Fluconazole

(floo kon' na zole)

PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

| See TERMINOLOGY & ABBREVIATIONS | 
Indication(s) & Dosage Superficial mucosal candidiasis
Adult: (Except genital candidiasis) Usual dose: 50 mg daily, may increase to 100 mg daily if needed. Recommended treatment duration: 7-14 days (oropharyngeal candidiasis, except in severely immunocompromised patients), 14 days (atrophic oral candidiasis associated with dentures), 14-30 days (other mucosal candidiasis including oesophagitis).
Child: >4 wk: Loading dose: 6 mg/kg followed by 3 mg/kg daily. 

Vaginal candidiasis
Adult: 150 mg as a single dose.

Candidal balanitis
Adult: 150 mg as a single dose.

Dermatophytosis
Adult: 50 mg daily for up to 6 wk.

Pityriasis versicolor
Adult: 50 mg daily for up to 6 wk.

Cutaneous candidiasis
Adult: 50 mg daily for up to 6 wk.

Systemic candidiasis
Adult: Initially, 400 mg followed by 200-400 mg daily. Max: 800 mg daily in severe infections. Treatment duration is based on clinical and mycological response but is usually at least 6-8 wk in cryptococcal meningitis. May also be given via IV infusion. To prevent relapse after a primary course of treatment for acute cryptococcal meningitis in AIDS patients: 100-200 mg daily, may also be given via IV admin. 
Child: >4 wk: 6-12 mg/kg daily; same doses may given every 72 hr in neonates up to 2 wk and every 48 hr in neonates 2-4 wk. Max: 400 mg daily. 

Cryptococcal infections
Adult: Initially, 400 mg followed by 200-400 mg daily. Max: 800 mg daily in severe infections. Treatment duration is based on clinical and mycological response but is usually at least 6-8 wk in cryptococcal meningitis. May also be given via IV infusion. To prevent relapse after a primary course of treatment for acute cryptococcal meningitis in AIDS patients: 100-200 mg daily, may also be given via IV admin. 
Child: >4 wk: 6-12 mg/kg daily; same doses may given every 72 hr in neonates up to 2 wk and every 48 hr in neonates 2-4 wk. Max: 400 mg daily. 
Renal impairment: Normal initial doses; adjust subsequent doses based on CrCl. Patients on dialysis: Single recommended dose after each session.


Prophylaxis of fungal infections in immunocompromised patients
Adult: 50-400 mg daily. May also be given via IV infusion.
Child: 3-12 mg/kg daily; may also be given via IV infusion. For infants <2 wk, doses should be given every 72 hr; 2-4 wk, doses should be given every 48 hr. Max: 400 mg daily, or 12 mg/kg at recommended intervals in infants. 

Renal impairment: Normal initial doses; adjust subsequent doses based on CrCl. Patients on dialysis: Single recommended dose after each session.

CrCl (ml/min) Dosage Recommendation
<50 and not receiving dialysis Maintenance dose: 50% of the recommended doses.

 

Special Populations: Renal impairment: Initially, administer normal loading or initial doses followed by maintenance doses based on creatinine clearance. CrCl: >50 mL/min: ½ of the standard dose. Patients on regular haemodialysis should be given a standard dose of fluconazole every dialysis session.

Administration Should be taken with food.
Overdosage Treatment is symptomatic and supportive, gastric lavage may be used if needed.
Contraindications Hypersensitivity.
Special Precautions Renal or hepatic impairment. May prolong QT interval. Pregnancy, lactation.
Adverse Drug Reaction(s) Nausea, abdominal pain, vomiting, diarrhoea, flatulence; elevated liver function values; headache; rash, exfoliative dermatitis. Rarely, angioedema, anaphylactic reactions and thrombocytopenia.
Potentially Fatal: Hepatotoxicity; rarely anaphylaxis; Stevens-Johnson syndrome.
Drug Interactions Rifampicin reduces fluconazole levels. Reduces theophylline clearance. Affects efficacy of oral contraceptives. May increase serum levels of alprazolam, triazolam, midazolam, diazepam. May raise serum concentrations and efficacy of oral sulphonylureas, phenytoin, ciclosporin, calcium channel blockers, tacrolimus, HMG-CoA reductase inhibitors (except pravastain and fluvastatin), warfarin and other anticoagulants. May reduce metabolism of caffeine. Avoid concurrent use with clopidogrel.
Potentially Fatal: Increased risk of cardiac arrhythmias with astemizole, cisapiride or terfenadine. Please consult detailed drug interactions before prescribing.
Pregnancy Category (FDA)

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Category D: For use in indications other than vaginal candidiasis. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Storage Store below 30°C.
Pharmacology Fluconazole decreases ergosterol synthesis by interfering with cytochrome P450 activity, thus inhibiting cell membrane formation of susceptible fungi including B dermatitidisCandida spp, C immitisC neoformans,Epidermophyton spp, H capsulatumMycosporum spp, Trichophyton spp, thus leading to cell death.
Absorption: Well absorbed after oral admin; peak plasma concentrations after 1-2 hr (oral), may be increased with multiple dosing.
Distribution: Widely distributed. Protein-binding: 12%.
Excretion: Via urine (80% as unchanged, 11% as metabolites); 30 hr (elimination half-life); increased in renal impairment. Removed by dialysis.
ATC Classification D01AC15 - fluconazole; Belongs to the class of imidazole and triazole derivatives for topical use. Used in the treatment of fungal infection. 
J02AC01 - fluconazole; Belongs to the class of systemic triazole derivative antimycotics. Used in the treatment of mycotic infections.

Brand/Product Info


Total Products : 101                                                                                                     
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
AFLUZOLE Ambee Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 240.90 & 220.80 MRP
AFLUZOLE Suspension Ambee Pharmaceuticals Ltd. Fluconazole 50mg/5ml Suspension 35ml: 78.30 MRP
ANFASIL Silva Pharmaceuticals Limited Fluconazole 50mg & 150mg Tablet 40's: 560.00 MRP
ANFASIL Suspension Silva Pharmaceuticals Limited Fluconazole 50mg/5ml Suspension 100ml: 81.00 MRP
CANAZOLE ACI Ltd. Fluconazole 50mg & 150mg & 200mg Capsule 50mg x30's, 150mg x10's, 200mg x10's: 240.90 & 220.80 & 250.00 MRP
CANAZOLE Suspension ACI Ltd. Fluconazole 50mg/5ml Suspension 35ml: 78.29 MRP
CANDID Amico Laboratories Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 210.00 & 220.00 MRP
CANDIDAL Radiant Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x12's: 240.00 & 270.00 MRP
CANDINIL 150 Healthcare Pharmacuticals Ltd. Fluconazole USP 150 mg Capsule 12's MRP 264 Tk
CANDINIL 35ml Healthcare Pharmacuticals Ltd. Fluconazole USP 50mg/5ml Suspension 35ml, MRP 78 Tk
CANDINIL 50 Healthcare Pharmacuticals Ltd. Fluconazole USP 50 mg Capsule 30's MRP 240 Tk
CANDIZOL S.N. Pharmaceuticals Ltd. Fluconazole 50mg Capsule 30's: 211.50 MRP
CON-50 Reliance Pharmaceuticals Ltd. Fluconazole 50mg Capsule 30's: 241.50 MRP
CONAZ Orion Pharma Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x12's: 160.60 & 264.96 MRP
CONAZOLE Apollo Pharmaceutical Laboratories Ltd. Fluconazole 50mg Capsule 24's: 90.00 IP
COSFLU 50 Cosmo Pharma Laboratories Ltd. Fluconazole 50mg Capsule 30's: 240.00 MRP
DEFUNGI NIPRO JMI Pharma Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 241.20 & 220.90 MRP
DERMA Alco Pharma Ltd Fluconazole 50mg & 150mg Tablet 50mg x30's, 150mg x12's: 160.00 & 240.00 MRP
DIFLU Aristopharma Ltd. Fluconazole 50mg & 150mg & 200mg Capsule 50mg x30's, 150mg x12's, 200mg x12's: 384.00 & 264.00 & 300.00 MRP
DIFLU Drop Aristopharma Ltd. Fluconazole BP 3mg/ml Eye Drop 5ml: 80.00 MRP
DIFLU Suspension Aristopharma Ltd. Fluconazole 50mg/5ml Suspension 35ml: 78.00 MRP
DIFLUCON Aexim Pharmaceutical Ltd. Fluconazole 50mg Capsule 30's: 150.00 MRP
F-ZOL Popular Pharmaceuticals Ltd. Fluconazole 50mg & 150mg & 200mg Capsule 50mg x30's, 150mg x12's, 200mg x12's: 240.90 & 264.96 & 300.00 MRP
F-ZOL I/V Popular Pharmaceuticals Ltd. Fluconazole 200mg/100ml (I/V) Infusion 100ml: 200.00 MRP
F-ZOL Suspension Popular Pharmaceuticals Ltd. Fluconazole 50mg/5ml Suspension 20ml, 35ml: 60.00 & 78.29 MRP
FCON Everest Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Tablet 50mg x30's, 150mg x12's: 240.00 & 240.00 MRP
FLUCANEX R A K Pharmaceuticals Pvt. Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x6's: 240.00 & 132.00 MRP
FLUCESS Sandoz/Novartis Fluconazole INN 50mg & 150mg Capsule 50mg x 30's: MRP 240.00; 150mg x 10's: MRP 220.00
FLUCO-S Seema Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 240.00 & 220.00 MRP
FLUCODER Eskayef Bangladesh Ltd Fluconazole USP 50mg & 150mg Capsule 50mg x30's & 150mg x10's MRP: 243.00 & 220.00
FLUCON Opsonin Pharma Limited Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 240.00 & 220.00 MRP
FLUCONAL The Acme Laboratories Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's,12's: 160.80; 220.80 & 264.96 MRP
FLUCONAL Suspension The Acme Laboratories Ltd. Fluconazole 50mg/5ml Suspension 35ml: 78.30 MRP
FLUCONAZOLE Bristol Pharma Limited Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 240.00 & 220.00 MRP
FLUCOSTAN Ziska Pharmaceuticals Ltd. Fluconazole 50mg Capsule 20's: 100.00 MRP
FLUDA Novo Healthcare and Pharma Ltd. Fluconazole 50mg Capsule 30's: 240.00 MRP
FLUDA Suspension Novo Healthcare and Pharma Ltd. Fluconazole 50mg/5ml Suspension 35ml: 78.00 MRP
FLUDEX Medicon Laboratories Ltd Fluconazole 50mg Capsule 30's: 200.00 MRP
FLUGAL 150 Square Pharmaceuticals Ltd. Fluconazole 150mg Capsule 2x10's: 442.80 MRP
FLUGAL 200 Square Pharmaceuticals Ltd. Fluconazole 200mg Capsule 2x6's: 302.04 MRP
FLUGAL 50 Square Pharmaceuticals Ltd. Fluconazole 50mg Capsule 3x10's: 242.10 MRP
FLUGAL SUSP Square Pharmaceuticals Ltd. Fluconazole 50mg/5 ml Suspension 35 ml: 78.53 MRP
FLUGARD Pharmasia Limited Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x12's: 240.00 & 264.00 MRP
FLUKZOL Sharif Pharmaceuticals Ltd. Fluconazole 50mg Capsule 30's: 240.00 MRP
FLUMA Modern Pharmaceuticals Ltd Fluconazole 150mg Capsule 12's: 240.00 MRP
FLUMART Desh Pharmaceuticals (Pvt) Ltd Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x12's: 210.00 & 240.00 MRP
FLUMYC Euro Pharma Ltd. Fluconazole 150mg Capsule 10's: 220.00 MRP
FLUNAC Drug International Ltd Fluconazole 50mg & 150mg Capsule 50mg x50's, 150mg x20's: 400.00 & 400.00 MRP
FLUNAC Suspension Drug International Ltd Fluconazole 50mg/5ml Suspension 35ml: 70.00 MRP
FLUNAZOL Pharmadesh Laboratories Limited Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x12's: 210.00 & 240.00 MRP
FLUNAZOL Suspension Pharmadesh Laboratories Limited Fluconazole 50mg/5ml Suspension 35ml: 75.00 MRP
FLUNOL Somatec Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x32's, 150mg x10's: 224.96 & 200.80 MRP
FLUNOL Suspension Somatec Pharmaceuticals Ltd. Fluconazole 50mg/5ml Suspension 35ml: 75.28 MRP
FLUSAF The White Horse Pharma Fluconazole 50mg & 150mg Capsule 50mg x50's, 150mg x30's: 400.00 & 660.00 MRP
FLUVIN-OD GlaxoSmithKline Bangladesh Limited Fluconazole 50mg & 150mg Tablet 50mg x30's, 150mg x10's: 240.90 & 200.75 MRP
FLUZO Pacific Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 240.00 & 220.00 MRP
FLUZOLE Globe Pharmaceuticals Ltd Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x20's: 150.00 & 280.00 MRP
FUNGA Doctors Chemical Works Ltd Fluconazole 50mg & 150mg Capsule 50mg x50's, 150mg x20's: 325.00 & 360.00 MRP
FUNGARD Cosmic Chemical Industries Limited Fluconazole 50mg Capsule 30's: 240.00 MRP
FUNGATA Biopharma Laboratories Ltd Fluconazole 50mg & 150mg Tablet 50mg x30's, 150mg x10's: 240.90 & 220.80 MRP
FUNGATA Suspension Biopharma Laboratories Ltd Fluconazole 50mg/5ml Suspension 35ml: 75.29 MRP
FUNGI-F Edruc Limited Fluconazole 50mg Capsule 30's: 240.00 MRP
FUNGITROL Rangs Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x20's, 150mg x12's: 140.00 & 240.00 MRP
FUNGITROL Suspension Rangs Pharmaceuticals Ltd. Fluconazole 50mg/5ml Suspension 35ml: 70.00 MRP
FUNZOLE Monico Pharma Limited Fluconazole 50mg & 150mg Tablet 50mg x30's, 150mg x12's: 240.00 & 264.00 MRP
FUNZOLE Suspension Monico Pharma Limited Fluconazole 50mg/5ml Suspension 35ml: 78.00 MRP
GALFIN General Pharmaceuticals Ltd Fluconazole 50mg & 150mg Capsule 50mg x20's, 150mg x10's: 240.90 & 220.80 MRP
ILUCA IBN SINA Pharmaceutical Industry Ltd. Fluconazole 50mg & 150mg Capsule 50mg x20's, 150mg x10's: 180.00, 276.00 IP
KENAZOL Belsen Pharmaceuticals Ltd. Fluconazole 50mg Capsule 30's: 240.00 MRP
LEUCODAR Chemist Laboratories Ltd. Fluconazole 50mg Capsule 20's: 120.00 MRP
LUCAN-R Renata Limited Fluconazole 50mg & 150mg Capsule 50mg x40's, 150mg x10's: 321.20 & 220.80 MRP
LUCAN-R Suspension Renata Limited Fluconazole 50mg/5ml Suspension 35ml: 78.30 MRP
LUCON Navana Pharmaceuticals Limited Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 240.90, 220.80 IP
MYCODER UniDerma Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x10's: 210.00 & 200.00 MRP
MYCODER Suspension UniDerma Pharmaceuticals Ltd. Fluconazole 50mg/5ml Suspension 35ml: 70.00 MRP
MYCOREST 50 Marksman Pharmaceuticals Ltd Fluconazole 50mg Capsule 30's: 180.00 MRP
NAZ Reman Drug Laboratories Ltd. Fluconazole BP 3mg/ml Eye Drop 5ml: 100.50 MRP
Nispore 150 Incepta Pharmaceuticals Limited Fluconazole USP 150 mg Capsule 10x1's:MRP 220 Tk
Nispore 200 Incepta Pharmaceuticals Limited Fluconazole USP 200 mg Capsule 10x1's:MRP 250 Tk
Nispore 50 Incepta Pharmaceuticals Limited Fluconazole USP 50 mg Capsule 10x3's:MRP 240 Tk
Nispore Drop Incepta Pharmaceuticals Limited Fluconazole 0.3% Eye Drop Drop 5ml:MRP 80 Tk
Nispore Suspension Incepta Pharmaceuticals Limited Fluconazole USP 50mg/5ml Suspension 35ml:MRP 78 Tk
NOGAL Kumudini Pharma Ltd Fluconazole 50mg Capsule 30's: 160.00 MRP
OLIF Kemiko Pharmaceuticals Ltd Fluconazole 50mg & 150mg Capsule 50mg x50's, 150mg x10's: 400.00 & 200.00 MRP
OMASTIN 150 Beximco Pharmaceuticals Ltd Fluconazole INN 150mg Capsule 20's: 440.00 MRP
OMASTIN 200 Beximco Pharmaceuticals Ltd Fluconazole INN 200mg Capsule 10's: 250.00 MRP
OMASTIN 50 Beximco Pharmaceuticals Ltd Fluconazole INN 50mg Capsule 50's: 400.00 MRP
OMASTIN DUO Beximco Pharmaceuticals Ltd Fluoconazole USP 150mg Capsule + Clotrimazole BP 10mg/gm Cream Combo 1s: 55.00 MRP
OMASTIN IV Beximco Pharmaceuticals Ltd Fluconazole INN 2mg/ml infusion Injection 1's: 200.00 MRP
OMASTIN SUSPENSION Beximco Pharmaceuticals Ltd Fluconazole INN 50mg/5ml Suspension 35ml: 78.00 MRP
ONICON Zenith Pharmaceuticals Ltd. Fluconazole 50mg Tablet 50's: 300.00 MRP
ONICON Suspension Zenith Pharmaceuticals Ltd. Fluconazole 50mg/5ml Suspension 35ml: 65.00 MRP
ORAF 150 Hallmark Pharmaceuticals Ltd Fluconazole 150mg Capsule 20's: 400.00 MRP
ORAF 50 Hallmark Pharmaceuticals Ltd Fluconazole 50mg Capsule 30's: 240.00 MRP
ORAF Suspension Hallmark Pharmaceuticals Ltd Fluconazole 50mg/5ml Suspension 35ml: 70.00 MRP
SACONA-50 Shamsul Alamin Pharmaceuticals Ltd Fluconazole 50mg Capsule 30's: 240.00 MRP
SEGAL Supreme Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x20's, 150mg x10's: 120.00 & 150.00 MRP
SEGAL Suspension Supreme Pharmaceuticals Ltd. Fluconazole 50mg/5ml Suspension 35ml: 65.00 MRP
XERODER Beacon Pharmaceuticals Limited Fluconazole 50mg & 150mg Capsule 50mg x30's, 150mg x8's: 240.00 & 176.00 MRP
XERODER I/V Beacon Pharmaceuticals Limited Fluconazole 200mg/100ml (I/V) Infusion 100ml: 199.00 MRP
ZOLEN Apex Pharmaceuticals Ltd. Fluconazole 50mg & 150mg Capsule 50mg x50's, 150mg x10's: 400.00 & 180.00 MRP

Gen. MedInfo

Why is Fluconazole prescribed?

Fluconazole is used to treat fungal infections, including yeast infections of the vagina, mouth, throat, esophagus (tube leading from the mouth to the stomach), abdomen (area between the chest and waist), lungs, blood, and other organs. Fluconazole is also used to treat meningitis (infection of the membranes covering the brain and spine) caused by fungus. Fluconazole is also used to prevent yeast infections in patients who are likely to become infected because they are being treated with chemotherapy or radiation therapy before a bone marrow transplant (replacement of unhealthy spongy tissue inside the bones with healthy tissue). Fluconazole is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection.

How should Fluconazole be used?

Fluconazole comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken once a day, with or without food. You may need to take only one dose of fluconazole, or you may need to take fluconazole for several weeks or longer. The length of your treatment depends on your condition and on how well you respond to fluconazole. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take fluconazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may inform you to take a double dose of fluconazole on the first day of your treatment. Follow these directions carefully.

Shake the liquid well before each use to mix the medication evenly.

You should begin to feel better during the first few days of treatment with fluconazole. If your symptoms do not improve or get worse, call your doctor.

Continue to take fluconazole until your doctor informs you that you should stop, even if you feel better. Do not stop taking fluconazole without talking to your doctor. If you stop taking fluconazole too soon, your infection may come back after a short time.

Other uses for Fluconazole

Fluconazole is also sometimes used to treat serious fungal infections that begin in the lungs and can spread through the body and fungal infections of the eye, prostate (a male reproductive organ), skin and nails. Fluconazole is also sometimes used to prevent fungal infections in people who are likely to become infected because they have human immunodeficiency virus (HIV) or cancer or have had a transplant operation (surgery to remove an organ and replace it with a donor or artificial organ). Talk to your doctor about the possible risks of using Fluconazole for your condition.

Fluconazole may be prescribed for other uses; ask your doctor for more information.

What special precautions to follow?

Before taking fluconazole,

  • inform your doctor if you are allergic to fluconazole, other antifungal medications such as itraconazole, ketoconazole (Nizoral), posaconazole, or voriconazole, any other medications, or any of the ingredients in fluconazole tablets or suspension. Ask your pharmacist for a list of the ingredients.
  • inform your doctor if you are taking astemizole, cisapride, pimozide, quinidine, or terfenadine. Your doctor will probably inform you not to take fluconazole if you are taking any of these medications.
  • inform your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking, or plan to take. Also you tonform your doctor you have taken fluconazole before starting to take any new medications within 7 days of receiving fluconazole. Be sure to mention any of the following: amitriptyline; amphotericin B; anticoagulants  such as warfarin; benzodiazepines such as midazolam; calcium channel blockers such as amlodipine, felodipine, isradipine, and nifedipine; carbamazepine; celecoxib; cholesterol-lowering medications  such as atorvastatin, fluvastatin, and simvastatin; clopidogrel; cyclophosphamide; cyclosporine; diuretics  such as hydrochlorothiazide; erythromycin; fentanyl; isoniazid; losartan; methadone; nevirapine; nonsteroidal anti-inflammatory drugs  such as ibuprofen  and naproxen; oral contraceptives; oral medication for diabetes such as glipizide, glyburide, and tolbutamide; nortriptyline; phenytoin; prednisone; rifabutin; rifampin; saquinavir; sirolimus; tacrolimus; theophylline; triazolam; valproic acid; vinblastine; vincristine; vitamin A; voriconazole; and zidovudine . Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with fluconazole, so be sure to inform your doctor about all the medications you are taking, even those that do not appear on this list.
  • inform your doctor if you have or have ever had cancer; acquired immunodeficiency syndrome (AIDS); an irregular heartbeat; a low level of calcium, sodium, magnesium, or potassium in your blood; rare, inherited conditions where the body is not able to tolerate lactose or sucrose;or heart, kidney, or liver disease.
  • inform your doctor if you are pregnant, especially if you are in the first 3 months of your pregnancy, plan to become pregnant, or are breast-feeding. If you become pregnant while taking fluconazole, call your doctor. Fluconazole may harm the fetus.
  • if you are having surgery, including dental surgery, inform the doctor or dentist that you are taking fluconazole.
  • you should know that fluconazole may make you dizzy or cause seizures. Do not drive a car or operate machinery until you know how Fluconazole affects you.

What special dietary instructions to follow?

Unless your doctor informs you otherwise, continue your normal diet.

What to do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Fluconazole cause?

Fluconazole may cause side effects. inform your doctor if any of these symptoms are severe or do not go away:

  • headache

  • dizziness

  • diarrhea

  • stomach pain

  • heartburn

  • change in ability to taste food

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or get emergency treatment:

  • nausea

  • vomiting

  • extreme tiredness

  • unusual bruising or bleeding

  • lack of energy

  • loss of appetite

  • pain in the upper right part of the stomach

  • yellowing of the skin or eyes

  • flu-like symptoms

  • dark urine

  • pale stools

  • seizures

  • rash

  • blistering or peeling skin

  • hives

  • itching

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or lower legs

  • difficulty breathing or swallowing

Fluconazole may cause other side effects. Consult your doctor if you have any unusual problems while taking Fluconazole.

What to know about storage and disposal of Fluconazole?

Keep Fluconazole in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Throw away any unused liquid medication after 14 days. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include the following:

  • hallucinations (seeing things or hearing voices that do not exist)

  • extreme fear that others are trying to harm you 

What other information to know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Fluconazole.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.