Ornidazole

(or nih da zole)  

Molecule Info

 |See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage

Oral route
Amoebiasis
Adult: 0.5 g bid for 5-10 days.
Child: 25 mg/kg as a single daily dose for 5-10 days.
Amoebic dysentery
Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.
Child: 40 mg/kg daily.
Giardiasis
Adult: 1-1.5 g as a single daily dose for 1-2 days.
Child: 30-40 mg/kg daily.
Trichomoniasis
Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.
Child: 25 mg/kg as a single dose.

Intravenous route
Severe amoebic dysentery
Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.
Child: 20-30 mg/kg body wt daily.
Amoebic liver abscess
Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.
Child: 20-30 mg/kg body wt daily.
Anaerobic bacterial infections
Adult: Initially, 0.5-1 g followed by 1 g daily as a single dose or in 2 divided doses for 5-10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hr orally as soon as possible.
Child: 10 mg/kg every 12 hr for 5-10 days.
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1 g by IV about 30 minutes before surgery.

Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic impairment: Severe: Double the interval between doses.
Reconstitution: Dilute to a concentration of ≤5 mg/ml.

Contraindications Hypersensitivity to ornidazole or to other nitroimidazole derivatives.
Special Precautions Renal and hepatic impairment. CNS diseases e.g. epilepsy or multiple sclerosis. May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Drug Reaction(s) Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.
Drug Interactions Potentiates effect of coumarin-type oral anticoagulants. Prolongs the muscle-relaxant effect of vecuronium bromide.
Potentially Fatal: Potentiates effect of coumarin-type oral anticoagulants. Prolongs the muscle-relaxant effect of vecuronium bromide. Please consult detailed drug interactions before prescribing.
Pharmacology Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Absorption: Readily absorbed (oral and intravaginal); peak plasma concentrations after 2 hr (oral), 12 hr (intravaginal).
Distribution: Body tissues and fluids (wide), CSF. Protein-binding: <15%.
Metabolism: Hepatic.
Excretion: Via urine (as conjugates and metabolites), via faeces (small amounts); 12-14 hr (elimination half-life).
ATC Classification P01AB03 - ornidazole; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases. 
J01XD03 - ornidazole; Belongs to the class of imidazole derivative antibacterials. Used in the systemic treatment of infections. 
G01AF06 - ornidazole; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.

Brand/Product Info


Total Products : 7       
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
OR-500 Zenith Pharmaceuticals Ltd. Ornidazole INN 500mg Film Coated Tablet 30's: 195.00 MRP
ORNID Drug International Ltd Ornidazole INN 500mg Film Coated Tablet 50's: 350.00 MRP
ORNIL Opsonin Pharma Limited Ornidazole INN 500mg Film Coated Tablet 20's: 130.00 MRP
ORNIZOL Alco Pharma Ltd Ornidazole INN 500mg Film Coated Tablet 30's: 180.00 MRP
ROBIC Square Pharmaceuticals Ltd. Ornidazole 500mg Tablet 5x6's: 210.60 MRP
TRONIZ Unimed & Unihealth Manufacturers Ltd. Ornidazole INN 500mg Film Coated Tablet 30's: 195.00 MRP
XYNOR Beximco Pharmaceuticals Ltd Ornidazole INN 500mg Film Coated Tablet 30's: 195.00 MRP