Tetracycline

(tet ra sye' kleen)

PCI  : Contraindicated in pregnancy

LCI  : Contraindicated in lactation

Molecule Info

 

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Indication(s) & Dosage

Susceptible infections
Adult: As hydrochloride: 250 or 500 mg orally every 6 hrs, increased to 4 g daily in severe infections. 
Child: As hydrochloride: ≥12 yr: usual adult dose. Max: 2 g daily.
Renal impairment: Mild impairment: Avoid.
Hepatic impairment: Max: 1 g daily. 

Acne
Adult: As hydrochloride: 500 mg-1 g orally daily in 4 divided doses for 1-2 wk or until clinical improvement occurs, then decreased slowly to maintenance dose of 125-500 mg daily until clinical improvement allows discontinuation of the drug. 
Renal impairment: Mild: Avoid
Hepatic impairment: Max: 1g/day.

Intrapleural
Pleural effusions
Adult: As hydrochloride: 500 mg dissolved in 30-50 mL of 0.9% NaCl instilled into pleural spaces.

Administration Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals w/ a full glass of water, in upright position. May be taken w/ meals to reduce GI discomfort.
Contraindications Hypersensitivity; pregnancy, lactation, children; renal impairment.
Special Precautions Hepatic impairment. Myasthenia gravis, SLE. Should be administered with plenty of water, while sitting or standing, and well before going to bed to avoid oesophageal ulceration. Avoid exposure to sunlight. Periodic evaluation of renal, hepatic and haematological system during prolonged therapy.
Adverse Drug Reaction(s) Oesophageal ulceration, nausea, vomiting, oral candidiasis, diarrhoea, epigastric burning, sore throat, black hairy tongue, pancreatitis, oncholysis, discolouration of tooth (children with developing teeth) and nails, tinnitus, visual disturbances, superinfections, photosensitivity, hypersensitivity,
Potentially Fatal: Anaphylaxis, hepatotoxicity, nephrotoxicity, blood dyscrasias.
Drug Interactions Absorption reduced by divalent and trivalent cations, Fe prep and antacids. Decreases effectiveness of oral contraceptives. Concurrent use may increase levels of lithium, digoxin, halofantrine and theophylline; decrease concentrations of atovaquone; increase anticoagulant effects with warfarin; increase risk of ergotism with ergot alkaloids.
Potentially Fatal: Nephrotoxic effects exacerbated by diuretics, methoxyflurane or other nephrotoxic drugs; avoid concurrent use with potentially hepatotoxic drugs. Increased incidence of benign intracranial hypertension with retinoids. Please consult manufacturer's PIL (Prescribing Information Leaflet) for detailed drug interactions.
Food Interaction Absorption reduced by milk, milk products, antacids containing aluminum, magnesium iron preparations and food.
Lab Interference Interferes with diagnostic tests eg, urinary determination of glucose, false increase in fluorometric determinations of urine catecholamines.
Pregnancy Category (FDA) Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Pharmacology Tetracycline exhibits its bacteriostatic action by reversible binding to the 30s subunits of the ribosome thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp., Rickettsia spp., spirochaetes, many aerobic and anaerobic Gram-positive and Gram-negative pathogenic bacteria, and some protozoa.
Absorption: Absorbed incompletely from the GIT (oral) with oral bioavailability 60-80%; absorption affected by the presence of divalent ot trivalent metal ions, food and milk.
Distribution: Widely distributed to body tissues and fluids, CSF (low, may be increased in meningitis), saliva (small amounts), eye, lung, bone (newly formed), teeth (recently calcified and newly developed). Crosses the placenta into the foetal circulation and enters breast milk. Protein-binding: 20-65%. Half life: 6-12 hr.
Excretion: Via urine by glomerular filtration (as unchanged, 55% via oral and 60% via IV); may be increased in alkaline urine. Via bile; may undergo enterohepatic reabsorption.
ATC Classification D06AA04 - tetracycline; Belongs to the class of topical tetracycline and derivatives agents used in the treatment of dermatological diseases. 
S02AA08 - tetracycline; Belongs to the class of antiinfectives used in the treatment of ear infections. 
J01AA07 - tetracycline; Belongs to the class of tetracyclines. Used in the treatment of systemic infections. 
S03AA02 - tetracycline; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. 
A01AB13 - tetracycline; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
S01AA09 - tetracycline; Belongs to the class of antibiotics. Used in the treatment of eye infections.

Brand/Product Info


Total Products : 31                               
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
A-TETRA The Acme Laboratories Ltd. Tetracycline 250mg Tablet 100's: 229.00 MRP
A-TETRA Capsule The Acme Laboratories Ltd. Tetracycline 250mg Capsule 100's: 203.00 MRP
A-TETRA Ointment The Acme Laboratories Ltd. Tetracycline hydrochloride 1% Eye Ointment 3.5gm, 5gm: 8.50 & 11.55 MRP
BACTOCYCLINE Medicon Laboratories Ltd Tetracycline 250mg Capsule 100's: 130.00 MRP
BPTETRA Bristol Pharma Limited Tetracycline 250mg Capsule 100's: 100.00 MRP
G-TETRACYCLINE Gonoshasthaya Pharmaceuticals Ltd Tetracycline 250mg Capsule 100's: 101.00 MRP
G-TETRACYCLINE 1% Gonoshasthaya Pharmaceuticals Ltd Tetracycline hydrochloride 1% Eye Ointment 5gm: 8.03 MRP
G-TETRACYCLINE Ointment Gonoshasthaya Pharmaceuticals Ltd Tetracycline 3% skin Ointmentent Ointment 20gm: 17.77 MRP
INDOTETRA Indo-Bangla Pharmaceuticals Works Ltd. Tetracycline 250mg & 500mg Capsule 100's each: 80.00 & 150.00 MRP
JMYCIN Jayson Pharmaceuticals Ltd. Tetracycline 250mg Capsule 100's: 131.00 MRP
MONATREX DS Amico Laboratories Ltd. Tetracycline 250mg Capsule 100's: 200.00 MRP
OMNIMYCIN Desh Pharmaceuticals (Pvt) Ltd Tetracycline 250mg Capsule 100's: 215.00 MRP
RANDAMYCIN Desh Pharmaceuticals (Pvt) Ltd Tetracycline 250mg Capsule 60's: 72.00 MRP
TETCLIN Pacific Pharmaceuticals Ltd. Tetracycline 250mg Capsule 100's: 100.00 MRP
TETRACIN Ziska Pharmaceuticals Ltd. Tetracycline 250mg Capsule 100's: 100.00 MRP
TETRACIN Ointment Opso Saline Ltd. Tetracycline hydrochloride 1% Eye Ointment 3gm: 8.53 MRP
TETRACYCLINE Pharmadesh Laboratories Limited Tetracycline 250mg Capsule 100's: 100.00 MRP
TETRACYCLINE, RPL Reliance Pharmaceuticals Ltd. Tetracycline 250mg Capsule 100's: 228.76 MRP
TETRACYCLINE-H Hudson Pharmaceuticals Ltd Tetracycline 250mg Capsule 100's: 100.00 MRP
TETRACYN Renata Limited Tetracycline 250mg & 500mg Capsule 100's each: 122.00 & 202.00 MRP
TETRAGEN General Pharmaceuticals Ltd Tetracycline 250mg Capsule 100's: 136.00 MRP
TETRALIN Belsen Pharmaceuticals Ltd. Tetracycline 250mg Capsule 100's: 75.00 MRP
TETRAM Capsule Modern Pharmaceuticals Ltd Tetracycline 250mg Capsule 100's: 132.00 MRP
TETRAM, Ambee Ambee Pharmaceuticals Ltd. Tetracycline 250mg Capsule 100's: 133.00 MRP
TETRAMET Medimet Pharmaceuticals Ltd Tetracycline 250mg Capsule 100's: 137.00 MRP
TETRAMIN Aexim Pharmaceutical Ltd. Tetracycline 250mg Capsule 100's: 100.00 MRP
TETRAMYCIN Asiatic Laboratories Ltd. Tetracycline 250mg Capsule 100's: 130.00 MRP
TETRASINA IBN SINA Pharmaceutical Industry Ltd. Tetracycline 250mg & 500mg Capsule 250mg x100's & 500mg x50's: 137.00 & 112.50 MRP
TETRAX 500 Square Pharmaceuticals Ltd. Tetracycline 500mg Capsule 10x10's: 229.00 MRP
TETRAZEN Zenith Pharmaceuticals Ltd. Tetracycline 250mg Capsule 100's: 100.00 MRP
TITACIN Supreme Pharmaceuticals Ltd. Tetracycline 250mg & 500mg Capsule 100's each: 130.00 & 200.00 MRP

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