(am loe' di peen)
P - Contraindicated in pregnancy
L - Caution when used during lactation
|Indication(s) & dosage||
Amlodipine is a calcium channel blocker and may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of:
|Administration||May be taken with or without food.
|Overdosage||Overdosage may cause marked peripheral vasodilation and hypotension.|
|Contraindications||Known hypersensitivity to dihydropyridines.|
|Special Precautions||Impaired liver or renal function, CHF, sick-sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, severe aortic stenosis. Caution when used in patients with idiopathic hypertrophic subaortic stenosis. Elderly, children. Pregnancy, lactation.|
|Adverse Drug Reaction(s)||Headache, peripheral oedema, fatigue, somnolence, nausea, abdominal pain, flushing, dyspepsia, palpitations, dizziness. Rarely pruritus, rash, dyspnoea, asthenia, muscle cramps.
Potentially Fatal: Hypotension, bradycardia, conductive system delay and CCF.
|Drug Interactions||Increased metabolism with rifampin. Reduced hypotensive effect with calcium. Potentiates effects of thiazide diuretics and ACE inhibitors. Avoid combination with Î²-blockers in patients with markedly impaired left ventricular function. May increase serum levels of CYP1A2 substrates e.g. aminophylline, fluvoxamine, ropinirole. CYP3A4 inhibitors (e.g. clarithromycin, doxycycline, isoniazid, nicardipine) may increase the effects of amlodipine. Additive BP-lowering effects when used with sildenafil, tadalafil or vardenafil.|
|Pregnancy Category (FDA)||Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.|
|Storage||Store at 15-30Â°C.|
|Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial O2 delivery in patients with vasospastic angina.
Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 6-12 hr.
Distribution: Protein-binding: 97.5%.
Metabolism: Hepatic: Extensive.
Excretion: Via urine (mainly as metabolites, 10% as unchanged); 35-50 hr (elimination half-life).
|ATC Classification||C08CA01 - amlodipine; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.|
Search Google: Amlodipine
|Brand Name||Manufacturer/Marketer||Composition||Dosage Form||Pack Size & Price|
|AMDIN||Alco Pharma Ltd||Amlodipine 5mg & 10mg||Tablet||5mg x 50's, 10mg x 30's: 200.00 & 180.00 MRP|
|AMDOCAL 10||Beximco Pharmaceuticals Ltd||Amlodipine Besilate BP eq. to Amlodipine 5mg||Tablet||60's: 420.00 MRP|
|AMDOCAL 5||Beximco Pharmaceuticals Ltd||Amlodipine Besilate BP eq. to Amlodipine 5mg||Tablet||100's: 500.00 MRP|
|AMDOPER||Hallmark Pharmaceuticals Ltd||Amlodipine 5mg||Tablet||5mg x 30's: 90.30 MRP|
|AMDOPIN||Ziska Pharmaceuticals Ltd.||Amlodipine 5mg||Tablet||5mg x 50's: 175.00 MRP|
|AMLO||Pharmadesh Laboratories Limited||Amlodipine 5mg||Tablet||5mg x 50's: 175.00 MRP|
|AMLOCARD||Drug International Ltd||Amlodipine 5mg & 10mg||Tablet||5mg x 100's, 10mg x 50's: 450.00 & 350.00 MRP|
|AMLOMARK 5||Marksman Pharmaceuticals Ltd||Amlodipine 5mg/tablet||Tablet||5mg x 30s pack: 60.00 MRP|
|AMLOPIN||The Acme Laboratories Ltd.||Amlodipine 5mg & 10mg||Tablet||5mg x 30's, 10mg x 30's: 120.30 & 180.60 MRP|
|AMLOSIN-5||Doctors Chemical Works Ltd||Amlodipine 5mg||Tablet||5mg x 30's: 102.30 MRP|
|AMLOSUN||Sun Pharmaceutical (Bangladesh) Ltd.||Amlodipine 5mg||Tablet||5mg x 50's: 202.50 MRP|
|Amlotab 5||Incepta Pharmaceuticals Limited||Amlodipine Besilate BP equivalent to Amlodipine 5mg||Tablet||10x5's :MRP 250 Tk|
|AMLOVAS||Popular Pharmaceuticals Ltd.||Amlodipine 5mg & 10mg||Tablet||5mg x 50's, 10mg x 30's: 175.50 & 180.60 MRP|
|AMLOWIDE||Beacon Pharmaceuticals Limited||Amlodipine 5mg||Tablet||5mg x 50's: 150.50 MRP|
|AMO 5||Opsonin Pharma Limited||Amlodipine 5mg/tablet||Tablet||5mg x 50s pack: 149.99 MRP|
|AMO-10||Delta Pharma Limited||Amlodipine 10mg||Tablet||10mg x 30's: 165.00 MRP|
|AMOCAL||Opsonin Pharma Limited||Amlodipine 5mg & 10mg||Tablet||5mg x 30's, 10mg x 30's: 120.00 & 180.00 MRP|
|AMPIL||The White Horse Pharma||Amlodipine 5mg||Tablet||5mg x 50's: 200.00 MRP|
|AMPRE||Kumudini Pharma Ltd||Amlodipine 5mg||Tablet||5mg x 30's: 105.00 MRP|
|AMTINOL||Euro Pharma Ltd.||Amlodipine 5mg||Tablet||5mg x 30's: 120.00 MRP|
|CAB||ACI Ltd.||Amlodipine 5mg||Tablet||5mg x 50's: 201.00 MRP|
|CALCHEK||General Pharmaceuticals Ltd||Amlodipine 5mg||Tablet||5mg x 50's: 201.00 MRP|
|CALOCK||Medimet Pharmaceuticals Ltd||Amlodipine 5mg & 10mg||Tablet||5mg x 50's, 10mg x 50's: 175.00 & 187.50 MRP|
|CALPIN||Globe Pharmaceuticals Ltd||Amlodipine 5mg||Tablet||5mg x 50's: 150.00 MRP|
|CALVASC||Unimed & Unihealth Manufacturers Ltd.||Amlodipine 5mg & 10mg||Tablet||5mg x 30's, 10mg x 30's: 120.00 & 240.00 MRP|
|CAMLODIN 10||Square Pharmaceuticals Ltd.||Amlodipine 10mg||Tablet||2x15's: 181.20 MRP|
|CAMLODIN 5||Square Pharmaceuticals Ltd.||Amlodipine 5mg||Tablet||4x15's: 301.20 MRP|
|CARDIPIN||Renata Limited||Amlodipine 5mg||Tablet||5mg x 50's: 200.00 MRP|
|CARDOSIA||Pharmasia Limited||Amlodipine 5mg||Tablet||5mg x 30's: 120.60 MRP|
|CCB||Orion Pharma Ltd.||Amlodipine 5mg||Tablet||5mg x 50's: 150.50 MRP|
|CORDIL||Techno Drugs||Amlodipine 5mg||Tablet||5mg x 30's: 90.00 MRP|
|CV NOR-10||Navana Pharmaceuticals Limited||Amlodipine 10mg||Tablet||10mg x 30's: 180.60 MRP|
|CV NOR-5||Navana Pharmaceuticals Limited||Amlodipine 5mg||Tablet||5mg x 30's: 120.60 MRP|
|DIPLME||Bristol Pharma Limited||Amlodipine 5mg||Tablet||5mg x 50's: 200.00 MRP|
|DIPLOR||IBN SINA Pharmaceutical Industry Ltd.||Amlodipine 5mg & 10mg||Tablet||5mg x 30's, 10mg x 30's: 127.50 IP, 210.60 IP|
|DOPIN||Medicon Laboratories Ltd||Amlodipine 5mg||Tablet||5mg x 30's: 120.00 MRP|
|EMLON||Biopharma Laboratories Ltd||Amlodipine 5mg & 10mg||Tablet||5mg x 50's, 10mg x 50's: 226.00 & 180.60 MRP|
|G-AMLODIPINE||Gonoshasthaya Pharmaceuticals Ltd||Amlodipine 5mg & 10mg||Tablet||30's each: 75.30 & 120.60 MRP|
|HIPRE||Pacific Pharmaceuticals Ltd.||Amlodipine 5mg & 10mg||Tablet||50's each: 200.00 & 180.00 MRP|
|HYPOTEN||Cosmic Chemical Industries Limited||Amlodipine 5mg||Tablet||30's: 105.00 MRP|
|IMPED||Rephco Laboratories Ltd.||Amlodipine 5mg||Tablet||30's: 105.00 MRP|
|IPIN||Chemist Laboratories Ltd.||Amlodipine 5mg||Tablet||30's: 105.00 MRP|
|LOCARD||Jayson Pharmaceuticals Ltd.||Amlodipine 5mg||Tablet||50's: 152.50 IP|
|LODIPIN-5||Aristopharma Ltd.||Amlodipine 5mg||Tablet||50's: 200.00 MRP|
|LOPIN||Edruc Limited||Amlodipine 5mg||Tablet||30's: 90.00 IP|
|M-CARD||Zenith Pharmaceuticals Ltd.||Amlodipine 5mg||Tablet||50's: 200.00 MRP|
|NELOB||Kemiko Pharmaceuticals Ltd||Amlodipine 5mg & 10mg||Tablet||50's each: 175.00 & 300.00 MRP|
|NELOD||Kemiko Pharmaceuticals Ltd||Amlodipine 5mg & 10mg/tablet||Tablet||5mg x 50s pack: 175.00 MRP ; 10mg x 50s pack: 300.00 MRP|
|NOPIDIN||Ad-din pharmaceuticals Ltd.||Amlodipine 5mg||Tablet||50's: 150.00 MRP|
|PRISTIN||Novo Healthcare and Pharma Ltd.||Amlodipine 5mg||Tablet||30's: 105.00 MRP|
|RAKLOPIN||R A K Pharmaceuticals Pvt. Ltd.||Amlodipine 5mg & 10mg||Tablet||5mg x 50's, 10mg x 30's: 200.00 & 180.00 MRP|
|RODIPINE||Rasa Pharmaceuticals Ltd.||Amlodipine 5mg/tablet||Tablet||5mg x 50s pack: 175.00 MRP|
|SIDOPIN||Eskayef Bangladesh Ltd||Amlodipine Besilate BP equivalent to Amlodipine 5mg||Tablet||50's MRP: 200.00|
|VASOPIN||Silva Pharmaceuticals Limited||Amlodipine 5mg & 10mg||Tablet||30's each: 120.46 & 150.97 MRP|
|VESOCAL||Rangs Pharmaceuticals Ltd.||Amlodipine 5mg & 10mg||Tablet||5mg x 50's, 10mg x 30's: 225.00 & 240.00 MRP|
|XELCARD||Healthcare Pharmacuticals Ltd.||Amlodipine 5mg/tablet||Tablet||5mg x 50s pack: 120.00 MRP|
|XELCARD||Healthcare Pharmacuticals Ltd.||Amlodipine Besilate BP equivalent to Amlodipine 5mg||Tablet||30's MRP 150 Tk|
Why this medication is prescribed for?
Amlodipine is used alone or in combination with other medications to treat high blood pressure and chest pain (angina). Amlodipine is in a class of medications called calcium channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. It controls chest pain by increasing the supply of blood to the heart. If taken regularly, amlodipine controls chest pain, but it does not stop chest pain once it starts. Your doctor may prescribe a different medication to take when you have chest pain.
How this medicine should be used?
Amlodipine comes as a tablet to take by mouth. It is usually taken once a day. To help you remember to take amlodipine, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take amlodipine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of amlodipine and gradually increase your dose.
Amlodipine controls high blood pressure and chest pain (angina) but does not cure them. Continue to take amlodipine even if you feel well. Do not stop taking amlodipine without talking to your doctor.
This medication may be prescribed for other uses; ask your doctor for more information.
Special precautions to follow
Before taking amlodipine,
- tell your doctor if you are allergic to amlodipine or any other medications.
- tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.
- tell your doctor if you have or have ever had heart failure or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking amlodipine, call your doctor.
Special dietary instructions to follow
If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.
In case of missing dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Side effects of this medication
Amlodipine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
swelling of the hands, feet, ankles, or lower legs
dizziness or lightheadedness
- flushing (feeling of warmth)
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
more frequent or more severe chest pain
rapid, pounding, or irregular heartbeat
If you experience a serious side effect, consult your doctor.
Storage conditions for this medicine
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.
In cases of emergency/overdose
In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
Symptoms of overdose may include:
- rapid heartbeat
Keep all appointments with your doctor. Your blood pressure should be checked regularly to determine your response to amlodipine.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Ref: U.S. National Library of Medicine.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.
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