Aluminium Hydroxide

(a loo' mi ni um) (hye drox' ide)

PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

| See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage Oral route
Antacid
Adult: Up to 1 g daily.
Hyperphosphataemia in patients with chronic renal failure
Adult: Dose is adjusted to the individual patient's requirement. Up to 10 g/day may be given in divided doses with meals. 
Max Dosage: 10 g daily in divided doses.
Administration May be taken with or without food.
Contraindications Hypersensitivity to aluminium salts.
Special Precautions Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.
Adverse Drug Reaction(s) Constipation; intestinal obstruction (with large doses); phosphate depletion may occur with prolonged admin or large doses.
Drug Interactions Enhanced absorption with citrates or ascorbic acid. Decreases absorption ofallopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphatesupplements, phenytoin, phenothiazines, trientine.
Food Interaction Food decreases gastric emptying time.
Pharmacology Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.
Absorption: Alumunium hydroxide reacts with hydrochloric acid in the stomach to form soluble aluminium chloride, which is absorbed from the GI tract.
Excretion: Absorbed aluminium is excreted via the urine. Insoluble aluminium salts formed in the intestines, eg, hydroxides, carbonates, phosphates and fatty acid derivatives, are excreted in the faeces.
ATC Classification A02AB01 - aluminium hydroxide; Belongs to the class of aluminium-containing antacids.

Brand/Product Info


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Gen. MedInfo

Why is Aluminum hydroxide prescribed?

Aluminum hydroxide is used for the relief of heartburn, sour stomach, and peptic ulcer pain and to promote the healing of peptic ulcers.

How should Aluminum hydroxide be used?

Aluminum hydroxide comes as a capsule, a tablet, and an oral liquid and suspension. The dose and frequency of use depend on the condition being treated. The suspension needs to be shaken well before administration. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Other uses for Aluminum hydroxide

Aluminum hydroxide is also used sometimes to decrease the amount of phosphate in the blood of patients with kidney disease. Talk to your doctor about the possible risks of using this drug for your condition.

What special precautions to follow?

Before taking aluminum hydroxide,

  • tell your doctor and pharmacist if you are allergic to aluminum hydroxide or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially allopurinol, alprazolam, chlordiazepoxide, chloroquine, cimetidine, clonazepam, clorazepate, dexamethasone, diazepam, diflunisal, digoxin, ethambutol, famotidine, halazepam, hydrocortisone, isoniazid, levothyroxine, lorazepam, methylprednisolone, oxazepam, penicillamine, prednisone, products containing iron, tetracycline, ticlopidine, and vitamins.
  • be aware that aluminum hydroxide may interfere with other medicines, making them less effective. Take your other medications 1 hour before or 2 hours after aluminum hydroxide.
  • tell your doctor if you have or have ever had hypertension, heart or kidney disease, or gastrointestinal bleeding.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking aluminum hydroxide, call your doctor.

What to do if I forget a dose 

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Aluminum hydroxide cause?

Aluminum hydroxide may cause side effects. Tell your doctor if these symptoms are severe or do not go away:

  • constipation

  • loss of appetite

If you experience any of the following symptoms, call your doctor immediately:

  • confusion

  • unusual tiredness or discomfort

  • muscle weakness

Ref: MedlinePlus, U.S. Natl. Library of Medicine