P : Contraindicated in pregnancy
L : Contraindicated in lactation
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Type 2 diabetes mellitus
Adult: Per tablet contains glipizide 2.5 mg and metformin 250 mg. As initial therapy: Start with 1 tablet once daily. May increase in steps of 1 tablet/day every 2 wk to lowest effective dose to a max of 4 tablets/day in divided doses. For patients previously treated with glibenclamide/sulphonylurea or metformin alone: Recommended starting dose: 2 tablets twice daily; starting dose should not exceed the daily doses of glipizide or metformin already being taken. Titrate subsequent doses based on blood glucose levels and patient's response. Daily max: 20 mg glipizide/2000 mg metformin.
|Administration||May be taken with or without food.
|Contraindications||Hypersensitivity. Type 2 diabetes mellitus; ketoacidosis; severe renal or hepatic insufficiency, diabetic coma, cardiac failure, recent MI, CHF. IDDM; severe infection; acute or chronic metabolic acidosis with or without coma; stress, trauma; severe impairment of thyroid function; dehydration, acute or chronic alcoholism. Pregnancy, lactation.|
|Special Precautions||Hypoglycaemia, stress, elderly. Thyroid impairment, monitor blood-glucose conc and renal function regularly.|
|Adverse Drug Reaction(s)||Glipizide: GI upsets, diarrhoea, nausea;
allergic skin reactions, leucopaenia, thrombocytopaenia, agranulocytosis, hyponatraemia; jaundice; haemolytic anaemia, pancytopaenia. Metformin: Anorexia,
nausea, vomiting, diarrhoea, wt loss, flatulence, occasional metallic taste; weakness; hypoglycaemia; rash, malabsorption of Vitamin
Potentially Fatal: Glipizide: Hypoglycaemia in presence of renal or hepatic damage and alcohol. Metformin: Lactic acidosis in presence of renal failure and alcoholism.
Decreased effect with beta-blockers, cholestyramine, hydantoins, thiazide diuretics and urinary alkalinizers.
Metformin: Additive effect with sulphonylureas. Antagonistic effects with diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers and isoniazid.
Potentially Fatal: Glipizide: Increased glipizide levels and effects with fluconazole, gemfibrozil, ketoconazole, NSAIDs, pioglitazone and sulfonamides. Increased hypoglycaemic effects with H2 antagonists, anticoagulants, androgens, cimetidine, salicylates, tricyclic antidepressants, probenecid, MAOIs, methyldopa, digitalis glycosides and urinary acidifiers.
Metformin: Lactic acidosis with alcohol and potentiation of hypoglycaemic effect. cimetidine and furosemide may increase plasma-metformin levels. Drugs eliminated via renal tubular secretion may increase metformin levels. Please consult detailed drug interactions before prescribing.
|Food Interaction||Absorption delayed.|
|Pregnancy Category (FDA)||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Pharmacology||Glipizide stimulates insulin release from pancreatic Î²-cells and reduces gluconeogenesis in liver cells. It also increases insulin sensitivity at target sites. Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).|
|ATC Classification||A10BB07 - glipizide; Belongs to the class of sulfonamides, urea derivatives.
Used in the treatment of diabetes.
A10BA02 - metformin; Belongs to the class of biguanides. Used in the treatment of diabetes.
Total Products : 8
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|GLYMIN PLUS||Healthcare Pharmacuticals Ltd.||Glipizide 2.5 mg + Metformin Hydrochloride 500 mg Tablet||Tablet||30's MRP 97.5 Tk|
|Mefoglip 250||Incepta Pharmaceuticals Limited||Glipizide 2.5 mg + Metformin Hydrochloride 250 mg Tablet||Tablet||10x5's:MRP 95 Tk|
|Mefoglip 500||Incepta Pharmaceuticals Limited||Glipizide 2.5 mg + Metformin Hydrochloride 500 mg Tablet||Tablet||10x3's:MRP 84 Tk|
|Mefoglip DS||Incepta Pharmaceuticals Limited||Glipizide 5 mg + Metformin Hydrochloride 500 mg Tablet||Tablet||10x3's:MRP 111 Tk|
|METGLIP||Pacific Pharmaceuticals Ltd.||Glipizide 2.5mg+ Metformin hydrochloride 250mg||Film Coated Tablet||50's: 95.00 MRP|
|METGLIP DS||Pacific Pharmaceuticals Ltd.||Glipizide 5mg+ Metformin hydrochloride 500mg||Film Coated Tablet||30's: 120.00 MRP|
|METGLIP Plus||Pacific Pharmaceuticals Ltd.||Glipizide 2.5mg+ Metformin hydrochloride 500mg||Film Coated Tablet||30's: 89.40 MRP|
|TICOZID Plus||The White Horse Pharma||Glipizide BP 2.5mg+ Metformin hydrochloride 500mg||Film Coated Tablet||50's: 200.00 MRP|
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