P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

 
Indication(s) & Dosage Topical/Cutaneous
Inflammed tinea pedis, tinea cruris and tinea corporis
Adult: ≥17 yr: As cream/lotion (per g containing clotrimazole 10 mg and betamethasone dipropionate 0.64 mg): Apply onto the affected area(s) bid. Recommended treatment duration: Up to 2 wk (tinea corporis and tinea cruris) and 4 wk (tinea pedis). Max: 45 g/wk.
Administration Should be taken on an empty stomach. Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush.
Overdosage Acute overdosage with topical application is unlikely to occur.
Contraindications Hypersensitivity.
Special Precautions Systemic absorption of betamethasone may result in suppression of the hypothalmic-pituitary-adrenal axis; prolonged or excessive use may increase systemic absorption of the drug. Monitor for signs of infection. Safety and efficacy have not been established in children <17 yr. Elderly. Pregnancy and lactation.
Adverse Drug Reactions Dry skin, burning sensation at the site of application, paresthesia, oedema, rash, secondary infections, stinging, skin atrophy.
Storage Topical/Cutaneous: Store at 25°C.
Pharmacology Betamethasone dipropionate is a corticosteroid that prevents and reduce inflammation by depressing the migration of polymorphonuclear leukocytes and fibroblasts; reversing capillary permeability and lysosomal stabilisation at the cellular level. Clotrimazole is an antifungal agent that binds to phospholipids in the fungal cell membrane. It causes loss of essential intracellular components by altering cell wall permeability.
Absorption: Betamethasone dipropionate: Percutaneous absorption depends on several factors e.g. use of occlusive dressings and integrity of the epidermal barrier.
Distribution: Betamethasone dipropionate: Once absorbed systemically, it is bound to plasma proteins in varying extents.
Metabolism: Betamethasone dipropionate: Once absorbed through the skin, it is metabolised mainly by the liver.
Excretion: Betamethasone dipropionate: Once absorbed through the skin, it is excreted largely renally; may also be excreted via the bile.
ATC Classification S01CB04 - betamethasone; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases. 
D01AC01 - clotrimazole; Belongs to the class of imidazole and triazole derivatives for topical use. Used in the treatment of fungal infection. 
D07AC01 - betamethasone; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases. 
H02AB01 - betamethasone; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations. 
S02BA07 - betamethasone; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear. 
A07EA04 - betamethasone; Belongs to the class of corticosteroids acting locally. Used in the treatment of intestinal inflammation. 
R03BA04 - betamethasone; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticooids. 
S03BA03 - betamethasone; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations. 
C05AA05 - betamethasone; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids. 
A01AB18 - clotrimazole; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
G01AF02 - clotrimazole; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections. 
D07XC01 - betamethasone; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases. 
R01AD06 - betamethasone; Belongs to the class of topical corticosteroids used as nasal decongestants. 
S01BA06 - betamethasone; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.

Brand/Product Info


Total Products : 11           
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
BET-CL The Acme Laboratories Ltd. Betamethasone Valerate 0.05%+ Clotrimazole BP 1% Cream 10gm: 29.00 MRP
BET-CL Ointment The Acme Laboratories Ltd. Betamethasone Valerate 0.1%+ Clotrimazole BP 1% Ointment 10gm: 29.00 MRP
BETAVATE-CL Drug International Ltd Betamethasone Valerate 0.1%+ Clotrimazole BP 1% Ointment 10gm: 25.00 MRP
BETNOVATE CL GlaxoSmithKline Bangladesh Limited Betamethasone Valerate 0.1%+ Clotrimazole BP 1% Ointment 10gm: 29.31 MRP
BETSON-CL Opsonin Pharma Limited Betamethasone Valerate 0.05%+ Clotrimazole BP 1% Cream 10gm: 25.00 MRP
BETSON-CL Ointment Opsonin Pharma Limited Betamethasone Valerate 0.1%+ Clotrimazole BP 1% Ointment 10gm: 29.20 MRP
CLOSON Medicon Laboratories Ltd Betamethasone Valerate 0.05%+ Clotrimazole BP 1% Cream 10gm: 25.00 MRP
CLOZOSONE UniDerma Pharmaceuticals Ltd. Betamethasone Valerate 0.05%+ Clotrimazole BP 1% Cream 10gm: 25.00 MRP
FUNGIN-B IBN SINA Pharmaceutical Industry Ltd. Betamethasone Valerate 0.1%+ Clotrimazole BP 1% Cream 10gm: 35.00 IP
ONI CRM Square Pharmaceuticals Ltd. Betamethasone + Clotrimazole (0.5mg + 10mg)/gm Cream 10 gm: 35.11 MRP
TOPIBET-CL Eskayef Bangladesh Ltd Betamethasone Valerate BP 0.1%+ Clotrimazole 1% Ointment 10mg MRP: 25.00