Phenoxymethyl penicillin (US, Penicillin V)

PCaution when used during lactation  - Caution when used during pregnancy

LCaution when used during lactation  - Caution when used during lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage

Prophylaxis of recurrent rheumatic fever
Adult: 250 mg bid.
Child: <5 yr: 125 mg bid; ≥5 yr: 250 mg bid. 

Streptococcal infections of the upper respiratory tract, including scarlet fever and erysipelas
Adult: 125-250 mg every 6-8 hr for 10 days. For streptococcal pharyngitis: 500 mg 3-4 times daily for 10 days. 
Child: For streptococcal pharyngitis: 250 mg bid-tid for 10 days. 

Pneumococcal infections of the respiratory tract, including otitis media
Adult: Mild to moderately severe: 250-500 mg every 6 hr until the patient is afebrile for at least 2 days. 

Staphylococcal infections of the skin and soft tissue
Adult: 250-500 mg every 6-8 hr. 

Fusospirochetosis (Vincent's infection) of the oropharynx
Adult: 250-500 mg every 6-8 hr. 

Renal impairment: Dose adjustment may be necessary.
Special Populations: Dosage may need to be modified in severe renal impairment.

Administration May be taken with or without food. Side effects eg sleepiness/drowsiness may be reduced if taken immediately after meals.
Contraindications Hypersensitivity to penicillins.
Special Precautions Monitor renal and haematologic systems periodically during prolonged therapy or if high dose is used. Use may result in overgrowth of nonsusceptible organisms. Cross-sensitivity with cephalosporins may occur. History of significant allergies and/or asthma. Pregnancy and lactation.
Adverse Drug Reaction(s) Nausea, vomiting, epigastric distress, diarrhoea, black hairy tongue; skin eruptions (maculopapular to exfoliative dermatitis), urticaria and other serum-sickness like reactions, laryngeal oedema; fever, eosinophilia.
Potentially Fatal: Anaphylaxis.
Drug Interactions Reduced absorption with neomycin. Levels/effects may be increased with probenecid. May reduce efficacy of estrogen-containing oral contraceptives.
Potentially Fatal: Increased risk of anaphylactic reactions with nadolol and propranolol. Please consult detailed drug interactions before prescribing.
Food Interaction Absorption may be slightly affected by food.
Lab Interference May interfere with: Diagnostic tests for urinary glucose using copper sulfate; direct Coombs' test; test for urinary or serum proteins; test for uric acid; urinary aminohippurate sodium and phenolsulfonphthalein excretion tests; diagnostic tests that use bacteria.
Pregnancy Category (FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Storage Oral: Store at 20-25°C (68-77°F). Solution must be stored in a refrigerator after reconstitution. Discard any unused solution after 14 days.
Pharmacology Phenoxymethylpenicillin inhibits the final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane, thus inhibiting bacterial cell wall synthesis. It may be less active against some susceptible organisms, particularly gram-negative bacteria. It is suitable for mild to moderate infections, not for chronic, severe or deep-seated infections.
Absorption: Rapidly, although variably absorbed from the GI tract; about 60% of an oral dose absorbed. Calcium and potassium salts are better absorbed than the free acid. Peak plasma concentrations in 30-60 min after a 500-mg dose.
Distribution: Protein-binding: About 80%. Widely distributed into body tissues; crosses the placenta and distributed in milk.
Metabolism: Hepatic.
Excretion: Primarily via urine (as unchanged drug and metabolites); via bile (small amounts). Plasma half-life: 30-60 min; may be increased to about 4 hr in severe renal impairment.
ATC Classification J01CE02 - phenoxymethylpenicillin; Belongs to the class of beta-lactamase sensitive penicillins. Used in the treatment of systemic infections.

Brand/Product Info


Total Products : 26                          
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
BIOPEN VK Biopharma Laboratories Ltd Phenoxymethyl penicillin 250mg Tablet 100's: 151.00 MRP
BIOPEN VK Syrup Biopharma Laboratories Ltd Phenoxymethyl penicillin 125mg/5ml Syrup 50ml, 100ml: 18.28 & 28.91 MRP
CYTAPEN-V Edruc Limited Phenoxymethyl penicillin 250mg Tablet 100's: 230.00 MRP
CYTAPEN-V Syrup Edruc Limited Phenoxymethyl penicillin 125mg/5ml Syrup 100ml: 22.00 MRP
ERACILLIN-K Gaco Pharmaceutical Ltd. Phenoxymethyl penicillin 250mg Tablet 100's: 148.00 MRP
ERACILLIN-K Syrup Gaco Pharmaceutical Ltd. Phenoxymethyl penicillin 125mg/5ml Syrup 50ml: 18.21 MRP
G-PENICILLIN V Gonoshasthaya Pharmaceuticals Ltd Phenoxymethyl penicillin 250mg Tablet 100's: 200.00 MRP
G-PENICILLIN V Syrup Gonoshasthaya Pharmaceuticals Ltd Phenoxymethyl penicillin 125mg/5ml Syrup 50ml: 17.77 MRP
H-PEN Hudson Pharmaceuticals Ltd Phenoxymethyl penicillin 250mg Tablet 100's: 135.00 MRP
OPEN Opsonin Pharma Limited Phenoxymethyl penicillin 250mg & 500mg Tablet 100's each: 228.00 & 268.00 MRP
OPEN Suspension Opsonin Pharma Limited Phenoxymethyl penicillin 125mg/5ml Suspension 50ml: 18.00 MRP
ORACYN-K Sanofi Phenoxymethyl penicillin 250mg & 500mg Tablet 250mg x500's, 500mg x250's: 1130.50 & 1100.01 MRP
ORACYN-K Suspension Sanofi Phenoxymethyl penicillin 125mg/5ml Suspension 50ml: 18.42 MRP
PACIN-V Zenith Pharmaceuticals Ltd. Phenoxymethyl penicillin 250mg Tablet 80's, 100's: 125.00 & 147.00 MRP
PENCIN-V Nipa Pharmaceuticals Ltd. Phenoxymethyl penicillin 250mg Tablet 100's: 152.00 MRP
PENICILLIN Bristol Pharma Limited Phenoxymethyl penicillin 250mg Tablet 100's: 228.00 MRP
PENICILLIN-V Indo-Bangla Pharmaceuticals Works Ltd. Phenoxymethyl penicillin 250mg Tablet 100's: 140.00 MRP
PENICILLIN-V Syrup Indo-Bangla Pharmaceuticals Works Ltd. Phenoxymethyl penicillin 125mg/5ml Syrup 50ml: 18.00 MRP
PENTablet Sonear Laboratories Ltd. Phenoxymethyl penicillin 250mg Tablet 100's: 229.00 MRP
PENVIK 250 Square Pharmaceuticals Ltd. Phenoxymethyl Penicillin 250mg Tablet 10x10's: 230.00 MRP
PENVIK DS Square Pharmaceuticals Ltd. Phenoxymethyl Penicillin 500mg Tablet 10x10's: 444.00 MRP
PENVIK FORTE Square Pharmaceuticals Ltd. Phenoxymethyl Penicillin 250mg/5 ml Powder for Suspension 100 ml: 58.64 MRP
PENVIK PFS Square Pharmaceuticals Ltd. Phenoxymethyl Penicillin 125mg/5 ml Powder for Suspension 100 ml: 29.05 MRP
PHARMAPEN Pharmadesh Laboratories Limited Phenoxymethyl penicillin 250mg Tablet 100's: 220.00 MRP
PHARMAPEN Syrup Pharmadesh Laboratories Limited Phenoxymethyl penicillin 125mg/5ml Syrup 60ml: 18.40 MRP
PHENOXYMETHYL PENICILLIN APC Pharmaceuticals Ltd. Phenoxymethyl penicillin 250mg Tablet 100's: 150.00 MRP

Gen. MedInfo

Why is this medication prescribed?

Phenoxymethyl penicillin/Penicillin V potassium is an antibiotic used to treat certain infections caused by bacteria such as pneumonia, scarlet fever, and ear, skin, and throat infections. It also is used to prevent recurrent rheumatic fever and chorea. Antibiotics will not work for colds, flu, or other viral infections.

This medication is sometimes prescribed for other uses; ask your doctor for more information.

How should this medicine be used?

Phenoxymethyl penicillin/Penicillin V potassium comes as a tablet and liquid to take by mouth. It is usually taken every 6 hours (four times a day) or every 8 hours (three times a day). Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take Phenoxymethyl penicillin/Penicillin V potassium exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly.

The tablets should be swallowed whole and taken with a full glass of water.

Continue to take Phenoxymethyl penicillin/Penicillin V potassium even if you feel well. Do not stop taking Phenoxymethyl penicillin/Penicillin V potassium without talking to your doctor.

What special precautions should I follow?

Before taking Phenoxymethyl penicillin/Penicillin V potassium,

  • tell your doctor if you are allergic to Phenoxymethyl penicillin/Penicillin V potassium, tartrazine (a yellow dye in some processed foods and drugs), or any other drugs.
  • tell your doctor what prescription and nonprescription medications you are taking, especially other antibiotics, anticoagulants ('blood thinners') such as warfarin, atenolol, aspirin or other nonsteroidal anti-inflammatory medicine such as naproxen or ibuprofen, oral contraceptives, probenecid and vitamins.
  • tell your doctor if you have or have ever had kidney or liver disease, allergies, asthma, blood disease, colitis, stomach problems, or hay fever.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Phenoxymethyl penicillin/Penicillin V potassium, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Phenoxymethyl penicillin/Penicillin V potassium.

What special dietary instructions should I follow?

Take Phenoxymethyl penicillin/Penicillin V potassium at least 1 hour before or 2 hours after meals.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Phenoxymethyl penicillin/Penicillin V potassium may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • upset stomach

  • diarrhea

  • vomiting

  • mild skin rash

If you experience any of the following symptoms, call your doctor immediately:

  • severe skin rash

  • itching

  • hives

  • difficulty breathing or swallowing

  • wheezing

  • vaginal infection

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Keep liquid medicine in the refrigerator, tightly closed, and throw away any unused medication after 14 days. Do not freeze. The liquid is good for 7 days at room temperature. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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