Ofloxacin

(oh floks' a sin)

PCI / LCIContraindication for pregnancy & lactation (breast feeding)

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication & Dosage Oral route
Leprosy
Adult: As part of a multidrug therapy: 400 mg daily or intermittently, depending on regimen.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Uncomplicated gonorrhoea
Adult: 400 mg as a single dose.
Oral route
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg bid for 10 days.
Renal impairment: Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Community-acquired pneumonia
Adult: 400 mg bid for 10 days.
Renal impairment: Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Uncomplicated skin infections
Adult: 400 mg bid for 10 days.
Renal impairment: Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr
Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.
Oral route
Non-gonococcal cervicitis/urethritis due to Chlamydia trachomatis
Adult: 200-300 mg bid for 7 days.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Mixed infection of the urethra and cervix due to C. trachomatis and Neisseria gonorrhoeae
Adult: 200-300 mg bid for 7 days.
Renal impairment: Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Pelvic inflammatory disease
Adult: 400 mg bid for 14 days.
Renal impairment: Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Uncomplicated cystitis
Adult: 200 mg bid for 3 days if due to E. Coli or Klebsiella pneumoniae; 7 days if due to other susceptible organisms.
Renal impairment: 
Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Complicated urinary tract infections
Adult: 200 mg bid for 10 days.
Renal impairment: Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.
Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.
Oral route
Chronic bacterial prostatitis
Adult: 300 mg bid for 6 wk.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Traveller's diarrhoea
Adult: 300 mg bid for 1-3 days.
Renal impairment: Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.

Oral route
Postexposure prophylaxis after suspected or confirmed exposure to inhalational anthrax
Adult: 400 mg bid for ≥60 days.
Renal impairment: Initial dose as normal then reduce.

CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.
Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.
Oral route
Legionnaire's disease
Adult: 400 mg bid for 2-3 wk.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr
<20 100 mg every 24 hr.
Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.
Oral route
Typhoid fever
Adult: 200-400 mg bid for 7-14 days.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.
Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.
Intravenous
Complicated urinary tract infections
Adult: 200 mg daily by IV infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.
Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.
Intravenous
Lower respiratory tract infections
Adult: 200 mg bid by IV infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.
Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.
Intravenous
Septicaemia
Adult: 200 mg bid by IV infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr.
Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.
Intravenous
Skin and soft tissue infections
Adult: 400 mg bid infused over at least 1 hr.
Renal impairment: Initial dose as normal then reduce.
CrCl (ml/min) Dosage Recommendation
20-50 Reduce dose by half or give usual dose only every 24 hr.
<20 100 mg every 24 hr

Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily.


Otic/Aural
Otic infections
Adult: Apply 10 drops of 0.3% solution in the affected ear once daily for 7 days. Lie with the affected ear upwards for 5 min to facilitate penetration into the ear canal.
Child: 6 mth-13 yr: 5 drops of 0.3% solution in the affected ear once daily for 7 days. >13 yr: 10 drops of 0.3% solution in the affected ear once daily for 7 days. Lie with the affected ear upwards for 5 min to facilitate penetration into the ear canal.


Ophthalmic
Bacterial conjunctivitis
Adult: As 0.3% ophth solution: 1-2 drops in the affected eye instilled every 2-4 hr for the first 2 days then 4 times daily for the next 5 days of treatment.
Child: >1 yr: 1-2 drops in the affected eye instilled every 2-4 hr for the first 2 days then 4 times daily for the next 5 days of treatment.
Ophthalmic
Bacterial corneal ulcer
Adult: As 0.3% ophth solution: Days 1-2: Instill 1-2 drops into the affected eye every 30 min while awake. Awaken approximately 4 and 6 hr after retiring and instill 1-2 drops. Days 3-7 (or 9 if necessary): Instill 1-2 drops hrly while awake. Thereafter: Instill 1-2 drops 4 times daily until condition fully resolved.

Child: >1 yr: Days 1-2: Instill 1-2 drops into the affected eye every 30 min while awake. Awaken approximately 4 and 6 hr after retiring and instill 1-2 drops. Days 3-7 (or 9 if necessary): Instill 1-2 drops hrly while awake. Thereafter: Instill 1-2 drops 4 times daily until condition fully resolved.

Special Populations: Reduce dose in patients with renal impairment: CrCl: 20-50 mL/min: 100-200 mg daily or usual dose every 24 hrs; CrCl: <20 mL/min: 100 mg every 24 hrs. Patients undergoing dialysis: 100 mg every 24 hrs.

Administration May be taken with or without food.
Overdose Empty stomach, ensure adequate hydration is maintained and observe patient. Treat symptomatically, ofloxacin is not removed efficiently by haemodialysis or peritoneal dialysis.
Contraindications Hypersensitivity to quinolones; pregnancy and lactation; prolongation of the QT interval; uncorrected hypokalaemia.
Special Precautions Epilepsy or other predisposition to seizures; known or suspected CNS disorders; renal, hepatic impairment; myasthaenia gravis; superinfection; children <18 yr; exposure to strong sunlight and UV light; ensure adequate hydration; elderly.
Adverse Drug Reactions Nausea, vomiting, abdominal pain, diarrhoea; headache, dizziness, insomnia, hallucinations; leucopenia and eosinophilia; vaginitis; dysgeusia; tendon damage and rupture; anorexia; tremor; photosensitivity; hypersensitivity reactions. Discontinue if psychiatric, neurological or hypersensitivity reactions occur.
Potentially Fatal: Anaphylaxis; rarely seizures.
Drug Interactions Probenecid decreases elimination. Antacids may reduce ofloxacin absorption, avoid for 2 hr either side of administration. Cimetidine may increase ofloxacin concentrations. Monitor blood glucose in patients on antidiabetic medication.
Potentially Fatal: Corticosteroids may increase risk of tendon rupture. Increases effects of oral anticoagulants, ciclosporin, theophylline. Increased risk of seizures with NSAIDs. Avoid in patients taking QT prolonging medication (e.g. class Ia or III antiarrythmics, astemizole, terfenadine, cisapride, erythromycin, pentamidine, phenothiazines and some TCA). Please consult detailed drug interactions before prescribing.
Food Interaction Absorption delayed in the presence of food.
Lab Interference May produce false-positive results for opiates in commercially available urine immunoassay kits.
Pregnancy Category (US FDA) Category C: Caution esp. in 1st trimester. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Ophthalmic/Aural formulations: Store at 15-25°C. Oral  formulationsStore at 20-25°C. 
Pharmacology Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms.
Absorption: Rapidly and well absorbed from the GI tract (oral); peak plasma concentrations after 0.5-2 hr. Rate, but not extent, delayed by the presence of food.
Distribution: Widely distributed into body fluids, CSF, tissues, bile (high concentrations); crosses the placenta and enters breast milk. Protein-binding: 20-32%.
Metabolism: <10% of a single dose is metbolised. Converted to desmethyl and N-oxide metabolites; desmethylofloxacin has moderate antibacterial activity.
Excretion: Via urine within 24-48 hr by tubular secretion and glomerular filtration (75-80% as unchanged, <5% as metabolites); via faeces (4-8%). Elimination is biphasic with half-lives of 4-5 hr and 20-25 hr; prolonged in renal impairment (15-60 hr).
ATC Classification S01AX11 - ofloxacin; Belongs to the class of other antiinfectives. Used in the treatment of eye infections. 
J01MA01 - ofloxacin; Belongs to the class of quinolones, fluoroquinolone. Used in the treatment of systemic infections.

Brand/Product Info


Total Products : 7       
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
FLOCET Opsonin Pharma Limited Ofloxacin 200mg & 400mg Tablet 200mg x20's, 400mg x10's: 240.00 & 220.00 MRP
OBACTIN IBN SINA Pharmaceutical Industry Ltd. Ofloxacin USP 0.5% Eye Drop 5ml: 85.00 MRP
OFLACIN Drug International Ltd Ofloxacin 200mg & 400mg Tablet 200mg x20's, 400mg x20's: 240.00 & 400.00 MRP
RUTIX 200 Square Pharmaceuticals Ltd. Ofloxacin 200mg Tablet 3x10's: 362.70 MRP
RUTIX 400 Square Pharmaceuticals Ltd. Ofloxacin 400mg Tablet 2x10's: 442.80 MRP
VISTA Aristopharma Ltd. Ofloxacin USP 0.3% Eye/Ear Drop 5ml: 85.00 MRP
VISTA Drop Aristopharma Ltd. Ofloxacin USP 0.3% Eye Drop 5ml: 85.00 MRP

Gen. MedInfo

Notice: (Raised in the US market)

[Posted 08/15/2013] ISSUE: ISSUE: FDA has required the drug labels and Medication Guides for all fluoroquinolone antibacterial drugs be updated to better describe the serious side effect of peripheral neuropathy. This serious nerve damage potentially caused by fluoroquinolones may occur soon after these drugs are taken and may be permanent.

BACKGROUND: The risk of peripheral neuropathy occurs only with fluoroquinolones that are taken by mouth or by injection. Approved fluoroquinolone drugs include levofloxacin (Levaquin), ciprofloxacin (Cipro), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), and gemifloxacin (Factive). The topical formulations of fluoroquinolones, applied to the ears or eyes, are not known to be associated with this risk.

RECOMMENDATION: Make sure your patients know to contact you if they develop symptoms of peripheral neuropathy. Make sure your patients receive the Medication Guide with every prescription. If a patient develops symptoms of peripheral neuropathy, the fluoroquinolone should be stopped, and the patient should be switched to another, non-fluoroquinolone antibacterial drug, unless the benefit of continued treatment with a fluoroquinolone outweighs the risk. Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program.

For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.

IMPORTANT WARNING:

Taking ofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor if you are taking oral or injectable steroids such as dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), or prednisone (Sterapred). If you experience any of the following symptoms of tendinitis, stop taking ofloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking ofloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or bear weight on an affected area.

Taking ofloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take ofloxacin. If you have myasthenia gravis and your doctor tells you that you should take ofloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment.

Talk to your doctor about the risks of taking ofloxacin.

Your doctor will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ofloxacin. Read the information carefully and ask your doctor if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or check the manufacturer's website to obtain the Medication Guide.

 

Why is this medication prescribed?

Ofloxacin is used to treat certain infections including bronchitis, pneumonia, and infections of the skin, bladder, urinary tract, reproductive organs, and prostate (a male reproductive gland). Ofloxacin is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections. Antibiotics will not work for colds, flu, or other viral infections.

How should this medicine be used?

Ofloxacin comes as a tablet to take by mouth. It is usually taken with or without food twice a day for 3 days to 6 weeks. The length of treatment depends on the type of infection being treated. Your doctor will tell you how long to take ofloxacin. Take ofloxacin at around the same times every day and try to space your doses 12 hours apart. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take ofloxacin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You should begin to feel better during the first few days of your treatment with ofloxacin. If your symptoms do not improve or if they get worse, call your doctor.

Take ofloxacin until you finish the prescription, even if you feel better. Do not stop taking ofloxacin unless you experience the symptoms of tendinitis or tendon rupture described in the IMPORTANT WARNING section or the symptoms of allergic reaction described in the SIDE EFFECTS section. If you stop taking ofloxacin too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Other uses for this medicine

Ofloxacin is also sometimes used to treat other types of infection, including infections of the bones and joints and of the stomach and intestines. Ofloxacin may also be used to treat or prevent anthrax or plague (serious infections that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to the germs that cause these infections in the air. Talk to your doctor about the risks of using ofloxacin to treat your condition.

This medication may be prescribed for other uses; ask your doctor for more information.

What special precautions should I follow?

Before taking ofloxacin,

  • tell your doctor if you are allergic or have had a severe reaction to ofloxacin; other quinolone or fluoroquinolone antibiotics such as ciprofloxacin, gatifloxacin , gemifloxacin, Levofloxacin, lomefloxacin , moxifloxacin, nalidixic acid, norfloxacin, and sparfloxacin ; or any other medications.
  • tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: other antibiotics; anticoagulants  such as warfarin; certain antidepressants; antipsychotics; cimetidine; cyclosporine; diuretics; insulin and oral medications for diabetes such as glyburide; certain medications for irregular heartbeat such as amiodarone, quinidine, procainamide, and sotalol; nonsteroidal anti-inflammatory drugs  such as ibuprofen  and naproxen; probenecid; and theophylline . Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • if you are taking antacids containing aluminum, calcium, or magnesium; didanosine; sucralfate; or supplements or multivitamins containing iron or zinc, take ofloxacin 2 hours before or 2 hours after you take these medications.
  • tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death) or an irregular heartbeat and if you have or have ever had nerve problems, seizures, a slow heartbeat, a low level of potassium in your blood, chest pain, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or mini-stroke), or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking ofloxacin, call your doctor.
  • you should know that this medication may cause dizziness, lightheadedness, and tiredness. Do not drive a car, operate machinery, or participate in activities requiring alertness or coordination until you know how ofloxacin affects you.
  • plan to avoid unnecessary or prolonged exposure to sunlight and ultraviolet light (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen. Ofloxacin may make your skin sensitive to sunlight or ultraviolet light. If your skin becomes reddened, swollen, or blistered, call your doctor.

What special dietary instructions should I follow?

Make sure you drink plenty of water or other fluids every day while you are taking ofloxacin.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one and do not take more than 2 doses of ofloxacin in one day.

What side effects can this medication cause?

Ofloxacin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • diarrhea

  • constipation

  • gas

  • vomiting

  • stomach pain or cramps

  • change in ability to taste food

  • loss of appetite

  • dry mouth

  • headache

  • dizziness

  • excessive tiredness

  • pain, swelling, or itching of the vagina

Some side effects can be serious. If you experience any of these symptoms, or those mentioned in the IMPORTANT WARNING section, stop taking ofloxacin and call your doctor immediately:

  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)

  • rash

  • itching

  • hives

  • difficulty breathing or swallowing

  • swelling of the face, lips, tongue, or throat

  • hoarseness

  • loss of consciousness

  • fever

  • blistering or peeling skin

  • yellowing of the skin or eyes

  • dark urine

  • muscle or joint pain

  • pale skin

  • shortness of breath

  • unusual bruising or bleeding

  • fast, pounding, or irregular heartbeat

  • fainting

  • seizures

  • confusion

  • hallucinati ons (seeing things or hearing voices that do not exist)

  • nightmares

  • difficulty falling asleep or staying asleep

  • uncontrollable shaking of a part of the body

  • depression

  • thoughts about killing or harming yourself

  • anxiety

  • not trusting others or feeling that others want to harm you

  • restlessness

  • pain, numbness, burning, tingling, or weakness in the hands, arms, legs, or feet

  • vision changes

Ofloxacin may cause problems with bones, joints, and tissues around joints in children. Ofloxacin should not be given to children younger than 18 years of age. Talk to your child's doctor about the risks of giving ofloxacin to your child.

Ofloxacin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include:

  • drowsiness

  • nausea

  • dizziness

  • hot and cold flushes

  • numbness and swelling of the face

  • slurred speech

  • confusion

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.