(or nih da zole)
||See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
Renal impairment: Haemodialysis patients: Give a supplemental dose
(50% of the usual dose) before dialysis.
|Contraindications||Hypersensitivity to ornidazole or to other nitroimidazole derivatives.|
|Special Precautions||Renal and hepatic impairment. CNS diseases e.g. epilepsy or multiple sclerosis. May impair ability to drive or operate machinery. Pregnancy and lactation.|
|Adverse Drug Reaction(s)||Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.|
|Drug Interactions||Potentiates effect of coumarin-type oral anticoagulants. Prolongs the muscle-relaxant effect of vecuronium bromide.
Potentially Fatal: Potentiates effect of coumarin-type oral anticoagulants. Prolongs the muscle-relaxant effect of vecuronium bromide. Please consult detailed drug interactions before prescribing.
|Pharmacology||Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is
converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and
cell death in susceptible organisms.
Absorption: Readily absorbed (oral and intravaginal); peak plasma concentrations after 2 hr (oral), 12 hr (intravaginal).
Distribution: Body tissues and fluids (wide), CSF. Protein-binding: <15%.
Excretion: Via urine (as conjugates and metabolites), via faeces (small amounts); 12-14 hr (elimination half-life).
|ATC Classification||P01AB03 - ornidazole; Belongs to the
class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.
J01XD03 - ornidazole; Belongs to the class of imidazole derivative antibacterials. Used in the systemic treatment of infections.
G01AF06 - ornidazole; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|OR-500||Zenith Pharmaceuticals Ltd.||Ornidazole INN 500mg||Film Coated Tablet||30's: 195.00 MRP|
|ORNID||Drug International Ltd||Ornidazole INN 500mg||Film Coated Tablet||50's: 350.00 MRP|
|ORNIL||Opsonin Pharma Limited||Ornidazole INN 500mg||Film Coated Tablet||20's: 130.00 MRP|
|ORNIZOL||Alco Pharma Ltd||Ornidazole INN 500mg||Film Coated Tablet||30's: 180.00 MRP|
|ROBIC||Square Pharmaceuticals Ltd.||Ornidazole 500mg||Tablet||5x6's: 210.60 MRP|
|TRONIZ||Unimed & Unihealth Manufacturers Ltd.||Ornidazole INN 500mg||Film Coated Tablet||30's: 195.00 MRP|
|XYNOR||Beximco Pharmaceuticals Ltd||Ornidazole INN 500mg||Film Coated Tablet||30's: 195.00 MRP|