Pantoprazole

(pan toe' pra zole)

PCaution when used during lactation - Caution when used during pregnancy

LCI - Contraindicated in lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |

Indication(s) & Dosage

Gastro-oesophageal reflux disease (GERD)
Adult: 20-40 mg orally once daily in the morning for 4 wk, increased to 8 wk if necessary. Maintenance: 20-40 mg daily, increased to 40 mg each morning if symptoms return.
Hepatic impairment: Doses >40 mg daily have not been studied in hepatically-impaired patients. 
Peptic ulcer
Adult: 40 mg orally once daily in the morning for 2-4 wk for duodenal ulceration or 4-8 wk for benign gastric ulceration.
Hepatic impairment: Doses >40 mg daily have not been studied in hepatically-impaired patients. 
H.pylori infection
Adult: Triple therapy: 40mg orally bid combined with clarithromycin 500 mg bid and either amoxicillin 1g bid or metronidazole 400mg bid.
Hepatic impairment: Doses >40 mg daily have not been studied in hepatically-impaired patients. 
Prophylaxis of NSAID-induced ulcers
Adult: 20 mg orally daily.
Hepatic impairment: Doses >40 mg daily have not been studied in hepatically-impaired patients. 
Zollinger-Ellison syndrome
Adult: Initially 80 mg daily orally, adjusted to individual requirements. Up to 240 mg daily may be used if needed. Daily doses >80 mg should be given in 2 divided doses. 
Hepatic impairment: Doses >40 mg daily have not been studied in hepatically-impaired patients. 

Intravenous
Zollinger-Ellison syndrome
Adult: As Na salt: 80 mg once or twice daily. Up to 240 mg daily may be given in divided doses. Convert to oral therapy as soon as possible. Dose to be given as slow inj or short-term infusion over 2-15 minutes. 
Hepatic impairment: May need to reduce dose. 
Intravenous
Gastro-oesophageal reflux disease
Adult: As Na salt: 40 mg daily. Convert to oral therapy as soon as possible. Dose to be given as slow inj or short-term infusion over 2-15 minutes. 
Hepatic impairment: May need to reduce doses. 
Intravenous
Peptic ulcer
Adult: As Na salt: 40 mg daily. Convert to oral therapy as soon as possible. Dose to be given as slow inj or short-term infusion over 2-15 minutes. 
Hepatic impairment: May need to reduce doses.
Special Populations: Reduce dose in patients with severe hepatic impairment or give only on alternate days. Max dose: 20 mg daily or 40 mg on alternate days.
Reconstitution: Reconstitute with 10 ml 0.9% sodium chloride (final concentration 4 mg/ml). Reconstituted solution may be given IV (over 2 minutes) or diluted to 100 ml in glucose 5%, 0.9% sodium chloride, or lactated Ringer's and infused over 15 min.
Incompatibility: Y site incompatibility: midazolam and zinc.

Administration

Normal release prep: May be taken with or without food. Admin instructions for modified release prep may vary according to brands, refer to lit.

Overdosage

Treatment: supportive. Not removed by haemodialysis.

Contraindications

Lactation.

Special Precautions

Long-term therapy may lead to bacterial overgrowth in the GI tract. Hepatic impairment; monitor liver function regularly (if enzymes increase, discontinue); pregnancy; not recommended in children <18 yr; long term use may lead to atrophic gastritis.

Adverse Drug Reaction(s)

Diarrhoea, dizziness, pruritus, skin rashes, GI tract infections, chest pain, headache, nausea, pain, anxiety, hyperglycaemia; malaise or lassitude; myalgia; oedema; insomnia; hyperlipidaemia; flatulence, abdominal pain, constipation, eructation, dyspepsia, rectal disorder; urinary frequency, UTI; abnormalities in liver function; local site reaction; hypertonia, neck pain, weakness; bronchitis, cough, dyspnoea, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, flu syndrome.

Drug Interactions

Decreased absorption of ketoconazole and itraconazole; may slightly increase digoxin plasma concentration; may reduce plasma concentration of atazanavir, avoid concomitant use; may enhance anticoagulant effect of coumarins; may cause gastric mucosal irritation with alcohol; may increase levels or effects of: bosentan, dapsone, fluoxetine, glimepiride, glipizide, losartan, montelukast, nateglinide, paclitaxel, phenytoin, warfarin, and zafirlukast; may decrease levels or effects of: aminoglutethimide, carbamazepine, phenytoin, and rifampicin.

Food Interaction

Long term use (>3 yr) may lead to vitamin B12 malabsorption. May decrease oral absorption of iron salts.

Lab Interference

May produce false positive urine screening tests for tetrahydrocannabinol.

Pregnancy Category (FDA)

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

Storage

Intravenous: IV (before reconstitution): <25 °C. Once reconstituted, store <25 °C and use within 12 hr. Oral: Store tablet at 15-30 °C.

Pharmacology

Pantoprazole inhibits H+/K+ ATPase pump function thereby reducing gastric acid secretion. It also has a role in the eradication of H. pylori.
Absorption: Well absorbed; peak plasma concentrations: Approx 2-2.5 hr after oral dose. Oral bioavailability: Approx 77% with enteric-coated formulation (does not vary after single or multiple doses).
Distribution: Protein-binding: 98%; volume of distribution: 11-24 L.
Metabolism: Hepatic; mainly by cytochrome CYP2C19 and slightly by CYP2D6 and CYP2C0.
Excretion: Via urine (approx 80%) and bile (approx 20%). Elimination half life: approx 1 hr (prolonged in hepatic impairment; in patients with cirrhosis the elimination half life may be 3-10 hr).

ATC Classification

A02BC02 - pantoprazole; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Brand/Product Info


Total Products : 74                                                                          
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
AUP-20 Decent Pharma Laboratories Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 20mg x 30's: 90.00 MRP
AUP-40 Decent Pharma Laboratories Ltd. Pantoprazole sodium sesquihydrate USP 40mg Tablet 40mg x 30's: 150.00 MRP
COSPRA 20 Cosmo Pharma Laboratories Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 20mg x 50's: 125.00 MRP
EUROPAN-20 Globe Pharmaceuticals Ltd Pantoprazole sodium sesquihydrate USP 20mg Tablet 30's: 90.00 MRP
EUROPAN-40 Globe Pharmaceuticals Ltd Pantoprazole sodium sesquihydrate USP 40mg Tablet 30's: 150.00 MRP
EUROPAN-40 Injection Globe Pharmaceuticals Ltd Pantoprazole 40mg IV Injection Injection 40mg amp: 70.00 MRP
EXOPAN Edruc Limited Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's: 150.00 IP
NEOPANTA Supreme Pharmaceuticals Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 30's 90.00 MRP
NOVAPAN-20 Novus Pharmaceuticals Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 30's 90.00 MRP
OTONIX Peoples Pharma Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 50's each: 120.00 & 200.00 MRP
P-20 Asiatic Laboratories Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's: 150.00 MRP
P-40 Asiatic Laboratories Ltd. Pantoprazole sodium sesquihydrate USP 40mg Tablet 50's: 250.00 MRP
PAMEL-20 Medicon Laboratories Ltd Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's 150.00 MRP
PAMEL-40 Medicon Laboratories Ltd Pantoprazole sodium sesquihydrate USP 40mg Tablet 50's: 250.00 MRP
PANLOC Kumudini Pharma Ltd Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 30's: 150.00 & 150.00 MRP
PANORAL Eskayef Bangladesh Ltd Pantoprazole Sodium USP equivalent to Pantoprazole 20mg Tablet 20mg x50's & 40mg x40's MRP: 120.00 & 200.00
PANPRAZO 20 Pacific Pharmaceuticals Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's: 150.00 MRP
PANPRIN-20 Doctors Chemical Works Ltd Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's: 150.00 MRP
PANPRO Biopharma Laboratories Ltd Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 50's each: 150.50 & 251.00 MRP
PANPRO Injection Biopharma Laboratories Ltd Pantoprazole 40mg IV Injection Injection 40mg/amp: 70.00 MRP
PANSEC Drug International Ltd Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 100's each: 400.00 & 600.00 MRP
PANSEC-40 Drug International Ltd Pantoprazole 40mg IV Injection Injection 40mg/amp: 70.00 MRP
PANSOS NIPRO JMI Pharma Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 50's each: 150.50 & 250.00 MRP
PANTAC Navana Pharmaceuticals Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 60's, 40mg x 30's: 180.00 & 150.00 MRP
PANTALOC 40 Aexim Pharmaceutical Ltd. Pantoprazole sodium sesquihydrate USP 40mg Tablet 30's: 120.00 MRP
PANTEX ACI Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 30's: 151.00 & 150.60 MRP
PANTEX Capsule ACI Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Capsule 40's each: 120.00 & 200.80 MRP
PANTEX IV ACI Ltd. Pantoprazole 40mg IV Injection Injection 40mg/amp: 70.26 MRP
PANTID Opsonin Pharma Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 50's each: 150.50 & 250.00 MRP
PANTID IV Opsonin Pharma Limited Pantoprazole 40mg IV Injection Injection 40mg/amp: 70.00 MRP
PANTIUM Radiant Pharmaceuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 60's, 40mg x 24's: 420.00 & 240.00 MRP
PANTO Somatec Pharmaceuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 30's: 150.50 & 150.60 MRP
PANTO SP Seema Pharmaceuticals Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's: 150.00 MRP
PANTOBEX 20 Beximco Pharmaceuticals Ltd Pantoprazole Sodium USP equivalent to Pantoprazole 20mg Tablet 100's: 500.00 MRP
PANTOBEX 40 Beximco Pharmaceuticals Ltd Pantoprazole Sodium USP equivalent to Pantoprazole 40mg Tablet 100's: 700.00 MRP
PANTOBEX INJECTION Beximco Pharmaceuticals Ltd Pantoprazole 40 mg IV Injection Injection 1's: 110.00 MRP
PANTOCHEM Chemist Laboratories Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 50's each: 150.50 & 250.00 MRP
PANTODAC Ziska Pharmaceuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 60's, 40mg x 30's: 180.00 & 150.00 MRP
PANTOFAST S.N. Pharmaceuticals Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 30's: 90.00 MRP
PANTOGEN General Pharmaceuticals Ltd Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 50's each: 150.50 & 251.00 MRP
PANTOGUT Popular Pharmaceuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 100's, 40mg x 50's: 400.00 & 300.00 MRP
PANTOGUT IV Popular Pharmaceuticals Ltd. Pantoprazole 40mg IV Injection Injection 40mg/amp: 70.26 MRP
PANTOLOK IBN SINA Pharmaceutical Industry Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 100's, 40mg x 50's: 300.00 IP, 250.00 IP
PANTON-AX Bristol Pharma Limited Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's: 150.00 MRP
Pantonix 20 Incepta Pharmaceuticals Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg Tablet 70's:MRP 280 Tk
Pantonix 40 Incepta Pharmaceuticals Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 40mg Tablet 70's:MRP 420 Tk
PANTONIX 40 Injection Incepta Pharmaceuticals Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 40 mg Injection 1's: 70.00 MRP
PANTOPRA Alco Pharma Ltd Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 30's each: 90.00 & 150.00 MRP
PANTOSEC IV Techno Drugs Pantoprazole 40mg IV Injection Injection 40mg/amp: 70.00 MRP
PANTOSIL Silva Pharmaceuticals Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 50's: 150.57 & 250.94 MRP
PANTOZOL Gaco Pharmaceutical Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 20's, 40mg x 20's: 60.00 & 100.00 MRP
PANTROL Apex Pharmaceuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 30's: 150.00 & 150.00 MRP
PANZER Sun Pharmaceutical (Bangladesh) Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 50's: 150.00 & 250.00 MRP
PANZOL Amico Laboratories Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 30's, 40mg x 30's: 105.00 & 165.00 MRP
PANZUM Everest Pharmaceuticals Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's 150.00 MRP
PENTOSA Pharmasia Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 30's, 40mg x 30's: 90.30 & 150.60 MRP
PRAMAX Concord Pharmaceuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 40's, 40mg x 30's: 120.00 & 180.00 MRP
PREGEL 20 Healthcare Pharmacuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg Tablet 50's MRP 200 Tk
PREGEL 40 Healthcare Pharmacuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 40mg Tablet 30's MRP 180 Tk
PRETONIX Pharmadesh Laboratories Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 30's: 150.00 & 150.30 MRP
PROPENTA 20 Shamsul Alamin Pharmaceuticals Ltd Pantoprazole sodium sesquihydrate USP 20mg Tablet 50's 150.00 MRP
PROTOCID The Acme Laboratories Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 50's: 150.00 & 250.00 MRP
PROTOCID IV The Acme Laboratories Ltd. Pantoprazole 40mg IV Injection Injection 40mg/amp: 70.26 MRP
PROTOLOC Beacon Pharmaceuticals Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 50's: 150.00 & 250.00 MRP
PROTON-P Aristopharma Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 50's: 200.00 & 300.00 MRP
PROTON-P IV Aristopharma Ltd. Pantoprazole 40mg IV Injection Injection 40mg/amp: 80.00 MRP
PROTONIL Renata Limited Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 30's: 151.00 & 150.30 MRP
PROTOPA-20 Apollo Pharmaceutical Laboratories Ltd. Pantoprazole sodium sesquihydrate USP 20mg Tablet 30's 90.00 IP
PROTOZIN Euro Pharma Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 30's, 40mg x 30's: 90.00 & 150.00 MRP
TOPRA Jayson Pharmaceuticals Ltd. Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 30's each: 90.00 IP, 150.60 IP
TRUPAN 20 Square Pharmaceuticals Ltd. Pantoprazole 20mg Tablet 6x10's: 301.20 MRP
TRUPAN 40 Square Pharmaceuticals Ltd. Pantoprazole 40mg Tablet 6x10's: 421.2 MRP
TRUPAN IV Square Pharmaceuticals Ltd. Pantoprazole 40mg/vial IV Injection 1x1's: 80.24 MRP
ZOPAN Kemiko Pharmaceuticals Ltd Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20mg & 40mg Tablet 20mg x 50's, 40mg x 50's: 150.00 & 250.00 MRP

Gen. MedInfo

Why this medicine is needed?

Pantoprazole is a gastric medicine.

It is used to treat conditions caused by excessive acidity in your stomach, such as stomach ulcers and reflux disease (reflux is also known as "heartburn", in which food or acid from your stomach backs up into your mouth, leaving a sour or bitter taste).

Pantoprazole treats these conditions by reducing the amount of acid your stomach makes.

Pantoprazole may also be used together with other medicines to treat a specific type of gastric problem called Helicobacter pylori or H. pylori gastritis.

How to take this medicine?

Take Pantoprazole exactly as directed by your doctor. Do not take more or less than instructed by your doctor.

You may need to take Pantoprazole for some time before the full benefits can be felt. Continue to take it even when you feel better and do not stop taking it unless advised by your doctor to do so.

You may take Pantoprazole with or without food. Try to take it at the same time each day.

However, if you are taking the controlled-release form of Pantoprazole, take it on an empty stomach 1 hour before meals. Swallow the tablet whole, do not chew or crush it.

What about forgotten dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

Remember to take your medicine regularly. Pantoprazole must be taken exactly as directed for it to be effective. If you often forget to take your medicine, let your doctor and pharmacist know.

When this should not be used?

Inform your doctor if you have ever had an allergic reaction to other gastric medicines such as omeprazole, lansoprazole or rabeprazole.

Before taking this medicine

Inform your doctor if you are pregnant or breastfeeding.

Do not breastfeed while you are being treated with Pantoprazole.

Alert your doctor if you have liver disease.

Let your doctor know if your gastric problem seems to be getting worse. Do not take Pantoprazole for a long period of time unless instructed by your doctor.

What side effects could appear?

Pantoprazole may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.

Other side effects with Pantoprazole may include headache, diarrhoea, nausea and wind in the stomach. These should get better or go away as your body adjusts to the medicine.

Let your doctor know if these side effects bother you or if they do not go away.

Can this be taken this with other medicines?

Inform your doctor if you are taking any other medicines, especially those listed here:

- warfarin (a blood-thinning medicine)
- ketoconazole, itraconazole, voriconazole or similar antifungal medicines
- tacrolimus (a transplant medicine)
- other medicines such as atazanavir and iron pills.

Do not take antacids together with Pantoprazole. If you must take antacids, take them at least 1 hour before or 2 hours after you have taken Pantoprazole. Antacids can reduce the effectiveness of Pantoprazole when taken together.

Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

What special dietary instructions to follow?

It may be helpful to discuss your diet with your doctor or dietitian. A change in diet may help improve your symptoms. For example, spicy food tends to worsen reflux and should be avoided. Likewise, carbonated ("fizzy") drinks such as soft drinks should also be avoided.

You should also try to avoid lying down soon after eating as this will worsen the reflux symptoms.

Avoid alcohol.

How to store this medicine?

Store in a cool, dry place away from the reach of children.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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