Naproxen

(na prox' en)

PCI  : Contraindicated in pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Oral route
Rheumatic disorders
Adult: 0.5-1 g as a single dose or in 2 divided doses, up to 1.5 g daily for patients who can tolerate lower doses, for up to 6 mth, if required.
Elderly: Consider dose reductions; use lowest possible effective dose.

Juvenile idiopathic arthritis
Child: â‰¥2 yr: 5-7.5 mg/kg bid. Max: 1 g/day. 

Dysmenorrhoea
Adult: Initially, 500 mg followed by 250 mg every 6-8 hr. Max: 1.25 g on the 1st day and 1 g thereafter.
Elderly: Consider dose reductions; use lowest possible effective dose.

Acute musculoskeletal disorders
Adult: Initially, 500 mg followed by 250 mg every 6-8 hr. Max: 1.25 g on the 1st day and 1 g thereafter.
Elderly: Consider dose reductions; use lowest possible effective dose.

Acute gout
Adult: Initially, 750 mg followed by 250 mg every 8 hr.
Elderly: Consider dose reductions; use lowest possible effective dose.

Acute migraine attacks
Adult: 750 mg at the onset of attack, followed after at least ½ an hr by further doses of 250-500 mg daily. Max: 1250 mg daily.
Elderly: Consider dose reductions; use lowest possible effective dose.
Administration Should be taken with food. Take immediately after meals.
Overdosage Symptoms: Drowsiness, heartburn, vomiting, CNS depression, leukocytosis, renal failure. Management: Supportive and symptomatic.
Contraindications Hypersensitivity. Aspirin or NSAID allergy. Perioperative pain in the setting of CABG surgery. Pregnancy (3rd trimester).
Special Precautions Pre-existing CV risk factors or disease e.g. fluid retention, CHF, hypertension. History of GI disease (bleeding or ulcers). Other forms of asthma. Hepatic impairment; closely monitor patients with any abnormal LFT. Renal impairment. Elderly. Lactation.
Adverse Drug Reaction(s) Oedema, palpitation, dizziness, drowsiness, headache, light headedness, vertigo, pruritus, skin eruption, ecchymosis, purpura, rash, fluid retention, abdominal pain, constipation, nausea, heartburn, diarrhoea, dyspepsia, stomatitis, flatulence, gross bleeding/perforation, indigestion, ulcers, vomiting, abnormal renal function, haemolysis, anaemia, increased bleeding time, elevated LFTs, visual disturbances, tinnitus, hearing disturbances, dyspnoea, diaphoresis, thirst.
Potentially Fatal: Anaphylactic/anaphylactoid reactions. Exfoliative dermatitis, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN).
Drug Interactions Antihypertensive effects of hypotensive agents may be reduced. May increase ciclosporin levels. Increased risk of seizures with fluoroquinolones. May reduce efficacy of diuretics. May diminish the cardioprotective effect of acetylated salicylates. Alcohol may enhance gastric mucosal irritation. Increased serum levels with probenecid.
Potentially Fatal: Increased risk of GI ulceration with corticosteroids. May increase lithium levels/toxicity. Severe bone marrow suppression, aplastic anaemia and GI toxicity may occur with methotrexate. Increased risk of bleeding with anticoagulants (e.g. warfarin, heparin, LMWHs) and antiplatelet agents (e.g. ticlopidine, clopidogrel, aspirin, abciximab, dipyridamole, eptifibatide, tirofiban). Absorption may be reduced with colestyramine (and other bile acid sequestrants). Please consult detailed drug interactions before prescribing.
Food Interaction Rate of absorption may be reduced with food. Avoid herbs/food with antiplatelet activity e.g. alfalfa, anise, bilberry, grapeseed, green tea, bladderwrack, turmeric, bromelain, cat's claw, celery, ginkgo biloba, coleus, cordyceps, dong quai, evening primrose, feverfew, fenugreek, garlic, ginger, red clover, horse chestnut, ginseng, guggul, horse chestnut seed, horseradish, licorice, prickly ash, reishi, sweet clover, white willow.
Lab Interference May interfere with 5-hydroxyindole acetic acid (5-HIAA) urinary assays. Discontinue 72 hr before adrenal function testing if the Porter-Silber test is used.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
 
Category D: In 3rd trimester or near delivery. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Storage Oral: Store at 15-30°C (59-86°F).
Pharmacology Naproxen has anti-inflammatory, analgesic, antipyretic actions. It reduces prostaglandin synthesis by inhibiting the enzyme cyclooxygenase. It also inhibits platelet aggregation.
Onset: Analgesic: 1 hr; anti-inflammatory: Approx 2 wk.
Duration: Analgesic: ≤7 hr; anti-inflammatory: ≤12 hr.
Absorption: Readily absorbed from the GI tract (oral); peak plasma concentrations after 2-4 hr. Well absorbed rectally.
Distribution: Diffuses into synovial fluid; crosses the placenta; enters breast milk. Protein-binding: 99%.
Excretion: Via urine (as unchanged drug and metabolites), faeces; 13 hr (elimination half-life).
ATC Classification G02CC02 - naproxen; Belongs to the class of antiinflammatory products for vaginal administration used in the treatment and prevention of inflammation. 
M02AA12 - naproxen; Belongs to the class of non-steroidal antiinflammatory preparations for topical use. Used in the treatment of joint and muscular pains. 
M01AE02 - naproxen; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products. Used in the treatment of inflammation and rheumatism.

Brand/Product Info


Total Products : 70                                                                      
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ANAFLEX ACI Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 251.00 & 270.90 MRP
ANAFLEX Gel ACI Ltd. Naproxen sodium 10% w/w Gel 15gm, 30gm: 62.23 & 116.00 MRP
ANAFLEX SR ACI Ltd. Naproxen sodium 500mg Tablet (sustained release) 20's: 281.00 MRP
ARNEX Silva Pharmaceuticals Limited Naproxen sodium 500mg Tablet 30's: 180.68 MRP
BPXEN Bristol Pharma Limited Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 200.00 & 255.00 MRP
COSNAP Cosmo Pharma Laboratories Ltd. Naproxen sodium 250mg Tablet 50's: 150.00 MRP
DIPROXEN Drug International Ltd Naproxen sodium 250mg & 500mg Tablet 250mg x100's & 500mg x50's: 425.00 & 350.00 MRP
DIPROXEN CR-500 Drug International Ltd Naproxen sodium 500mg Tablet (controlled release) 30's: 300.00 MRP
DIPROXEN Gel Drug International Ltd Naproxen sodium 10% w/w Gel 15gm: 60.00 MRP
EPROX Euro Pharma Ltd. Naproxen sodium 500mg Tablet 50's: 350.00 MRP
FRITT Somatec Pharmaceuticals Ltd. Naproxen sodium 250mg & 500mg Tablet 50's each: 200.00 & 351.50 MRP
INDOPROX Indo-Bangla Pharmaceuticals Works Ltd. Naproxen sodium 250mg & 500mg Tablet 30's each: 160.00 & 210.00 MRP
NAID Pacific Pharmaceuticals Ltd. Naproxen sodium 250mg & 500mg Tablet 50's each: 200.00 & 376.00 MRP
NAN 500 Reliance Pharmaceuticals Ltd. Naproxen sodium 500mg Tablet 50's: 386.50 MRP
NAPIUM Kumudini Pharma Ltd Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 200.00 & 204.00 MRP
NAPIX-500 Modern Pharmaceuticals Ltd Naproxen sodium 500mg Tablet 20's: 140.00 MRP
NAPOXEN Edruc Limited Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 200.00 & 210.00 MRP
NAPRO Aristopharma Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 210.00 & 210.00 MRP
NAPRO-A The Acme Laboratories Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x100's, 500mg x30's: 401.00 & 210.60 MRP
NAPRO-A Suspension The Acme Laboratories Ltd. Naproxen sodium 125mg/5ml Suspension 50ml: 35.14 MRP
NAPROBEN 500 Benham Pharmaceuticals Ltd Naproxen sodium 500mg Tablet 30's: 180.00 MRP
NAPROCID Gaco Pharmaceutical Ltd. Naproxen sodium 250mg & 500mg Tablet 30's each: 120.00 & 210.00 MRP
NAPRONIL-500 Pharmasia Limited Naproxen sodium 500mg Tablet 30's: 210.90 MRP
NAPROPAIN R A K Pharmaceuticals Pvt. Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 200.00 & 210.00 MRP
NAPROSON Jayson Pharmaceuticals Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 203.00 & 210.90 MRP
NAPROSYN Radiant Pharmaceuticals Ltd. Naproxen sodium 250mg & 500mg Tablet 50's each: 350.00 & 650.00 MRP
NAPROX Eskayef Bangladesh Ltd Naproxen BP 500mg Tablet 500mg x3's & 500mg x6's MRP: 84.30, 168.60
NAPROX Gel Eskayef Bangladesh Ltd Naproxen BP 100mg/gm Gel 15gm MRP: 60.00
NAPROX Suspension Eskayef Bangladesh Ltd Naproxen BP 125mg/5ml Suspension 15ml & 20ml & 30ml MRP: 80.30, 85.32, 130.49
NAPROXEN Amico Laboratories Ltd. Naproxen sodium 500mg Tablet 30's: 210.00 MRP
NAPROXEN SR Zenith Pharmaceuticals Ltd. Naproxen sodium 500mg Tablet (sustained release) 30's: 210.00 MRP
NAPROXIN Ambee Pharmaceuticals Ltd. Naproxen sodium 250mg & 500mg Tablet 30's each: 127.80 & 207.60 MRP
NAPRYN 250 Healthcare Pharmacuticals Ltd. Naproxen BP 250 mg Tablet 50's MRP 350 Tk
NAPRYN 500 Healthcare Pharmacuticals Ltd. Naproxen BP 500mg Tablet 50's MRP 550 Tk
NAPRYN GEL Healthcare Pharmacuticals Ltd. Naproxen BP 100mg/gm Gel 15gm, MRP 70 Tk
NAPSOD Unimed & Unihealth Manufacturers Ltd. Naproxen sodium 275mg & 550mg Tablet 30's each: 150.00 & 270.00 MRP
NAPTODIN-500 Desh Pharmaceuticals (Pvt) Ltd Naproxen sodium 500mg Tablet 50's: 350.00 MRP
NASOX Seema Pharmaceuticals Ltd. Naproxen sodium 500mg Tablet 20's: 200.00 MRP
NASPRO Popular Pharmaceuticals Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 251.00 & 270.90 MRP
NAX-N-250 Novus Pharmaceuticals Ltd. Naproxen sodium 250mg Tablet 50's: 200.00 MRP
NAX-N-500 Novus Pharmaceuticals Ltd. Naproxen sodium 500mg Tablet 30's: 210.00 MRP
NAXO Navana Pharmaceuticals Limited Naproxen sodium 250mg & 500mg Tablet 50's each: 210.00 & 351.50 MRP
NOOZE 500 Syntho Laboratories Ltd. Naproxen sodium 500mg Tablet 30's: 180.00 MRP
NOXEN 500 Everest Pharmaceuticals Ltd. Naproxen sodium 500mg Tablet 30's: 210.00 MRP
NPX 250 NIPRO JMI Pharma Ltd. Naproxen sodium 250mg Tablet 50's: 200.00 MRP
NPX 500 SR NIPRO JMI Pharma Ltd. Naproxen sodium 500mg Tablet 30's: 420.00 MRP
NUPRAFEN 250 Beximco Pharmaceuticals Ltd Naproxen BP 250mg Tablet 100's: 420.00 MRP
NUPRAFEN 500 Beximco Pharmaceuticals Ltd Naproxen BP 500mg Tablet 50's: 392.50 MRP
NUPRALGIN IBN SINA Pharmaceutical Industry Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x48's, 500mg x24's: 240.00 & 216.00 MRP
PAIROX Asiatic Laboratories Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 250.00 & 240.00 MRP
PROXEN 500 Monico Pharma Limited Naproxen sodium 250mg Tablet 50's: 350.00 MRP
RANOXEN Rangs Pharmaceuticals Ltd. Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 200.00 & 210.00 MRP
REPRO 500 Doctors Chemical Works Ltd Naproxen sodium 250mg Tablet 30's: 210.00 MRP
ROXEN 250 Hallmark Pharmaceuticals Ltd Naproxen sodium 250mg Tablet 50's: 201.00 MRP
SERVINAPROX Sandoz/Novartis Naproxen Sodium BP 250mg & 500mg Tablet 250mg x 50's: MRP 350.00; 500mg x 30's: MRP 360.00
SONAP 250 Square Pharmaceuticals Ltd. Naproxen Sodium 250mg Tablet 5x10's: 201.50 MRP
SONAP 500 Square Pharmaceuticals Ltd. Naproxen Sodium 500mg Tablet 5x6's: 211.20 MRP
SONAP SUPP Square Pharmaceuticals Ltd. Naproxen Sodium 500mg Suppository 2x5's: 120.90 MRP
SUXEN Supreme Pharmaceuticals Ltd. Naproxen sodium 10% w/w Gel 15gm: 62.00 MRP
Ticoflex 250 Incepta Pharmaceuticals Limited Naproxen BP 250 mg Tablet 10x5's:MRP 200 Tk
Ticoflex 500 Incepta Pharmaceuticals Limited Naproxen BP 250 mg Tablet 10x5's:MRP 350 Tk
Ticoflex Gel Incepta Pharmaceuticals Limited Naproxen BP 100mg/gm Gel 15gm x 1:MRP 60 Tk
Ticoflex SR Incepta Pharmaceuticals Limited Naproxen BP 500 mg Tablet 10x3's:MRP 240 Tk
Ticoflex Suspension Incepta Pharmaceuticals Limited Naproxen BP 125mg/5ml Suspension 50ml:MRP 35 Tk
TICOLAX The White Horse Pharma Naproxen sodium BP 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 250.00 & 240.00 MRP
TOFA Kemiko Pharmaceuticals Ltd Naproxen sodium 250mg & 500mg Tablet 50's each: 200.00 & 400.00 MRP
ULTRANAX Ad-din pharmaceuticals Ltd. Naproxen sodium 500mg Tablet 30's: 240.00 MRP
XENAPRO Renata Limited Naproxen sodium 250mg & 500mg Tablet 250mg x50's, 500mg x30's: 200.50 & 240.90 MRP
XPRO Apex Pharmaceuticals Ltd. Naproxen sodium 500mg Tablet 30's: 210.00 MRP
ZENOSYN Sharif Pharmaceuticals Ltd. Naproxen sodium 500mg Tablet 30's: 210.00 MRP

Gen. MedInfo

IMPORTANT WARNING:

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take naproxen right before or right after the surgery.

NSAIDs such as naproxen may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or who drink three or more alcoholic drinks per day while taking naproxen. Tell your doctor if you take any of the following medications: anticoagulants (''blood thinners'') such as warfarin; aspirin; other NSAIDs such as ibuprofen and ketoprofen or oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Deltasone). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking naproxen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to naproxen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription naproxen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

 

Why is this medication prescribed?

Prescription naproxen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), juvenile arthritis (a form of joint disease in children), and ankylosing spondylitis (arthritis that mainly affects the spine). Prescription naproxen tablets, extended-release tablets, and suspension are also used to relieve shoulder pain caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint), tendinitis (inflammation of the tissue that connects muscle to bone), gouty arthritis (attacks of joint pain caused by a build-up of certain substances in the joints), and pain from other causes, including menstrual pain (pain that happens before or during a menstrual period). Nonprescription naproxen is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Naproxen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

How should this medicine be used? 

Prescription naproxen comes as a regular tablet, an enteric coated tablet (delayed-release tablet), an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth. The extended-release tablets are usually taken once a day. The tablets, enteric coated tablets, and suspension are usually taken twice a day for arthritis. The tablets and suspension are usually taken every 8 hours for gout, and every 6 to 8 hours as needed for pain. If you are taking naproxen on a regular basis, you should take it at the same time(s) every day.

Nonprescription naproxen comes as tablet and a gelatin coated tablet to take by mouth. It is usually taken with a full glass of water every 8 to 12 hours as needed. Nonprescription naproxen may be taken with food or milk to prevent nausea.

Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take naproxen exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or written on the package.

Shake the liquid well before each use to mix the medication evenly. Use the measuring cup provided to measure each dose of the liquid.

Swallow the enteric coated tablets and extended release tablets whole; do not split, chew, or crush them.

If you are taking naproxen to relieve the symptoms of arthritis, your symptoms may begin to improve within 1 week. It may take 2 weeks or longer for you to feel the full benefit of the medication.

Stop taking nonprescription naproxen and call your doctor if your symptoms get worse, you develop new or unexpected symptoms, the part of your body that was painful becomes red or swollen, your pain lasts for more than 10 days, or your fever lasts for more than 3 days.

Other uses for this medicine 

Naproxen is also sometimes used to treat Paget's disease of bone (a condition in which the bones become abnormally thick, fragile, and misshapen) and Bartter syndrome (a condition in which the body does not absorb enough potassium, causing muscle cramping and weakness and other symptoms). Talk to your doctor about the risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow? 

Before taking naproxen, 

  • tell your doctor if you are allergic to naproxen, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and ketoprofen (Orudis KT, Actron), any medications for pain or fever, or any other medications.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme  inhibitors such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandolapril; angiotensin II receptor antagonists  such as candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, and valsartan; beta blockers such as atenolol, labetalol, metoprolol, nadolol, and propranolol; cholestyramine; diuretics; lithium, medications for diabetes; methotrexate; probenecid; selective serotonin reuptake inhibitors such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline; sulfa medications such as sulfamethoxazole; and warfarin . If you are taking the enteric coated tablets, also tell your doctor if you are taking antacids or sucralfate . Your doctor may need to change the doses of your medication or monitor you more carefully for side effects.
  • do not take nonprescription naproxen with any other medication for pain unless your doctor tells you that you should.
  • tell your doctor if you have been told to follow a low sodium diet and if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the inside of the nose); swelling of the hands, arms, feet, ankles, or lower legs; anemia (red blood cells do not bring enough oxygen to all parts of the body); or liver or kidney disease.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while taking naproxen, call your doctor.

talk to your doctor about the risks and benefits of taking naproxen if you are 65 years of age or older. Older adults should usually take lower doses of naproxen for short periods of time because higher doses used regularly may not be more effective and are more likely to cause serious side effects.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking naproxen.
  • you should know that this medication may make you dizzy, drowsy, or depressed. Do not drive a car or operate machinery until you know how this drug affects you.
  • remember that alcohol can add to the drowsiness caused by this medication.

What special dietary instructions should I follow? 

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose? 

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause? 

Naproxen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: 

  • constipation

  • diarrhea

  • gas

  • excessive thirst

  • headache

  • dizziness

  • lightheadedness

  • drowsiness

  • difficulty falling asleep or staying asleep

  • burning or tingling in the arms or legs

  • cold symptoms

  • ringing in the ears

  • hearing problems

Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more naproxen until you speak to your doctor: 

  • changes in vision

  • feeling that the tablet is stuck in your throat

  • unexplained weight gain

  • sore throat, fever, chills, and other signs of infection

  • blisters

  • rash

  • skin reddening

  • itching

  • hives

  • swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs

  • difficulty breathing or swallowing

  • hoarseness

  • excessive tiredness

  • pain in the upper right part of the stomach

  • nausea

  • yellowing of the skin or eyes

  • flu-like symptoms

  • bruises or purple blotches under the skin

  • fast heartbeat

  • cloudy, discolored, or bloody urine

  • back pain

  • difficult or painful urination

  • decreased urination

  • loss of appetite

  • confusion

 Naproxen may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication? 

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose 

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include the following: 

  • dizziness

  • extreme tiredness

  • drowsiness

  • stomach pain

  • heartburn

  • nausea

  • vomiting

  • slow or difficult breathing

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.