PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

Indication(s) & Dosage Susceptible infections
Adult: As sulfate: 1-2 g every 12 hr via IV inj over 3-5 minutes or infuse over 20-30 minutes.
Renal impairment: Loading dose: 1-2 g followed by a maintenance dose adjusted according to CrCl.
CrCl (ml/min) Dosage Recommendation
20-50 0.5-1 g bid.
5-20 0.5-1 g once daily.
<5 (in haemodialysis patients) 0.5 or 1 g once daily with half-dose after each dialysis session.
Special Populations: Renal impairment: 1-2 g loading dose followed by a maintenance dose adjusted according to CrCl: 20-50 mL/min: 0.5-1 g bid; 5-20 mL/min: 0.5-1 g once daily; ≤5 mL/min (patients on haemodialysis): 0.5-1 g once daily including ½ after each dialysis.
Contraindications Hypersensitivity; porphyria.
Special Precautions Allergy to penicillin or to cephalosporins; renal impairment, monitor renal and haematological status; pregnancy and lactation.
Adverse Drug Reaction(s) Rash, pruritus, urticaria; nausea, vomiting, abdominal pain, diarrhoea; increased plasma levels of ASAT, ALAT, gamma-GT, LDH, bilirubin and/or alkaline phosphatase; interstitial nephritis, acute renal failure; thrombocytopaenia, eosinophilia, haemolytic anaemia, neutropaenia, agranulocytosis; thrombophloebitis, pain at Inj site; convulsions, fever; haemorrhage.
Potentially Fatal: Pseudomembranous colitis.
Drug Interactions Reduced clearance with probenecid. Please consult detailed drug interactions before prescribing. 
Lab Interference Interferes with Jaffe method of creatinine conc measurement in determining renal function.
Storage Intravenous: Store below 25°C.
Pharmacology Cefpirome binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Distribution: Widely distributed into body tissues and fluids; enters breast milk. Protein-binding: 10%
Excretion: Mainly by the kidneys via the urine (80-90% as unchanged); significantly removed by haemodialysis; 2 hrs (elimination half-life); prolonged in renal impairment.
ATC Classification J01DE02 - cefpirome.

Brand/Product Info

Total Products : 1 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
FORCE IV Square Pharmaceuticals Ltd. Cefpirome 1 gm IV Injection 1x1's: 402.72 MRP