mph Bangladesh

PCI  : Contraindicated in pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

Indication(s) & Dosage Dissolution of cholesterol-rich gallstones
Adult: 6-12 mg/kg daily as a single dose at bedtime or in 2-3 divided doses continued for 3-4 mth after radiological disappearance of stones. Doses may be divided unequally with a higher dose given before bedtime to counteract increase in biliary cholesterol saturation which occurs in early morning. Max: 15 mg/kg.
Hepatic impairment: Chronic liver disease (except primary biliary cirrhosis): use with caution.

Primary biliary cirrhosis
Adult: 10-15 mg/kg daily in 2-4 divided doses.

Prophylaxis of gallstones in patients undergoing rapid weight loss
Adult: 300 mg bid. 
Hepatic impairment: Chronic liver disease (except primary biliary cirrhosis): use with caution.
Administration Should be taken with food.
Contraindications Calcified and pigment gallstones, radio opaque gallstones. Nonfunctioning gall bladders; chronic liver and peptic ulcer disease. Inflammatory disease of colon and small intestine. Pregnancy.
Special Precautions 50% of successfully treated patients will develop further gallstones within 10 yr. Lactation.
Adverse Drug Reaction(s) Diarrhoea, pruritus, nausea, vomiting, gallstone calcification.
Drug Interactions Cholestyramine, charcoal and antacids may reduce effectiveness. Aluminum-based antacids may reduce absorption. Oestrogens and clofibrate may counteract effectiveness of ursodeoxycholic acid by increasing cholesterol elimination in bile. Possible increase in ciclosporin serum concentration. Decreased effectiveness of dapsone. Possible decrease in serumciprofloxacin and nitrendipine.
Pregnancy Category (FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Pharmacology Ursodeoxycholic acid suppresses hepatic synthesis and secretion of cholesterol and also inhibits intestinal absorption of cholesterol.
Absorption: Rapidly and completely absorbed from the GI tract.
Distribution: Protein binding: 96-98%. Undergoes enterohepatic recycling.
Metabolism: Partly conjugated in the liver before being excreted into the bile. Free and conjugated forms undergo 7a-dehydroxylation to lithocholic acid under the influence of gut bactera. Some are reabsorbed and then further conjugated and sulfated by the liver.
Excretion: Faeces.
ATC Classification A05AA02 - ursodeoxycholic acid; Belongs to the class of bile acids.


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Brand/Product Info

Total Products : 5     
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
LICONOR Opsonin Pharma Limited Ursodeoxycholic acid BP 150 & 300mg Tablet 30's each: 330.00 & 200.00 MRP
LICONOR Suspension Opsonin Pharma Limited Ursodeoxycholic acid BP 250mg/5ml Suspension 250mg: 180.00 MRP
ULIV The Acme Laboratories Ltd. Ursodeoxycholic acid BP 150 & 300mg Tablet 150mg x 20's, 300mg x 10's: 241.00 & 200.70 MRP
URSOCOL Sun Pharmaceutical (Bangladesh) Ltd. Ursodeoxycholic acid BP 150 & 300mg Tablet 150mg x 50's, 300mg x 30's: 552.50 & 603.00 MRP
URSODIL General Pharmaceuticals Ltd Ursodeoxycholic acid BP 300mg Tablet 10's: 200.70 MRP
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