anaemia caused by vitamin B12 deficiency
Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.
Administration May be taken with or without food.
Adverse Drug Reactions Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site.
Potentially Fatal: Anaphylactoid reactions (parenteral).
Drug Interactions Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol. Please consult detailed drug interactions before prescribing.
Lab Interference May interfere with precise diagnosis in patients with folate deficiency.
Storage Oral: Store at room temperature. Protect from moisture and light. Parenteral:Store at room temperature. Do not expose to direct light.
Pharmacology Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
Absorption: Peak plasma concentrations after 3 hr (oral); 0.9 hr (IM); 3 min (IV).
Excretion: Via urine.
ATC Classification B03BA05 - mecobalamin.

Brand/Product Info


Total Products : 22                      
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
COLAMIN Rangs Pharmaceuticals Ltd. Mecobalamin 500mcg Tablet 30's: 120.00 MRP
MACLON The White Horse Pharma Mecobalamin 500mcg Tablet 50's: 200.00 MRP
MB-12 The Acme Laboratories Ltd. Mecobalamin 500mcg Tablet 30's: 120.30 MRP
MB-12 Injection The Acme Laboratories Ltd. Mecobalamin 500mcg/ml Injection 5 amps: 150.55 MRP
MECOBAL General Pharmaceuticals Ltd Mecobalamin 500mcg Tablet 50's: 175.50 MRP
MECOL Aristopharma Ltd. Mecobalamin 500mcg Tablet 50's: 200.00 MRP
Mecolagin Chew Incepta Pharmaceuticals Limited Mecobalamin INN 0.5mg Chewable Tablet 15x4's:MRP 240 Tk
Mecolagin Injection Incepta Pharmaceuticals Limited Mecobalamin INN 500mcg/ml Injection 1x5's:MRP 150 Tk
MECOLIN Drug International Ltd Mecobalamin 500mcg Tablet 50's: 200.00 MRP
MECOMIN Peoples Pharma Ltd. Mecobalamin 500mcg Tablet 50's: 175.05 MRP
MECOPEN Eskayef Bangladesh Ltd Mecobalamin INN 0.5mg Tablet 50's MRP: 200.00
METHICOL Square Pharmaceuticals Ltd. Mecobalamin 500 mcg Tablet 6x10's: 241.80 MRP
METHICOL INJ Square Pharmaceuticals Ltd. Mecobalamin 500 mcg /ml IM/IV Injection 1x5's: 151.00 MRP
NERVEX Orion Pharma Ltd. Mecobalamin 500mcg Tablet 50's: 210.00 MRP
NERVITON Opsonin Pharma Limited Mecobalamin 500mcg Tablet 50's: 200.00 MRP
NERVITON Injection Opsonin Pharma Limited Mecobalamin 500mcg/ml Injection 5 amps: 150.00 MRP
NERVO-12 Apex Pharmaceuticals Ltd. Mecobalamin 500mcg Tablet 50's: 200.00 MRP
NEURAL TAB Healthcare Pharmacuticals Ltd. Mecobalamin INN 0.5mg Tablet 60's MRP 255 Tk
PEDIAL Globe Pharmaceuticals Ltd Mecobalamin 500mcg Tablet 50's: 200.00 MRP
PHYTON ACI Ltd. Mecobalamin 500mcg Tablet 50's: 201.00 MRP
PHYTON Injection ACI Ltd. Mecobalamin 500mcg/ml Injection 5 amps: 150.55 MRP
REMYLIN IBN SINA Pharmaceutical Industry Ltd. Mecobalamin 500mcg Tablet 30's: 135.00 MRP