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P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication & Dosage Ophthalmic
Ocular inflammation with suspected or confirmed bacterial infection
Adult: Each g of ophthalmic ointment contains dexamethasone 0.1%, neomycin sulfate equivalent to neomycin 3.5 mg and polymyxin B sulfate 10,000 units. Apply a small amount into the conjunctival sac(s) of the affected eye(s) up to 3-4 times daily. Each ml of ophthalmic liquid contains dexamethasone 0.1%, neomycin sulfate equivalent to neomycin 3.5 mg and polymyxin B sulfate 10,000 units. Instill 1-2 drops in the conjunctival sac(s) of the affected eye(s) up to 4-6 times daily; may be used up to hrly in severe disease. Reduce frequency once condition improves.
Administration Tab: Should be taken on an empty stomach. Take before meals.
Cap: May be taken with or without food. Take consistently either always w/ or always w/o meals.
Overdosage Prolonged excessive use may lead to systemic effects.
Contraindications Hypersensitivity. Epithelial herpes simplex keratitis (dendritic keratitis), varicella and viral diseases of the cornea and conjunctiva. Mycobacterial infection or fungal diseases of the eye. Amoeba infections or untreated purulent infections of the eye.
Special Precautions Prolonged use may cause glaucoma, damage to the optic nerve, defects in visual acuity and fields of vision, posterior subcapsular cataract formation and increased risk of secondary ocular infections. Increased risk of perforations in diseases which can cause thinning of the cornea or sclera. Corticosteroids may mask infection or worsen existing infections in acute purulent conditions of the eye. Regular monitoring of the intraocular pressure is recommended if product is used for ≥10 days. Long term application of topical corticosteroids may also increase the risk of ocular fungal infections. Neomycin sulfate may cause cutaneous sensitisation. Pregnancy and lactation.
Adverse Drug Reactions Allergic sensitisations. Increased intraocular pressure and delayed wound healing. Irritation, burning, stinging, itching and dermatitis.
Storage Ophthalmic: Store at 2-25°C. Stable for 28 days after opening.
Pharmacology Dexamethasone is a corticosteroid with mainly glucocorticoid activity; it is used topically mainly for its anti-inflammatory action. Neomycin is a broad-spectrum aminoglycoside antibiotic that is used topically for the treatment of infections of the skin, ear and eye due to susceptible staphylococci and other organisms. Polymyxin B is active only against gram-negative bacteria especially Pseudomonas aeruginosa.
Absorption: Dexamethasone/neomycin/polymyxin B: Sufficiently absorbed after ophthalmic application to exert pharmacological effects.
ATC Classification S01CB01 - dexamethasone; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases. 
S01AA18 - polymyxin B; Belongs to the class of antibiotics. Used in the treatment of eye infections. 
D06AX04 - neomycin; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. 
H02AB02 - dexamethasone; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations. 
B05CA09 - neomycin; Belongs to the class of antiinfectives used as irrigating solutions. 
J01GB05 - neomycin; Belongs to the class of other aminoglycosides. Used in the treatment of systemic infections. 
C05AA09 - dexamethasone; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids. 
S02AA07 - neomycin; Belongs to the class of antiinfectives used in the treatment of ear infections. 
D07AB19 - dexamethasone; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases. 
A07AA01 - neomycin; Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
J01XB02 - polymyxin B; Belongs to the class of polymyxins used in the treatment of systemic infections. 
A07AA05 - polymyxin B; Belongs to the class of antibiotics. Used for the treatment of intestinal infections. 
D10AA03 - dexamethasone; Belongs to the class of topical corticosteroids used in the treatment of acne. 
R02AB01 - neomycin; Belongs to the class of antibiotics used in throat preparations. 
S03AA01 - neomycin; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. 
S03AA03 - polymyxin B; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. 
S03BA01 - dexamethasone; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations. 
S02AA11 - polymyxin B; Belongs to the class of antiinfectives used in the treatment of ear infections. 
S02BA06 - dexamethasone; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear. 
A01AB08 - neomycin; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
A01AC02 - dexamethasone; Belongs to the class of local corticosteroid preparations. Used in the treatment of diseases of the mouth. 
D07XB05 - dexamethasone; Belongs to the class of moderately potent (group II) corticosteroids in other combinations. Used in the treatment of dermatological diseases. 
R01AD03 - dexamethasone; Belongs to the class of topical corticosteroids used as nasal decongestants. 
S01AA03 - neomycin; Belongs to the class of antibiotics. Used in the treatment of eye infections. 
S01BA01 - dexamethasone; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.

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