Tenoxicam

(Ten-ox-ee-kam)

PCI  : Contraindicated in pregnancy

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Oral route
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: 20 mg as a single daily dose given for 7 days in acute musculoskeletal disorders and up to 14 days in severe cases. Max: 40 mg/day (short term use).
Parenteral route
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: Initially, 20 mg IM/IV as a single dose given for 1-2 days.
Administration Should be taken with food. Take w/ or immediately after meals.
Contraindications Active or history of recurrent GI bleed or peptic ulcer, hypersensitivity to NSAIDs, severe heart failure, haemorrhagic diathesis, asthma, pregnancy (3rdtrimester).
Special Precautions History of peptic ulceration, renal, cardiac or hepatic impairment, cerebovascular disease, fluid retention, inflammatory bowel disease, pregnancy, elderly.
Adverse Drug Reaction(s) GI upsets including epigastric pain and gastritis, nausea, hypersensitivity reactions, headache, dizziness, sleep disturbances.
Potentially Fatal: CV thrombotic events, blood dyscrasias, nephrotoxicity, hepatotoxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome.
Drug Interactions Risk of nephrotoxicity may be increased with ACE inhibitors, ciclosporin, tacrolimus or diuretics. Increased risk of hyperkaelemia with ACE inhibitors, potassium sparing diuretics.
Potentially Fatal: Risk of nephrotoxicity may be increased with ACE inhibitors, ciclosporin, tacrolimus or diuretics. Increased risk of hyperkaelemia with ACE inhibitors, potassium sparing diuretics. Please consult manufacturer's PIL (Prescribing Information Leaflet) for detailed drug interactions.
Food Interaction Absorption slowed but overall bioavailability not reduced.
Storage Oral: Do not store above 30°C Parenteral: Do not store above 30°C
Pharmacology Tenoxicam is a potent inhibitor of prostaglandin synthesis by blocking the enzyme cyclo-oxygenase. Additional actions contributing to its anti-inflammatory effect includes inhibition of leucocyte function including phagocytosis and chemotaxis, and scavenging free O2 radicals. It has no effect on renal function at the usual doses.
Absorption: Absorbed well from the GIT (oral); peak plasma concentrations after 2 hr (fasting), 6 hr (non-fasting).
Distribution: Penetrates synovial fluid. Protein-binding: 98.5%
Metabolism: Hepatic; completely to inactive metabolites.
Excretion: Via urine (as metabolites), via bile (as conjugates of the metabolites); 60-75 hr (elimination half-life)
ATC Classification M01AC02 - tenoxicam; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, oxicams.

Brand/Product Info


Total Products : 11           
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ENGCAM The Acme Laboratories Ltd. Tenoxicam 20mg Tablet 30's: 240.00 MRP
INOTEN Opsonin Pharma Limited Tenoxicam 20mg Tablet 30's: 240.00 MRP
MOBICAM Beximco Pharmaceuticals Ltd Tenoxicam 20mg Tablet 30's: 240.00 MRP
OXICAM ACI Ltd. Tenoxicam 20mg Tablet 30's: 240.90 MRP
TENOFLEX Beacon Pharmaceuticals Limited Tenoxicam 20mg Tablet 30's: 240.00 MRP
Tenopain Incepta Pharmaceuticals Limited Tenoxicam 20mg Tablet 10x3's:MRP 240 Tk
TENORIX Orion Pharma Ltd. Tenoxicam 20mg Tablet 30's: 240.90 MRP
TEXICAM Apex Pharmaceuticals Ltd. Tenoxicam 20mg Tablet 20's: 160.00 MRP
TILCOTIL Radiant Pharmaceuticals Ltd. Tenoxicam 20mg Tablet 50's: 850.50 MRP
XICOTIL Aristopharma Ltd. Tenoxicam 20mg Tablet 8's: 160.00 IP
XTEN Square Pharmaceuticals Ltd. Tenoxicam 20mg Tablet 3x10's: 240.90