Molecule Info

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Indication(s) & Dosage Oral route
Mild to moderate pain
Adult: 12.5 mg every 4-6 hr or 25 mg every 8 hr. Max: 75 mg/day. 
Elderly: Initial total daily dose should not exceed 50 mg/day. May increase to the doses recommended for general population only if well tolerated. 
Renal impairment: Mild renal impairment: Reduce initial dose to 50 mg/day. Not to be used in moderate to severe renal impairment.
Hepatic impairment: Mild to moderate impairment: Reduce initial dose to 50 mg/day. Not to be used in severe hepatic impairment.
Administration Should be taken on an empty stomach. Take 30 min before meals, esp for quick relief of acute pain.
Overdosage Administer activated charcoal if more than 5 mg/kg has been ingested by an adult or a child within an hr. Symptomatic therapy should be provided. Dexketoprofen is dialysable.
Contraindications Hypersensitivity to Dexketoprofen, or other NSAIDs. Patients with history of asthma attacks, bronchospasm, angioedema, urticaria, acute rhinitis or nasal polyps that were precipitated by Aspirin or other NSAIDs. Active/suspected/recurrent peptic ulcer or haemorrhage. Chronic dyspepsia; GI bleeding or other active bleedings; Crohn's disease or ulcerative colitis; bronchial asthma; severe heart failure; severe hepatic impairment; moderate to severe renal impairment; haemorrhagic diathesis and other coagulation disorders. Pregnancy and lactation.
Special Precautions History of GI disease, GI symptoms; NSAIDS are associated with serious GI side effects e.g. bleeding, ulceration or perforation. May cause deterioration of renal function, fluid retention and oedema; caution in renal and/or hepatic impairment, HTN, heart failure. May inhibit platelet aggregation and prolong bleeding time, concomitant use with warfarin or heparin is not recommended. Non-selective NSAIDs are also associated with a small increased risk of thrombotic events (e.g. stroke, MI). Long term use may impair female fertility. Safety and efficacy in children and adolescent have not been established. Increased risk of NSAIDS adverse reactions in elderly patients.
Adverse Drug Reaction(s) Nausea, vomiting, dyspepsia, abdominal pain, diarrhoea, gastric, peptic ulcer, GI bleeding, dry mouth, flatulence, headache, dizziness, somnolence, insomnia, palpitations, paraesthesia, syncope, HTN, hypotension, bradypnoea, bronchosposm, fatigue, asthenia, malaise, rash, urticaria, acne, photosensitivity reactions, facial oedema, polyruria, nephritis or nephrotic syndrome, menstrual disorder, prostatic disorder, peripheral oedema, pancreatitis, abnormal LFT, increased plasma urea nitrogen, neutropenia, thrombocytopenia.
Potentially Fatal: Anaphylactic shock, Steven-Johnson Syndrome and toxic epidermal necrolysis.
Drug Interactions Concomitant use of salicylates, other NSAIDs, anticoagulant (e.g. warfarin, heparin) or corticosteroids may increase risk of bleeding and combination use is not recommended. Caution if used with thrombolytics, anti-platelets, selective serotonin reuptake inhibitors, pentoxyfylline due to elevated bleeding risk. May increase toxic effects of hydantoines and sulphonamides. May reduce effects of antihypertensives. Increased risk of red cell line toxicity with zidovudine, monitor complete blood count and reticulocyte count. Renal function may be worsened when used with ciclosporin or tacrolimus. May increase hypoglycaemic effect of sulfonylureas. Probenacid may increase plasma concentration of Dexketoprofen.
Potentially Fatal: Concomitant use of salicylates, other NSAIDs, anticoagulant (e.g. warfarin, heparin) or corticosteroids may increase risk of bleeding and combination use is not recommended. Caution if used with thrombolytics, anti-platelets, selective serotonin reuptake inhibitors, pentoxyfylline due to elevated bleeding risk. May increase toxic effects of hydantoines and sulphonamides. May reduce effects of antihypertensives. Increased risk of red cell line toxicity with zidovudine, monitor complete blood count and reticulocyte count. Renal function may be worsened when used with ciclosporin or tacrolimus. May increase hypoglycaemic effect of sulfonylureas. Probenacid may increase plasma concentration of Dexketoprofen. Please consult detailed drug interactions before prescribing.
Food Interaction Reduced absorption rate when administered with food.
Storage Oral: Store at below 30°C; protect from light.
Pharmacology Dexketoprofen is an isomer of ketoprofen. It is a propionic acid derivative with analgesic, anti-inflammatory and antipyretic properties. It is a non-steroidal anti-inflammatory drug (NSAID) that reduces prostaglandin synthesis via inhibition of cyclooxygenase pathway (both COX-1 and COX-2) activity.
Onset: About 30 min.
Duration: About 4-6 hr.
Absorption: Cmax: About 30 min.
Distribution: Vd: <0.25 L/kg. Highly protein bound.
Excretion: Mainly eliminated via glucuronide conjugation and followed by renal excretion. Elimination half-life: About 1.65 hr.
ATC Classification M01AE17 - dexketoprofen; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.

Brand/Product Info


Total Products : 1 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
Actidex Incepta Pharmaceuticals Limited Dexketoprofen Trometamol equivalent to Dexketoprofen INN 25mg Tablet 10x5's:MRP 200 Tk