Molecule Info

Contents & Description

Glucosamine Sulfate 250 mg as Glucosamine Sulfate Potassium Chloride USP & Chondroitin Sulfate 200 mg as Chondroitin Sulfate Sodium USP

A double strength formulation of Glucosamine sulfate 500mg + Chondroitin sulfate 400mg may not be available.

Indications
  • Adjunctive therapy/treatment of Osteoarthritis of fingers, shoulder joints & weight bearing joints of the body.
  • As a dietary supplement to prevent Osteoarthritis
Dosage

Adult 1-2 tab(s) tds. Mild or moderate OA 1-2 tab(s) bd for 6 wk. Severe OA Initially 2 tab(s) tds for 8-12 wk. Maintenance dose: 1-2 tab(s) bd/tds for 3-4 mth.

Dosage recommendation based on body weight:

  • <54 Kg : 800 mg Chondroitin Sulfate & 1000 mg Glucosamine Sulfate per day
  • 54 Kg - 91 Kg: 1200 mg Chondroitin Sulfate & 1500 mg Glucosamine Sulfate per day
  • >91 Kg: 1600 mg Chondroitin Sulfate & 2000 mg Glucosamine Sulfate per day
Contraindications Hypersensitivity to glucosamine & chondroitin; allergy to shellfish.
Special Precautions

Severe hepatic or renal insufficiency; patients under insulin therapy. Monitor blood glucose levels regularly. Pregnancy (1st trimester) & lactation. Children.

Adverse Drug Reactions Erythema, pruritus. Rarely, drowsiness, headache, insomnia, GI disturbances.
 Pregnancy/lactation

Women who are pregnant or who could become pregnant should not supplement with Glucosamine Sulfate or Chondroitin Sulfate. Glucosamine and Chondroitin has not been studied enough to determine their effects on a developing fetus. No studies have evaluated the use of Glucosamine and Chondroitin during pregnancy or lactation. It should be taken with caution and medical advice during pregnancy and lactation.

Drug Interactions May increase insulin resistance & affect glucose tolerance; reduce antidiabetic agent effectiveness. Increase INR value w/ warfarin & potentiates anticoagulant effect.
Pharmacology

Glucosamine (2-amino-2-deoxy-alpha-D-glucose) is a natural amino-sugar, produced by the body and found in certain foods. It is the most fundamental building block required for biosynthesis of glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan Sulfate, and Chondroitin Sulfate. GAGs binds with protein and form proteoglycans, the essential building block of articular cartilage. When cartilage in a joint deteriorates, Osteoarthritis develops. It also helps to form ligaments, tendon, nails, and various other connective tissues. When we take artificially synthesized Glucosamine Sulfate supplement, it increases Glucosamine level in the body, thus facilitates production and repair of cartilage. Glucosamine also activates chondrocytes in the
cartilage which help produce GAGs and proteoglycans.
Chondroitin Sulfate is a glycosaminoglycan (acid muco-polysaccharide) found in connective tissue, especially in the articular cartilage of all mammals. Chondroitin Sulfate supplement acts similarly as Glucosamine Sulfate, since it also provide substrate for proteoglycans. Chondroitin also protects existing healthy cartilage from premature decline by preventing the MMP (Matrix metalloproteinase) enzyme that breakdowns the proteoglycans.
Combining Glucosamine with Chondroitin Sulfate shows synergistic effect. Data supports that this combination has been shown to be very much effective in severe cases of Osteoarthritis that treats both sign and symptoms of Osteoarthritis & modifies disease progression. It prevents Osteoarthritis in case of normal adults. In Osteoarthritic pain it is as effective as NSAIDs with significantly better tolerability and clinical compliance. It is also helpful during the repair phase of musculo-skeletal soft tissue injuries such as tendon or ligament strains.

ATC Classification M01AX05 - glucosamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.

Brand/Product Info


Total Products : 22                      
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ARTH-A The Acme Laboratories Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 48's: 385.92 MRP
ARTHROSIN Unimed & Unihealth Manufacturers Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 30's: 240.00 MRP
ARTICULEX IBN SINA Pharmaceutical Industry Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 48's: 396.00 IP
ARTIFLEX Rangs Pharmaceuticals Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 30's: 240.00 MRP
AUSTOMIN Hallmark Pharmaceuticals Ltd Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 30's: 225.00 MRP
CARTICEL Plus Opsonin Pharma Limited Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 30's: 240.00 MRP
CARTIFIT Globe Pharmaceuticals Ltd Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 48's: 240.00 MRP
CARTIGEN Somatec Pharmaceuticals Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 30's: 240.90 MRP
CARTIL Silva Pharmaceuticals Limited Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 30's: 240.90 MRP
CARTILAGE Plus Renata Limited Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 30's: 240.90 MRP
CARTILEX ACI Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 50's: 401.50 MRP
CONTILEX Square Pharmaceuticals Ltd. Glucosamine + Chondroitin (250mg + 200mg) Tablet 5x6's: 241.80 MRP
GLUCOTIN Drug International Ltd Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 50's: 300.00 MRP
GLUSTIN Plus General Pharmaceuticals Ltd Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 50's: 401.50 MRP
Joinix Plus Incepta Pharmaceuticals Limited Glucosamine Sulfate INN 250mg +Chondroitin Sulfate INN 200mg Film Coated Tablet 10x5's:MRP 400 Tk
JOINTEC Max Beximco Pharmaceuticals Ltd Glucosamine Sulfate 750 mg + Diacerein 50 mg Film Coated Tablet 30's: 360.00 MRP
JOINTEC PLUS Beximco Pharmaceuticals Ltd Glucosamine Hydrochloride 250mg (as Glucosamine Hydrochloride USP) + Chondroitin Sulfate Sodium USP 200mg Tablet 60's: 480.00 MRP
JORIX Apex Pharmaceuticals Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 30's: 210.00 MRP
MASO Plus Kemiko Pharmaceuticals Ltd Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 50's: 350.00 MRP
NOSTIS Ambee Pharmaceuticals Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 50's: 401.50 MRP
OSTOFID Plus The White Horse Pharma Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 48's: 210.00 MRP
REJOIN Aristopharma Ltd. Glucosamine sulfate INN 250mg+ Chondroitin sulfate INN 200mg Tablet 50's: 400.00 MRP

Gen. MedInfo

Glucosamine and Chondroitin Sulfate

About 27 million Americans suffer from osteoarthritis, an often painful condition in which the cushioning cartilage between bones wears away. Many people are trying new therapies and dietary supplements such as glucosamine and chondroitin sulfate in their search for relief.

Glucosamine is found naturally in the body. It stimulates the formation and repair of articular cartilage. Over-the-counter supplements come from animal sources. Chondroitin sulfate is another natural substance found in the body. It prevents other body enzymes from degrading the building blocks of joint cartilage. The type sold in health-food stores and pharmacies is derived from animal products.

The Hope and the Hype

People who use these nutritional supplements hope that they will relieve the pain of osteoarthritis, and perhaps even repair or restore the joint cartilage. Recent evidence seems to support the first claim. Both glucosamine and chondroitin sulfate have been used in Europe for several years, with few reported side effects. Both supplements also have some anti-inflammatory effects that may account for the pain relief.

But there is no proof that either substance, taken singly or in combination, will actually slow the degenerative process or restore cartilage in arthritic joints. All studies done to date have been short and focused on pain relief. A long-term study is just beginning, sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Center for Complementary and Alternative Medicine.

Dietary supplements like glucosamine and chondroitin sulfate are not tested or analyzed by the Food and Drug Administration before they are sold to consumers. That means consumers can't be sure they're getting what they pay for when they purchase bottles labeled "Glucosamine/Chondroitin." In fact, a recent study by ConsumerLab.com showed that almost half of the glucosamine/ chondroitin supplements tested did not contain the labeled amounts of ingredients.

Don't Stop Your Current Regimen of Diet, Exercise, Medication, or Other Therapies

The effectiveness of these treatments is proven, and nutritional supplements should remain just complementary to your good health practices. You may need to take the supplements for a couple of months before you see any results, which makes it all that more important to continue your current treatments.

Ref:  AAOS.org


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.