Ceftriaxone

(sef try ax' one) 

PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

| See TERMINOLOGY & ABBREVIATIONS | 
Indication(s) & Dosage

Intramuscular route
Uncomplicated gonorrhoea
Adult: 250 mg as a single dose.

Prophylaxis of secondary meningococcal meningitis
Adult: 250 mg as a single dose.
Child: 125 mg as a single dose.

Parenteral route
Susceptible infections
Adult: 1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections.
Child: <50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day.


Prophylaxis of surgical infections
Adult: 1 g as a single dose given 0.5-2 hr prior to surgery via deep IM inj or slow IV inj over at least 2-4 minutes or IV infusion over at least 30 minutes. A 2 g dose is recommended for colorectal surgery.

Intravenous route
Typhoid fever
Adult: 2 g once daily for 14 days.

Renal impairment:

CrCl (ml/min) Dosage Recommendation
<10 Max: 2 g daily.
Special Populations: Reduce dose in patients with severe renal impairmentand those with both renal and hepatic impairment.
Incompatibility: Y-site incompatibility: Alatrofloxacin, amphotericin B cholesteryl sulfate complex, pentamidine, parenteral nutrition solutions (containing calcium), amsacrine, azithromycin, calcium, filgrastim, fluconazole, Hartmann's solution, labetalol, vinorelbine. Admixture incompatibility: Aminophylline, amsacrine, fluconazole, linezolid, calcium, clindamycin, theophylline.
Contraindications Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of ceftriaxone administration due to risk of calcium-ceftriaxone precipitate formation.
Special Precautions History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection.
Adverse Drug Reaction(s) Superinfection; anaphylaxis; diarrhoea; local reactions; blood dyscrasias; rash, fever, pruritus; elevated transaminases and alkaline phosphatase; leucopenia, neutropenia.
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Drug Interactions Disulfiram-like reaction with alcohol.
Potentially Fatal: Nephrotoxicity with aminoglycosides and furosemide. Please consult detailed drug interactions before prescribing. 
Lab Interference May interfere with urinary glucose test. False-positive Coomb's test.
Pregnancy Category (FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Storage Intramuscular: Store below 25°C. Intravenous: Store below 25°C.Parenteral: Store at 25°C.
Pharmacology Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Peak plasma concentrations after 2 hr (IM).
Distribution: Distributed widely into body tissues and fluids; CSF (therapeutic concentrations). Crosses the placenta and enters breast milk; bile (high concentrations). Protein-binding: 85-95%.
Excretion: Via the urine (40-65% as unchanged); via the bile to the faeces (remainder as unchanged and microbiologically inactive compounds); 6-9 hr (elimination half-life).
ATC Classification J01DD04 - ceftriaxone.

Brand/Product Info


Total Products : 96                                                                                                
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
3GC I/M Opso Saline Ltd. Ceftriaxone 500mg (I/M) with 1% Lidocaine Injection 500mg vial: 120.44 MRP
3GC I/V Opso Saline Ltd. Ceftriaxone 1gm & 2gm (I/V) with water Injection 1gm, 2gm: 160.60 & 301.13 MRP
ACIPHIN I/M ACI Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.34, 120.45 MRP, 190.72 MRP
ACIPHIN I/V ACI Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.34, 120.45 MRP, 190.72, 301.13 MRP
ARIXON 1GM Beximco Pharmaceuticals Ltd Ceftriaxone 1gm (as Ceftriaxone Sodium USP) IV Injection 1's: 190.00 MRP
ARIXON 1GM IM Beximco Pharmaceuticals Ltd Ceftriaxone 1gm (as Ceftriaxone Sodium USP) IM Injection 1's: 190.00 MRP
ARIXON 250 Beximco Pharmaceuticals Ltd Ceftriaxone 250mg (as Ceftriaxone Sodium USP) IV Injection 1's: 100.00 MRP
ARIXON 250 IM Beximco Pharmaceuticals Ltd Ceftriaxone 250mg (as Ceftriaxone Sodium USP) IM Injection 1's: 100.00 MRP
ARIXON 2GM Beximco Pharmaceuticals Ltd Ceftriaxone 2gm (as Ceftriaxone Sodium USP) IV Injection 1's: 300.00 MRP
ARIXON 500 Beximco Pharmaceuticals Ltd Ceftriaxone 500mg (as Ceftriaxone Sodium USP) IV Injection 1's: 130.00 MRP
ARIXON 500 IM Beximco Pharmaceuticals Ltd Ceftriaxone 500mg (as Ceftriaxone Sodium USP) IM Injection 1's: 130.00 MRP
AXON I/M Aristopharma Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00, 120.00, 150.00 MRP
AXON I/V Aristopharma Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.00, 120.00, 150.00, 260.00 MRP
AXOSIN I/M IBN SINA Pharmaceutical Industry Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00, 120.46, 180.00 IP
AXOSIN I/V IBN SINA Pharmaceutical Industry Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.00, 120.46, 180.00, 290.00 IP
CEFIXON I/M Techno Drugs Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 80.00, 120.00, 160.00 MRP
CEFIXON I/V Techno Drugs Ceftriaxone 500mg & 1gm & 2gm (I/V) with water Injection 500mg,1gm & 2gm vial: 120.00, 160.00, 250.00 MRP
CEFTIZONE I/M Renata Limited Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 100.34, 140.53, 200.75 MRP
CEFTIZONE I/V Renata Limited Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 100.38, 140.53, 200.75, 341.28 MRP
CEFTRIX I/M Novo Healthcare and Pharma Ltd. Ceftriaxone 250mg & 500mg (I/M) with Lidocaine Injection 250mg & 500mg vial: 90.00 & 130.00 MRP
CEFTRIX I/V Novo Healthcare and Pharma Ltd. Ceftriaxone 1gm & 2gm (I/V) with water Injection 1gm, 2gm: 190.00 & 300.00 MRP
CEFTRON 1G IM Square Pharmaceuticals Ltd. Ceftriaxone 1 gm IM Injection 1x1's: 190.58 MRP
CEFTRON 1G IV Square Pharmaceuticals Ltd. Ceftriaxone 1 gm IV Injection 1x1's: 190.58 MRP
CEFTRON 250 IM Square Pharmaceuticals Ltd. Ceftriaxone 250mg IM Injection 1x1's: 100.30 MRP
CEFTRON 250 IV Square Pharmaceuticals Ltd. Ceftriaxone 250mg IV Injection 1x1's: 100.30 MRP
CEFTRON 2G Square Pharmaceuticals Ltd. Ceftriaxone 2 gm IV Injection 1x1's: 302.04 MRP
CEFTRON 500 IM Square Pharmaceuticals Ltd. Ceftriaxone 500mg IM Injection 1x1's: 130.39 MRP
CEFTRON 500 IV Square Pharmaceuticals Ltd. Ceftriaxone 500mg IV Injection 1x1's: 130.39 MRP
DICEPHIN I/M Drug International Ltd Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00, 125.00, 160.00 MRP
DICEPHIN I/V Drug International Ltd Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.00, 125.00, 160.00, 280.00 MRP
ENOCEF I/M Sanofi Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 100.38, 150.57, 200.75 MRP
ENOCEF I/V Sanofi Ceftriaxone 250mg, 500mg & 1gm (I/V) with water Injection 250mg, 500mg,1gm: 100.38, 150.57, 200.75 MRP
ERACEF I/M Popular Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 85.32, 120.45, 180.68 MRP
ERACEF I/V Popular Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg,1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm, 1gm x10's, 2gm: 85.32, 120.45, 180.68, 1806.81 & 301.13 MRP
Exephin 1 gm Incepta Pharmaceuticals Limited Ceftriaxone 1gm (as Ceftriaxone Sodium USP) IV Injection 1gm x 1:MRP 190 Tk
Exephin 1 gm IM Incepta Pharmaceuticals Limited Ceftriaxone 1gm (as Ceftriaxone Sodium USP) IM Injection 1gm x 1:MRP 190 Tk
Exephin 2 gm Incepta Pharmaceuticals Limited Ceftriaxone 2gm (as Ceftriaxone Sodium USP) IV Injection 2gm x 1:MRP 300 Tk
Exephin 250 IM Incepta Pharmaceuticals Limited Ceftriaxone 250mg (as Ceftriaxone Sodium USP) IM Injection 250 mgx1's:MRP 100 Tk
Exephin 250 mg Incepta Pharmaceuticals Limited Ceftriaxone 500mg (as Ceftriaxone Sodium USP) IV Injection 250 mgx1's:MRP 100 Tk
Exephin 500 IM Incepta Pharmaceuticals Limited Ceftriaxone 500mg (as Ceftriaxone Sodium USP) IM Injection 500 mgx1's:MRP 130 Tk
Exephin 500 mg Incepta Pharmaceuticals Limited Ceftriaxone 500mg (as Ceftriaxone Sodium USP) IV Injection 500 mgx1's:MRP 130 Tk
G-CEFTRIAX I/M Gonoshasthaya Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 75.00, 120.00, 150.00 MRP
G-CEFTRIAX I/V Gonoshasthaya Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 75.00, 120.00, 150.00, 200.00 MRP
IMACEF I/V General Pharmaceuticals Ltd Ceftriaxone 1gm & 2gm (I/V) with water Injection 1gm, 2gm: 160.60 & 301.13 MRP
IMACEFI/M General Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.34, 120.48, 160.60 MRP
INOXON I/M Rephco Laboratories Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 80.00, 120.00, 160.00 MRP
INOXON I/V Rephco Laboratories Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 80.00, 120.00, 160.00, 300.00 MRP
KEPTRIX I/M Apex Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00,120.00 & 160.00 MRP
KFPTRIX I/V Apex Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/V) with water Injection 500mg,1gm & 2gm vial: 120.00, 160.00 & 300.00 MRP
MEGION IM Sandoz/Novartis Ceftriaxone 250mg, 500mg & 1gm vial (with lidocaine) Injection (IM) 250mg vial: MRP 100.00; 500mg vial: MRP 140.00;1gm vial: MRP 190.00
MEGION IV Sandoz/Novartis Ceftriaxone 250mg,500mg & 1gm vial (with water) Injection (IV) 250mg vial: MRP 100.00; 500mg vial: MRP 140.00; 1gm vial: MRP 190.00
ODATRIX I/M Unimed & Unihealth Manufacturers Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00,120.00 & 160.00 MRP
ODATRIX I/V Unimed & Unihealth Manufacturers Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.00,120.00,160.00 & 300.00 MRP
ORICEF 1gm, IM Healthcare Pharmacuticals Ltd. Ceftriaxone 1gm (as Ceftriaxone Sodium USP) IM Injection 1gm, MRP 320 Tk
ORICEF 1gm, IV Healthcare Pharmacuticals Ltd. Ceftriaxone 1gm (as Ceftriaxone Sodium USP) IV Injection 1gm, MRP 320 Tk
ORICEF 250mg, IM Healthcare Pharmacuticals Ltd. Ceftriaxone 250mg (as Ceftriaxone Sodium USP) IM Injection 250mg, MRP 130 Tk
ORICEF 250mg, IV Healthcare Pharmacuticals Ltd. Ceftriaxone 500mg (as Ceftriaxone Sodium USP) IV Injection 250mg, MRP 130 Tk
ORICEF 2gm, IV Healthcare Pharmacuticals Ltd. Ceftriaxone 2gm (as Ceftriaxone Sodium USP) IV Injection 2gm, MRP 490 Tk
ORICEF 500mg, IM Healthcare Pharmacuticals Ltd. Ceftriaxone 500mg (as Ceftriaxone Sodium USP) IM Injection 500mg, MRP 200 Tk
ORICEF 500mg, IV Healthcare Pharmacuticals Ltd. Ceftriaxone 500mg (as Ceftriaxone Sodium USP) IV Injection 500mg, MRP 200 Tk
ORYX I/M Rangs Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 80.00,150.00 & 200.00 MRP
ORYX I/V Rangs Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm, 2gm: 80.00,150.00, 200.00 & 350.00; 1gm x10's: 2,000.00 MRP
PARCEF I/M Jayson Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.34, 125.47, 189.71 IP
PARCEF I/V Jayson Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/V) with water Injection 250mg, 500mg, 1gm: 90.34, 125.47, 189.71 IP
PERIX I/M Monico Pharma Limited Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00,120.00 & 160.00 MRP
PERIX I/V Monico Pharma Limited Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.00,120.00,160.00 & 300.00 MRP
POWERCEF I/M Chemist Laboratories Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 80.00,130.00 & 160.00 MRP
POWERCEF I/V Chemist Laboratories Ltd. Ceftriaxone 500mg & 1gm (I/V) with water Injection 500mg & 1gm vial: 130.00 & 160.00 MRP
RAKXON I/M R A K Pharmaceuticals Pvt. Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 95.00,130.00 & 180.00 MRP
RAKXON I/V R A K Pharmaceuticals Pvt. Ltd. Ceftriaxone 1gm & 2gm (I/V) with water Injection 1gm, 2gm: 180.00 & 300.00 MRP
RIT I/M Kemiko Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 85.00,120.00 & 160.00 MRP
RIT I/V Kemiko Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 85.00,120.00,160.00 & 300.00 MRP
ROFECIN I/M Radiant Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 170.00, 250.00 & 415.00 MRP
ROFECIN I/V Radiant Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 170.00, 250.00, 415.00 & 788.00 MRP
TOPCEF I/M Navana Pharmaceuticals Limited Ceftriaxone 250mg & 500mg (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.33, 130.48 & 185.69 MRP
TOPCEF I/V Navana Pharmaceuticals Limited Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.33, 130.48, 185.69 & 301.12 MRP
TRAX I/M Medimet Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00,120.00 & 160.00 MRP
TRAX I/V Medimet Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg & 1gm (I/V) with water Injection 250mg, 500mg,1gm: 90.00,120.00 & 160.00 MRP
TRAXON I/M Opsonin Pharma Limited Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00,120.00 & 160.00 MRP
TRAXON I/V Opsonin Pharma Limited Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.00,120.00,160.00 & 300.00 MRP
TRIBAC I/M Globe Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00,120.00 & 160.00 MRP
TRIBAC I/V Globe Pharmaceuticals Ltd Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.00,120.00,160.00 & 300.00 MRP
TRIJECT IM Eskayef Bangladesh Ltd Ceftriaxone 250mg, 500mg & 1gm vial (with lidocaine) Injection 250mg, 500mg & 1gm MRP: 90.00, 120.00 & 160.00
TRIJECT IV Eskayef Bangladesh Ltd Ceftriaxone 250mg, 500mg, 1gm & 2gm vial (with water) Injection 250mg, 500mg, 1gm, 2gm MRP: 90.00,120.00,160.00 & 260.00
TRIMAX I/M Pharmasia Limited Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.00,120.00 & 160.00 MRP
TRIMAX I/V Pharmasia Limited Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.00,120.00,160.00 & 300.00 MRP
TRIPHIN I/M Ziska Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 80.00,120.00 & 160.00 MRP
TRIPHIN I/V Ziska Pharmaceuticals Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 80.00,120.00,160.00 & 250.00 MRP
TRIZON I/M The Acme Laboratories Ltd. Ceftriaxone 250mg & 500mg (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.34, 120.46 & 160.60 MRP
TRIZON I/V The Acme Laboratories Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.34,120.46,160.60 & 260.99 MRP
VERTEX I/M Orion Pharma Ltd. Ceftriaxone 250mg, 500mg & 1gm (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.34,120.45 & 160.60 MRP
VERTEX I/V Orion Pharma Ltd. Ceftriaxone 250mg, 500mg, 1gm & 2gm (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.34,120.45,160.60 & 231.14 MRP
WINNER I/M Biopharma Laboratories Ltd Ceftriaxone 250mg & 500mg (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.34,120.45 & 180.68 MRP
WINNER I/V Biopharma Laboratories Ltd Ceftriaxone 250mg & 500mg (I/V) with water Injection 250mg, 500mg, 1gm & 2gm: 90.34,120.45,180.68 & 300.00 MRP
XYLIB I/M Libra Pharmaceuticals Ltd. Ceftriaxone 250mg & 500mg (I/M) with Lidocaine Injection 250mg, 500mg & 1gm: 90.34, 120.45, 160.61 IP
XYLIB I/V Libra Pharmaceuticals Ltd. Ceftriaxone 250mg & 500mg (I/V) with water Injection 250mg, 500mg,1gm: 90.34, 120.45, 160.61 IP

Gen. MedInfo

Why is this medication prescribed?

Ceftriaxone injection is used to treat certain infections caused by bacteria such as gonorrhea (a sexually transmitted disease), pelvic inflammatory disease (infection of the female reproductive organs that may cause infertility), meningitis (infection of the membranes that surround the brain and spinal cord), and infections of the lungs, ears, skin, urinary tract, blood, bones, joints, and abdomen. Ceftriaxone injection is also sometimes given before certain types of surgery to prevent infections that may develop after the operation. Ceftriaxone injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics will not work for colds, flu, or other viral infections.

How should this medicine be used? 

Ceftriaxone injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). It is sometimes given as a single dose and sometimes given once or twice a day for 4-14 days, depending on the type of infection being treated. You may receive ceftriaxone injection in a hospital or doctor's office, or you may administer the medication at home. If you are using ceftriaxone injection at home, use it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use ceftriaxone injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

You should begin to feel better during the first few days of your treatment with ceftriaxone injection. If your symptoms do not improve or get worse, call your doctor.

If you will be using more than one dose of ceftriaxone injection, use the medication until you finish the prescription, even if you feel better. If you stop using ceftriaxone injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Other uses for this medicine 

Ceftriaxone injection is also sometimes used to treat endocarditis (infection of the heart lining and valves), chancroid (genital sores caused by bacteria), Lyme disease (an infection that is transmitted by tick bites that may cause problems with the heart, joints, and nervous system), relapsing fever (an infection that is transmitted by tick bites that causes repeated episodes of fever), shigella (an infection that causes severe diarrhea), typhoid fever (a serious infection that is common in developing countries), salmonella (an infection that causes severe diarrhea), and Whipple's disease (a rare infection that causes serious problems with digestion). Ceftriaxone injection is also sometimes used to prevent infection in people who have been sexually assaulted or who have been bitten by humans or animals. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using ceftriaxone injection, 

  • tell your doctor if you are allergic to ceftriaxone injection, other cephalosporin or penicillin antibiotics, or any other medications.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any intravenous medications or feedings that contain calcium such as total parenteral nutrition (TPN, a liquid feeding that is given intravenously to people who cannot eat or digest food).
  • tell your doctor if you have or have ever had problems with your digestive system, especially colitis (inflammation of the large intestine), malnutrition (you do not eat or cannot digest the nutrients needed for good health), or kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using ceftriaxone injection, call your doctor.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose? 

Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

What side effects can this medication cause? 

Ceftriaxone injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: 

  • pain, tenderness, hardness, or warmth in the place where ceftriaxone was injected

  • headache

  • dizziness

  • sweating

  • flushing

  • diarrhea

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • rash

  • bloody, watery stools

  • fever

  • stomach cramps

  • stomach pain or bloating

  • nausea and vomiting

  • heartburn

  • chest pain

Ceftriaxone injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication? 

If you will be injecting ceftriaxone injection at home, your health care provider will tell you where you should store it and how long you may keep it. Follow these directions carefully. Be sure to store ceftriaxone in the container it came in and out of reach of children. Throw away any medication that is outdated or no longer needed. Talk to your health care provider about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.