(a' troe peen)
P : Caution when used during pregnancy
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
|Administration||May be taken with or without food. Take with food or water.
|Overdosage||May cause hyperthermia, hypertension, increased respiratory rate, nausea and vomiting. May also lead to CNS stimulation. Severe intoxication may lead to CNS depression, coma, respiratory failure and death.|
|Contraindications||Glaucoma, chronic respiratory disease, sick sinus syndrome, thyrotoxicosis, cardiac failure, pyloric stenosis, prostatic hypertrophy.|
|Special Precautions||Reflux oesophagitis, elderly, infants and children. Pregnancy.|
|Adverse Drug Reaction(s)||Dry mouth, dysphagia, constipation, flushing and dryness of skin, tachycardia, palpitations, arrhythmias, mydriasis, photophobia, cycloplegia, raised intraocular pressure. Toxic doses cause tachycardia, hyperpyrexia, restlessness, confusion, excitement, hallucinations, delirium and may progress to circulatory failure and resp depression. Eye drops: Systemic toxicity esp in children, on prolonged use may lead to irritation, hyperaemia, oedema and conjunctivitis. Increased intraocular pressure. Inhalation: Dryness of mouth, throat.
Potentially Fatal: Atrial arrhythmias, AV dissociation, multiple ventricular ectopics.
|Drug Interactions||Additive anticholinergic effects with quinidine, antidepressants and some antihistamines.
|Pregnancy Category (FDA)||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Storage||Parenteral: Store at 15-30Â°C. Ophthalmic: Store at 15-30Â°C.
|Pharmacology||Atropine is an anticholinergic agent which competitively blocks the muscarinic receptors in peripheral tissues such as the heart, intestines, bronchial muscles, iris and secretory glands. Some central stimulation may occur. Atropine abolishes bradycardia and reduces heart block due to vagal activity. Smooth muscles in the bronchi and gut are relaxed while glandular secretions are reduced. It also has mydriatic and cycloplegic effect.
Absorption: Readily absorbed from the GI tract; also absorbed from mucous membranes, eye, and through intact skin.
Distribution: Distributes throughout the body and crosses the blood-brain barrier and placenta.
Metabolism: Incomplete metabolism in the liver.
Excretion: Excreted in urine as unchanged drug and metabolites. Half-life reported to be 4 hr.
|ATC Classification||A03BA01 - atropine; Belongs to the class of belladonna alkaloids, tertiary amines. Used in the treatment of functional gastrointestinal disorders.
S01FA01 - atropine; Belongs to the class of anticholinergics used as mydriatics and cycloplegics.
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ATROPINE||Jayson Pharmaceuticals Ltd.||Atropine sulphate 0.6mg/1ml||Injection||10 amps : 50.00 MRP|
|ATROPINE, Chemist||Chemist Laboratories Ltd.||Atropine sulphate 0.6mg/1ml||Injection||50 amps : 126.00 MRP|
|ATROPINE, Edruc||Edruc Limited||Atropine sulphate 0.6mg/1ml||Injection||10 amps : 30.00 MRP|
|ATROPINE-OSL Drop||Opso Saline Ltd.||Atropine sulphate 1%||Eye Drop||5ml vial: 25.95 MRP|
|ATROPINE-OSL Ointment||Opso Saline Ltd.||Atropine sulphate 1% w/v||Eye Ointment||3gm: 14.05 MRP|
|G-ATROPINE||Gonoshasthaya Pharmaceuticals Ltd||Atropine sulphate 0.6mg/1ml||Injection||10 amps: 31.00 MRP|
|G-ATROPINE||Gonoshasthaya Pharmaceuticals Ltd||Atropine sulphate 1%||Eye Drop||5ml vial: 27.31 MRP|
|ITROPIN||Nipa Pharmaceuticals Ltd.||Atropine sulphate 1%||Eye Drop||5ml vial: 25.29 MRP|
|MYDRI-ATROPINE Drop||Reman Drug Laboratories Ltd.||Atropine sulphate 1%||Eye Drop||5ml, 10ml vial: 25.00 & 35.00 MRP|
|MYDRI-ATROPINE Ointment||Reman Drug Laboratories Ltd.||Atropine sulphate 1% w/v||Eye Ointment||4gm: 25.00 MRP|
|MYDRIPINE Drop||Gaco Pharmaceutical Ltd.||Atropine sulphate 1%||Eye Drop||10ml vial: 25.89 MRP|
|MYDRIPINE Ointment||Gaco Pharmaceutical Ltd.||Atropine sulphate 1% w/v||Eye Ointment||5gm: 14.31 MRP|
|| See Brand Manufacturer's Prescribing Information |
||| Latest mph edition: 04 Dec 2013 |||| Back to top ||