Aztreonam

(az' tree oh nam)

PCaution when used during lactation:Caution when used during pregnancy

LCI  :Contraindicated in lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage

Bone and joint infections
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 

Gonorrhoea
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 

Intra-abdominal infections
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 

Lower respiratory tract infections
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 

Meningitis
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 

Septicaemia
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 

Skin and soft tissue infections
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 

Pelvic infections
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 

Susceptible infections
Adult: 1-8 g daily in divided doses every 6-12 hr by slow IV inj over 3-5 minutes or as IV infusion over 20-60 minutes. Max: 8 g/day. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion. 
Child: and infants >1 wk: 30 mg/kg every 6 or 8 hr; ≥2 yr: 50 mg/kg every 6 or 8 hr for severe infections. Dose may be given via deep IM inj or slow IV inj or infusion. Doses >1 g should be given via IV route. Max (≥2 yr): 8 g/day. 
Gonorrhoea
Adult: 1 g I/M as a single dose.
Cystitis
Adult: 1 g I/M as a single dose.

Urinary tract infections
Adult: 0.5-1 g every 8-12 hr. Dose may be given via deep IM inj or IV inj over 3-5 minutes or IV infusion.

Renal impairment: Moderate-severe impairment: Same initial doses, adjust maintenance doses according to the patient's CrCl. Haemodialysis: A supplementary dose of 1/8 of the initial dose may be given after each session.

CrCl (ml/min) Dosage Recommendation
10-30 Maintenance dose: Half of initial dose
<10 Maintenance dose: One-quarter of initial dose

Incompatibility: Incompatible with cefradine, metronidazole, nafcillin and vancomycin.

Administration Should be taken with food.
Overdosage If needed, haemodialysis and/or peritoneal dialysis may be used to remove drug from serum.
Contraindications Hypersensitivity; lactation.
Special Precautions Hypersensitivity to other β-lactams; renal and hepatic impairment; pregnancy.
Adverse Drug Reaction(s) IV: Phloebitis and thrombophloebitis. IM: Pain and swelling at inj site; diarrhoea, nausea, vomiting, altered taste; jaundice, hepatitis, high liver enzymes; long prothrombin time, partial thromboplastin time; rash, urticaria, eosinophilia.
Potentially Fatal: Thrombocytopenia, neutropenia; overgrowth of susceptible organisms; pseudomembranous colitis.
Drug Interactions Concurrent use with oral anticoagulants may increase prothrombin time.

Lab Interference Intereferes with urine glucose test using cupric sulfate. False-positive with Coomb's test.
Pregnancy Category (FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Storage Intramuscular: Once reconstituted, it should be used within 48 hr if stored at 15-30°C or 7 days if stored at 2-8°C. Parenteral: Once reconstituted, it should be used within 48 hr if stored at 15-30°C or 7 days if stored at 2-8°C.
Pharmacology Aztreonam exhibits bactericidal action by inhibiting bacterial cell wall synthesis due to its high affinity for penicillin-binding protein 3 (PBP-3) of gram-negative bacteria. It is highly resistant to hydrolysis by β-lactamases. It is active against Enterobacteriaceae sppE. coliKlebsiella, Proteus, Providencia, Salmonella, Serratia, Shigella and Yersinia spp..
Absorption: Absorbed poorly from the GI tract (oral).
Distribution: Body tissues and fluids (wide), bile, CSF (especially in the presence of meningitis), crosses the placenta and enters breast milk. Protein-binding: 56%.
Metabolism: Minimal metabolism; SQ-26992 (primary metabolite, inactive).
Excretion: Via urine by renal tubular secretion and glomerular filtration (60-70% as unchanged), via faeces (small amounts of unchanged drug and metabolites); 1.7 hr (elimination half-life). Removed by dialysis and peritoneal dialysis (lesser extent).
ATC Classification J01DF01 - aztreonam; Belongs to the class of monobactams. Used in the treatment of systemic infections.

 

Brand/Product Info


Total Products : 2  
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ATREON 1G Square Pharmaceuticals Ltd. Aztreonam 1 gm IM/IV Injection 1x1's: 451.36 MRP
ATREON 500 Square Pharmaceuticals Ltd. Aztreonam 500mg IM/IV Injection 1x1's: 300.90 MRP

Gen. MedInfo

About your treatment

Your doctor has ordered aztreonam, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for 30 to 60 minutes, two to four times a day.

Aztreonam eliminates bacteria that cause many kinds of infection, including pneumonia and gynecological, urinary tract, skin, bone, joint, stomach, and blood infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Your health care provider (e.g. doctor) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.

Precautions

Before administering aztreonam,
  • tell your doctor if you are allergic to aztreonam, penicillin, cephalosporins [e.g., cefaclor, cefadroxil, or cephalexin], or any other drugs.
  • tell your doctor what prescription and nonprescription medications you are taking, especially antibiotics and vitamins.
  • tell your doctor if you have or have ever had kidney, heart, or gastrointestinal disease (especially colitis).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking aztreonam, call your doctor.
  • if you have diabetes and regularly check your for sugar level.

Administering your medication

Before you administer aztreonam, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.

It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.

Side effects

Aztreonam may cause side effects. Tell your health care provider if any of these symptoms are severe or do not go away:
  • diarrhea

  • upset stomach

  • vomiting

  • cramps

  • bloating

  • changes in taste sensation

If you experience any of the following symptoms, call your health care provider immediately:
  • rash

  • itching

  • fever

  • chills

  • facial swelling

  • sneezing

  • wheezing

  • difficulty breathing

  • unusual bleeding or bruising

  • unusual tiredness

  • confusion

  • seizures

  • sore mouth or throat

Storing your medication

  • Your health care provider probably will give you a several-day supply of aztreonam at a time. If you are receiving aztreonam intravenously (in your vein), you probably will be told to store it in the refrigerator or freezer.

  • Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.

  • If you are told to store additional aztreonam in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.

  • Do not refreeze medications.

If you are receiving aztreonam intramuscularly (in your muscle), your health care provider will tell you how to store it properly.

Store your medication only as directed. Make sure you understand what you need to store your medication properly.

Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Signs of infection
If you are receiving aztreonam in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible:
  • tenderness

  • warmth

  • irritation

  • < p>drainage

  • redness

  • swelling

  • pain

This medication may cause other side effects.  Consult your doctor if you have any unusual problems while taking this.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 Ref: MedlinePlus, U.S. Natl. Library of Medicine


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