(bak' loe fen)
P : Caution when used during pregnancy
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
|Administration||Should be taken with food.
|Overdosage||Symptoms include muscular hypotonia, drowsiness, respiratory depression, coma and convulsions. Gastric lavage may be used.|
|Contraindications||Hypersensitivity. Active peptic ulcer disease.|
|Special Precautions||Cerebrovascular disorders, epilepsy, severe psychotic disorders, confusional states, history of peptic ulcer, resp depression, diabetes (DM), hepatic or renal impairment, elderly, pregnancy. Avoid sudden withdrawal.|
|Adverse Drug Reaction(s)||Sedation, drowsiness, ataxia, dizziness, headache, confusion, hallucinations, skin reactions, GI symptoms, enuresis.
Potentially Fatal: Respiratory or CV depression, seizures.
|Drug Interactions||Hypotensive effect may be increased with antihypertensives. Concomittant use with levodopa in Parkinson patients may result in confusion, agitation, hallucinations.
Potentially Fatal: CNS depressants and alcohol may potentiate CNS effects.
|Pregnancy Category (FDA)||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Storage||Oral: Store below 25Â°C.|
|Pharmacology||Baclofen is an antispastic. It inhibits both monosynaptic and polysynaptic reflexes at spinal level.
Absorption: Rapidly and almost completely absorbed from GIT (oral); peak plasma conc after 1-3 hr.
Distribution: Blood-brain barrier, CSF (equivalent to 12% conc found in plasma). Protein-binding: 30%.
Metabolism: Hepatic (15% of the dose).
Excretion: Via urine (70-80% as unchanged drug); elimination half-life (Via urine (70-80% as unchanged drug); elimination half-life (t1/2): 3-4 hr (plasma), 5 hr (CSF). 3-4 hr (plasma), 5 hr (CSF).
|ATC Classification||M03BX01 - baclofen; Belongs to the class of otheragents used as centrally-acting muscle relaxants.|
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|AXANT||Novus Pharmaceuticals Ltd.||Baclofen BP 10mg & 25mg||Tablet||10mg x30's, 25mg x20's: 135.00 & 160.00 MRP|
|BACLOFEN||Apex Pharmaceuticals Ltd.||Baclofen BP 10mg||Tablet||20's: 120.00 MRP|
|BACLOFLEX||Somatec Pharmaceuticals Ltd.||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
|BACLON||Orion Pharma Ltd.||Baclofen BP 5mg & 10mg||Tablet||5mg x50's, 10mg x30's: 226.00 & 240.00 MRP|
|BACOFEN||IBN SINA Pharmaceutical Industry Ltd.||Baclofen BP 5mg & 10mg||Tablet||5mg x50's, 10mg x30's: 225.00 & 240.00 MRP|
|BECLO||Opsonin Pharma Limited||Baclofen BP 5mg, 10mg & 25mg||Tablet||5 & 10mg x30's: 135.00 & 240.00 ; 25mg x20's: 400.00 MRP|
|BECLOVAN||Aristopharma Ltd.||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
|C-BAC||Chemist Laboratories Ltd.||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
|FENOBAC||Eskayef Bangladesh Ltd||Baclofen BP 5mg & 10mg||Tablet||5mg x50's & 10mg x30's MRP: 225.00 & 240.00|
|FLEXIBAC||Beacon Pharmaceuticals Limited||Baclofen BP 5mg & 10mg||Tablet||50's each: 225.00 & 401.50 MRP|
|Flexifen 10||Incepta Pharmaceuticals Limited||Baclofen BP 10mg||Tablet||10x3's:MRP 240 Tk|
|Flexifen 25||Incepta Pharmaceuticals Limited||Baclofen BP 25mg||Tablet||4x5's:MRP 320 Tk|
|Flexifen 5||Incepta Pharmaceuticals Limited||Baclofen BP 5mg||Tablet||10x5's:MRP 225 Tk|
|FLEXILAX 10||Square Pharmaceuticals Ltd.||Baclofen 10mg||Tablet||5x10's: 403.00 MRP|
|FLEXILAX 5||Square Pharmaceuticals Ltd.||Baclofen 5mg||Tablet||3x10's: 136.20 MRP|
|LIOREL||ACI Ltd.||Baclofen BP 5mg & 10mg||Tablet||5mg x50's, 10mg x30's: 226.00 & 240.90 MRP|
|LIORESAL||Novartis (Bangladesh) Ltd.||Baclofen BP 10mg & 25mg||Tablet||10mg x 50's: MRP 577.50; 25mg x 50's: MRP 1123.00|
|LIOSAL||Delta Pharma Limited||Baclofen BP 10mg||Tablet||20's: 160.00 MRP|
|LOSPAN 10MG||Beximco Pharmaceuticals Ltd||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
|LOSPAN 25MG||Beximco Pharmaceuticals Ltd||Baclofen BP 25mg||Tablet||30's: 480.00 MRP|
|MYOREL 10||Healthcare Pharmacuticals Ltd.||Baclofen BP 10mg||Tablet||30's MRP 247.5 Tk|
|MYOREL 25||Healthcare Pharmacuticals Ltd.||Baclofen BP 25mg||Tablet||30's MRP 600 Tk|
|MYOREL 5||Healthcare Pharmacuticals Ltd.||Baclofen BP 5mg||Tablet||30's MRP 150 Tk|
|REFLEXEN||NIPRO JMI Pharma Ltd.||Baclofen USP 10mg & 25mg||Tablet||30's each: 240.00 & 600.00 MRP|
|RELOFEN||Ad-din pharmaceuticals Ltd.||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
|REMBAC||Monico Pharma Limited||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
|RESTOBAC||General Pharmaceuticals Ltd||Baclofen BP 10mg||Tablet||30's: 240.90 MRP|
|SPAFEN||R A K Pharmaceuticals Pvt. Ltd.||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
|SPINAFEN||Globe Pharmaceuticals Ltd||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
|SPINOFEN||Sharif Pharmaceuticals Ltd.||Baclofen BP 10mg||Tablet||30's: 240.00 MRP|
Why is this medication prescribed?
Baclofen acts on the spinal cord nerves and decreases the number and severity of muscle spasms caused by multiple sclerosis or spinal cord diseases. It also relieves pain and improves muscle movement.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Baclofen comes as a tablet to take by mouth. It usually is taken three times a day at evenly spaced intervals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take baclofen exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. This drug must be taken regularly for a few weeks before its full effect is felt.
Continue to take baclofen even if you feel well. Do not stop taking baclofen without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually.
What special precautions should I follow?Before taking baclofen,
- tell your doctor and pharmacist if you are allergic to baclofen or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially muscle relaxants, sleeping pills, tranquilizers, and vitamins.
- tell your doctor if you have or have ever had kidney disease, epilepsy, ulcers, a stroke, a rheumatic disease, cerebral palsy, Parkinson's disease, or a psychiatric condition.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking baclofen, call your doctor immediately.
- you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how baclofen affects you.
- remember that alcohol can add to the drowsiness caused by this drug.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?Baclofen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
This medication may cause other side effects. Consult your doctor if you have any unusual problems while taking this.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: MedlinePlus, U.S. Natl. Library of Medicine
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.