PCI  : Contraindicated in pregnancy

LCI  : Contraindicated in lactation

Molecule Info

Indication(s) & Dosage Type 2 diabetes mellitus
Adult: Per tablet contains glipizide 2.5 mg and metformin 250 mg. As initial therapy: Start with 1 tablet once daily. May increase in steps of 1 tablet/day every 2 wk to lowest effective dose to a max of 4 tablets/day in divided doses. For patients previously treated with glibenclamide/sulphonylurea or metformin alone: Recommended starting dose: 2 tablets twice daily; starting dose should not exceed the daily doses of glipizide or metformin already being taken. Titrate subsequent doses based on blood glucose levels and patient's response. Daily max: 20 mg glipizide/2000 mg metformin.
Administration May be taken with or without food.
Contraindications Hypersensitivity. Type 2 diabetes mellitus; ketoacidosis; severe renal or hepatic insufficiency, diabetic coma, cardiac failure, recent MI, CHF. IDDM; severe infection; acute or chronic metabolic acidosis with or without coma; stress, trauma; severe impairment of thyroid function; dehydration, acute or chronic alcoholism. Pregnancy, lactation.
Special Precautions Hypoglycaemia, stress, elderly. Thyroid impairment, monitor blood-glucose conc and renal function regularly.
Adverse Drug Reaction(s) Glipizide: GI upsets, diarrhoea, nausea; allergic skin reactions, leucopaenia, thrombocytopaenia, agranulocytosis, hyponatraemia; jaundice; haemolytic anaemia, pancytopaenia. Metformin: Anorexia, nausea, vomiting, diarrhoea, wt loss, flatulence, occasional metallic taste; weakness; hypoglycaemia; rash, malabsorption of Vitamin
Potentially Fatal: Glipizide: Hypoglycaemia in presence of renal or hepatic damage and alcohol. Metformin: Lactic acidosis in presence of renal failure and alcoholism.
Drug Interactions Glipizide: Decreased effect with beta-blockers, cholestyramine, hydantoins, thiazide diuretics and urinary alkalinizers.
Metformin: Additive effect with sulphonylureas. Antagonistic effects with diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers and isoniazid.
Potentially Fatal: Glipizide: Increased glipizide levels and effects with fluconazole, gemfibrozil, ketoconazole, NSAIDs, pioglitazone and sulfonamides. Increased hypoglycaemic effects with H2 antagonists, anticoagulants, androgens, cimetidine, salicylates, tricyclic antidepressants, probenecid, MAOIs, methyldopa, digitalis glycosides and urinary acidifiers.
Metformin: Lactic acidosis with alcohol and potentiation of hypoglycaemic effect. cimetidine and furosemide may increase plasma-metformin levels. Drugs eliminated via renal tubular secretion may increase metformin levels. Please consult detailed drug interactions before prescribing.
Food Interaction Absorption delayed.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Pharmacology Glipizide stimulates insulin release from pancreatic β-cells and reduces gluconeogenesis in liver cells. It also increases insulin sensitivity at target sites. Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).
ATC Classification A10BB07 - glipizide; Belongs to the class of sulfonamides, urea derivatives. Used in the treatment of diabetes. 
A10BA02 - metformin; Belongs to the class of biguanides. Used in the treatment of diabetes.

Brand/Product Info

Total Products : 8        
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
GLYMIN PLUS Healthcare Pharmacuticals Ltd. Glipizide 2.5 mg + Metformin Hydrochloride 500 mg Tablet Tablet 30's MRP 97.5 Tk
Mefoglip 250 Incepta Pharmaceuticals Limited Glipizide 2.5 mg + Metformin Hydrochloride 250 mg Tablet Tablet 10x5's:MRP 95 Tk
Mefoglip 500 Incepta Pharmaceuticals Limited Glipizide 2.5 mg + Metformin Hydrochloride 500 mg Tablet Tablet 10x3's:MRP 84 Tk
Mefoglip DS Incepta Pharmaceuticals Limited Glipizide 5 mg + Metformin Hydrochloride 500 mg Tablet Tablet 10x3's:MRP 111 Tk
METGLIP Pacific Pharmaceuticals Ltd. Glipizide 2.5mg+ Metformin hydrochloride 250mg Film Coated Tablet 50's: 95.00 MRP
METGLIP DS Pacific Pharmaceuticals Ltd. Glipizide 5mg+ Metformin hydrochloride 500mg Film Coated Tablet 30's: 120.00 MRP
METGLIP Plus Pacific Pharmaceuticals Ltd. Glipizide 2.5mg+ Metformin hydrochloride 500mg Film Coated Tablet 30's: 89.40 MRP
TICOZID Plus The White Horse Pharma Glipizide BP 2.5mg+ Metformin hydrochloride 500mg Film Coated Tablet 50's: 200.00 MRP

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