Molecule Info

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Warnings Subjects must not have any history of haematological disease to intake Tiemonium. Detecting sensitivity prior to treatment still not available and during treatment even agranulocytosis development cannot be predicted. Immediately discontinue Tiemonium and perform emergency blood count in the event of appearance of fever and/or sore throat and/or mouth ulcers to avoid the risk of mortality. The patient will require urgent hospitalization if there is agranulocytosis.
Shock essentially occur in predisposed subjects after parenteral intake and rarely after oral intake. History of allergy to pyrazoles must be carefully investigated.
Description

Tiemonium methylsulfate is a synthetic type of antispasmodic agent. It stabilizes the cell membrane of the GI tract by strengthening calcium bonding with phospholipids and proteins.

Indication(s) Tiemonium methylsulphate is an antispasmodic drug. It reduces muscle spasms of the intestine, biliary system, uterus & urinary bladder. It is indicated for the pain in gastrointestinal & biliary disease in the urology and gynecology such as gastroenteritis, diarrhea, dysentery, biliary colic, enterocolitis, cholecystytis, colonopathyes, mild cystitis, & spasmodic dysmenorrhoea.
Dosage & Administration
Dosage is reserved for adults only.
Tablet: 2-6 tabs/day in divided doses. Tablets should be swallowed with a glass of water.
Ampoule:½-2 amps/day in slow IV injection (over 3 min) or infusion. Deep IM administration may be used if IV administration is impossible. Because of the hypertonicity of noramidopyrine, do not use the SC route.
Overdosage
Symptoms: Clinical signs are those of anticholinergic agents: Dry mouth, mydriasis, paralysis of accommodation, drying up of secretions and especially tachycardia, agitation, confusion and hallucination, possibly resulting in delirium, and respiratory depression.
Treatment: Symptomatic with respiratory and cardiac monitoring in hospital.
Contraindication(s)
Risk of angle-closure glaucoma and urinary retention related to bladder neck disorders.
Related to Wheat Starch (Tablet): Gluten intolerance.
Use in pregnancy: No reliable animal teratogenesis data are available. At the present time, the clinical data are not relevant enough to evaluate a possible malformative or foetotoxic effect of Tiemonium when administered during pregnancy. The risk of haematological repercussions on the foetus is also not evaluated, but cannot be excluded. In view of these data and the risk of agranulocytosis related to noramidopyrine, the use of this drug is not recommended in pregnant women.
Use in lactation: Anticholinergic antispasmodics decreases milk secretion and diffuse into milk (risk of anticholinergic effects in infants at therapeutic doses). Consequently, Tiemonium is contraindicated in nursing mothers.
Precaution(s)

Use carefully in the case of benign prostatic hyperplasia; renal and/or liver failure; coronary insufficiency, arrhythmias, hyperthyroidism; chronic bronchitis because of the increased viscosity of bronchial secretions; paralytic ileus, intestinal atony in elderly subjects, toxic megacolon. Use carefully during the acute phase of myocardial infarction (due to the risk of tachycardia).
Effects on the Ability to Drive or Operate Machinery: Car drivers and machine operators must be informed about the risks related to disturbances of accommodation.

Cautions during usage:

Injectable Solution: IV injection should be performed slowly at least (over 3 min) because of the risk of hypotension in case of rapid injection. A yellow colour may occur when used in infusions. The solution should be prepared extemporaneously and the bottle should be kept in the dark. Caution should be taken in cases of chronic bronchitis, coronary insufficiency, ambient hyperthermia, renal insufficiency, hepatic insufficiency, pregnancy and lactation.

Adverse Drug Reaction(s) Dry mouth; thickening of bronchial secretions; reduction of lacrimal secretion; disorders of accommodation; tachycardia, palpitations; constipation; urinary retention; excitability; irritability; mental confusion in the elderly subjects.
Pharmacology

Tiemonium is an antimuscarinic agent (quaternary ammonium) with peripheral effect like atropine. It strengthens calcium bonding with phospholipids and proteins and thereby stabilize GI tract cell membrane.

ATC Classification
A03AB - Synthetic anticholinergics, used to treat functional bowel problems.

Brand/Product Info


Total Products : 65                                                                 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ALGIN Renata Limited Tiemonium Methylsulfate INN 50mg Tablet 50's: 250.50 MRP
ALGIN Injection Renata Limited Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps : 75.15 MRP
DYSMA Rangs Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
EMOGIN Somatec Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
EMONIUM Beximco Pharmaceuticals Ltd Tiemonium Methyl Sulphate 50mg Tablet 50's: 250.00 MRP
EMONIUM IM/IV Beximco Pharmaceuticals Ltd Tiemonium Methyl Sulphate 5mg/2ml ampoule IM/IV Injection 5's: 75.00 MRP
NORVIS Square Pharmaceuticals Ltd. Tiemonium Methylsulphate 50mg Tablet 5x10's: 301.00 MRP
NORVIS INJ Square Pharmaceuticals Ltd. Tiemonium Methylsulphate 5mg/2 ml Injection 2x5's: 250.00 MRP
NORVIS SUPP Square Pharmaceuticals Ltd. Tiemonium Methylsulphate 20mg Suppository 2x5's: 80.30 MRP
NORVIS SYP Square Pharmaceuticals Ltd. Tiemonium Methylsulphate 10mg/5 ml Syrup 100 ml: 87.26 MRP
NORVIS SYRUP Square Pharmaceuticals Ltd. Tiemonium Methylsulfate 10mg/5ml Syrup 100ml: 87.00 MRP
ONIUM Orion Pharma Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 251.00 MRP
ONIUM Injection Orion Pharma Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps: 75.30 MRP
PARILLEX Drug International Ltd Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
PREVIP General Pharmaceuticals Ltd Tiemonium Methylsulfate INN 50mg Tablet 50's: 201.00 MRP
RELVIS Biopharma Laboratories Ltd Tiemonium Methylsulfate INN 50mg Tablet 50's: 201.00 MRP
SEEMALGINE Seema Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 30's: 120.00 MRP
SPANIUM Ziska Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
SPANIUM Injection Ziska Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps: 75.00 MRP
TIEMO Alco Pharma Ltd Tiemonium Methylsulfate INN 50mg Tablet 30's: 120.00 MRP
TIENUM Chemist Laboratories Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
TIENUM Injection Chemist Laboratories Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps: 75.00 MRP
TIMEM Silva Pharmaceuticals Limited Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.75 MRP
TIMETH Edruc Limited Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 IP
TIMOBEN 50 Benham Pharmaceuticals Ltd Tiemonium Methylsulfate INN 50mg Tablet 30's: 120.00 MRP
TIMOLAX Shamsul Alamin Pharmaceuticals Ltd Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
TIMONAC R A K Pharmaceuticals Pvt. Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
TIMONIL Popular Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 201.03 MRP
TIMONIL Injection Popular Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps: 75.30 MRP
TIMOPA Cosmic Chemical Industries Limited Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
TIMOTHY Eskayef Bangladesh Ltd Tiemonium Methylsulfate INN 50mg Tablet 50's MRP: 200.00
TIMOTHY Injection Eskayef Bangladesh Ltd Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps MRP: 75.00
TIMOVIS Kumudini Pharma Ltd Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
Timozin Incepta Pharmaceuticals Limited Tiemonium Methylsulfate INN 50mg Tablet 10x5's:MRP 250 Tk
Timozin Injection Incepta Pharmaceuticals Limited Tiemonium Methylsulfate INN 5mg/2ml IV/IM Injection 1x5's:MRP 75 Tk
TINILUX Sharif Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 30's: 120.00 MRP
TINIUM The Acme Laboratories Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.50 MRP
TINIUM Injection The Acme Laboratories Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps: 75.25 MRP
TINO Delta Pharma Limited Tiemonium Methylsulfate INN 50mg Tablet 30's: 120.00 MRP
TITOS Novo Healthcare and Pharma Ltd. Tiemonium Methylsulfate INN 50mg Tablet 30's: 120.00 MRP
TIUM Ad-din pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 30's: 105.00 MRP
TMS Medicon Laboratories Ltd Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
TYNIUM ACI Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 201.00 MRP
TYNIUM Injection ACI Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps: 75.30 MRP
VERALGIN Aristopharma Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 250.00 MRP
VERALGIN Injection Aristopharma Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 2ml amp x 10's: 150.00 MRP
VISARIN Pharmasia Limited Tiemonium Methylsulfate INN 50mg Tablet 50's: 201.00 MRP
VISCER Techno Drugs Tiemonium Methylsulfate INN 50mg Tablet 50's: 175.00 MRP
VISCER Injection Techno Drugs Tiemonium Methylsulfate INN 5mg/2ml Injection 2ml amp x 10's: 120.00 MRP
VISCERAL IBN SINA Pharmaceutical Industry Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 225.00 MRP
VISCERAL Injection IBN SINA Pharmaceutical Industry Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 10 amps: 160.00 MRP
VISCERALGINE Nuvista Pharma Limited Tiemonium Methylsulfate INN 50mg Tablet 50's: 347.00 MRP
VISCERALGINE Injection Nuvista Pharma Limited Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps, 10 amps: 125.00 & 250.00 MRP
VISEGIN Unimed & Unihealth Manufacturers Ltd. Tiemonium Methylsulfate INN 50mg Tablet 30's: 150.00 MRP
VISET Healthcare Pharmacuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's MRP 300 Tk
VISET Injection Healthcare Pharmacuticals Ltd. Tiemonium Methylsulfate INN 5mg/2ml Injection 10's: 160 MRP
VISET SYRUP Healthcare Pharmacuticals Ltd. Tiemonium Methylsulfate INN 25mg/5ml Syrup 100ml, MRP 90 Tk
VISNOR Apex Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
VISNOR Injection Apex Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Injection 10 amps: 150.00 MRP
VISPAM Everest Pharmaceuticals Ltd. Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
VISPAZIN Globe Pharmaceuticals Ltd Tiemonium Methylsulfate INN 50mg Tablet 50's: 200.00 MRP
VISPAZIN Injection Globe Pharmaceuticals Ltd Tiemonium Methylsulfate INN 5mg/2ml Injection 10 amps: 100.00 MRP
VISRAL Opsonin Pharma Limited Tiemonium Methylsulfate INN 50mg Tablet 50's: 250.00 MRP
VISRAL Injection Opsonin Pharma Limited Tiemonium Methylsulfate INN 5mg/2ml Injection 5 amps: 75.00 MRP
ZEUM 50 Sandoz/Novartis Tiemonium Methylsulfate INN 50mg Tablet 50's: MRP 325.00

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