P  - Caution when used during pregnancy

L  - Contraindicated in lactation

Molecule Info

 
Indication & Dosage Oral
Prophylaxis of ischaemic events
Adult: Each tablet contains clopidogrel 75 mg and aspirin 75 mg: 1 tablet once daily.
CrCl (ml/min) Dosage Recommendation
<10 Avoid use.
Hepatic impairment: Severe hepatic impairment: Avoid use.
Oral
Acute coronary syndrome
Adult: Each tablet contains clopidogrel 75 mg and aspirin 75 mg: Loading dose: 4 tablets; maintenance: 1 tablet daily.
CrCl (ml/min) Dosage Recommendation
<10 Avoid use.
Hepatic impairment: Severe hepatic impairment: Avoid use.
Contraindications Hypersensitivity to aspirin, NSAIDs or clopidogrel; active peptic ulceration; children <12 yr; patients with haemophilia or haemorrhagic disorders; gout; severe renal or hepatic impairment; lactation.
Special Precautions History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion or heavy ethanol consumption; asthma or allergic disorders; tinnitus; dehydrated patients; uncontrolled hypertension; impaired renal or hepatic function; children and elderly; pregnancy. Patients at risk of increased bleeding from trauma, surgery, or other pathological conditions. Increased risk of Reye's syndrome when used in patients with chicken pox, influenza or flu symptoms. Caution when used in patients with nasal allergies or nasal polyps. For patients undergoing elective surgery and an antiplatelet effect is not needed, clopidogrel should be discontinued 7-10 days before surgery.
Adverse Drug Reactions Aspirin: GI disturbances, epigastric discomfort, prolonged bleeding time, rhinitis, urticaria; angioedema, salicylism, tinnitus. Clopidogrel: Dyspepsia, abdominal pain, nausea, vomiting, flatulence, constipation, gastritis, gastric and duodenal ulcers. Serious events include bleeding and GI haemorrhage. GI upset, diarrhoea, paraesthesia, vertigo, headache, dizziness, leucopaenia, eosinophilia, rash and pruritus.
Potentially Fatal: Aspirin: Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (childn <12 yrs). Hepatotoxicity; CNS depression, which may lead to coma; CV collapse, resp failure; paroxysmal bronchospasm and dyspnoea. Clopidogrel: Bleeding disorders including GI intracranial haemorrhage and thrombotic thrombocytopenic purpura.
Drug Interactions Aspirin: Corticosteroids, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Use with coumarins, anagrelide, agatroban, LMWH, bivalirudin, dasatinib, iloprost, lepirudin and tenecteplase may increase the risk of bleeding. Clopidogrel: Co-administration of clopidogrel with NSAIDs may increase the risk of stomach and intestinal bleeding. There is an increased risk of bleeding with coumarins, agatroban, dasatinib, heparin, LMWH, gingko biloba and iloprost. Increased risk of bleeding if clopidogrel and drotrecogin alfa are given within 7 days. May increase bupropion level and side effects (lightheadedness , GI discomfort).
Potentially Fatal: Aspirin and clopidogrel: Increased risk of bleeding with dabigatran. Please consult detailed drug interactions before prescribing.
Lab Interference Aspirin: Affects urinary glucose tests using cupric sulfate(false-positive) and glucose oxidase(false-negative). Interferes with thyroid function tests.
Pharmacology Aspirin inhibits the formation of thromboxane A2 in the platelets. This inhibits platelet aggregation and coagulation. This action lasts until the enzyme cyclo-oxygenase is regenerated in the platelets. Clopidogrel is a prodrug and is metabolised an active thiol metabolite. The active metabolite selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GP IIb/IIIa complex, thereby inhibiting platelet aggregation.
Absorption: Aspirin: Rapid absorption (oral). Clopidogrel: Rapid, incomplete absorption.
Distribution: Aspirin: Widely distributed; Protein binding: 80-90%. Clopidogrel: Protein binding: 98% (parent drug).
Metabolism: Aspirin: Hydrolysed to salicylate in the gut wall; salicylate metabolised hepatically. Clopidogrel: Extensive hepatic metabolism; converted to inactive carboxylic acid derivative and thiol derivative(active).
Excretion: Aspirin: Via urine by glomerular filtration, active renal tubular secretion and passive tubular reabsorption; haemodialysis (as salicylate); 15-20 minutes (elimination half-life, parent drug). Clopidogrel: Via urine (50%) and faeces (46%) as unchanged drug and metabolites. Elimination half-life: Approx 6 hr.
ATC Classification B01AC04 - clopidogrel; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.

Brand/Product Info


Total Products : 28                            
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ANCLOG PLUS Square Pharmaceuticals Ltd. Clopidogrel 75mg + Aspirin 75mg Tablet 4x10's: 481.20 MRP
ANLET Plus Globe Pharmaceuticals Ltd Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 240.00 MRP
ASCLOP Biopharma Laboratories Ltd Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 330.00 MRP
ASPIN Plus Aristopharma Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 330.00 MRP
CARDOGREL Plus Pharmasia Limited Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 20's: 220.80 MRP
CLAS Delta Pharma Limited Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 20's: 160.00 MRP
CLOGNIL Plus Orion Pharma Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 331.20 MRP
CLONTAS Opsonin Pharma Limited Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 330.00 MRP
CLOPID-As Drug International Ltd Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 50's: 600.00 MRP
CLOPIDOL Plus Alco Pharma Ltd Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 20's: 240.00 MRP
CLOPIGEL Plus Pacific Pharmaceuticals Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 300.00 MRP
CLOPILET A Sun Pharmaceutical (Bangladesh) Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 330.00 MRP
CLOREL-A ACI Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 331.20 MRP
COMBIPLAT Beacon Pharmaceuticals Limited Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 331.20 MRP
DOREL Plus General Pharmaceuticals Ltd Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 20's: 220.80 MRP
ECOSPRIN Plus The Acme Laboratories Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 20's: 220.80 MRP
LIREL Plus Silva Pharmaceuticals Limited Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 331.25 MRP
LIVOCARD Plus The White Horse Pharma Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 360.00 MRP
Lopirel Plus Incepta Pharmaceuticals Limited Clopidogrel-Aspirin Plus Tablet 10x3's:MRP 360 Tk
LOPLATE Plus Kemiko Pharmaceuticals Ltd Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 330.00 MRP
NOCLOG Plus Eskayef Bangladesh Ltd Clopidogrel INN 75mg+ Aspirin USP 75mg Film Coated Tablet 20's MRP: 220.00
ODREL PLUS Beximco Pharmaceuticals Ltd Clopidogrel Bisulphate INN equivalent to 75mg Clopidogrel +Aspirin USP 75mg Film Coated Tablet 30's: 360.00 MRP
PLADEX-A Unimed & Unihealth Manufacturers Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 375.00 MRP
PLAGRIN Plus Renata Limited Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 20's: 220.80 MRP
PLAVIX Plus Navana Pharmaceuticals Limited Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 20's: 241.00 MRP
PRECLOT AS Popular Pharmaceuticals Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 331.21 MRP
REPLET PLUS Healthcare Pharmacuticals Ltd. Clopidogrel Bisulphate INN equivalent to 75mg Clopidogrel+ Aspirin USP 75mg Tablet 30's MRP 330 Tk
ZESPRIN Zenith Pharmaceuticals Ltd. Clopidogrel bisulphate INN 75mg+ Aspirin BP 75mg Film Coated Tablet 30's: 330.00 MRP