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LCaution when used during lactation - Caution when used during lactation

Molecule Info

 

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Content

Micronized purified flavonoid fraction/tablet.............................500 mg
. Diosmin (90%)....................................................................450 mg
. Flavonoids expressed as hesperidin (10%).............................50 mg

Indication(s) & Dosage

- Treatment of symptoms related to venolymphatic insufficiency (heavy legs, pain, early morning restless legs)
- Treatment of functional symptoms related to acute hemorrhoidal attack.

Dosage

  • Usual dosage: 2 tablets daily in two divided doses, midday and evening at meal times. 
  • Acute hemorrhoidal attack: 6 tablets per day for the first 4 days, then 4 tablets per day for 3 days.
Administration Should be taken with food. Take after meals.
Special warning & precautions

Acute hemorrhoidal attack: Administration of this medicine is no substitute for the specific treatment of other anal disorders. The treatment must be short-term. If the symptoms do not disappear rapidly, proctological examination should be performed and the treatment reviewed.

Use in Pregnancy

Pregnancy: Experimental studies in animals have not demonstrated any teratogenic effect in animals. Furthermore, no adverse effects have been reported to date in humans.
Lactation: In the absence of data concerning excretion into breast milk, breast feeding is not recommended during treatment.

Adverse Drug Reaction(s)

A few cases of minor gastrointestinal and neurovegetative disorders have been reported which did not require suspension of treatment.

Drug Interactions Metabolism of metronidazole may be reduced by concurrent admin of diosmin.
Pharmacology

PHARMACODYNAMIC PROPERTIES: Venotonic and vascular protector.

- Pharmacology
It is active upon the return vascular system in the following way:
. it reduces venous distensibility and stasis,
. in the microcirculation, it normalises capillary permeability and increases capillary resistance.

- Clinical pharmacology
Double blind controlled studies using methods by which the effects of the product on venous haemodynamics could be demonstrated and quantifed have confirmed the above pharmacological properties in man.

. Dose-effect relationship: a statistically significant dose-effect relationship was established with respect to venous plethysmographic parameters: capacitance, distensibility and rate of emptying. The optimum dose-effect ratio was obtained with 2 tablets.

Venous tonic activity: Diosmin-hesperidin increases venous tone: venous occlusion plethysmography with a mercury stress gauge demonstrated a decrease in the rate of emptying.

. Microcirculatory activity: double-blind controlled studies showed a statistically significant difference between placebo and the drug. In patients presenting with signs of capillary fragility, Diosmin-hesperidin increases capillary resistance, as measured by angiosterrometry.

- Clinical trials
Double-blind placebo-controlled trials have demonstrated the activity of the drug in phlebology, in the treatment of chronic venous insufficiency of the lower limbs (both functional and organic).

PHARMACOKINETICS PROPERTIES
In man, following oral administration of the substance containing 14C Diosmin :

- excretion is mainly faecal, a mean of 14% of the dose administered is excreted in the urine
- the elimination half-life is 11 hours.
- the drug is extensively metabolised as evidenced by the presence of various phenol acids in the urine.

ATC Classification C05CA03 - diosmin; Belongs to the class of bioflavonoids used as capillary stabilizing agents.

Search Google: Diosmin + hesperidin HemorrhoidsChronic venous insufficiency

Brand/Product Info



Total Products : 10          
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
AVONOID Unimed & Unihealth Manufacturers Ltd. Diosmin INN 450mg+ Hesperidin INN 50mg Tablet (FC) 30's: 240.00 MRP
DAFLON 500 Servier Bangladesh Operation Diosmin INN 450mg + Hesperidin INN 50mg Tablet 30's: 365.70 IP
DIOHES Opsonin Pharma Limited Diosmin INN 450mg+ Hesperidin INN 50mg Tablet (FC) 30's: 240.00 MRP
DIORIN Incepta Pharmaceuticals Limited Diosmin 450mg+ Hesperidin 50mg tablet Tablet 30's: 240.00 MRP
HEMONOR Apex Pharmaceuticals Ltd. Diosmin INN 450mg+ Hesperidin INN 50mg Tablet (FC) 30's: 240.00 MRP
HEMORAL Aristopharma Ltd. Diosmin INN 450mg+ Hesperidin INN 50mg Tablet (FC) 30's: 240.00 MRP
HEMORIF Square Pharmaceuticals Ltd. Diosmin 450mg+ Hesperidin 50mg Tablet 3x10's: 241.80 MRP
NORMANAL Renata Limited Diosmin INN 450mg+ Hesperidin INN 50mg Tablet (FC) 30's: 240.00 MRP
PILESTOP The Acme Laboratories Ltd. Diosmin INN 450mg+ Hesperidin INN 50mg Tablet (FC) 30's: 240.00 MRP
SANGRIL Healthcare Pharmacuticals Ltd. Micronised Diosmin INN 450mg + Hesperidin INN 50mg tablet 30's MRP 255 Tk

| See Brand Manufacturer's Prescribing Information |
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