Cefalexin (Cephalexin)

(sef a lex' in) 

PCaution when used during lactation   - Caution when used during pregnancy

LCaution when used during lactation   - Caution when used during lactation

Molecule Info

Indication(s) & Dosage

Susceptible infections

Adult: 1-2 g daily given in divided doses at 6-, 8-, 12-hr intervals, increased to 6 g in deep-seated infections. Child: 25-100mg/kg daily in divided doses. Max: 4 g daily.

Prophylaxis of recurrent urinary tract infections

Adult: 125mg at night.

CrCl

Dosage Recommendation

40-50

Max: 3 g daily.

10-40

Max: 1. 5 g daily.

<10

Max: 750mg daily.

Special Populations: Reduce dose in patients with severe renal impairment. Parenteral admin should be considered when high doses are required.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to cephalosporins.

Special Precautions

Hypersensitivity to penicillins; pseudomembranous colitis; renal failure; pregnancy and lactation.

Adverse Drug Reaction(s)

Pain at inj site; hypersensitivity; GI disturbances; eosinophilia, neutropenia, leucopenia, thrombocytopenia. Potentially Fatal: Anaphylactic reactions; nephrotoxicity.

Drug Interactions

Probenecid produces higher and prolonged serum levels. Potentially Fatal: Increased nephrotoxicity with aminoglycosides and furosemide.

Food Interaction

Rate of absorption is delayed by food.

Lab Interference

False-positive for urine sugar, Coomb's test and serum or creatinine with Jaffe reaction.

Pregnancy Category (FDA)

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect  that was not confirmed in controlled studies in women in the 1sttrimester .

Storage

Oral: Store at 25°C.

Pharmacology

Cefalexin binds to one or more of the penicillin-binding proteins  which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption: Almost completely absorbed from the GI tract with peak plasma concentrations after 1 hr; may be delayed if taken with food. Distribution: Widely distributed but does not penetrate the CSF; bile . Crosses the placenta and enters the breast milk . Protein-binding: Up to 15% Metabolism: Not metabolised. Excretion: Via the urine within 6 hr by glomerular filtration and renal tubular secretion; via the bile. May be removed by haemodialysis and peritoneal dialysis; 1 hr .

ATC Classification

J01DB01 - cefalexin;

Brand/Product Info


Total Products : 27                           
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ACELEX The Acme Laboratories Ltd. Cephalexin 100mg/1ml Drop 15ml: 42.66 MRP
ACELEX Capsule The Acme Laboratories Ltd. Cephalexin 250mg & 500mg Capsule 250mg x20's, 50's; 500mg x20's, 40's: 132.60, 330.00; 250.80, 500.00 MRP
ACELEX Suspension The Acme Laboratories Ltd. Cephalexin 125mg/5ml Suspension 100ml: 77.29 MRP
ALEXIN Renata Limited Cephalexin 250mg & 500mg Capsule 50's each: 279.00 & 571.00 MRP
ALSPORIN Renata Limited Cephalexin 250mg & 500mg Tablet 250mg x100's & 500mg x50's: 660.00 & 609.50 MRP
ALSPORIN Suspension Renata Limited Cephalexin 125mg/5ml Suspension 100ml: 82.24 MRP
CEFALEX Drug International Ltd Cephalexin 500mg Capsule 50's: 400.00 MRP
CEFALEX Suspension Drug International Ltd Cephalexin 125mg/5ml Suspension 100ml: 81.00 MRP
CEPHALEN Beximco Pharmaceuticals Ltd Cephalexin Capsule 100's: 673.00 MRP
CEPHALEN 500 Beximco Pharmaceuticals Ltd Cephalexin Capsule 50's: 630.00 MRP
CEPHALEN SUSP Beximco Pharmaceuticals Ltd Cephalexin Suspension 100ml: 81.81 MRP
CEPHAXIN Pharmadesh Laboratories Limited Cephalexin 500mg Capsule 20's: 210.60 MRP
CEPHAXIN Suspension Pharmadesh Laboratories Limited Cephalexin 125mg/5ml Suspension 100ml: 72.27 MRP
CEPORAL Medimet Pharmaceuticals Ltd Cephalexin 250mg & 500mg Capsule 250mg x40's, 500mg x20's: 220.00 & 200.00 MRP
CEPORAL Suspension Medimet Pharmaceuticals Ltd Cephalexin 125mg/5ml Suspension 100ml: 78.00 MRP
CEPOREX GlaxoSmithKline Bangladesh Limited Cephalexin 250mg & 500mg Capsule 250mg x100's & 500mg x50's: 688.41 & 634.54 MRP
CEPOREX Suspension GlaxoSmithKline Bangladesh Limited Cephalexin 125mg/5ml Suspension 100ml: 84.27 MRP
G-CEFALEXIN Gonoshasthaya Pharmaceuticals Ltd Cephalexin 250mg Capsule 50's: 201.00 MRP
G-CEFALEXIN Suspension Gonoshasthaya Pharmaceuticals Ltd Cephalexin 125mg/5ml Suspension 100ml: 75.79 MRP
HI-CEF Hudson Pharmaceuticals Ltd Cephalexin 500mg Capsule 20's: 525.00 MRP
HI-CEF Suspension Hudson Pharmaceuticals Ltd Cephalexin 125mg/5ml Suspension 100ml: 70.00 MRP
NEOREX Eskayef Bangladesh Ltd Cephalexin 500mg Capsule 500mg x48's MRP: 625.00
NEOREX Suspension Eskayef Bangladesh Ltd Cephalexin 125mg/5ml Suspension 100ml MRP: 83.5.00
NUFEX General Pharmaceuticals Ltd Cephalexin 500mg Capsule 20's: 180.60 MRP
NUFEX Suspension General Pharmaceuticals Ltd Cephalexin 125mg/5ml Suspension 100ml: 78.29 MRP
SUPRALEX Biopharma Laboratories Ltd Cephalexin 250mg & 500mg Capsule 30's each: 195.60 & 361.50 MRP
SUPRALEX Suspension Biopharma Laboratories Ltd Cephalexin 125mg/5ml Suspension 100ml: 77.29 MRP

Gen. MedInfo

Why is Cefalexin prescribed?

Cefalexin/Cephalexin is a cephalosporin antibiotic used to treat certain infections caused by bacteria such as pneumonia and bone, ear, skin, and urinary tract infections. Antibiotics will not work for colds, flu, or other viral infections.

Cefalexin is sometimes prescribed for other uses; ask your doctor for more information.

How should Cefalexin be used?

Cefalexin/Cephalexin may come as a capsule, tablet, and liquid to take by mouth. It is usually taken every 6 hours (four times a day) or every 12 hours (twice a day) for 7 to 10 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cephalexin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly. The capsules and tablets should be swallowed whole and taken with a full glass of water. Continue to take cephalexin even if you feel well. Do not stop taking cephalexin without talking to your doctor.

What special precautions to follow?

Before taking Cefalexin/cephalexin,

  • inform your doctor if you are allergic to cephalexin or any other cephalosporin antibiotic such as cefadroxil  or cephradine, penicillin, or any other drugs.
  • inform your doctor what prescription and nonprescription medications you are taking, especially other antibiotics, anticoagulants  such as warfarin, probenecid, and vitamins.
  • inform your doctor if you have or have ever had kidney or liver disease, colitis, or stomach problems.
  • inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking cephalexin, consult your doctor.
  • if you are having surgery, including dental surgery, inform the doctor or dentist that you are taking cephalexin.
  • What special dietary instructions to follow?
  • Cephalexin may cause an upset stomach. Take cephalexin with food or milk.

What to do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Cefalexin cause?

Cefalexin/Cephalexin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • upset stomach
  • diarrhea
  • vomiting
  • mild skin rash

If you experience any of the following symptoms, consult your doctor immediately:

  • severe skin rash
  • itching
  • hives
  • difficulty breathing or swallowing
  • wheezing
  • unusual bleeding or bruising
  • sore throat
  • painful mouth or throat sores
  • vaginal infection

Cefalexin/Cephalexin may cause other side effects.  Consult your doctor if you have any unusual problems while taking this.

What other information to know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Cefalexin.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 Ref: MedlinePlus, U.S. Natl. Library of Medicine


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.