(jen ta mye' sin)
P : Contraindicated in pregnancy
L : Caution when used during lactation
Indication(s) & Dosage
Biliary tract infections
Cat scratch disease
Urinary tract infections
Adult: 3-5 mg/kg/day,
given in divided doses every 8 hr for 7-10 days.
Prophylaxis of surgical infections
Renal impairment: Haemodialysis: Administer dose after dialysis session and monitor levels.
Haemodialysis may be useful in the removal of gentamicin from the blood, and is important if renal function is, or becomes compromised. Rate of removal is lower by peritoneal dialysis compared to haemodialysis.
History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.
Concurrent use of neuromuscular blocking agents; myasthenia gravis, parkinsonism; conditions predisposing to ototoxicity and nephrotoxicity; lactation. Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses, in infants, elderly, patients with renal impairment, cystic fibrosis or significant obesity. Monitor auditory and renal functions.
Dizziness or vertigo; acute renal failure, interstitial nephritis, acute tubular necrosis;
electrolyte imbalances; transient elevation of serum bilirubin and aminotransferases; purpura; nausea, vomiting; convulsions, mental depression,
hallucinations. Atrophy or rat necrosis at inj sites.
Synergistic with ampicillin, benzylpenicillin and other Î²-lactam
antibiotics. Increased risk of severe respiratory depression when used concurrently with anaesthetics or opioids. May reduce renal clearance of zalcitabine
and induce hypocalcaemia when used with biphosphonates. Not to be used with agalsidase alfa or beta as it may inhibit Î±-galactosidase activity.
|ROUTE(S) : OPHTH / OTIC / TOPICAL
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
ROUTE(S) : PARENT.
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Intramuscular: Store at 15-30Â°C. Ophthalmic: Store at 2-30Â°C.Topical/Cutaneous: Store at 2-30Â°C.
Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits
of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
S01AA11 - gentamicin; Belongs to the class of antibiotics. Used in the treatment of eye infections.
Search Google: Gentamicin
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|EGEN||Edruc Limited||Gentamicin 80mg/2ml||Injection||5 amps: 47.50 MRP|
|G-GENTAMICIN Drop||Gonoshasthaya Pharmaceuticals Ltd||Gentamicin 0.3% eye/ear drop||Eye/Ear Drop||10ml: 25.10 MRP|
|G-GENTAMICIN Inj||Gonoshasthaya Pharmaceuticals Ltd||Gentamicin 40mg/2ml, 80mg/2ml||Injection||40mg x25's & 80mg x10's: 150.50 & 90.30 MRP|
|G-GENTAMICIN Ointment||Gonoshasthaya Pharmaceuticals Ltd||Gentamicin 0.3% Ointment||Ointment||25gm: 19.72 MRP|
|GENACYN 20||Square Pharmaceuticals Ltd.||Gentamicin 20mg/2 ml||IM/IV Injection||2x5's: 61.10 MRP|
|GENACYN 80||Square Pharmaceuticals Ltd.||Gentamicin 80mg/2 ml||IM/IV Injection||2x5's: 101.80 MRP|
|GENACYN DROP||Square Pharmaceuticals Ltd.||Gentamicin 0.3%||Eye/Ear Drops||10 ml: 32.12 MRP|
|GENACYN OINT||Square Pharmaceuticals Ltd.||Gentamicin 0.1%||Ointment||10 gm: 12.09 MRP|
|GENTA Drop||Renata Limited||Gentamicin 0.3% eye/ear drop||Eye/Ear Drop||10ml: 31.93 MRP|
|GENTACIN||The Acme Laboratories Ltd.||Gentamicin 0.3% ointment||Eye Ointment||3.5gm: 9.75 MRP|
|GENTASOL||Techno Drugs||Gentamicin 80mg/2ml||Injection||10 amps: 95.00 MRP|
|GENTIN||Opso Saline Ltd.||Gentamicin 0.3% eye/ear drop||Eye/Ear drop||10ml: 31.37 MRP|
|GENTIN Cream||Opsonin Pharma Limited||Gentamicin 0.3% cream||Cream||10gm: 11.00 MRP|
|GENTIN Drop||Opso Saline Ltd.||Gentamicin 0.3% eye/ear drop||Eye Drop||10ml: 31.37 MRP|
|GENTIN Injection||Opsonin Pharma Limited||Gentamicin 20mg/2ml,80mg/2ml||Injection||25 amps each: 150.00 & 250.00 MRP|
|GENTIN Ointment||Opso Saline Ltd.||Gentamicin 0.3% ointment||Eye Ointment||3gm: 9.03 MRP|
|GENTO Drop||Gaco Pharmaceutical Ltd.||Gentamicin 0.3% eye/ear drop||Eye/Ear Drop||10ml: 31.50 MRP|
|GENTO Eye Oint||Gaco Pharmaceutical Ltd.||Gentamicin 0.3% ointment||Eye Ointment||5gm: 10.10 MRP|
|GENTO Ointment||Gaco Pharmaceutical Ltd.||Gentamicin 0.3% Ointment||Ointment||5gm: 9.10 MRP|
|IGEN||ACI Ltd.||Gentamicin 0.3% eye/ear drop||Eye/Ear Drop||10ml: 32.02 MRP|
|INTAMYCIN||Incepta Pharmaceuticals Limited||Gentamicin USP 80mg/2ml as Gentamicin Sulfate||Injection||10's: 100 MRP|
|MONAMYCIN||Amico Laboratories Ltd.||Gentamicin 0.3% cream||Cream||15gm: 16.75 MRP|
|OPTIMYCIN||Aristopharma Ltd.||Gentamicin 80mg/2ml||Injection||10 amps: 100.00 MRP|
|RECIN Drop||Reman Drug Laboratories Ltd.||Gentamicin 0.3% eye/ear drop||Eye/Ear Drop||10ml: 35.00 MRP|
Gentamicin can cause severe hearing and kidney problems. Before administering gentamicin, tell your doctor what prescription and nonprescription medications you are taking, especially diuretics ('water pills'), cisplatin (Platinol), amphotericin (Amphotec, Fungizone), other antibiotics, and vitamins.
If you experience any of the following symptoms, call your health care provider immediately: dizziness, vertigo, ringing in the ears, hearing loss, numbness, muscle twitching or weakness, difficulty breathing, decreased urination, rash, itching, or sore throat.
About Gentamicin Injection/Ophthalmic
Your doctor has ordered gentamicin, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for at least 30 minutes, one to three times a day.
Gentamicin eliminates bacteria that cause many kinds of infections, including lung, skin, bone, joint, stomach, blood, and urinary tract infections. This medication is sometimes prescribed for other uses; ask your doctor for more information.
Ophthalmic gentamicin is used to treat certain eye infections. Gentamicin is in a class of medications called antibiotics. It works by killing the bacteria that cause infection.
Your health care provider may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.
Ophthalmic gentamicin comes as a solution (liquid) to instill in the eyes and as an eye ointment to apply to the eyes. The eye drops are usually instilled every 4 to 8 hours and the eye ointment is usually applied two to four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part that you do not understand. Use gentamicin eye drops or eye ointment exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
To instill the eye drops, follow these steps:
Wash your hands thoroughly with soap and water.
Check the dropper tip to make sure that it is not chipped or cracked.
Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.
While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.
Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.
Brace the remaining fingers of that hand against your face.
While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.
Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.
Place a finger on the tear duct and apply gentle pressure.
Wipe any excess liquid from your face with a tissue.
If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.
Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.
Wash your hands to remove any medication.
To apply the eye ointment, follow these steps:
Wash your hands thoroughly with soap and water.
Use a mirror or have someone else apply the ointment.
Avoid touching the tip of the tube against your eye or anything else. The ointment must be kept clean.
Tilt your head forward slightly.
Holding the tube between your thumb and index finger, place the tube as near as possible to your eyelid without touching it.
Brace the remaining fingers of that hand against your cheek or nose.
With the index finger of your other hand, pull the lower lid of your eye down to form a pocket.
Place a small amount of ointment into the pocket made by the lower lid and the eye. A 1/2-inch (1.25-centimeter) strip of ointment usually is enough unless otherwise directed by your doctor.
Gently close your eyes and keep them closed for 1 to 2 minutes to allow the medication to be absorbed.
Replace and tighten the cap right away.
Wipe off any excess ointment from your eyelids and lashes with a clean tissue. Wash your hands again.
PrecautionsBefore administering gentamicin,
- tell your doctor if you are allergic to amikacin, gentamicin, kanamycin, neomycin, netilmicin, streptomycin, tobramycin or any other drugs.
- tell your doctor what prescription and nonprescription medications you are taking, especially diuretics ('water pills'), cisplatin, amphotericin, other antibiotics, and vitamins.
- tell your doctor if you have or have ever had kidney disease, vertigo, hearing loss, ringing in the ears, myasthenia gravis, or Parkinson's disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking gentamicin, call your doctor immediately. Gentamicin can harm the fetus.
Administering your medication
Before you administer gentamicin, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.
It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.
Gentamicin occasionally causes side effects. To reduce this risk, your health care provider may adjust your dose based on your blood test results. Follow the directions in the IMPORTANT WARNING section for the symptoms listed there and tell your health care provider if any of the following symptoms are severe or do not go away:
- upset stomach
- pale skin
Storing your medication
Your health care provider probably will give you a several-day supply of gentamicin at a time. If you are receiving gentamicin intravenously (in your vein), you probably will be told to store it in the refrigerator or freezer.
Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.
If you are told to store additional gentamicin in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.
Do not refreeze medications.
If you are receiving gentamicin intramuscularly (in your muscle), your health care provider will tell you how to store it properly.
Store your medication only as directed. Make sure you understand what you need to store your medication properly.
Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury
This medication may cause other side effects. Consult your doctor if you have any unusual problems while taking this.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: MedlinePlus, U.S. Natl. Library of Medicine
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.