Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Acute uncomplicated cystitis
Adult: Initially 400 mg followed by 200 mg tid for 8 doses.
Child: <40 kg with UTI: 20-40 mg/kg/day in 3-4 divided doses.

Chronic or recurrent bacteriuria
Adult: 400 mg 3-4 times daily. 
Child: <40 kg with UTI: 20-40 mg/kg/day in 3-4 divided doses.
Contraindications Hypersensitivity, porphyria.
Special Precautions Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum K concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. May cause oesophageal injury.
Adverse Drug Reaction(s) Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropaenia; thrombocytopaenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Induction of carnitine deficiency.
Potentially Fatal: Anaphylaxis.
Drug Interactions Probenecid prolongs T1/2 of pivmecillinam. May cause prolonged bleeding when taken with anticoagulants. May decrease the efficacy of oral contraceptives. Increased risk of carnitine deficiency when used with valproate. Please consult detailed drug interactions before prescribing.
Lab Interference May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.
Pharmacology Pivmecillinam has the antimicrobial activity of mecillinam to which it is hydrolysed in vivo. It interferes with the synthesis of bacterial cell wall. It is active against many gm-ve bacteria, esp Enterobacteriaceae includingEscherichia coli, Enterobacter, Klebsiella, Salmonella and Shigella spp; indole-positive Proteus and Serratia marcescens are resistant. It is inactivated by β-lactamases, but is more stable than ampicillin.
Absorption: Well absorbed.
Distribution: Peak plasma concentrations about 1-2 hr after a 400 mg dose.
Metabolism: Hydrolysed to mecillinam, pivalic acid and formaldehyde.
Excretion: About 45% excreted in the urine as mecillinam within the first 6 hr.
ATC Classification J01CA08 - pivmecillinam; Belongs to the class of penicillins with extended spectrum. Used in the treatment of systemic infections.

 

Brand/Product Info


Total Products : 8        
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ALEXID Aristopharma Ltd. Pivmecillinam hydrochloride 200mg Tablet 50's: 750.00 MRP
BACILEX Pharmadesh Laboratories Limited Pivmecillinam hydrochloride 200mg Tablet 20's: 360.00 MRP
EMCIL 200 Square Pharmaceuticals Ltd. Pivmecillinam 200mg Tablet 5x6's: 451.50 MRP
LEXIPEN Techno Drugs Pivmecillinam hydrochloride 200mg Tablet 30's: 300.00 MRP
PINAM Kemiko Pharmaceuticals Ltd Pivmecillinam hydrochloride 200mg Tablet 30's: 360.00 MRP
PIVCILIN Rangs Pharmaceuticals Ltd. Pivmecillinam hydrochloride 200mg Tablet 20's: 240.00 MRP
PIVICIL General Pharmaceuticals Ltd Pivmecillinam hydrochloride 200mg Tablet 20's: 241.00 MRP
RELEXID Renata Limited Pivmecillinam hydrochloride 200mg Tablet 30's: 360.00 MRP

Back to top