Lansoprazole

(lan soe' pra zole)

PCaution when used during lactation / LCaution when used during lactation : Caution - pregnancy &  lactation (breast feeding)

Molecule Info

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Indication(s) & Dosage

Peptic ulcer
Adult: 30 mg once daily in the morning given for 4 weeks (duodenal ulcer) or for 8 weeks (gastric ulcer).
Hepatic impairment: Severe impairment: Max dose: 30 mg/day.
Oral
Hypersecretory conditions
Adult: Initially, 60 mg daily and adjust as required. Daily doses >120 mg should be given in 2 divided doses.
Hepatic impairment: Severe impairment: Max dose: 30 mg/day.
Oral
Acid-related dyspepsia
Adult: 15-30 mg once daily in the morning for 2-4 weeks.
Hepatic impairment: Severe impairment: Max dose: 30 mg/day.
Oral
Gastro-oesophageal reflux disease
Adult: 30 mg once daily in the morning for 4-8 weeks. Maintenance: 15-30 mg once daily according to response.
Child: and erosive oesophagitis: 1-11 yr: ≤30 kg: 15 mg once daily; >30 kg: 30 mg once daily. May increase doses up to 30 mg bid if patient is still symptomatic after 2 or more weeks of treatment. 12-17 yr: For erosive oesophagitis: 30 mg once daily for up to 8 weeks; For nonerosive gastro-oesophageal reflux disease: 15 mg once daily for up to 8 weeks. 
Hepatic impairment: Severe impairment: Max dose: 30 mg/day.
NSAID-associated ulceration
Adult: 15-30 mg daily orally for 4-8 weeks.
Hepatic impairment: Severe impairment: Max dose: 30 mg/day.
Prophylaxis of NSAID-induced ulcers
Adult: 15-30 mg daily orally for 4-8 weeks.
Hepatic impairment: Severe impairment: Max dose: 30 mg/day.
H.pylori infection
Adult: 1-week triple therapy: 30 mg orally bid combined with clarithromycin 500 mg bid and either amoxicillin 1 g bid or metronidazole 400 mg bid.
Hepatic impairment: Severe impairment: Max dose: 30 mg/day.

Intravenous
Erosive oesophagitis
Adult: 30 mg over 30 minutes daily for up to 7 days.
Hepatic impairment: Consider dose adjustment.
Special Populations: Patients with severe hepatic impairment: Max dose: 30 mg daily.

Administration

Should be taken with food. Take immediately after meals.

Special Precaution(s)

Hepatic impairment. Gastric malignancy should be ruled out. Pregnancy and lactation.

Adverse Drug Reaction(s)

Diarrhoea, abdominal pain, nausea, constipation, headache, dizziness, eosinophilia, myalgia, glossitis, stomatitis, rash.

Drug Interactions

Reduced bioavailability with antacids and sucralfate. May decrease the absorption of atazanavir, itraconazole and ketoconazole. May increase plasma concentration of cilostazol.

Pregnancy Category (FDA)

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

Storage

Intravenous: Store at 25°C (77°F). Oral: Store at 25°C (77°F).

Pharmacology

Lansoprazole inhibits gastric acid secretion by inhibiting the H+/K+ ATPase, which is also known as the proton pump. Both basal and stimulated acid are inhibited.
Absorption: Rapidly absorbed from the GIT (oral); peak plasma concentrations after 1.5 hr.
Distribution: Protein-binding: 97%.
Metabolism: Extensively hepatic; converted to 5-hydroxyl-lansoprazole and lansoprazole sulfone.
Excretion: Via faeces (main) and urine (15-30% of a dose); 1-2 hr (elimination half-life).

ATC Classification
A02BC03 - lansoprazole; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Brand/Product Info


Total Products : 17                 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ENSO Kemiko Pharmaceuticals Ltd Lansoprazole INN 15mg & 30mg Capsule 15mg x 20's, 30mg x 20's: 60.00 & 100.00 MRP
LANOZOLE Medimet Pharmaceuticals Ltd Lansoprazole INN 15mg & 30mg Capsule 15mg x 40's, 30mg x 20's: 120.00 & 100.00 MRP
LANSEC Drug International Ltd Lansoprazole INN 30mg Capsule 30mg x 70's: 420.00 MRP
LANSINA IBN SINA Pharmaceutical Industry Ltd. Lansoprazole INN 30mg Capsule 30mg x 25's: 150.00 IP
LANSO 15 Square Pharmaceuticals Ltd. Lansoprazole 15mg Capsule 5x10's: 176.00 MRP
LANSO 30 Square Pharmaceuticals Ltd. Lansoprazole 30mg Capsule 5x6's: 181.20 MRP
LANSODIN The Acme Laboratories Ltd. Lansoprazole INN 15mg & 30mg Capsule 28's each: 98.28 & 168.56 MRP
LANSOPRIL Amico Laboratories Ltd. Lansoprazole INN 30mg Capsule 30mg x 30's: 150.00 MRP
LANSOPROL Ziska Pharmaceuticals Ltd. Lansoprazole INN 30mg Capsule 30mg x 20's: 80.00 MRP
LANSOZOL Chemist Laboratories Ltd. Lansoprazole INN 30mg Capsule 30mg x 50's: 250.00 MRP
LANTID Opsonin Pharma Limited Lansoprazole INN 15mg & 30mg Capsule 15mg x 22's, 30mg x 18's: 60.00 & 90.00 MRP
LANZOL-30 Doctors Chemical Works Ltd Lansoprazole INN 30mg Capsule 30mg x 40's: 200.00 MRP
LAP Ambee Pharmaceuticals Ltd. Lansoprazole INN 30mg Capsule 30mg x 28's: 140.28 MRP
LAZO-30 Desh Pharmaceuticals (Pvt) Ltd Lansoprazole INN 30mg Capsule 30mg x 30's: 150.00 MRP
PROTOLAN 15 Beximco Pharmaceuticals Ltd Lansoprazole INN 15mg Capsule 30's: 120.00 MRP
PROTOLON 30 Beximco Pharmaceuticals Ltd Lansoprazole INN 30mg Capsule 30's: 180.00 MRP
ZOTON General Pharmaceuticals Ltd Lansoprazole INN 15mg & 30mg Capsule 15mg x30's, 30mg x20's: 105.30 & 120.40 MRP

Gen. MedInfo

Why this medication is prescribed?

Prescription medicine lansoprazole is used to treat gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach). Prescription lansoprazole is used to treat the symptoms of GERD, allow the esophagus to heal, and prevent further damage to the esophagus. Prescription lansoprazole is also used to treat ulcers (sores in the lining of the stomach or intestine), to prevent more ulcers from developing in people whose ulcers have already healed, and to decrease the risk that people who are taking nonsteroidal anti-inflammatory drugs (NSAIDs) will develop ulcers. Prescription lansoprazole is also used to treat conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome. Prescription lansoprazole is also used in combination with other medications to treat and prevent stomach ulcers caused by a certain type of bacteria (H. pylori). Nonprescription (over-the-counter) lansoprazole is used to treat frequent heartburn (heartburn that occurs two or more days per week). Lansoprazole is in a class of medications called proton pump inhibitors. It works by decreasing the amount of acid made in the stomach.

How to use this medicine?

Prescription lansoprazole may come as a capsule (may be delayed-release) or a tablet to take by mouth. This is usually taken once a day, before a meal. When taken in combination with other medications to eliminate H. pylori, prescription lansoprazole is taken twice a day (every 12 hours) or three times a day (every 8 hours), before a meal, for 10 to 14 days. Additional 14-day treatments may be repeated once every 4 months if needed. Take lansoprazole at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lansoprazole exactly as directed. Do not take more or less of it or take it more often or for a longer time than prescribed by your doctor or stated on the package. Tell your doctor if you have taken nonprescription lansoprazole for a longer period of time than stated on the package.

Swallow the capsules whole; do not split, chew, or crush them. Do not break, cut or chew the orally disintegrating tablets (if available). Place a tablet on your tongue and wait up to one minute for it to dissolve. After the tablet dissolves, swallow it with or without water. If you cannot swallow the tablet, you may place it in an oral syringe, draw up 4 mL of water for a 15 mg tablet or 10 mL of water for a 30-mg tablet, shake the syringe gently to dissolve the tablet, and squirt the contents into your mouth immediately. Then draw an additional 2 mL of water into the syringe, shake gently, and squirt that water into your mouth. Do not swallow the mixture more than 15 minutes after you dissolve the tablet.

The capsule contents and orally disintegrating tablets can both be given through a feeding tube. If you have a feeding tube, ask your doctor how you should take the medication. Follow these directions carefully.

Do not take lansoprazole for immediate relief of heartburn symptoms. It may take 1 to 4 days for you to feel the full benefit of the medication. Call your doctor if your symptoms get worse or do not improve after 14 days or if your symptoms return sooner than 4 months after you finish your treatment. 

Continue to take lansoprazole even if you feel well. Do not stop taking prescription lansoprazole without talking to your doctor. If your condition does not improve or gets worse, call your doctor. 

What should be done in case of forgotten dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

Remember to take your medicine regularly. Lansoprazole must be taken exactly as directed for it to be effective. If you often forget to take your medicine, let your doctor know.

When should not to use this medicine?

Inform your doctor if you have ever had an allergic reaction to other gastric medicines such as omeprazole, pantoprazole or rabeprazole.

What special precautions to follow?

Before taking lansoprazole,
    • tell your doctor if you are allergic to lansoprazole, any other medications, or any of the ingredients in lansoprazole capsules or orally disintegrating tablets. Ask your doctor or pharmacist for a list of the ingredients.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antibiotics, including ampicillin, anticoagulants (blood thinners) such as warfarin, atazanavir, digoxin, diuretics ('water pills'), iron supplements, ketoconazole (Nizoral), methotrexate, tacrolimus (Prograf), and theophylline. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • if you are taking sucralfate, take it at least 30 minutes after you take lansoprazole.
    • you may take antacids with lansoprazole. If you feel you need an antacid, ask your doctor to recommend one and to tell you when and how to take it.
    • tell your doctor if you have or have ever had a low level of magnesium in your bloodor liver disease.
    • if you plan to take nonprescription lansoprazole, first tell your doctor if your heartburn has lasted 3 months or longer or if you have experienced any of the following symptoms: lightheadedness, sweating, or dizziness along with your heartburn; chest pain or shoulder pain; shortness of breath or wheezing; pain that spreads to your arms, neck, or shoulders; unexplained weight loss; nausea; vomiting, especially if the vomit is bloody; stomach pain; difficulty swallowing food or pain when you swallow food; or black or bloody stools. You may have a more serious condition that cannot be treated with nonprescription medication.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lansoprazole, call your doctor.

if you are 50 years of age or older, ask your doctor if it is safe for you to use prescription or nonprescription lansoprazole. The risk that you may develop a severe form of diarrhea caused by bacteria or that you may fracture your wrist, hip, or spine may be higher if you are an older adult.

  • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that the orally disintegrating tablets may contain aspartame, which forms phenylalanine.

Can it be taken with other medicines?

Inform your doctor if you are taking any other medicines, especially those listed here:

- warfarin (a blood-thinning medicine)
- ketoconazole, itraconazole, voriconazole or similar antifungal medicines
- tacrolimus (a transplant medicine)
- other medicines such as atazanavir and iron pills.

Do not take antacids together with Lansoprazole. If you must take antacids, take them at least 1 hour before or 2 hours after you have taken Lansoprazole. Antacids can reduce the effectiveness of Lansoprazole when taken together.

Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

What special dietary instructions to follow?

Unless your doctor tells you otherwise, continue your normal diet. You should also try to avoid lying down soon after eating as this will worsen the reflux symptoms.
Avoid alcohol.

What side effects may be caused?

Lansoprazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • constipation

  • nausea

  • headache

  • dizziness

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • rash

  • blistering or peeling skin

  • hives

  • swelling of the eyes, face, lips, mouth, tongue, or throat

  • difficulty breathing or swallowing

  • hoarseness

  • irregular, fast, or pounding heartbeat

  • excessive tiredness

  • dizziness

  • light headedness

  • muscle spasms

  • uncontrollable shaking of a part of the body

  • seizures

  • severe diarrhea with watery stools

  • stomach pain

  • fever

Lansoprazole may cause other side effects. Call your doctor if you have any unusual problems while you are taking the medication.

People who take proton pump inhibitors such as lansoprazole may be more likely to fracture their wrists, hips, or spine than people who do not take one of these medications. The risk is highest in people who take high doses of one of these medications or take them for 1 year or longer. Talk to your doctor about the risk of taking lansoprazole.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain laboratory tests before and during your treatment, especially if you have severe diarrhea. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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