PCI  :Contraindicated in pregnancy

LCI  :Contraindicated in lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage

Oral route
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg once daily for 10 days.

Prophylaxis of surgical infections
Adult: 400 mg as a single dose 1-6 hr before procedure.

Uncomplicated urinary tract infections
Adult: 400 mg once daily. Due to E. coli: For 3 successive days. Due to K. pneumoniae, P. mirabilis or S. saprophyticus: For 10 successive days.

Complicated urinary tract infections
Adult: Due to E. coli, K. pneumoniae, P. mirabilis
 or P. aeruginosa: 400 mg once daily for 14 successive days.

Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.

CrCl (ml/min) Dosage Recommendation
10-40 Initially, 400 mg daily. Maintenance: 200 mg daily.


Ophthalmic
Bacterial conjunctivitis
Adult: 
Instil 0.3% solution into the affected eye/s.

Otic/Aural
Otitis externa
Adult: 
Instil 0.3% solution into the affected ear/s.

Otitis media
Adult: 
Instil 0.3% solution into the affected ear/s.

Special Populations: 
Reduce dose in patients with moderate to severe renal impairment. CrCl: <40 mL/min: Initially, 400 mg. Maintenance: 200 mg daily.

Administration Should be taken on an empty stomach. Take ½ hr before meals.
Overdosage Empty the stomach by inducing vomiting or by gastric lavage. Treatment is supportive. Maintain adequate hydration. Haemodialysis or peritoneal dialysis is unlikely to be helpful.
Contraindications Hypersensitivity to the drug or other quinolones; children <18 yr; pregnancy and lactation.
Special Precautions Avoid prolonged exposure to sunlight or artificial UV light. Known or suspected CNS disorders e.g. severe cerebral arteriosclerosis, epilepsy or other factors that predispose to seizures. Avoid in patients with known QT prolongation, uncorrected hypokalaemia. May impair ability to drive or operate machinery. Renal impairment.
Adverse Drug Reaction(s) Nausea, abdominal pain or discomfort, diarrhoea; headache, dizziness, insomnia; rash, pruritus, photosensitivity; thrombocytopenia.
Potentially Fatal: Anaphylactic or anaphylactoid reactions.
Drug Interactions Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid.
Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents. Please consult detailed drug interactions before prescribing.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Pharmacology Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.
Absorption: Rapid and complete from the GI tract (oral); peak plasma concentrations after 1-1.5 hr. Absorption delayed with food.
Distribution: Widely distributed; lungs and prostate. Protein-binding: 10%.
Excretion: Via urine (as unchanged drug and small amounts of glucuronide metabolites); may be prolonged in renal impairment. Via faeces (small amounts as unchanged drug); 7-8 hr (elimination half-life).
ATC Classification J01MA07 - lomefloxacin; Belongs to the class of quinolones, fluoroquinolone. Used in the treatment of systemic infections. 
S01AX17 - lomefloxacin; Belongs to the class of other antiinfectives. Used in the treatment of eye infections.

Brand/Product Info


Total Products : 25                         
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
CONTRA DROP Beximco Pharmaceuticals Ltd Lomefloxacin 0.3% Eye Drops Drop 5ml: 60.00 MRP
CONTRA Eye Drop Beximco Pharmaceuticals Ltd Lomefloxacin 0.3% Eye Drop 5 ml: 60.00 MRP
LOFLOX Opso Saline Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 60.23 MRP
LOMEBAC Popular Pharmaceuticals Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 70.00 MRP
LOMECIN Reman Drug Laboratories Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye/Ear Drop 5ml: 70.00 MRP
LOMECIN Drop Reman Drug Laboratories Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 70.00 MRP
LOMECIN Ointment Reman Drug Laboratories Ltd. Lomefloxacin hydrochloride 3mg/gm Eye Ointment 3gm: 60.00 MRP
LOMEFLOX Aristopharma Ltd. Lomefloxacin 400mg Tablet 20's: 300.00 MRP
LOMEFLOX Drop Aristopharma Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 70.00 MRP
Lomequin Eye Incepta Pharmaceuticals Limited Lomefloxacin 0.3% Eye Drops Drop 5ml:MRP 70 Tk
LUMEX Gaco Pharmaceutical Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye/Ear Drop 5ml: 50.00 MRP
LUMEX Drop Gaco Pharmaceutical Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 60.50 MRP
LYFLOX IBN SINA Pharmaceutical Industry Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye/Ear Drop 5ml: 70.00 MRP
LYFLOX Drop IBN SINA Pharmaceutical Industry Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 70.00 MRP
MEFLOCIN Asiatic Laboratories Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 60.00 MRP
MEXLO 0.003 Square Pharmaceuticals Ltd. Lomefloxacin 0.3% Eye Drops 5 ml: 70.21 MRP
MEXLO 400 Square Pharmaceuticals Ltd. Lomefloxacin 400mg Tablet 2x10's: 302.00 MRP
MEXLO Drop Square Pharmaceuticals Ltd. Lomefloxacin 0.3% Eye Drop 5ml: 60.22 MRP
NAMICIN Nipa Pharmaceuticals Ltd. Lomefloxacin 400mg Tablet 20's: 300.00 MRP
NAMICIN Drop Nipa Pharmaceuticals Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 60.00 MRP
OMEFLOX ACI Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 50.19 MRP
OPTHAFLOX Drug International Ltd Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 50.00 MRP
OPTIFLOX Jayson Pharmaceuticals Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 50.00 MRP
OPTILOM EYE DROP Healthcare Pharmacuticals Ltd. Lomefloxacin 0.3% Eye Drops Drop 10ml, MRP 70 Tk
SAFQUIN Apex Pharmaceuticals Ltd. Lomefloxacin hydrochloride 3mg/ml (0.3% w/v) Eye Drop 5ml: 60.00 MRP

Gen. MedInfo