P / L : Contraindication for pregnancy & lactation (breast feeding)
|| See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||
Gliclazide is indicated for:
|Dosage & Administration||
For Gliclazide 80mg plain formulation: Initially, 40-80 mg daily gradually increased to 320 mg daily if necessary. Doses >160 mg daily may be given in 2 divided doses.
If a dose is forgotten, the patient should be advised to skip the missed dose and take his or her usual dose at the regular time the next day. The dose taken on the next day should not be increased to account for the missed dose.
|Contraindications||Type 1 DM, diabetes complicated with ketoacidosis; hypersensitivity; severe renal and hepatic impairment. Pregnancy and lactation.|
|Special Precautions||Monitor blood glucose concentration. May require insulin during metabolic stress. Care when transferring from combination therapy. Increased risk of severe hypoglycaemia in elderly, debilitated patients, patients with hepatic or renal impairment. Risk of hypogylcaemia when caloric intake is deficient, after strenuous exercise, when taken with ethanol or when >1 antidiabetic drug is used.|
|Adverse Drug Reaction(s)||GI disturbances, skin reaction, leucopenia, thrombocytopenia, agranulocytosis, haemolytic anaemia, cholestatic jaundice, vomiting, diarrhoea, gastritis, increased transaminases.|
|Drug Interactions||Nausea and flushing with alcohol. Hypoglycaemic effect increased by salicylates, phenylbutazone, clofibrate, sulphonamides, oral anticoagulants and MAOIs. Hypoglycaemic effect diminished by rifampicin, barbiturates, alcohol, diuretics, diazoxide, corticosteroids, β-blockers, oestrogens and sympathomimetic drugs; dose adjustment may be required.
|Pharmacology||Gliclazide stimulates insulin secretion from pancreatic β-cells, reduces hepatic gluconeogenesis, and lowers blood glucose concentrations. It also inhibits platelet aggregation at therapeutic doses.
Duration: >12 hr.
Absorption: Readily absorbed from the GI tract (oral).
Distribution: Protein-binding: 94%.
Metabolism: Extensively hepatic; converted to inactive metabolites.
Excretion: Urine (60-70% metabolites and small amounts of unchanged drug); faeces (10-20%); 10-12 hr (elimination half-life).
|ATC Classification||A10BB09 - gliclazide; Belongs to the class of sulfonamides, urea derivatives. Used in the treatment of diabetes.|
*MR: Modified Release
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|ADMIRA MR||Unimed & Unihealth Manufacturers Ltd.||Gliclazide 30mg||Tablet (Modified Release)||30's: 180.00 MRP|
|ADMIRA-80||Unimed & Unihealth Manufacturers Ltd.||Gliclazide 80mg||Tablet||30's: 180.00 MRP|
|COMPRID XR 30||Square Pharmaceuticals Ltd.||Gliclazide 30mg||Tablet||3x10's: 181.20 MRP|
|COMPRID XR 60||Square Pharmaceuticals Ltd.||Gliclazide 60mg||Tablet||3x10's: 330.90 MRP|
|COMPRID,||Square Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||6x10's: 421.20 MRP|
|Consucon||Incepta Pharmaceuticals Limited||Gliclazide 80mg Tablet||Tablet||10x5's :MRP 300 Tk|
|Consucon MR||Incepta Pharmaceuticals Limited||Gliclazide 30mg Tablet||Tablet||10x5's:MRP 350 Tk|
|DIACON||Apex Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||50's: 225.00 MRP|
|DIACON-80||Millat Pharmaceuticals Ltd||Gliclazide 80mg||Tablet||50's: 300.00 MRP|
|DIAGLE||Aexim Pharmaceutical Ltd.||Gliclazide 80mg||Tablet||50's: 225.00 MRP|
|DIAMICRON MR||Servier Bangladesh Operation||Gliclazide 30mg & 60mg modified release tablets||Tablet||30's each: 345.90 & 541.50 IP|
|DIAPRID||Alco Pharma Ltd||Gliclazide 80mg||Tablet||30's: 150.00 MRP|
|DIAPRO||Beximco Pharmaceuticals Ltd||Gliclazide 80mg tablet||Tablet||50's: 350.00 MRP|
|DIAPRO MR||Beximco Pharmaceuticals Ltd||Gliclazide 30mg MR tablet||Tablet (Modified Release)||30's: 210.00 MRP|
|DIATROL||Pacific Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||50's, 100's: 400.00 & 800.00 MRP|
|DIATROL MR||Pacific Pharmaceuticals Ltd.||Gliclazide 30mg||Tablet (Modified Release)||50's: 400.00 MRP|
|DIGREEN||Nipa Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||50's: 225.00 MRP|
|DIMEROL||Drug International Ltd||Gliclazide 80mg||Tablet||50's: 350.00 MRP|
|DIMEROL-MR||Drug International Ltd||Gliclazide 30mg||Tablet (Modified Release)||50's: 300.00 MRP|
|EUCRON||Euro Pharma Ltd.||Gliclazide 80mg||Tablet||50's: 300.00 MRP|
|EZIDE||Edruc Limited||Gliclazide 80mg||Tablet||50's: 300.00 IP|
|GIDE||Medicon Laboratories Ltd||Gliclazide 80mg||Tablet||50's: 300.00 MRP|
|GLAD||Sandoz/Novartis||Gliclazide 80mg||Tablet||5x10's, MRP 350.00|
|GLAZID||Techno Drugs||Gliclazide 80mg||Tablet||30's, 60's: 180.00 & 360.00 MRP|
|GLICA||Modern Pharmaceuticals Ltd||Gliclazide 80mg||Tablet||40's: 200.00 MRP|
|GLICASIL||Silva Pharmaceuticals Limited||Gliclazide 80mg||Tablet||50's: 250.94 MRP|
|GLICLID||The Acme Laboratories Ltd.||Gliclazide 80mg||Tablet||40's: 144.00 MRP|
|GLICRON||Renata Limited||Gliclazide 80mg||Tablet||30's: 150.00 MRP|
|GLICRON CR||Renata Limited||Gliclazide 30mg||Capsule(controlled release)||30's: 180.60 MRP|
|GLIMICRON||The White Horse Pharma||Gliclazide 80mg||Tablet||50's: 350.00 MRP|
|GLIMICRON MR||The White Horse Pharma||Gliclazide 30mg||Tablet (Modified Release)||50's: 300.00 MRP|
|GLITAB||Hudson Pharmaceuticals Ltd||Gliclazide 80mg||Tablet||100's: 450.00 MRP|
|GLITZ||Sharif Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||30's: 210.00 MRP|
|GLIZID||Opsonin Pharma Limited||Gliclazide 80mg||Tablet||30's: 180.00 MRP|
|GLIZID MR||Opsonin Pharma Limited||Gliclazide 30mg||Tablet (Modified Release)||30's: 180.00 MRP|
|GLUCOSTAT||Biopharma Laboratories Ltd||Gliclazide 80mg||Tablet||50's: 301.00 MRP|
|GLUCOZID||Aristopharma Ltd.||Gliclazide 80mg||Tablet||50's: 300.00 MRP|
|GLUZIT||Popular Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||50's: 276.00 MRP|
|GORED||General Pharmaceuticals Ltd||Gliclazide 80mg||Tablet||50's: 301.00 MRP|
|GORED MR||General Pharmaceuticals Ltd||Gliclazide 30mg||Tablet (Modified Release)||28's: 247.24 MRP|
|KEZID||Kemiko Pharmaceuticals Ltd||Gliclazide 80mg||Tablet||50's: 300.00 MRP|
|LOZIDE||ACI Ltd.||Gliclazide 80mg||Tablet||40's: 240.80 MRP|
|OCLAZID||Orion Pharma Ltd.||Gliclazide 80mg||Tablet||50's: 301.00 MRP|
|OCLAZID MR||Orion Pharma Ltd.||Gliclazide 30mg||Tablet (Modified Release)||30's: 180.60 MRP|
|ORAZID||Somatec Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||30's: 150.60 MRP|
|PROGLID||Supreme Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||30's: 150.00 MRP|
|SINAZID||IBN SINA Pharmaceutical Industry Ltd.||Gliclazide 80mg||Tablet||50's: 325.00 IP|
|SUCLEER||R A K Pharmaceuticals Pvt. Ltd.||Gliclazide 80mg||Tablet||50's: 300.00 MRP|
|SUCLEER MR||R A K Pharmaceuticals Pvt. Ltd.||Gliclazide 30mg||Tablet (Modified Release)||30's: 180.00 MRP|
|SUCOTAB||Globe Pharmaceuticals Ltd||Gliclazide 80mg||Tablet||50's: 250.00 MRP|
|SUGRED||Ad-din pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||30's: 180.00 MRP|
|XIDO||Delta Pharma Limited||Gliclazide 80mg||Tablet||50's: 250.00 MRP|
|ZENZIDE||Zenith Pharmaceuticals Ltd.||Gliclazide 80mg||Tablet||30's: 150.00 MRP|
|ZIDE||Pharmadesh Laboratories Limited||Gliclazide 80mg||Tablet||50's: 300.00 MRP|
Why is Gliclazide prescribed?
Gliclazide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Gliclazide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. Gliclazide will only help lower blood sugar in people whose bodies produce insulin naturally. Gliclazide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).
The information in this section for gliclazide varies according to the condition being treated and the particular preparation used.
How should Gliclazide be used?
Gliclazide comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. To help you remember to take gliclazide, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take gliclazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
In diabetes, the body may not be able to produce enough insulin or the insulin that it produces may not have the full effect. In some instances, the body may not be able to produce any insulin at all. These can all lead to problems controlling the blood sugar level.
It is very important that your blood sugar level is well controlled. Blood sugar levels which are too high or too low can be dangerous. Your prescriber or a member of your diabetes team will be able to give you information on how to recognise the warning signs of high and low blood sugar levels. They will also be able to inform you what to do if either of these occurs.
Warning signs can vary from person to person. If the usual warning signs of poorly controlled blood sugar levels change or disappear, you should contact your prescriber or a member of your diabetes team.
The amount of Gliclazide you need to control your blood sugar levels will be worked out by your prescriber or your diabetes team. They may also advise you to measure your blood sugar regularly & they will show you how to do this. If you are having problems controlling or measuring your blood sugar, you should contact your prescriber or a member of your diabetes team.
Other information about Gliclazide:
- your doctor may start you on a low dose of Gliclazide and then increase the dose depending on how you respond to treatment
- your prescriber may vary the dose of your medicine to find what is best for controlling your blood sugar level, especially if your circumstances change. These circumstances may include: if you have a high temperature; if you have an infection; changes to your health during periods of illness, trauma or emotional stress; if you are about to have surgery; changes to your diet and timing of your meals; or changes to the amount of physical activity that you are doing
Do not share your medicine with other people. It may not be suitable for them and may harm them.
If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.
Whether Gliclazide is suitable for you
Gliclazide is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing Gliclazide knows your full medical history.
Your prescriber may only prescribe Gliclazide with special care or may not prescribe it at all if you:
- are allergic or sensitive to or have had a bad reaction to sulphonylureas or sulphonamides in the past
- are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
- are breast-feeding
- are elderly
- have certain types of heart and circulation or metabolic problems such as thyroid problems, adrenal or pituitary gland problems that increase the risk of having hypoglycaemia
- have glucose-6-phosphate dehydrogenase deficiency
- have ketoacidosis or are at risk of going into a coma
- have kidney problems
- have liver problems
- have type-1 diabetes
- you are at risk of developing hypoglycaemia because of having an inadequate diet. This includes being malnourished, having a low-calorie diet, eating at irregular intervals, skipping meals, fasting, or exercising excessively
Furthermore, the prescriber may only prescribe Gliclazide with special care or may not prescribe it at all for a child, an adolescent or for someone who is in a coma.
As part of the process of assessing suitability to take Gliclazide a prescriber may also arrange tests:
- to check that Gliclazide is having the desired effect
- to check that Gliclazide is not having any undesired effects
Over time it is possible that Gliclazide can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Gliclazide has become unsuitable, it is important that the prescriber is contacted immediately.
Alcohol can interact with certain medicines.
In the case of Gliclazide:
- Gliclazideinteracts with alcohol
It is best to avoid drinking alcohol and medicines containing alcohol while you are taking Gliclazide.
Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.
In the case of Gliclazide:
- Gliclazide is not known to interact with food. You should continue on the diet advised by your dietician or prescriber
For more advice speak to your prescriber, nutritionist or pharmacist.
Driving and operating machinery
When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.
In the case of Gliclazide:
- your ability to drive or operate machinery may be affected if your blood sugar levels are low
You should see how Gliclazide affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.
Family planning and pregnancy
Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.
In the case of Gliclazide:
- do not take Gliclazide during pregnancy
- if you become pregnant, or think you have become pregnant while taking Gliclazide, you must contact your prescriber
People with diabetes may start to have insulin instead of Gliclazide to control their blood sugar during pregnancy. If you are taking Gliclazide and are planning to become pregnant, become pregnant or think that you are pregnant, talk to a member of your diabetes team. For more information on managing your diet and your diabetes during your pregnancy, talk to your prescriber or a member of your diabetes or antenatal team.
Certain medicines can pass into breast milk and may reach your baby through breast-feeding.
In the case of Gliclazide:
- it is not known whether Gliclazide passes into breast milk
- women who are breast-feeding must not take Gliclazide
Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with Gliclazide. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop Gliclazide without taking advice from your doctor.
Taking other medicines
If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.
The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.
inform your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also inform your prescriber about medicines which you have bought over the counter without prescriptions.
The following medicines may interact with Gliclazide:
- ritodrine when injected into a vein
- salbutamol when injected into a vein
- terbutaline when injected into a vein
The following types of medicine may interact with Gliclazide:
- ACE inhibitors
- dipeptidyl peptidase-4 inhibitors
- GLP-1 receptor agonists
- H2 antagonists
- monoamine oxidase inhibitors
- non-steroidal anti-inflammatories
- other antidiabetics
If you are taking Gliclazide and one of the above medicines or types of medicines, make sure your prescriber knows about it.
Complementary preparations and vitamins
Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.
If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Gliclazide.
Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.
If you experience any unusual effects while taking Gliclazide in combination with complementary preparations and vitamins, you tonform your prescriber.
What other information to know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Gliclazide.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: MedlinePlus, U.S. Natl. Library of Medicine
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.
|| See Gliclazide Product Monograph from Brand Manufacturer |||Manufacturer's|
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*Trademark name & prescribing information are the property of their respective Manufacturers.