mph Bangladesh


(feb ux' oh stat)

Molecule Info

Indication(s) Treatment of chronic hyperuricemia in conditions where urate deposition has already occurred (including a history or presence of tophus &/or gouty arthritis).
Dosage Adult 80 mg once daily. May be increased to 120 mg once daily if serum uric acid is >6 mg/dL after 2-4 wk.
Administration May be taken with or without food.
Contraindications Pregnancy & lactation.
Special Precautions Ischemic heart disease or CHF; acute gouty attacks (gout flare); xanthine deposition (eg malignant disease or Lesch-Nyhan syndrome); altered thyroid function. Perform liver function test prior to treatment & periodically thereafter. Severe renal & hepatic impairment. Childn <18 yr.
Adverse Drug Reaction(s) Liver function abnormalities, diarrhea, headache, nausea & rash.
Drug Interactions Mercaptopurine, azathioprine, theophylline, NSAIDs eg naproxen & probenecid.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
ATC Classification M04AA03 - febuxostat; Belongs to the class of preparations inhibiting uric acid production. Used in the treatment of gout.

Brand/Product Info

Total Products : 12            
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
BARIF 40 Square Pharmaceuticals Ltd. Febuxostat 40mg Tablet 3x10's: 360.90 MRP
BARIF 80 Square Pharmaceuticals Ltd. Febuxostat 80mg Tablet 1x10's: 220.60 MRP
FEBURIC 40 Beximco Pharmaceuticals Ltd Febuxostat INN 40mg Film Coated Tablet 30's: 360.00 MRP
FEBUS ACI Ltd. Febuxostat INN 40mg & 80mg Tablet 40mg x30's, 80mg x30's: 360.00 &660.00 MRP
Febustat 40 Incepta Pharmaceuticals Limited Febuxostat INN 40mg Tablet 10x3's:MRP 360 Tk
Febustat 80 Incepta Pharmaceuticals Limited Febuxostat INN 80mg Tablet 10x3's:MRP 660 Tk
FEBUX Aristopharma Ltd. Febuxostat INN 40mg & 80mg Tablet 40mg x30's, 80mg x10's: 360.00 &220.00 MRP
FEBUX 40 Monico Pharma Limited Febuxostat INN 40mg Tablet 20's: 240.00 MRP
FELURIC 40 Healthcare Pharmacuticals Ltd. Febuxostat INN 40mg Tablet 30's MRP 360 Tk
FELURIC 80 Healthcare Pharmacuticals Ltd. Febuxostat INN 80mg Tablet 20's MRP 440 Tk
URISTAT IBN SINA Pharmaceutical Industry Ltd. Febuxostat INN 40mg & 80mg Tablet 40mg x30's, 80mg x20's: 360.00 &240.00 MRP
UROSTAT General Pharmaceuticals Ltd Febuxostat INN 40mg & 80mg Tablet 40mg x20's, 80mg x10's: 240.00 &220.00 MRP

Gen. MedInfo

Why is this medication prescribed?

Febuxostat is used to treat gout. Gout is a type of arthritis in which uric acid, a naturally occurring substance in the body, builds up in the joints and causes sudden attacks of redness, swelling, pain, and heat in one or more joints. Febuxostat is in a class of medications called xanthine oxidase inhibitors. It works by decreasing the amount of uric acid that is made in the body. Febuxostat is used to prevent gout attacks, but not to treat them once they occur.

How should this medicine be used?

Febuxostat comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take febuxostat at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take febuxostat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may increase your dose of febuxostat after 2 weeks if a laboratory test shows that you still have too much uric acid in your blood.

It may take several months before febuxostat begins to prevent gout attacks. Febuxostat may increase the number of gout attacks during the first few months of your treatment. Your doctor may prescribe another medication such as colchicine or a nonsteroidal anti-inflammatory drug (NSAID) to prevent gout attacks during the first 6 months of your treatment. Continue to take febuxostat even if you have gout attacks during your early treatment.

Febuxostat controls gout but does not cure it. Continue to take febuxostat even if you feel well. Do not stop taking febuxostat without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor for more information.

What special precautions should I follow?

Before taking febuxostat,

  • tell your doctor if you are allergic to febuxostat, any other medications, or any of the ingredients in febuxostat. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking azathioprine (Imuran), mercaptopurine, or theophylline. Your doctor will probably tell you not to take febuxostat if you are taking one or more of these medications.
  • tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention cancer chemotherapy medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had chest pain; an organ transplant; cancer; a stroke; Lesch-Nyhan syndrome (an inherited disease that causes high levels of uric acid in the blood, joint pain, and problems with motion and behavior); or heart, kidney, or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking febuxostat, call your doctor.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Febuxostat may cause side effects. Tell your doctor if either of these symptoms is severe or does not go away:

  • nausea

  • joint pain

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • rash

  • chest pain

  • shortness of breath

  • slow or difficult speech

  • dizziness or faintness

  • weakness or numbness of an arm or leg

Febuxostat may cause you to have high levels of liver enzymes in your blood. This may be a sign of liver damage. Your doctor will monitor you carefully during your treatment.

Febuxostat may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.

This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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