Metronidazole

(me troe ni' da zole)

PCI / LCIContraindication for pregnancy & lactation (breast feeding)

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
WARNING Metronidazole has been shown to be carcinogenic in mice and rats. Unnecessary use of the drug should be avoided. It's use should be reserved for approved therapeutic indications.
Indication(s) & Dosage

Symptomatic Trichomoniasis 

Metronidazole is indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).

Asymptomatic Trichomoniasis 

Metronidazole is indicated in the treatment of asymptomatic T. vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.

Treatment of Asymptomatic Sexual Partners 

T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her sexual partner is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the sexual partner should be treated with Metronidazole in cases of reinfection.

Amebiasis 

Metronidazole is indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess.

In amebic liver abscess, Metronidazole therapy does not obviate the need for aspiration or drainage of pus.

Anaerobic Bacterial Infections 

Metronidazole is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Metronidazole therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Metronidazole.

INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus species, and Peptostreptococcus species.

SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, and Fusobacterium species.

GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, and Fusobacterium species.

BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. fragilis group and Clostridium species.

BONE AND JOINT INFECTIONS, (as adjunctive therapy), caused by Bacteroides species including the B. fragilis group.

CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.

LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the B. fragilis group.

ENDOCARDITIS caused by Bacteroides species including the B. fragilis group.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Metronidazole and other antibacterial drugs, Metronidazole should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Oral route

Amoebiasis
Adult: 400-800 mg tid for 5-10 days or 1.5-2.5 g as a single daily dose for 2-3 days. Alternatively, 1.5-2.5 g as a single dose for 2-3 days.
Child: 1-3 yr: ¼ adult dose; 3-7 yr: 1/3 adult dose; 7-10 yr: ½ adult dose. Alternatively, 35-50 mg/kg daily in divided doses.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Balantidiasis
Adult: 400-800 mg tid for 5-10 days or 1.5-2.5 g as a single daily dose for 2-3 days. Alternatively, 1.5-2.5 g as a single dose for 2-3 days.
Child: 1-3 yr: ¼ adult dose; 3-7 yr: 1/3 adult dose; 7-10 yr: ½ adult dose. Alternatively, 35-50 mg/kg daily in divided doses.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Blastocystis hominis infection
Adult: 400-800 mg tid for 5-10 days or 1.5-2.5 g as a single daily dose for 2-3 days. Alternatively, 1.5-2.5 g as a single dose for 2-3 days.
Child: 1-3 yr: ¼ adult dose; 3-7 yr: 1/3 adult dose; 7-10 yr: ½ adult dose. Alternatively, 35-50 mg/kg daily in divided doses.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Trichomoniasis
Adult: 2 g as a single dose, or 800 mg in the morning and 1.2 g in the evening for 2 days, or 0.6-1 g daily in 2-3 divided doses for 7 days. There should be an interval of 4-6 wk if treatment needs to be repeated.
Child: 1-3 yr: 50 mg tid; 3-7 yr: 100 mg bid; 7-10 yr: 100 mg tid. All doses to be taken for 7 days. Alternatively, 15 mg/kg daily in divided doses for 7 days.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Giardiasis

Adult: 2 g once daily for 3 consecutive days, or 400 mg tid for 5 days, or 500 mg bid for 7-10 days.
Child: 1-3 yr: ¼ adult dose; 3-7 yr: 1/3 adult dose; 7-10 yr: ½ adult dose. Alternatively, 15 mg/kg daily in divided doses.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Bacterial vaginosis
Adult: 2 g as a single dose, or 400-500 mg bid for 5-7 days.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Acute necrotising ulcerative gingivitis

Adult: 200 mg tid for 3 days.
Elderly: Dose reductions may be required.

Acute dental infections

Adult: 200 mg tid for 3 days.
Elderly: Dose reductions may be required.

Anaerobic bacterial infections
Adult: Initially, 800 mg followed by 400 mg 8 hly for about 7 days. Other recommended doses: 500 mg 8 hrly or 7.5 mg/kg 6 hrly (max: 4 g in 24 hr).
Child: 7.5 mg/kg 8 hrly.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Prophylaxis of postoperative anaerobic bacterial infections
Adult: 400 mg by mouth 8 hrly in the 24 hr prior to surgery followed postoperatively by IV or rectal admin until oral therapy is possible. Other sources recommend that oral doses be initiated only 2 hr prior to surgery and that number of doses for all admin routes be limited to a total of 4.
Elderly: Dose reduction may be necessary.

Eradication of H. pylori associated with peptic ulcer disease
Adult: In combination with another antibacterial (e.g. clarithromycin) plus either a proton pump inhibitor (e.g. lansoprazole) or ranitidine bismuth citrate: 400 mg bid. In combination with omeprazole and amoxicillin: 400 mg tid. Continue treatment for 1 wk.
Elderly: Dose reduction may be necessary.

Leg ulcers and pressure sores
Adult: 400 mg tid for 7 days.
Elderly: Dose reduction may be necessary.

Antibiotic-associated colitis
Adult: 250-500 mg bid-tid for 10-14 days. Transfer to oral vancomycin is recommended if there is no clear clinical response after 2 days of treatment.
Child: 20 mg/kg/day 6 hrly. Max dose: 2 g/day. Transfer to oral vancomycin is recommended if there is no clear clinical response after 2 days of treatment.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Intravenous route

Anaerobic bacterial infections
Adult: 500 mg infused as 100 ml of a 5 mg/ml solution at 5 ml/min 8 hrly. Alternatively, 15 mg/kg infusion followed by 7.5 mg/kg 6 hrly; infuse over 1 hr (max: 4 g in 24 hr). Substitute oral therapy as soon as possible.
Child: 7.5 mg/kg 8 hrly.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Prophylaxis of postoperative anaerobic bacterial infections
Adult: 500 mg by IV infusion shortly before operation and repeated 8 hrly; oral doses of 200 or 400 mg 8 hrly being substituted as soon as possible. Patient undergoing colorectal surgery: 15 mg/kg infused over 30-60 min, completed about 1 hr prior to surgery, followed by 2 further IV doses of 7.5 mg/kg infused at 6 and 12 hr after the initial dose.
Elderly: Use lower end of adult dose recommendations. Do not admin as a single dose.

Topical/Cutaneous route
Bacterial vaginosis
Adult: Apply 5 g of a 0.75% gel once or bid for 5 days.
Rectal route
Anaerobic infections
Adult: As a 1-g suppository 8 hrly for 3 days, then 12 hrly. Substitute oral therapy as soon as possible. May be unsuitable for initiating therapy in severe infections. 
Child: <1 yr: 125 mg; 1-5 yr: 250 mg; 5-10 yr: 500 mg. All doses to be given 8 hrly for 3 days, then 12 hrly thereafter. May be unsuitable for initiating therapy in severe infections.
Elderly: Dose reduction may be necessary.

Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1 g 8 hrly starting 2 hr before surgery.
Elderly: Dose reduction may be necessary.

Topical/Cutaneous route
Fungating tumours
Adult: Apply as a 0.75 or 0.8% gel to the affected area. 

Rosacea
Adult: Apply and rub a thin film once daily (1% formulation) or bid (0.75% formulation) to entire affected areas after washing. Significant response should be noticed within 3 wk. Clinical studies have demonstrated continuing improvement through 9 wk of therapy.

Special Populations: Reduce dose in patients with severe hepatic impairment.
Reconstitution: Reconstitute powder for inj by adding 4.4 ml of sterile or bacteriostatic water for inj, 0.9% sodium chloride inj or bacteriostatic sodium chloride inj to a vial labeled as containing 500 mg metronidazole. Reconstituted solution contains approx 100 mg/ml metronidazole and must be further diluted with 0.9% sodium chloride inj, 5% dextrose inj or lactated Ringer's inj to a concentration of ≤8 mg/ml metronidazole. Neutralise reconstituted and diluted metronidazole hydrochloride solution by adding approx 5 mEq of sodium bicarbonate inj for each 500 mg metronidazole.
Incompatibility: Incompatible with aztreonam, dopamine, meropenem.

Hepatic impairment: Severe: 1/3 of usual dose given once daily.

CrCl (ml/min) Dosage Recommendation (Oral/IV/PR formulations)
<10 Consider reducing dose during long-term therapy.
Administration

Immediate-release: Should be taken on an empty stomach. Take ½ hr before meals.
Extended-release: Should be taken with food. Swallow whole, do not chew/crush/divide.

Overdosage

Symptoms: Nausea, vomiting, ataxia, seizures, peripheral neuropathy. Management: Symptomatic and supportive.

Contraindications

History of hypersensitivity to metronidazole or other nitroimidazole derivatives. Pregnancy (1st trimester) and lactation.

Special Precautions

Patients with CNS diseases; discontinue IV therapy if abnormal neurologic symptoms occur. History of seizure disorder. Evidence or a history of blood dyscrasias; perform total and differential leukocyte counts before and after treatment. Severe hepatic impairment; monitor plasma levels. Predisposition to oedema (inj contains sodium). Prolonged use may result in fungal or bacterial superinfection.

Adverse Drug Reaction(s)

GI disturbances e.g. nausea, unpleasant metallic taste, vomiting, diarrhoea or constipation. Furred tongue, glossitis, and stomatitis due to overgrowth of Candida. Rarely, antibiotic-associated colitis. Weakness, dizziness, ataxia, headache, drowsiness, insomnia, changes in mood or mental state. Numbness or tingling in the extremities, epileptiform seizures (high doses or prolonged treatment). Transient leucopenia and thrombocytopenia. Hypersensitivity reactions. Urethral discomfort and darkening of urine. Raised liver enzyme values, cholestatic hepatitis, jaundice. Thrombophlebitis (IV).
Potentially Fatal: Anaphylaxis.

Drug Interactions Acute psychoses or confusion with disulfiram. Additive/synergistic effect with other antimicrobials. Effects reduced with phenobarbital or phenytoin.
Potentially Fatal: Disulfiram-like reaction with alcohol. Increased risk of adverse effects of coumarin anticoagulants, phenytoin, lithium, ciclosporin, fluorouracil. Increased risk of neurological effects with cimetidine.

Lab Interference May interfere with tests for aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglycerides, glucose and lactate dehydrogenase (LDH).
Pregnancy Category (FDA)

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

Storage

Intravenous: Store at 15-30°C and protect from light.

Pharmacology

Metronidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is effective against a wide range of organisms including E. histolyticaT. vaginalis, Giardia, anaerobes e.g. Bacterioides sp, Fusobacterium sp, Clostridium sp,Peptococcus sp and Peptostreptococcus sp, and moderately active againstGardnerella sp and Campylobacter sp.
Absorption: Readily absorbed from the GI tract (oral), poorly absorbed from the vagina (intravaginal); peak plasma concentrations after 1-2 hr (oral), 5-12 hr (rectal), 8 hr (intravaginal). May be delayed by the presence of food.
Distribution: Protein-binding: <20%. Widely distributed in body tissues and fluids e.g. bile, bone, breast milk, cerebral abscesses, CSF, liver and liver abscesses, saliva, semenal fluid, vaginal secretions (concentrations similar to those in plasma); crosses the placenta and rapidly enters fetal circulation.
Metabolism: Hepatic via side-chain oxidation and glucuronide formation.
Excretion: Mainly via urine (as metabolites); via faeces (small amounts). Elimination half-life: 8 hr; longer in neonates and severe hepatic impairment.

ATC Classification D06BX01 - metronidazole; Belongs to the class of other topical chemotherapeutics used in the treatment of dermatological diseases. 
P01AB01 - metronidazole; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases. 
J01XD01 - metronidazole; Belongs to the class of imidazole derivative antibacterials. Used in the treatment of systemic infections. 
A01AB17 - metronidazole; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
G01AF01 - metronidazole; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.

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Brand/Product Info


Total Products : 148                                                                                                                                                    
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
AMEZOL Cosmic Chemical Industries Limited Metronidazole 400mg Tablet 100's: 100.00 MRP
AMEZOL Suspension Cosmic Chemical Industries Limited Metronidazole 200mg/5ml Suspension 60ml: 24.21 MRP
AMOBIN Doctors Chemical Works Ltd Metronidazole 400mg Tablet 100's: 114.00 MRP
AMOBIN Suspension Doctors Chemical Works Ltd Metronidazole 200mg/5ml Suspension 60ml: 24.00 MRP
AMODIS 400 Square Pharmaceuticals Ltd. Metronidazole 400mg Tablet 20x10's: 254.00 MRP
AMODIS 500 Square Pharmaceuticals Ltd. Metronidazole 5mg/ml IV Infusion 100 ml: 53.56 MRP
AMODIS SUSP Square Pharmaceuticals Ltd. Metronidazole 200mg/5 ml Suspension 60 ml: 29.89 MRP
AMOGIT Marksman Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 95.00 MRP
AMOTREX ACI Ltd. Metronidazole 200mg & 400mg Tablet 100's each: 66.00 & 115.00 MRP
AMOTREX Syrup ACI Ltd. Metronidazole 200mg/5ml Syrup 60ml: 25.09 MRP
ANAMET Navana Pharmaceuticals Limited Metronidazole 400mg Tablet 100's: 114.00 MRP
ANAMET Suspension Navana Pharmaceuticals Limited Metronidazole 200mg/5ml Suspension 60ml: 25.50 MRP
ANTIPRO Rangs Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 21.00 MRP
ANTIPRO 400 Rangs Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
ANZOLE Monico Pharma Limited Metronidazole 200mg/5ml Suspension 60ml: 25.00 MRP
ANZOLE 400 Monico Pharma Limited Metronidazole 400mg Tablet 100's: 101.00 MRP
APETRYL APC Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 20.00 MRP
APETRYL-400 APC Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 113.00 MRP
APZYL Apollo Pharmaceutical Laboratories Ltd. Metronidazole 200mg/5ml Suspension 60ml: 24.00 MRP
BENMET Pacific Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 114.00 MRP
BENMET Suspension Pacific Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 20.00 MRP
BIOZYL Biopharma Laboratories Ltd Metronidazole 400mg Tablet 100's: 100.00 MRP
BIOZYL I/V Biopharma Laboratories Ltd Metronidazole 500mg/100ml (I/V) Infusion 100ml: 52.59 MRP
BIOZYL Suspension Biopharma Laboratories Ltd Metronidazole 200mg/5ml Suspension 60ml: 25.09 MRP
CEDOL Central Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 100.00 MRP
CEDOL Suspension Central Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 22.00 MRP
D-METRO Desh Pharmaceuticals (Pvt) Ltd Metronidazole 200mg/5ml Suspension 60ml: 21.00 MRP
D-METRO-400 Desh Pharmaceuticals (Pvt) Ltd Metronidazole 400mg Tablet 100's: 100.00 MRP
DECAGYL Decent Pharma Laboratories Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
DECAGYL Syrup Decent Pharma Laboratories Ltd. Metronidazole 200mg/5ml Syrup 60ml: 25.50 MRP
DIROZYL The Acme Laboratories Ltd. Metronidazole 200mg & 400mg Tablet 200 & 400mg x100's, 500mg x20's: 67.00 & 101.00; 23.80 MRP
DIROZYL I/V The Acme Laboratories Ltd. Metronidazole 500mg/100ml (I/V) Infusion 100ml vial: 50.20 MRP
DIROZYL Suppository The Acme Laboratories Ltd. Metronidazole 500mg Suppository 10 sticks: 120.50 MRP
DIROZYL Suspension The Acme Laboratories Ltd. Metronidazole 200mg/5ml Suspension 60ml: 25.10 MRP
DYMET Syntho Laboratories Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
DYMET Suspension Syntho Laboratories Ltd. Metronidazole 200mg/5ml Suspension 60ml: 22.00 MRP
EGYL Euro Pharma Ltd. Metronidazole 400mg Tablet 100's: 114.00 MRP
EGYL Suspension Euro Pharma Ltd. Metronidazole 200mg/5ml Suspension 60ml: 24.85 MRP
ELYGYL S.N. Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
ELYGYL Suspension S.N. Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 22.08 MRP
FILMET 200 Beximco Pharmaceuticals Ltd Metronidazole BP 200mg Tablet 200's: 138.00 MRP
FILMET 400 Beximco Pharmaceuticals Ltd Metronidazole BP 400mg Tablet 250's: 252.50 MRP
FILMET DS Beximco Pharmaceuticals Ltd Metronidazole BP 800mg Tablet 100's: 201.00 MRP
FILMET IV Beximco Pharmaceuticals Ltd Metronidazole 0.5% w/v (500mg) IV Injection 100ml: 53.40 MRP
FILMET SUSP Beximco Pharmaceuticals Ltd Metronidazole Benzoate BP 320mg eq. to Metronidazole 200mg/5ml Suspension 60ml: 25.75 MRP
FLAGYL Sanofi Metronidazole 200mg & 400mg Tablet 200mg x500's, 400mg x250's: 332.50 & 285.95 MRP
FLAGYL I/V Sanofi Metronidazole 500mg/100ml (I/V) Infusion 100ml: 85.22 MRP
FLAGYL Suspension Sanofi Metronidazole 200mg/5ml Suspension 60ml: 24.94 MRP
Flamyd 250 Incepta Pharmaceuticals Limited Metronidazole BP 250 mg Tablet 10x10's:MRP 78 Tk
Flamyd 500 Incepta Pharmaceuticals Limited Metronidazole BP 500 mg Tablet 10x10's:MRP 135 Tk
Flamyd Gel Incepta Pharmaceuticals Limited Metronidazole BP 7.5 mg/gm Gel 30gm x1's:MRP 50 Tk
Flamyd IV Incepta Pharmaceuticals Limited Metronidazole BP 500mg/100ml IV Infusion 100ml:MRP 53.4 Tk
Flamyd Suspension Incepta Pharmaceuticals Limited Metronidazole Benzoate BP equivalent to Metronidazole 200mg/5ml Suspension 60ml:MRP 25 Tk
FLORAZOL NIPRO JMI Pharma Ltd. Metronidazole 400mg Tablet 200's: 200.00 MRP
FLORAZOL Suspension NIPRO JMI Pharma Ltd. Metronidazole 200mg/5ml Suspension 60ml: 24.00 MRP
G- METRONIDAZOLE Gonoshasthaya Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 102.00 MRP
G-METRONIDAZOLE Gonoshasthaya Pharmaceuticals Ltd Metronidazole 125mg/5ml Suspension 50ml, 60ml, 100ml: 17.26 MRP, 21.00 & 30.45 MRP
G-METRONIDAZOLE I/V Gonoshasthaya Pharmaceuticals Ltd Metronidazole 500mg/100ml (I/V) Infusion 100ml: 35.53 MRP
KEMET Kemiko Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 112.00 MRP
KEMET Suspension Kemiko Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 22.00 MRP
KILPRO Techno Drugs Metronidazole 400mg Tablet 100's: 100.00 MRP
KILPRO I/V Techno Drugs Metronidazole 500mg/100ml (I/V) Infusion 100ml: 55.00 MRP
KLION Ambee Pharmaceuticals Ltd. Metronidazole 200mg & 400mg Tablet 100's each: 67.00 & 109.00 MRP
KLION Suspension Ambee Pharmaceuticals Ltd. Metronidazole 125mg/5ml Suspension 60ml: 23.35 MRP
LIBRAZOL I/V Libra Pharmaceuticals Ltd. Metronidazole 500mg/100ml (I/V) Infusion 100ml: 49.76 MRP
M-400 Pharmasia Limited Metronidazole 400mg Tablet 100's: 110.00 MRP
M-DAZOLE Modern Pharmaceuticals Ltd Metronidazole 200mg & 400mg Tablet 100's each: 66.00 & 114.00 MRP
M-DAZOLE Suspension Modern Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 25.67 MRP
MECOZOL Amico Laboratories Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
MECOZOL Suspension Amico Laboratories Ltd. Metronidazole 200mg/5ml Suspension 60ml: 25.00 MRP
MEDIZOL Medicon Laboratories Ltd Metronidazole 400mg Tablet 100's: 110.00 MRP
MEDIZOL Suspension Medicon Laboratories Ltd Metronidazole 200mg/5ml Suspension 60ml: 21.00 MRP
MELAGYL Reliance Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 102.00 MRP
MELAGYL Suspension Reliance Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 22.00 MRP
MENILET Alco Pharma Ltd Metronidazole 400mg Tablet 100's: 101.00 MRP
MENILET Suspension Alco Pharma Ltd Metronidazole 200mg/5ml Suspension 60ml: 21.24 MRP
MENOL Supreme Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
MENOL Suspension Supreme Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 21.60 MRP
METASON Jayson Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 115.00 MRP
METASON Suspension Jayson Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 25.10 MRP
METCO Eskayef Bangladesh Ltd Metronidazole BP 400mg Tablet 100's MRP: 114.00
METCO Suspension Eskayef Bangladesh Ltd Metronidazole Benzoate BP equivalent to Metronidazole 200mg/5ml Suspension 60ml MRP: 25.12.00
METFIL Bristol Pharma Limited Metronidazole 400mg Tablet 100's: 100.00 MRP
METONID Popular Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 114.00 MRP
METONID I/V Popular Pharmaceuticals Ltd. Metronidazole 500mg/100ml (I/V) Infusion 100ml: 52.79 MRP
METONID Suspension Popular Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 25.24 MRP
METRA Ad-din pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 105.00 MRP
METRA Suspension Ad-din pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 24.00 MRP
METRION General Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 114.00 MRP
METRION Suspension General Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 25.76 MRP
METRIZOL Cosmo Pharma Laboratories Ltd. Metronidazole 400mg Tablet 100's: 101.00 MRP
METRO Indo-Bangla Pharmaceuticals Works Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
METRO 400 Ziska Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 105.00 MRP
METRO I/V Opso Saline Ltd. Metronidazole 500mg/100ml (I/V) Infusion 100ml: 35.13 MRP
METRO Suspension Ziska Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 25.00 MRP
METROBAC I/V Ziska Pharmaceuticals Ltd. Metronidazole 500mg/100ml (I/V) Infusion 100ml: 53.00 MRP
METROCON-400 Concord Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
METROGYL Rephco Laboratories Ltd. Metronidazole 400mg Tablet 100's: 110.00 MRP
METROGYL Suspension Rephco Laboratories Ltd. Metronidazole 200mg/5ml Suspension 60ml: 25.00 MRP
METROL Indo-Bangla Pharmaceuticals Works Ltd. Metronidazole 200mg/5ml Suspension 60ml: 21.00 MRP
METROMAX 500 Novo Healthcare and Pharma Ltd. Metronidazole 500mg Tablet 100's: 135.00 MRP
METROMAX I/V Novo Healthcare and Pharma Ltd. Metronidazole 500mg/100ml (I/V) Injection 100ml: 52.00 MRP
METROPILL Medimet Pharmaceuticals Ltd Metronidazole 200mg & 400mg Tablet 100's each: 60.00 & 110.00 MRP
METROPILL Suspension Medimet Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 22.00 MRP
METROSIL Silva Pharmaceuticals Limited Metronidazole 400mg Tablet 100's: 100.38 MRP
METROSIL Suspension Silva Pharmaceuticals Limited Metronidazole 200mg/5ml Suspension 60ml: 19.07 MRP
METROSON Hudson Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 105.00 MRP
METROSON Suspension Hudson Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 18.00 MRP
METROZEN Zenith Pharmaceuticals Ltd. Metronidazole 400mg Tablet 200's: 214.00 MRP
METROZEN Suspension Zenith Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 21.30 MRP
METRYL Opsonin Pharma Limited Metronidazole 200mg, 400mg & 500mg Tablet 100's each: 62.00 & 108.00 & 135.00 MRP
METRYL I/V Opsonin Pharma Limited Metronidazole 500mg/100ml (I/V) Infusion 100ml: 53.00 MRP
METRYL Suspension Opsonin Pharma Limited Metronidazole 200mg/5ml Suspension 60ml: 24.00 MRP
METSINA IBN SINA Pharmaceutical Industry Ltd. Metronidazole 200mg & 400mg Tablet 100's each: 63.00 & 115.00 MRP
METSINA Suspension IBN SINA Pharmaceutical Industry Ltd. Metronidazole 200mg/5ml Suspension 60ml: 25.75 MRP
MEZ Renata Limited Metronidazole 400mg Tablet 100's: 125.00 MRP
MEZ I/V Renata Limited Metronidazole 500mg/100ml (I/V) Infusion 100ml: 70.00 MRP
MICOGYL Globe Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 100.00 MRP
MICOGYL Suspension Globe Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 22.00 MRP
NEOGYL Millat Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 24.88 MRP
NEOGYL-400 Millat Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 114.00 MRP
NIDA Sonear Laboratories Ltd. Metronidazole 400mg Tablet 100's: 82.00 MRP
NIDAZYL Orion Pharma Ltd. Metronidazole 400mg Tablet 100's: 114.00 MRP
NIDAZYL I/V Orion Pharma Ltd. Metronidazole 500mg/100ml (I/V) Infusion 100ml: 52.00 MRP
NIDAZYL Suspension Orion Pharma Ltd. Metronidazole 200mg/5ml Suspension 60ml: 21.08 MRP
ONIDA Mystic Pharmaceuticals Limited Metronidazole 400mg Tablet 100's: 100.00 MRP
ONIDA Suspension Mystic Pharmaceuticals Limited Metronidazole 200mg/5ml Suspension 60ml: 21.00 MRP
ORMET Belsen Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 112.00 MRP
ORMET Suspension Belsen Pharmaceuticals Ltd. Metronidazole 125mg/5ml Suspension 60ml: 20.00 MRP
PHIDAZOLE Pharmadesh Laboratories Limited Metronidazole 400mg Tablet 400mg x200's: 198.00 MRP
PHIDAZOLE Suspension Pharmadesh Laboratories Limited Metronidazole 200mg/5ml Suspension 60ml: 24.50 MRP
PROTEC Hallmark Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 108.00 MRP
PROTEC Suspension Hallmark Pharmaceuticals Ltd Metronidazole 200mg/5ml Suspension 60ml: 21.08 MRP
PROZOL Shamsul Alamin Pharmaceuticals Ltd Metronidazole 400mg Tablet 100's: 90.00 MRP
QUGYL Aexim Pharmaceutical Ltd. Metronidazole 200mg/5ml Suspension 60ml: 24.00 MRP
QUGYL-400 Aexim Pharmaceutical Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
REMAGYL Reman Drug Laboratories Ltd. Metronidazole 200mg/5ml Suspension 60ml: 21.50 MRP
SEEMAGYL Seema Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 24.00 MRP
SOMET Somatec Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 18.81 MRP
STRAZYL Asiatic Laboratories Ltd. Metronidazole 400mg Tablet 100's: 102.00 MRP
STRAZYL Suspension Asiatic Laboratories Ltd. Metronidazole 200mg/5ml Suspension 60ml: 24.84 MRP
TILOMET The White Horse Pharma Metronidazole 200mg & 400mg Tablet 100's each: 66.00 & 114.00 MRP
TRICOZYL Edruc Limited Metronidazole 400mg Tablet 100's: 103.00 IP
TRICOZYL Suspension Edruc Limited Metronidazole 200mg/5ml Suspension 60ml: 21.24 MRP
VARIZIL Drug International Ltd Metronidazole 400mg Tablet 100's: 86.00 MRP
VARIZIL I/V Drug International Ltd Metronidazole 500mg/100ml (I/V) Infusion 100ml: 45.00 MRP
VIGIL Salton Pharmaceuticals Ltd. Metronidazole 400mg Tablet 100's: 100.00 MRP
VIGIL Suspension Salton Pharmaceuticals Ltd. Metronidazole 200mg/5ml Suspension 60ml: 22.08 MRP

Gen. MedInfo

IMPORTANT WARNING:

Metronidazole can cause cancer in laboratory animals. Talk to your doctor about the risks and benefits of using Metronidazole.

Why is Metronidazole prescribed?

Metronidazole eliminates bacteria and other microorganisms that cause infections of the reproductive system, gastrointestinal tract, skin, vagina, and other areas of the body. Antibiotics will not work for colds, flu, or other viral infections.

Metronidazole is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should Metronidazole be used?

Metronidazole comes as a tablet to take by mouth. It is usually taken two or three times a day for 5 to 10 days or longer. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metronidazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions to follow?

Before taking metronidazole,
  • inform your doctor and pharmacist if you are allergic to metronidazole or any other drugs.
  • inform your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants ('blood thinners') such as warfarin, astemizole, disulfiram, lithium, phenobarbital, phenytoin, and vitamins.
  • inform your doctor if you have or have ever had blood, kidney, or liver disease or Crohn's disease.
  • inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking metronidazole, call your doctor.
  • know that you should not drink alcohol while taking this drug. Alcohol may cause an upset stomach, vomiting, stomach cramps, headaches, sweating, and flushing (redness of the face).
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Metronidazole may make your skin sensitive to sunlight.

What to do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Metronidazole cause?

Metronidazole may cause side effects. inform your doctor if any of these symptoms are severe or do not go away:
  • vomiting

  • diarrhea

  • upset stomach

  • loss of appetite

  • dry mouth; sharp, unpleasant metallic taste

  • dark or reddish-brown urine

  • furry tongue; mouth or tongue irritation

  • numbness or tingling of hands or feet

If you experience any of the following symptoms, consult your doctor immediately:
  • rash

  • itching

  • stuffy nose

  • fever

  • joint pain

 Ref: MedlinePlus, U.S. Natl. Library of Medicine 


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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| Latest mph edition: 26 Dec 2013 |
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*Trademark name & prescribing information are the property of their respective Manufacturers.