mph Bangladesh


(ben' zoe kane)

P - Caution when used during pregnancy

Molecule Info

Indication & Dosage Mouth/Throat
Sore throat
Adult: Up to 10 mg lozenge may be dissolved slowly in the mouth and repeated every 2 hr as necessary.
Child: Not recommended for child under 3 yr old. 
Elderly: May require lower doses. 
Surface anaesthesia of mouth and throat
Adult: As gel, paste, spray or solution up to 20%: Apply to affected area up to 4 times daily. 
Elderly: May require lower doses. 
Topical analgesia and anaesthesia
Adult: As gel, paste, cream, lotion, spray, solution or suppository up to 20%: Apply to affected area as directed. 
Elderly: May require lower doses.

Special Populations: Elderly: May require lower concentrations and/or lower dosages of mucosal-local anaesthetics, esp for endoscopic procedures.
Contraindications Hypersensitivity. Complete heart block. Low plasma-cholinesterase concentrations. Pyrogenic infection at or near the skin. Inj into or application to inflamed, infected tissues, to damaged skin mucosa or on perforated tympanic membrane.
Special Precautions Elderly, debilitated, child. Epilepsy, impaired cardiac conduction or resp function, shock or hepatic impairment. Myasthenia gravis. Avoid: Contact with middle ear; prolonged use or application on extensive areas of the skin. Avoid eating or drinking for at least 3-4 hr after the anaesthetic; rubbing or touching the eye while anaesthesia persists. The anaesthetised eye should be protected from dust and bacterial contamination. Chemical burns must be neutralised before treatment with benzocaine. Pregnancy.
Adverse Drug Reactions Hypersensitivity reactions; vertigo; nystagmus; sensitization. CNS excitation; tinnitus; blurred vision; nausea and vomiting; muscle twitching and tremors; convulsions. Numbness of tongue and perioral region; drowsiness. CVS effects; angioedema; contact dermatitis; burning and stinging effects.
Drug Interactions Antagonism with sulfonamides; aminosalicylic acid; anticholinesterases; suxamethonium; antiarrhythmics; MAOIs; TCAs.
Lab Interference Cytoscopic procedures following pyelography. Pancreatic function determination using bentiromide.
Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Pharmacology Benzocaine is a local anaesthetic which acts by preventing the generation and transmission of impulses along nerve fibers and at nerve endings. Depolarisation and ion-exchange are inhibited. In general, loss of pain occurs before loss of sensory, autonomic and motor functions.
Onset: 1 min.
Duration: 15-20 min.
ATC Classification C05AD03 - benzocaine ; Belongs to the class of products containing local anesthetics. Used in the treatment of hemorrhoids. 
D04AB04 - benzocaine ; Belongs to the class of topical anesthetics used in the treatment of pruritus. 
R02AD01 - benzocaine ; Belongs to the class of local anesthetics used in throat preparations. 
N01BA05 - benzocaine ; Belongs to the class of esters of aminobenzoic acid. Used as local anesthetics.

Brand/Product Info

Total Products : 1 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
OROGEL D-GEL Square Pharmaceuticals Ltd. Benzocaine 20% w/w Dental Gel 5 gm: 50.15 MRP
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