P - Caution when used during pregnancy
L - Contraindicated in lactation
|| See TERMINOLOGY & ABBREVIATIONS |
|ATC Classification||C01DX16 - nicorandil; Belongs to the class of other vasodilators. Used in the treatment of cardiac disease.|
|Indication(s)||ANGINA PECTORIS Adult: 10 mg bid, increase if necessary. Usual dose: 10-20 mg bid. May use 5 mg bid for patients prone to headache. Max dose: 30 mg bid.
|Dosage & Administration||
It comes as a tablet to be taken by mouth, with or without food.Adult: Oral, Initial: 10 mg twice daily. Usual dose: 10-20 mg twice daily. Max: 30 mg twice daily.
|Contraindications||Cardiogenic shock; hypotension; left ventricular failure with low filling pressure; lactation.|
|Special Precautions||Hypovolaemia, low systolic BP, acute pulmonary oedema, pregnancy. May impair ability to drive or operate machinery.|
|Adverse Drug Reaction(s)||Headache (usually transitory), flushing, dizziness, nausea, vomiting and weakness. Hypotension and reflex tachycardia at high doses.|
|Drug Interactions||Hypotensive interaction may occur with alcohol, TCAs, antihypertensives and other vasodilators.
Potentially Fatal: Hypotensive interaction may occur with alcohol, TCAs, antihypertensives and other vasodilators.
|Pregnancy Category (FDA)||Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Nicorandil, a vasodilator, is prescribed for the treatment and management of angina pectoris. The drug relaxes the blood vessels and alleviates the angina.
Nicorandil mediates vasodilatation by opening of potassium channels by stimulation of guanylate cyclase. Nicorandil significantly reduce preload and afterload of cardiovascular physiology and thereby improves coronary blood flow.
Nicorandil dilates arterioles and large coronary arteries by opening the potassium channels, and stimulates guanylate cyclase causing venous vasodilatation. It therefore reduces preload and afterload, and improves coronary blood flow.
Absorption: Absorbed well from the GI tract (oral); peak plasma concentrations after 30-60 min.
|| See UK MHRA Summary of Product Characteristics for Nicorandil |||| NICORANDIL ||