(in' su lin) (as' part)
P / L : Caution - pregnancy & lactation (breast feeding)
||See TERMINOLOGY & ABBREVIATIONS ||
|Indication(s) & Dosage||Subcutaneous
Adult: Administer 5-10 min before meal. Usual range: 0.5-1 units/kg/day. When used in a meal-related SC inj treatment regimen, insulin aspart may provide 50-70% of total insulin requirement with the remainder provided by an intermediate-acting or long-acting insulin.
Renal impairment: Decreased dose may be necessary.
Hepatic impairment: Decreased dose may be necessary.
Special Populations: Renal impairment: CrCl 10-50 mL/min: 75% of normal dose; <10 mL/min: 25-50% of normal dose and monitor glucose closely.
|Administration||May be taken with or without food.
|Special Precautions||Renal or hepatic impairment; pregnancy; lactation. Transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections; hypokalaemia.|
|Adverse Drug Reaction(s)||Hypoglycaemia; oedema; pruritus; rash; hypersensitivity reactions; lipoatrophy or lipohypertrophy with SC Inj (rotate Inj site).|
|Drug Interactions||Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by Beta-blockers, clonidine.|
|Pregnancy Category (FDA)||Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).|
|Pharmacology||Insulin aspart, a rapid-acting analog of human insulin, lowers blood glucose levels; it regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.
Onset: 0.5 hr.
Duration: 3-5 hrs.
|ATC Classification||A10AB05 & A10AD05- insulin aspart; Belongs to the class of fast-acting insulins and analogues as well as intermediate-acting combined with fast-acting insulins and analogues. Used in the treatment of diabetes.
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|NOVORAPID Flexpen||Novo Nordisk Pharma (Private) Ltd.||Insulin Aspart, recombinant (rDNA) rapid acting human insulin analog 100 units/ml penfill||Injection||3ml: 860.00 MRP|
|NOVORAPID Penfill||Novo Nordisk Pharma (Private) Ltd.||Insulin Aspart, recombinant (rDNA) rapid acting human insulin analog 100 units/ml penfill||Pre-filled Pen||3ml x5's: 3850.00 MRP|
Why is Insulin aspart prescribed?
Insulin aspart is used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat people with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) who need insulin to control their diabetes. In patients with type 1 diabetes, insulin aspart is usually used with another type of insulin, unless it is used in an external insulin pump. In patients with type 2 diabetes, insulin aspart also may be used with another type of insulin or with oral medication(s) for diabetes. Insulin aspart is a short-acting, manmade version of human insulin. Insulin aspart works by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar.
How to use Insulin aspart?
Insulin aspart comes as a solution (liquid) to inject subcutaneously (under the skin). It is usually injected 5 to 10 minutes before eating a meal. Your doctor will inform you how many times you tonject insulin aspart each day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Use insulin aspart exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Never use insulin aspart when you have symptoms of hypoglycemia (low blood sugar) or if you have checked your blood sugar and found it to be low. Do not inject insulin into a skin area that is red, swollen, itchy, or thickened.
Insulin aspart controls diabetes but does not cure it. Continue to use insulin aspart even if you feel well. Do not stop using insulin aspart without talking to your doctor. Do not switch to another brand or type of insulin or change the dose of any type of insulin you are using without talking to your doctor. Always check the insulin label to make sure you received the right type of insulin from the pharmacy.
Insulin aspart comes in vials, cartridges that contain medication and are to be placed in dosing pens, and dosing pens that contain cartridges of medication. Be sure you know what type of container your insulin aspart comes in and what other supplies, such as needles, syringes, or pens, you will need to inject your medication.
If your insulin aspart comes in vials, you will need to use syringes to inject your dose. Ask your doctor to show you how to inject insulin aspart using a syringe. Ask your doctor if you have questions about the type of syringe you should use.
If your insulin aspart comes in cartridges, you will need to buy an insulin pen separately. Check the manufacturer's information for the patient to see what type of pen is right for the cartridge size you are using. Carefully read the instructions that come with your pen, and ask your doctor to show you how to use it. Ask your doctor if you have questions about the type of pen you should use.
If your insulin aspart comes in pens, be sure to read and understand the manufacturer's instructions. Ask your doctor to show you how to use the pen. Follow the directions carefully, and always prime the pen before use.
Never reuse needles or syringes and never share needles, syringes, cartridges, or pens. If you are using an insulin pen, always remove the needle right after you inject your dose. Throw away needles and syringes in a puncture-resistant container. Ask your doctor how to dispose of the puncture-resistant container.
Your doctor may inform you to mix your insulin aspart with another type of insulin (NPH insulin) in the same syringe. Your doctor will inform you exactly how to do this. Always draw insulin aspart into the syringe first, always use the same brand of syringe, and always inject the insulin immediately after mixing. Insulin aspart should not be mixed with insulin preparations other than NPH insulin.
Your doctor may inform you to dilute insulin aspart before injection to allow easier measurement of your dose. Your doctor will inform you exactly how to do this.
You can inject your insulin aspart in your thighs, stomach, upper arms, or buttocks. Never inject insulin aspart into a vein or muscle. Change (rotate) the injection site within the chosen area with each dose; try to avoid injecting the same site more often than once every 1 to 2 weeks.
Always look at your insulin aspart before you inject it. It should be clear and colorless. Do not use your insulin aspart if it is colored, cloudy, thickened, or contains solid particles, or if the expiration date on the bottle has passed.
Insulin aspart also can be used with an external insulin pump. Before using insulin aspart in a pump system, read the pump label to make sure the pump can be used for continuous delivery of fast-acting insulin. Read the pump manual for recommended reservoir and tubing sets, and ask your doctor to show you how to use the insulin pump. Do not dilute insulin aspart or mix it with any other type of insulin when using it in an external insulin pump. When using insulin aspart with an external insulin pump, replace the insulin in the reservoir at least every 6 days, and change the infusion set and infusion set insertion site at least every 3 days. If the infusion site is red, itchy, or thickened, inform your doctor and use a different infusion site.
When using insulin apart in an external insulin pump, high blood sugar may occur quickly if the pump stops working properly or if the insulin in the pump reservoir is exposed to direct sunlight or temperatures greater than 98.6Â°F (37Â°C). High blood sugar may also occur if the tubing leaks or becomes blocked, disconnected, or kinks. If the problem cannot be found quickly and corrected, call your doctor right away. You may need to temporarily use insulin by subcutaneous injection (using syringes or an insulin pen). Make sure you have back-up insulin and any necessary supplies on hand, and ask your doctor to show you how to use them.
Other uses for Insulin aspart
Insulin aspart may be prescribed for other uses; ask your doctor for more information.
What special precautions to follow?
- inform your doctor if you are allergic to insulin (Humulin, Novolin, others), any of the ingredients of insulin aspart, or any other medications. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
- inform your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandolapril; beta blockers such as atenolol, labetalol, metoprolol, nadolol, and propranolol; certain cholesterol-lowering medications such as fenofibrate, gemfibrozil, and niacin; clonidine; danazol; digoxin; disopyramide; diuretics; fluoxetine; hormone replacement therapy; isoniazid; lithium; medications for asthma and colds; medications for mental illness and nausea; monoamine oxidase inhibitors, including isocarboxazid, phenelzine, selegiline and tranylcypromine; octreotide; oral contraceptives; oral medications for diabetes; oral steroids such as dexamethasone, methylprednisolone, and prednisone; pentamidine; reserpine; salicylate pain relievers such as aspirin, choline magnesium trisalicylate, choline salicylate, diflunisal, magnesium salicylate, and salsalate; somatropin; sulfa antibiotics; and thyroid medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- inform your doctor if you have or have ever had nerve damage caused by your diabetes or if you have any other medical conditions, including kidney or liver disease.
- inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using insulin aspart, call your doctor.
- if you are having surgery, including dental surgery, inform the doctor or dentist that you are using insulin aspart.
- alcohol may cause a change in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are using insulin aspart.
- ask your doctor what to do if you get sick, experience unusual stress, or change your diet, exercise, or activity schedule. These changes can affect your dosing schedule and the amount of insulin you will need.
- ask your doctor how often you should check your blood sugar. Be aware that hypoglycemia may affect your ability to perform tasks such as driving and ask your doctor if you need to check your blood sugar before driving or operating machinery.
Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthful diet, and to eat about the same amounts of the same kinds of food at about the same times each day. Skipping or delaying meals or changing the amount or kind of food you eat can cause problems with your blood sugar control.
Insulin aspart must be injected shortly before or after a meal. If you remember your dose before or shortly after your meal, inject the missed dose right away. If some time has passed since your meal, follow the instructions provided by your doctor or call your doctor to find out whether you tonject the missed dose. Do not inject a double dose to make up for a missed one.
Insulin aspart may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.
Insulin aspart may cause side effects. inform your doctor if any of these symptoms are severe or do not go away
redness, swelling, or itching at the site of the injection
changes in the feel of your skin, skin thickening (fat build-up), or a little depression in the skin (fat breakdown)
swelling of the hands and feet
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency treatment:
rash and/or itching over the whole body
shortness of breath
Insulin aspart may cause other side effects. Call your doctor if you have any unusual problems while using Insulin aspart.
What to know about storage and disposal of Insulin aspart?
Keep Insulin aspart in the container it came in and out of reach of children. Store unopened insulin aspart vials, cartridges, and pens in the refrigerator but do not freeze them. Unopened refrigerated insulin aspart can be stored until the date shown on the company's label.
If no refrigerator is available (for example, when on vacation), store the vials, cartridges, or pens at room temperature and away from direct sunlight and extreme heat. Unrefrigerated vials, cartridges, and pens can be used within 28 days or after that time they must be thrown away. Unrefrigerated pens containing Novolog Mix 70/30 can be used within 14 days or after that time they must be thrown away. Opened vials can be stored for 28 days at room temperature or in the refrigerator. If your doctor informs you to dilute your insulin aspart, the vial of diluted medication can be stored for up to 28 days in the refrigerator or at room temperature. Opened cartridges and pens may be stored at room temperature for up to 28 days; do not refrigerate them. Opened pens containing Novolog Mix 70/30 may be stored at room temperature for up to 14 days; do not refrigerate them. Throw away any insulin aspart that has been exposed to extreme heat or cold.
Throw away any medication that is outdated or no longer needed.
What other information to know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Insulin aspart.
Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: MedlinePlus, U.S. Natl. Library of Medicine
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.