mph Bangladesh

PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

Indication(s) & Dosage Hyperthyroidism, Adjunct to radio-iodine therapy, Grave's disease, Preparation for thyroidectomy
Adult: Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth.
Child: 4-12 yr: Initially, 15 mg daily.
Administration May be taken with or without food.
Contraindications Hyperthyroidism due to nodular goitre.
Special Precautions Liver diseases, pregnancy, lactation.
Adverse Drug Reaction(s) Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia.
Potentially Fatal: Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre.
Drug Interactions Potentially Fatal: Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid. Please consult detailed drug interactions before prescribing.
Pregnancy Category (FDA) Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Storage Oral: Store below 25°C.
Pharmacology Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase.
Absorption: Rapid from the GIT (oral); peak plasma concentrations after 1-2 hrs.
Distribution: High concentrations in the thyroid gland; crosses the placenta; enters breast milk.
Metabolism: Hepatic; converted to methimazole.
Excretion: Urine (<12% unchanged drug); 3-6 hrs (elimination half-life).
ATC Classification H03BB01 - carbimazole; Belongs to the class of sulfur-containing imidazole derivative agents. Used in the management of thyroid diseases.

Brand/Product Info

Total Products : 2  
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
CARBIROID The White Horse Pharma Carbimazole BP 5mg Tablet 100's: 480.00 MRP
CARBIZOL 5 Square Pharmaceuticals Ltd. Carbimazole 5mg Tablet 6x10's: 180.60 MRP
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