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Polyethylene Glycol 3350

(pol ee eth' i leen) (glye' col)

P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

Indication & Dosage Oral
Bowel evacuation
Adult: As macrogol 4000 or 3350 mixed with electrolytes: 200-300 ml of an aqueous solution containing about 59, 60 or 105 g/l of the macrogol, repeated every 10-15 min until the rectal effluent is clear. Max: 3-4 litres.
Child: 25-40 ml/kg/hr of an aqueous solution containing about 59, 60 or 105 g/l of the macrogol.
Chronic constipation
Adult: As an aqueous solution containing 105 g/l of the macrogol: 125 ml up to tid for a max of 2 wk.
Child: As an aqueous solution containing 105 g/l of the macrogol: 2-6 yr, 62.5 ml daily. 7-11 yr, 125 ml daily. Max: 250 ml.
Faecal impaction
Adult: As an aqueous solution containing 105 g/l of the macrogol: 8 doses of 125 mL within 6 hr for a max of 3 days. Not >2 doses per hr in patients with impaired CV function.
Child: As an aqueous solution containing 105 g/l of the macrogol: 2-4 yr, initially, 2 doses of 62.5 ml over 12 hr, escalating over 7 days to a max of 8 doses within 12 hr. 5-11 yr, initially, 4 doses of 62.5 ml over 12 hr, escalating over 7 days to a max of 12 doses within 12 hr.
Administration May be taken with or without food. May be taken w/ meals for better absorption & to reduce GI discomfort.
Contraindications Intestinal perforation or obstruction, paralytic ileus; severe inflammatory conditions of the intestinal tract e.g. Crohn's disease, ulcerative colitis and toxic megacolon; unexplained abdominal pain.
Special Precautions Impaired gag reflex; reflux oesophagitis; DM; discontinue use if there is fluid and electrolyte imbalance; pregnancy and lactation.
Adverse Drug Reactions Abdominal distension and pain; nausea, diarrhoea; anal irritation; allergic reactions e.g. rash, hives or swelling due to fluid retention.
Pharmacology Macrogols are polyethylene glycol (PEG) compounds of varying molecular weight used for a wide range of purposes as pharmaceutical excipients. Macrogols of higher molecular weight are used as osmotic laxatives and bowel purgatives.
ATC Classification A06AD15 - macrogol ; Belongs to the class of osmotically acting laxatives. Used in the treatment of constipation.

Brand/Product Info

Total Products : 1 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
Aqualax Incepta Pharmaceuticals Limited Polyethylene glycol 3350 USP NF powder for solution 85gm Powder for solution 85 gm:MRP 120 Tk

Gen. MedInfo

Why is this medication prescribed?

Polyethylene glycol 3350 is used to treat occasional constipation. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. It works by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass.

How should this medicine be used?

Polyethylene glycol 3350 comes as a powder to be mixed with a liquid and taken by mouth. It is usually taken once a day as needed for up to 2 weeks. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take polyethylene glycol 3350 exactly as directed.

Polyethylene glycol 3350 may be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than your doctor tells you to.

It may take 2 to 4 days for polyethylene glycol 3350 to produce a bowel movement.

To use the powder, follow these steps:

  1. If you are using polyethylene glycol 3350 from a bottle, use the measuring line on the bottle cap to measure a single dose (about 1 heaping tablespoon). If you are using polyethylene glycol 3350 packets, each packet contains a single dose.

  2. Pour the powder into a cup containing 8 ounces (240 milliliters) of water, juice, soda, coffee, or tea.

  3. Stir to dissolve the powder.

  4. Drink immediately.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor for more information.

What special precautions should I follow?

Before taking polyethylene glycol 3350,

  • tell your doctor if you are allergic to polyethylene glycol or any other medications.
  • tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.
  • tell your doctor if you have or have ever had a bowel obstruction (blockage in the intestine) and if you have symptoms of bowel obstruction (upset stomach, vomiting, and stomach pain or bloating).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking polyethylene glycol 3350, call your doctor.

What special dietary instructions should I follow?

Eat a well-balanced diet that includes fiber-rich foods, such as unprocessed bran, whole-grain bread, and fresh fruits and vegetables. Drink plenty of fluids and exercise regularly.

What should I do if I forget a dose?

This medication is usually taken as needed.

What side effects can this medication cause?

Polyethylene glycol 3350 may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • bloating

  • cramping

  • gas

    < /li>

Some side effects can be serious. The following symptoms are uncommon, but if you experience either of them, call your doctor immediately:

  • diarrhea

  • hives

Polyethylene glycol 3350 may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include:

  • diarrhea

  • thirst

  • confusion

  • seizure< /p>

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref:  U.S. National Library of Medicine.

This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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