Hyoscine (US, Scopolamine)

(hy-oh-seen)/(skoe pol' a meen)

PCaution when used during lactation / LCaution when used during lactation : Caution - pregnancy &  lactation (breast feeding)

Molecule Info

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Indication(s) & Dosage

Oral route

Gastrointestinal tract spasm
Adult: As butylbromide: 20 mg 4 times daily.
Child: As butylbromide: 6-12 yr: 10 mg tid.

Genitourinary spasm
Adult: As butylbromide: 20 mg 4 times daily.
Child: As butylbromide: 6-12 yr: 10 mg tid.

Prophylaxis of motion sickness
Adult: As hydrobromide: 300 mcg 30 min before a journey, then 300 mcg every 6 hr if required. Max: 3 doses in 24 hr.
Child: As hydrobromide: 3-4 yr: 75 mcg 20 min before a journey, repeated if needed. Max dose: 150 mcg in 24 hr. 4-10 yr: 75-150 mcg, >10 yr: 150-300 mcg.
Max Dosage: 3 doses in 24 hrs.

Parenteral route
Gastrointestinal tract spasm
Adult: As butylbromide: 20 mg IM/IV repeated after 30 min if needed. Max: 100 mg daily.
Max Dosage: 100 mg daily.

Genitourinary spasm
Adult: As butylbromide: 20 mg IM/IV repeated after 30 min if needed. Max: 100 mg daily.
Max Dosage: 100 mg daily.

Transdermal route
Prophylaxis of motion sickness
Adult: As patch delivering 1 mg over 3 days: Apply 1 patch at least 4 hr before exposure to motion. To be applied behind the ear. 

Subcutaneous route
Prophylaxis of nausea and vomitting
Adult: As hydrobromide: 0.3-0.6 mg.
Child: As hydrobromide: 0.006 mg/kg.

Subcutaneous route
Preoperative sedation
Adult: As hydrobromide: 0.6 mg 3-4 times daily.

Parenteral route
Premedication before anaesthesia
Adult: As hydrobromide: 0.2-0.6 mg via SC or IM inj 30-60 minutes before induction of anesth. 
Child: As hydrobromide: 15 mcg/kg via SC or IM inj, 30-60 minutes before induction of anesth. 

Ophthalmic route
Mydriasis and cycloplegia for refraction
Adult: As hydrobromide: Instil 1-2 drops of 0.25% soln to eye(s) 1 hr before procedure.
Child: As hydrobromide: Instil 1 drop of 0.25% soln to eye(s) bid for 2 days before procedure.

Iridocyclitis
Adult: As hydrobromide: Instil 1-2 drops of 0.25% solution to eye(s) up to 4 times daily.
Child: As hydrobromide: Instil 1 drop of 0.25% soln to eye(s) up to tid.

Overdosage Symptoms: Dilated pupils, flushed skin, tachycardia, hypertension, ECG abnormalities, acute psychosis, CNS depression, circulatory collapse, hyperpyrexia, respiratory failure. Management: Artificial respiration with oxygen. Manage fever with ice or alcohol sponges. For severe life-threatening symptoms, give physostigmine 1-2 mg SC or IV slowly; repeat administration after 2 hr as necessary.
Contraindications Narrow-angle glaucoma, acute haemorrhage, paralytic ileus, tachycardia due to cardiac insufficiency, myasthenia gravis.
Special Precautions Hepatic/renal disease, pyloric stenosis, urinary retention, prostatic hyperplasia, psychosis, seizure disorders, ulcerative colitis, coronary artery disease, tachyarrhythmias, heart failure, hypertension. Elderly, children, pregnancy, lactation.
Adverse Drug Reaction(s) Flushing, postural hypotension, tachycardia, fibrillation. Rarely psychotic reactions. Dizziness, drowsiness, fatigue, headache, memory loss. Dry skin, erythema, increased sensitivity to light, rash. Bloatedness, constipation, dry throat, dysphagia, nausea, vomiting, xerostomia. Dysuria, urinary retention. Tremor, weakness. Impaired accommodation, blurred vision, cycloplegia, dryness, narrow-angle glaucoma, increased intraocular pain, itching, photophobia, pupil dilation. Dry nose. Decreased diaphoresis, heat intolerance. Ophthalmic: Somnolence, dermatitis, oedema, exudate, follicular conjunctivitis, increased IOP, local irritation, photophobia, vascular and respiratory congestion.
Potentially Fatal: CNS depression, coma, circulatory and respiratory failure.
Drug Interactions Additive sedative effects with alcohol or other CNS depressants. Reduced effects with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine, tacrine).
Potentially Fatal: Effect potentiated by other anticholinergic drugs and TCAs.

Lab Interference May interfere with the gastric secretion test.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Ophthalmic formulation: Store at 8-27°C (46-80°F). Oral, Parenteral & Subcutaneous formulationsStore at room temperature of 15-30°C (58-86°F). Transdermal formulationStore at 20-25°C (68-77°F).
Pharmacology Hyoscine competitively blocks muscarinic receptors and has central and peripheral actions. It relaxes smooth muscle and reduces gastric and intestinal motility.
Onset: Oral route, IM: 0.5-1 hr; IV: 10 min.
Duration: Oral route, IM: 4-6 hr; IV: 2 hr.
Absorption: Tertiary salts: Readily absorbed. Quaternary salts: Poorly absorbed.
Distribution: Reversibly bound to plasma proteins.
Metabolism: Hepatic.
Excretion: Via urine (as metabolites); 4.8 hr (elimination half-life).

Brand/Product Info


Total Products : 35                                   
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ANCOPAN Bristol Pharma Limited Hyoscine Butylbromide BP 10mg Tablet 100's, 50's: 180.00 & 175.00 MRP
ANTIPEN Nipa Pharmaceuticals Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 162.00 MRP
BROMID Eskayef Bangladesh Ltd Hyoscine Butylbromide BP 10mg Tablet 100's & 50's MRP: 180.00 & 175.00
BROSPAN Gaco Pharmaceutical Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 182.00 MRP
BROSPAN Injection Gaco Pharmaceutical Ltd. Hyoscine Butylbromide BP 20mg/1ml Injection 1 ampoule: 7.84 MRP
BUSCON IBN SINA Pharmaceutical Industry Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 344.00 MRP
BUSCON Injection IBN SINA Pharmaceutical Industry Ltd. Hyoscine Butylbromide BP 20mg/1ml Injection 10 amps: 71.00 MRP
BUTABROM Indo-Bangla Pharmaceuticals Works Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 220.00 MRP
BUTACIN Ziska Pharmaceuticals Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 175.00 MRP
BUTAPAN Sanofi Hyoscine Butylbromide BP 10mg Tablet 500's, 100's: 1709.05 & 600.00 MRP
BUTAPAN Injection Sanofi Hyoscine Butylbromide BP 20mg/1ml Injection 1ml amp.x 10's: 78.87 MRP
BUTASON Hudson Pharmaceuticals Ltd Hyoscine Butylbromide BP 10mg Tablet 100's: 175.00 MRP
COLIK ACI Ltd. Hyoscine Butylbromide BP 10mg & 20mg Tablet 100's each: 344.00 & 351.00 MRP
COLIK Injection ACI Ltd. Hyoscine Butylbromide BP 20mg/1ml Injection 1ml amp x 5's: 39.40 MRP
COLIPAN Medimet Pharmaceuticals Ltd Hyoscine Butylbromide BP 10mg Tablet 100's, 50's: 300.00 & 282.50 MRP
COLIPAN Injection Medimet Pharmaceuticals Ltd Hyoscine Butylbromide BP 10mg Injection 10 amps: 78.50 MRP
G-HYOSCINE Gonoshasthaya Pharmaceuticals Ltd Hyoscine Butylbromide BP 10mg Tablet 100's: 161.00 MRP
G-HYOSCINE Injection Gonoshasthaya Pharmaceuticals Ltd Hyoscine Butylbromide BP 20mg/1ml Injection 10 amps: 61.00 MRP
HYBUCIN Supreme Pharmaceuticals Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 160.00 MRP
HYO 10 Somatec Pharmaceuticals Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 161.00 MRP
HYSIN Edruc Limited Hyoscine Butylbromide BP 20mg/1ml Injection 10 amps: 77.50 MRP
HYSIN 10 Edruc Limited Hyoscine Butylbromide BP 10mg Tablet 100's: 348.00 MRP
HYSOCIN Pharmadesh Laboratories Limited Hyoscine Butylbromide BP 10mg Tablet 100's: 344.00 MRP
HYSOMA Modern Pharmaceuticals Ltd Hyoscine Butylbromide BP 10mg Tablet 100's: 167.00 MRP
HYSOMIDE Opsonin Pharma Limited Hyoscine Butylbromide BP 10mg Tablet 100's, 100's: 180.00 & 350.00 MRP
HYSOMIDE Injection Opsonin Pharma Limited Hyoscine Butylbromide BP 20mg/1ml Injection 25 amps: 187.50 MRP
LOPAN Navana Pharmaceuticals Limited Hyoscine Butylbromide BP 10mg Tablet 100's: 343.00 MRP
PASMODIL 20 S.N. Pharmaceuticals Ltd. Hyoscine Butylbromide BP 10mg Tablet 50's: 170.00 MRP
RELAPAN Chemist Laboratories Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 152.00 MRP
RELAPAN Injection Chemist Laboratories Ltd. Hyoscine Butylbromide BP 20mg/1ml Injection 10 amps,: 60.70 MRP
SAPEN Shamsul Alamin Pharmaceuticals Ltd Hyoscine Butylbromide BP 10mg Tablet 100's: 180.00 MRP
SPANIL Beximco Pharmaceuticals Ltd Hyoscine Butylbromide BP 10mg Tablet 100's: 344.00 MRP
SPASMOSON Jayson Pharmaceuticals Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 163.00 MRP
SPASMOSON Injection Jayson Pharmaceuticals Ltd. Hyoscine Butylbromide BP 20mg/1ml Injection 1ml amp x 10's: 78.80 MRP
SPASMOZEN Zenith Pharmaceuticals Ltd. Hyoscine Butylbromide BP 10mg Tablet 100's: 180.00 MRP

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