Nitazoxanide

(nye ta zox' a nide) 

PCaution when used during lactation / LCaution when used during lactation : Caution during pregnancy and lactation

Molecule Info

Indication & Dosage Giardiasis, Cryptosporidiosis
Adult: 500 mg every 12 hr for 3 days.
Child: 1-3 yr: 100 mg every 12 hr; 4-11 yr: 200 mg every 12 hr; ≥12 yr: 500 mg every 12 hr. All doses to be taken for 3 days.
Administration Should be taken with food.
Contraindications Hypersensitivity.
Special Precautions Renal and hepatic impairment. Pregnancy and lactation. Children <1 yr.
Adverse Drug Reactions Headache, abdominal pain, diarrhoea, nausea, vomiting, allergic reactions, anaemia, anorexia, increased appetite, increased creatinine and LFT, diaphoresis, dizziness, eye and urine discolouration, fever, flatulence, hypertension, infection, malaise, nausea, pruritus, rhinitis, enlarged salivary glands, tachycardia.
Drug Interactions May possibly interact with highly protein-bound drugs e.g. warfarin.
Food Interaction Increased AUC with food.
Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Storage Oral: Suspension: Store at 15-30°C (59-86°F). Tablet: Store at room temperature.
Pharmacology Nitazoxanide is an antiprotozoal agent. Both nitazoxanide and its active metabolite (tizoxanide) interfere with the pyruvate:ferredoxin 2-oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic metabolism in susceptible organisms.
Absorption: Absorbed from the GI tract (oral). Extent of absorption enhanced with food; peak plasma concentrations of tizoxanide and glucuronide metabolite after 1-4 hr.
Distribution: Protein-binding: >99%.
Metabolism: Rapidly hydrolysed to tizoxanide (active desacetyl metabolite) which partially undergoes conjugation, primarily by glucuronidation.
Excretion: Via faeces (2/3 of an oral dose); via urine (remaining dose).
ATC Classification P01AX11 - nitazoxanide; Belongs to the class of other agents used in the treatment amoebiasis and other protozoal diseases.

 Search Google: Nitazoxanide

Brand/Product Info


Total Products : 64                                                                
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ADNIX Alco Pharma Ltd Nitazoxanide INN 500mg Tablet 12's: 120.00 MRP
ADNIX Suspension Alco Pharma Ltd Nitazoxanide INN 100mg/5ml Suspension 30ml: 35.00 MRP
ALINIX Healthcare Pharmacuticals Ltd. Nitazoxanide INN 500mg Tablet 30's MRP 300 Tk
ALINIX 30ml Healthcare Pharmacuticals Ltd. Nitazoxanide INN 100 mg/5ml Powder for suspension Suspension 30ml, MRP 35 Tk
ALINIX 60ml Healthcare Pharmacuticals Ltd. Nitazoxanide INN 100 mg/5ml Powder for suspension Suspension 60ml, MRP 50 Tk
ANTIZOA R A K Pharmaceuticals Pvt. Ltd. Nitazoxanide INN 500mg Tablet 30's: 300.00 MRP
ATINID Biopharma Laboratories Ltd Nitazoxanide INN 500mg Tablet 20's: 200.80 MRP
ATINID Suspension Biopharma Laboratories Ltd Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.13 & 50.19 MRP
DIANIDE General Pharmaceuticals Ltd Nitazoxanide INN 500mg Tablet 6's: 60.24 MRP
DIANIDE Suspension General Pharmaceuticals Ltd Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.00 & 50.00 MRP
DIAR ACI Ltd. Nitazoxanide INN 500mg Tablet 10's: 100.40 MRP
DIAR Suspension ACI Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.13 & 50.19 MRP
DIAZOX Kumudini Pharma Ltd Nitazoxanide INN 500mg Tablet 24's: 240.00 MRP
DIAZOX Suspension Kumudini Pharma Ltd Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.00 & 50.00 MRP
NIAZID Apex Pharmaceuticals Ltd. Nitazoxanide INN 500mg Tablet 28's: 280.00 MRP
NIAZID Suspension Apex Pharmaceuticals Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml: 35.00 MRP
NICUD Suspension Monico Pharma Limited Nitazoxanide INN 100mg/5ml Suspension 30ml: 35.00 MRP
NIDOR Suspension Pharmasia Limited Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.00 & 50.00 MRP
NIDOR-500 Pharmasia Limited Nitazoxanide INN 500mg Tablet 18's: 180.72 MRP
NIDOZOX 500 The Acme Laboratories Ltd. Nitazoxanide INN 500mg Tablet 18's: 180.72 MRP
NIDOZOX Suspension The Acme Laboratories Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml: 35.14 MRP
NITANID Drug International Ltd Nitazoxanide INN 500mg Tablet 20's: 200.00 MRP
NITANID Suspension Drug International Ltd Nitazoxanide INN 100mg/5ml Suspension 60ml: 50.00 MRP
NITASOL IBN SINA Pharmaceutical Industry Ltd. Nitazoxanide INN 500mg Tablet 12's: 132.00 IP
NITASOL Suspension IBN SINA Pharmaceutical Industry Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 36.00 IP, 50.00 IP
NITAX Delta Pharma Limited Nitazoxanide INN 500mg Tablet 10's: 80.00 MRP
NITAX Suspension Delta Pharma Limited Nitazoxanide INN 100mg/5ml Suspension 30ml: 30.00 MRP
NITAXIDE Beximco Pharmaceuticals Ltd Nitazoxanide INN 500mg Tablet 20's: 200.00 MRP
NITAXIDE 30ML Beximco Pharmaceuticals Ltd Nitazoxanide INN 100mg/5ml Powder for suspension Suspension 30ml: 35.00 MRP
NITAXIDE 60ML Beximco Pharmaceuticals Ltd Nitazoxanide INN 100mg/5ml Powder for suspension Suspension 60ml: 50.00 MRP
Nitazox Incepta Pharmaceuticals Limited Nitazoxanide INN 500 mg Tablet 10x3's:MRP 300 Tk
Nitazox 100 ml Incepta Pharmaceuticals Limited Nitazoxanide INN 100mg/5ml Suspension 30ml:MRP 35 Tk
Nitazox 60 ml Incepta Pharmaceuticals Limited Nitazoxanide INN 100mg/5ml Suspension 60ml:MRP 50 Tk
NITIDE NIPRO JMI Pharma Ltd. Nitazoxanide INN 500mg Tablet (film-coated) 30's: 300.00 MRP
NITIDE Suspension NIPRO JMI Pharma Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.00 & 50.00 MRP
NITOXIN Aristopharma Ltd. Nitazoxanide INN 500mg Tablet (film-coated) 30's: 300.00 MRP
NITOXIN Suspension Aristopharma Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.00 & 50.00 MRP
NIXAR Sharif Pharmaceuticals Ltd. Nitazoxanide INN 500mg Tablet (film-coated) 20's: 200.00 MRP
NIXAR Suspension Sharif Pharmaceuticals Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml: 35.00 MRP
NIZONID Medicon Laboratories Ltd Nitazoxanide INN 500mg Tablet (film-coated) 12's: 120.00 MRP
NIZONID Suspension Medicon Laboratories Ltd Nitazoxanide INN 100mg/5ml Suspension 30ml: 35.00 MRP
NIZOX Somatec Pharmaceuticals Ltd. Nitazoxanide INN 500mg Tablet (film-coated) 12's: 120.36 MRP
NIZOX Suspension Somatec Pharmaceuticals Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 30.11 & 50.19 MRP
NTZ Suspension Asiatic Laboratories Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.00 & 50.00 MRP
PROXA-A Ad-din pharmaceuticals Ltd. Nitazoxanide INN 500mg Tablet (film-coated) 20's: 180.00 MRP
TAZONID Popular Pharmaceuticals Ltd. Nitazoxanide INN 500mg Tablet (film-coated) 30's: 301.20 MRP
TAZONID Suspension Popular Pharmaceuticals Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml: 32.12 MRP
TAZOX Novo Healthcare and Pharma Ltd. Nitazoxanide INN 500mg Tablet (film-coated) 12's: 120.00 MRP
TAZOX Suspension Novo Healthcare and Pharma Ltd. Nitazoxanide INN 100mg/5ml Suspension 30ml: 35.00 MRP
TOZA Eskayef Bangladesh Ltd Nitazoxanide INN 500mg Film Coated Tablet 12's MRP: 120.00
TOZA Suspension Eskayef Bangladesh Ltd Nitazoxanide INN 100mg/5ml Powder for suspension Suspension 30ml & 60ml MRP: 35.00 & 50.00
XANIDE Globe Pharmaceuticals Ltd Nitazoxanide INN 500mg Tablet (film-coated) 12's: 120.00 MRP
XANIDE Suspension Globe Pharmaceuticals Ltd Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.00 & 50.00 MRP
XANITA Renata Limited Nitazoxanide INN 500mg Tablet (film-coated) 18's: 180.72 MRP
XANITA Suspension Renata Limited Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.18 & 50.00 MRP
ZOANA Orion Pharma Ltd. Nitazoxanide INN 500mg Tablet (film-coated) 12's: 120.48 MRP
ZOANA Suspension Orion Pharma Ltd. Nitazoxanide INN 100mg/5ml Suspension 32ml, 62ml: 35.13 & 50.19 MRP
ZOX Square Pharmaceuticals Ltd. Nitazoxanide 500mg Tablet 5x6's: 302.10
ZOX SUSP 30 Square Pharmaceuticals Ltd. Nitazoxanide 100mg/5 ml Suspension 30 ml: 35.24
ZOX SUSP 60 Square Pharmaceuticals Ltd. Nitazoxanide 100mg/5 ml Suspension 60 ml: 50.35
ZOXAN Opsonin Pharma Limited Nitazoxanide INN 500mg Tablet 18's: 180.00 MRP
ZOXAN Suspension Opsonin Pharma Limited Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 35.00 & 50.00 MRP
ZOXANID Silva Pharmaceuticals Limited Nitazoxanide INN 500mg Tablet 12's, 30's: 120.46, 301.13 MRP
ZOXANID Suspension Silva Pharmaceuticals Limited Nitazoxanide INN 100mg/5ml Suspension 30ml, 60ml: 30.11 & 50.19 MRP

Gen. MedInfo

Why is this medication prescribed?

Nitazoxanide is used to treat diarrhea in children and adults caused by the protozoa Cryptosporidium or Giardia. Protozoa are suspected as the cause when diarrhea lasts more than 7 days. Nitazoxanide is in a class of medications called antiprotozoal agents. It works by stopping the growth of certain protozoa that cause diarrhea.

How should this medicine be used?

Nitazoxanide may come as a tablet and a suspension (liquid) to take by mouth. It is usually taken with food every 12 hours for 3 days. Take nitazoxanide at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take nitazoxanide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before each use to mix the medication evenly.

Other uses for this medicine

 

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking nitazoxanide,

  • tell your doctor if you are allergic to nitazoxanide or any other medications.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had human immunodeficiency virus (HIV), problems with the immune system, or liver or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking nitazoxanide, call your doctor.

What special dietary instructions should I follow?

 

To prevent dehydration caused by diarrhea, make sure you or your child gets enough to drink. Take small, frequent sips of water, fruit juice, sports drinks, or broth.

What should I do if I forget a dose?

 

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Nitazoxanide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • stomach pain

  • headache

  • upset stomach

  • vomiting

  • discolored urine

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • skin rash

  • itching

Nitazoxanide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication?

 

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Throw away any unused nitazoxanide suspension after 7 days. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

 

In case of overdose, consult your local physician. If the victim has collapsed or is not breathing, consult nearest medical emergency services.

What other information should I know?

 

Keep all appointments with your doctor.

Patients with diabetes should know that there are 1.48 grams of sucrose in each teaspoon (5 mL) of nitazoxanide suspension.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have diarrhea after you finish the nitazoxanide, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref: US Natl. Library of Medicine

| See FDA approved Brand Manufacturer's Prescribing Information |
  | Back to top |