Baclofen

(bak' loe fen)

PCaution when used during lactation : Caution when used during pregnancy

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage

Oral route
Severe chronic spasticity
Adult: Initially, 5 mg tid for 3 days increased to 10 mg tid for 3 days, then in similar increments and intervals until either 20 mg tid is reached or until desired effect is obtained. Max: 100 mg daily. 
Child: 0.75-2 mg/kg daily. May initiate with 2.5 mg 4 times daily, increased gradually every 3 days until desired effect is obtained. Maintenance: 6-10 yr: 30-60 mg daily; 2-6 yr: 20-30 mg daily; 12 mth-2 yr: 10-20 mg daily. Max: >10 yr: 2.5 mg/kg daily. 
Elderly: Initiate with lower doses.
Renal impairment: Dose reduction may be required. Patients on chronic haemodialysis: 5 mg daily. 

Intrathecal
Severe chronic spasticity
Adult: Test dose: 25 or 50 mcg administered into the intrathecal space by barbotage over at least 1 minute; increase dose by 25 mcg not more often than every 24 hr until 100 mcg/dose to determine appropriate dose. Non-responders to a test dose of 100 mcg are not suitable for intrathecal treatment. For responders with response lasting >8-12 hr, the test dose that was used to produce the response can be given as a 24-hr infusion; if the test-dose response lasted ≤8-12 hr, then a dose equivalent to twice the test dose is given. Adjust daily dosage as required. Maintenance: 12 mcg-2 mg daily for spasticity of spinal origin; 22 mcg-1.4 mg daily for spasticity of cerebral origin. 
Child: 4-18 yr with spasticity of cerebral origin: Initially, 25 mcg over at least 1 minute via catheter or lumbar puncture, increase by 25 mcg every 24 hr to a max of 100 mcg to determine appropriate dose then dose-titration phase. Maintenance: <12 yr: 24 mcg-1.2 mg daily; >12 yr: 1.4 mg daily.

Administration Should be taken with food.
Overdosage Symptoms include muscular hypotonia, drowsiness, respiratory depression, coma and convulsions. Gastric lavage may be used.
Contraindications Hypersensitivity. Active peptic ulcer disease.
Special Precautions Cerebrovascular disorders, epilepsy, severe psychotic disorders, confusional states, history of peptic ulcer, resp depression, diabetes (DM), hepatic or renal impairment, elderly, pregnancy. Avoid sudden withdrawal.
Adverse Drug Reaction(s) Sedation, drowsiness, ataxia, dizziness, headache, confusion, hallucinations, skin reactions, GI symptoms, enuresis.
Potentially Fatal: Respiratory or CV depression, seizures.
Drug Interactions Hypotensive effect may be increased with antihypertensives. Concomittant use with levodopa in Parkinson patients may result in confusion, agitation, hallucinations.
Potentially Fatal: CNS depressants and alcohol may potentiate CNS effects.

Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Oral: Store below 25°C.
Pharmacology Baclofen is an antispastic. It inhibits both monosynaptic and polysynaptic reflexes at spinal level.
Absorption: Rapidly and almost completely absorbed from GIT (oral); peak plasma conc after 1-3 hr.
Distribution: Blood-brain barrier, CSF (equivalent to 12% conc found in plasma). Protein-binding: 30%.
Metabolism: Hepatic (15% of the dose).
Excretion: Via urine (70-80% as unchanged drug); elimination half-life (Via urine (70-80% as unchanged drug); elimination half-life (t1/2): 3-4 hr (plasma), 5 hr (CSF). 3-4 hr (plasma), 5 hr (CSF).
ATC Classification M03BX01 - baclofen; Belongs to the class of otheragents used as centrally-acting muscle relaxants.

Brand/Product Info


Total Products : 30                              
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
AXANT Novus Pharmaceuticals Ltd. Baclofen BP 10mg & 25mg Tablet 10mg x30's, 25mg x20's: 135.00 & 160.00 MRP
BACLOFEN Apex Pharmaceuticals Ltd. Baclofen BP 10mg Tablet 20's: 120.00 MRP
BACLOFLEX Somatec Pharmaceuticals Ltd. Baclofen BP 10mg Tablet 30's: 240.00 MRP
BACLON Orion Pharma Ltd. Baclofen BP 5mg & 10mg Tablet 5mg x50's, 10mg x30's: 226.00 & 240.00 MRP
BACOFEN IBN SINA Pharmaceutical Industry Ltd. Baclofen BP 5mg & 10mg Tablet 5mg x50's, 10mg x30's: 225.00 & 240.00 MRP
BECLO Opsonin Pharma Limited Baclofen BP 5mg, 10mg & 25mg Tablet 5 & 10mg x30's: 135.00 & 240.00 ; 25mg x20's: 400.00 MRP
BECLOVAN Aristopharma Ltd. Baclofen BP 10mg Tablet 30's: 240.00 MRP
C-BAC Chemist Laboratories Ltd. Baclofen BP 10mg Tablet 30's: 240.00 MRP
FENOBAC Eskayef Bangladesh Ltd Baclofen BP 5mg & 10mg Tablet 5mg x50's & 10mg x30's MRP: 225.00 & 240.00
FLEXIBAC Beacon Pharmaceuticals Limited Baclofen BP 5mg & 10mg Tablet 50's each: 225.00 & 401.50 MRP
Flexifen 10 Incepta Pharmaceuticals Limited Baclofen BP 10mg Tablet 10x3's:MRP 240 Tk
Flexifen 25 Incepta Pharmaceuticals Limited Baclofen BP 25mg Tablet 4x5's:MRP 320 Tk
Flexifen 5 Incepta Pharmaceuticals Limited Baclofen BP 5mg Tablet 10x5's:MRP 225 Tk
FLEXILAX 10 Square Pharmaceuticals Ltd. Baclofen 10mg Tablet 5x10's: 403.00 MRP
FLEXILAX 5 Square Pharmaceuticals Ltd. Baclofen 5mg Tablet 3x10's: 136.20 MRP
LIOREL ACI Ltd. Baclofen BP 5mg & 10mg Tablet 5mg x50's, 10mg x30's: 226.00 & 240.90 MRP
LIORESAL Novartis (Bangladesh) Ltd. Baclofen BP 10mg & 25mg Tablet 10mg x 50's: MRP 577.50; 25mg x 50's: MRP 1123.00
LIOSAL Delta Pharma Limited Baclofen BP 10mg Tablet 20's: 160.00 MRP
LOSPAN 10MG Beximco Pharmaceuticals Ltd Baclofen BP 10mg Tablet 30's: 240.00 MRP
LOSPAN 25MG Beximco Pharmaceuticals Ltd Baclofen BP 25mg Tablet 30's: 480.00 MRP
MYOREL 10 Healthcare Pharmacuticals Ltd. Baclofen BP 10mg Tablet 30's MRP 247.5 Tk
MYOREL 25 Healthcare Pharmacuticals Ltd. Baclofen BP 25mg Tablet 30's MRP 600 Tk
MYOREL 5 Healthcare Pharmacuticals Ltd. Baclofen BP 5mg Tablet 30's MRP 150 Tk
REFLEXEN NIPRO JMI Pharma Ltd. Baclofen USP 10mg & 25mg Tablet 30's each: 240.00 & 600.00 MRP
RELOFEN Ad-din pharmaceuticals Ltd. Baclofen BP 10mg Tablet 30's: 240.00 MRP
REMBAC Monico Pharma Limited Baclofen BP 10mg Tablet 30's: 240.00 MRP
RESTOBAC General Pharmaceuticals Ltd Baclofen BP 10mg Tablet 30's: 240.90 MRP
SPAFEN R A K Pharmaceuticals Pvt. Ltd. Baclofen BP 10mg Tablet 30's: 240.00 MRP
SPINAFEN Globe Pharmaceuticals Ltd Baclofen BP 10mg Tablet 30's: 240.00 MRP
SPINOFEN Sharif Pharmaceuticals Ltd. Baclofen BP 10mg Tablet 30's: 240.00 MRP

Gen. MedInfo

Why is this medication prescribed?

Baclofen acts on the spinal cord nerves and decreases the number and severity of muscle spasms caused by multiple sclerosis or spinal cord diseases. It also relieves pain and improves muscle movement.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Baclofen comes as a tablet to take by mouth. It usually is taken three times a day at evenly spaced intervals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take baclofen exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. This drug must be taken regularly for a few weeks before its full effect is felt.

Continue to take baclofen even if you feel well. Do not stop taking baclofen without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually.

What special precautions should I follow?

Before taking baclofen,
  • tell your doctor and pharmacist if you are allergic to baclofen or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially muscle relaxants, sleeping pills, tranquilizers, and vitamins.
  • tell your doctor if you have or have ever had kidney disease, epilepsy, ulcers, a stroke, a rheumatic disease, cerebral palsy, Parkinson's disease, or a psychiatric condition.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking baclofen, call your doctor immediately.
  • you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how baclofen affects you.
  • remember that alcohol can add to the drowsiness caused by this drug.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Baclofen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • drowsiness

  • dizziness

  • weakness

  • confusion

  • upset stomach

If you experience either of the following symptoms, call your doctor immediately:
  • difficulty breathing

  • seizures

This medication may cause other side effects.  Consult your doctor if you have any unusual problems while taking this.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 Ref: MedlinePlus, U.S. Natl. Library of Medicine


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.