PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

 | See TERMINOLOGY & ABBREVIATIONS |
Indication & Dosage Subcutaneous
Diabetes mellitus
Adult: Usual insulin requirement: 0.3-1 IU/kg/day; may be given in 1-2 divided doses. Dose should be individualised, to be adjusted according to patient's needs. May be used alone or in combination with a fast-acting insulin. 
Renal impairment: Dosage reduction may be needed. 
Hepatic impairment: Dosage reduction may be needed.
Administration Should be taken with food.
Overdosage Overdose may lead to hypoglycaemic attack. Mild hypoglycaemia can be treated by oral admin of glucose or sugary products. Severe attack whereby the patient has become unconscious may require treatment using IM or SC glucagon (0.5-1 mg); IV glucose must be given concurrently if patient does not respond after 10-15 minutes. Oral carbohydrate should be administered after patient regains consciousness to prevent relapse.
Special Precautions Monitor for signs of hypoglycaemia. Insulin requirements may change when there is illness, emotional disturbance or other stresses. Renal and hepatic impairment. Monitor blood glucose and haemoglobin A1c. Caution when changing insulin as changes in strength, brand, type, manufacturer and source may result in dosage changes. Inj area should be rotated to reduce the risk of lipodystrophy and inj-site reactions e.g. redness and inflammation. β-blockers may mask symptoms of hypoglycaemia. Pregnancy and lactation.
Adverse Drug Reactions Inj site reactions e.g. swelling, redness, itch and pain.
Potentially Fatal: Anaphylactic reactions.
Drug Interactions Concurrent use with oral antidiabetic agents, MAOIs, ACE inhibitors, salicylates, alcohol, anabolic steroids and non-selective β-blockers may reduce insulin requirements. Drugs that may increase insulin requirements include: Oral contraceptives, thiazides, thyroid hormones, growth hormone, danazol and β-sympathomimetics. Octreotide may affect insulin requirement.
Storage Subcutaneous: Unopened vial or pen: Store at 2-8°C. Used vial and pen should be stored below 25°C; discard after 4 wk.
Pharmacology Insulin isophane (human) is a crystalline suspension of human insulin with protamine and zinc. It is an intermediate-acting insulin. Insulin facilitates the uptake of glucose by binding to receptors on muscle and fat cells; it also inhibits glucose output from liver.
Onset: 1-2 hr.
Duration: 18-24 hr.
Absorption: Takes 6-12 hr to reach peak levels.
Excretion: Urine.

Brand/Product Info


Total Products : 11           
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ANSULIN N 100 Square Pharmaceuticals Ltd. Insulin Human (rDNA) 100 IU/ml SC Injection 10 ml: 415.00 MRP
ANSULIN N 40 Square Pharmaceuticals Ltd. Insulin Human (rDNA) 40 IU/ml SC Injection 10 ml: 195.00 MRP
ANSULIN N PEN Square Pharmaceuticals Ltd. Insulin Human (rDNA) 100 IU/ml SC Injection 3 ml: 220.00 MRP
HUMULIN N Eli Lilly/International Agencies (Bd.) Ltd. Neutral isophane (NPH) human insulin (rDNA) 100 IU/ml Injection 4ml & 10ml vial x1's; 3ml cartridge x5's: 316.00 & 666.00; 1957.30 MRP
INSUL N Popular Pharmaceuticals Ltd. Neutral isophane human insulin (rDNA) BP 40 IU & 100 IU/ml Injection 40 IU x10ml: 195.00; 100 IU 10ml vial x1's & 3ml cartridge x5's: 415.00 & 1110.00 MRP
INSULATARD HM Novo Nordisk Pharma (Private) Ltd. Neutral isophane human insulin (rDNA) BP 100 IU/ml, Penfill Injection 3ml x5's: 1830. 00 MRP
INSULATARD HM 100IU Novo Nordisk Pharma (Private) Ltd. Neutral isophane human insulin (rDNA) BP 100 IU/ml Injection 10ml vial: 580.00 MRP
INSULATARD HM 40IU Novo Nordisk Pharma (Private) Ltd. Neutral isophane human insulin (rDNA) BP 40 IU/ml Injection 10ml vial: 260.00 MRP
INSULET N Aristopharma Ltd. Neutral isophane human insulin (rDNA) BP 100 IU/ml Injection 4ml & 10ml vial: 169.70 & 415.00 MRP
INSUMAN Basal Sanofi Neutral isophane (NPH) human insulin (rDNA) 100 IU/ml Injection 5ml vial: 281.70 MRP
MAXSULIN N Incepta Pharmaceuticals Limited Human Insulin (rDNA) BP 40 & 100 IU/ml as Isophane Human Insulin (NPH) Injection 10ml vial each: 195.00 & 415.00 MRP