mph Bangladesh


(loe per' a mide)

PCaution when used during lactation - Caution when used during pregnancy

LCaution when used during lactation - Caution when used during lactation

Molecule Info

Indication(s) & Dosage Acute diarrhoea
Adult: As hydrochloride: Initially, 4 mg followed by 2 mg after each loose stool. Usual dose: 6-8 mg daily. As oxide: Initially, 2-4 mg followed by 1 mg after each loose stool. Max dose as hydrochloride: 16 mg daily; as oxide: 8 mg daily.
Child: As hydrochloride: 4-8 yr: 1 mg 3 or 4 times daily for up to 3 days; 9-12 yr: 2 mg 4 times daily for up to 5 days.

Chronic diarrhoea
Adult: As hydrochloride: Initially, 4-8 mg daily in divided doses, adjusted if necessary. Max: 16 mg daily; discontinue if no improvement at this dose after 10 days.
Child: Treatment in children is generally not recommended but the following doses have been suggested: 1 mth-1 yr: As hydrochloride, 100-200 mcg/kg bid given 30 min before feeds (Max: 2 mg/kg daily); 1-12 yr: As hydrochloride, 100-200 mcg/kg (Max: 2 mg/dose) 3 to 4 times daily (Max: 16 mg daily).
Administration May be taken with or without food.
Overdosage Urinary retention, paralytic ileus and CNS depression may occur. Perform gastric lavage (not necessary if spontaneous vomiting occurs) followed by administration of a slurry of 100 g activated charcoal. If symptoms of overdose occur, naloxone may be given as an antidote.
Contraindications Conditions when inhibition of peristalsis is undesirable (e.g. ileus or megacolon); antibiotic induced colitis; active inflammatory bowel disease; if abdominal distention develops during use; abdominal pain in the absence of diarrhoea.
Special Precautions Concomitant specific therapy must be given in those with infectious diarrhoea; hepatic dysfunction; infants; pregnancy, lactation.
Adverse Drug Reaction(s) Abdominal pain, distention, and discomfort; paralytic ileus; constipation, dry mouth, drowsiness, dizziness, fatigue, rash.
Potentially Fatal: Toxic megacolon.
Drug Interactions Bioavailability increased by co-trimoxazole, ritonavir, saquinavir. Respiratory depression reported when administered with quinidine. Loperamide increases GI absorption of desmopressin and decreases exposure to saquinavir.
Pregnancy Category (FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Pharmacology Loperamide inhibits peristalsis and prolongs transit time by acting directly on intestinal wall muscles. It also reduces faecal volume, increases viscosity and decreases fluid and electrolyte loss.
Onset: 0.5-1 hr.
Absorption: Absorbed from the GI tract. Peak plasma concentrations achieved after 2.5 hr (oral solution) or 4-5 hr (capsule).
Excretion: Excreted in the urine (<2%) and faeces (30% as unchanged drug). Elimination half life of around 10.8 hr.
ATC Classification A07DA03 - loperamide; Belongs to the class of antipropulsives. Used in the treatment of diarrhea.


Search Google: Loperamide 

Brand/Product Info

Total Products : 5     
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
IMOTIL CAP Square Pharmaceuticals Ltd. Loperamide 2mg Capsule 20x10's: 200.00 MRP
LOPAMID The Acme Laboratories Ltd. Loperamide hydrochloride 2mg Capsule 100's: 57.00 MRP
LOPERIN Opsonin Pharma Limited Loperamide hydrochloride 2mg Capsule 100's: 53.00 MRP
LORAMIDE Bristol Pharma Limited Loperamide hydrochloride 2mg Capsule 200's: 100.00 MRP
NOMOTIL Ziska Pharmaceuticals Ltd. Loperamide hydrochloride 2mg Capsule 200's: 120.00 MRP

Gen. MedInfo

Why do I need Loperamide?

Loperamide helps to treat diarrhoea.

Loperamide makes the stools firmer and less watery. It also helps to reduce the number of times you need to run to the toilet.

How do I take Loperamide?

Take Loperamide exactly as directed by your doctor. Do not take more or less than instructed by your doctor.

Do not take more than 8 capsules or 80 mL in 24 hours.

Take Loperamide with or without food.

If your symptoms do not improve within 48 hours (acute diarrhoea) or 10 days (long-term diarrhoea), consult your doctor.

You may stop taking Loperamide if you have no more diarrhoea. Follow your doctor's instructions.

What to do if I have forgotten to take Loperamide?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

When to not use Loperamide?

Alert your doctor if your diarrhoea is accompanied by high fever or blood in stool.

Alert your doctor if you recently took a course of antibiotics. In such cases, your diarrhoea may be caused by inflammation of the digestive tract (antibiotic-associated colitis). Your doctor needs to know if you were recently treated with antibiotics and what type of antibiotics.

Alert your doctor if you have stomach pain, swelling or constipation.

Do not give Loperamide to children unless specifically instructed to do so by the child's doctor.

Loperamide is not meant for children younger than 4 years old.

What to take note of while taking Loperamide?

Alert your doctor if you are pregnant or breastfeeding.

Alert your doctor if you have liver disease.

Drink lots of water to replace the fluids lost through diarrhoea.

What side effects could appear?

Loperamide may cause stomach cramps, bloating, constipation, nausea, skin itch, rashes and dry mouth. 

Let your doctor know if these side effects bother you or if they do not go away.

Loperamide may cause other side effects. Consult your doctor if you have unusual problems while taking Loperamide.

Can I take this with other medicines?

Inform your doctor if you are taking any other medicines, especially those listed below:

- saquinavir, ritonavir (antiviral medicines)
- quinidine (heart medicine)

Always inform your doctor if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

What special dietary instructions to follow?

Avoid alcohol.

How to store Loperamide?

Store in a cool, dry place away from the reach of children. Medicines must be used within the expiry date. 

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