Senna (Sennosides) A & B
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Constipation
Adult: 15-30 mg (as total sennosides) 1-2 times daily.
Child: 2-6 yr: 3.75-7.5 mg once daily in the morning; 6-12 yr: 7.5-15 mg once daily at night or in the morning; â‰¥12 yr: 15-30 mg at bedtime.
Adult: 105-157.5 mg of sennosides on the day before the procedure. May be given as a liquid preparation.
|Contraindications||Nausea or vomiting, undiagnosed abdominal pain, intestinal obstruction.|
|Special Precautions||Inflammatory bowel disease. Avoid prolonged use.|
|Adverse Drug Reaction(s)||Mild abdominal discomfort e.g. colic and cramps; diarrhoea, hypokalaemia and atonic non-functioning colon (prolonged use); reversible melanosis coli (chronic use). May colour the urine yellowish-brown at acidic pH or red at alkaline pH.|
|Pregnancy Category (FDA)||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Pharmacology||Sennosides A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified sennosides (sennosides A and B) are used similarly to senna.
Duration: 6-12 hr.
Absorption: Some absorption following oral admin.
Distribution: Enters the breast milk.
Metabolism: Unabsorbed senna undergoes hydrolysis in the colon to release the active anthraquinones while absorbed senna undergoes hepatic metabolism.
Excretion: Excreted in the urine & faeces.
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